NOS2 (nitric oxide synthase 2)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 4843
Gene name Nitric oxide synthase 2
Gene symbol NOS2
Synonyms (NCBI Gene)
HEP-NOSINOSNOSNOS2A
Chromosome 17
Chromosome location 17q11.2
Summary Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducibl
miRNA miRNA information provided by mirtarbase database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT007347 hsa-miR-26a-5p qRT-PCRWestern blot 23338972
MIRT007347 hsa-miR-26a-5p Luciferase reporter assay 26854724
MIRT007347 hsa-miR-26a-5p Luciferase reporter assay 26854724
MIRT732802 hsa-miR-155-5p Luciferase reporter assayqRT-PCRWestern blotting 33318876
MIRT737162 hsa-miR-939-5p qRT-PCR 33368266
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
APC Activation 11935128
FOS Activation 12788789
FOS Repression 9776360
FOSL2 Activation 12788789
IKBKB Repression 17478759
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
81
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IEA
GO:0001912 Process Positive regulation of leukocyte mediated cytotoxicity TAS 10450191
GO:0002227 Process Innate immune response in mucosa NAS 18390757
GO:0004517 Function Nitric-oxide synthase activity IBA
GO:0004517 Function Nitric-oxide synthase activity IDA 7504305, 7682706, 35772285
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
163730 7873 ENSG00000007171
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P35228
Protein name Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2)
Protein function Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7504305, PubMed:7531687, PubMed:7544004, PubMed:7682706). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitr
PDB 1NSI , 2LL6 , 2NSI , 3E7G , 3EJ8 , 3HR4 , 4CX7 , 4NOS , 5TP6 , 5XN3 , 6JWM , 6JWN , 6KEY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02898 NO_synthase 135 → 497 Nitric oxide synthase, oxygenase domain Domain
PF00258 Flavodoxin_1 541 → 672 Flavodoxin Domain
PF00667 FAD_binding_1 725 → 947 FAD binding domain Domain
PF00175 NAD_binding_1 979 → 1093 Oxidoreductase NAD-binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. Expressed in chondrocytes (PubMed:7504305). {ECO:0000269|PubMed:7504305}.
Sequence 
MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPL
VETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIM
TPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ
LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNI
RSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYG
RFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVG
GLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINI
AVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEM
LNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVT
ILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPG
NGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGD
ELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDL
SKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQ
PALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQ
LLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQL
PILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCF
VRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPD
EDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLY
VCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDR
VAVQPSSLEMSAL
Sequence length 1153
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Arginine biosynthesis
Arginine and proline metabolism
Metabolic pathways
Calcium signaling pathway
HIF-1 signaling pathway
Peroxisome
Apelin signaling pathway
Relaxin signaling pathway
Alzheimer disease
Amyotrophic lateral sclerosis
Pathways of neurodegeneration - multiple diseases
Pertussis
Leishmaniasis
Chagas disease
Toxoplasmosis
Amoebiasis
Tuberculosis
Pathways in cancer
Small cell lung cancer 		  ROS and RNS production in phagocytes
Nitric oxide stimulates guanylate cyclase
Interleukin-4 and Interleukin-13 signaling
Peroxisomal protein import
Inhibition of nitric oxide production
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (5)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Malaria, resistance to protective rs9282799 RCV000015051
Malaria, severe, resistance to protective rs1800482 RCV000015052
Malaria, susceptibility to Uncertain significance rs1908748329 RCV002252323
NOS2-related disorder Benign; Likely benign rs1060826, rs2297512, rs1060822, rs2297518, rs1137933, rs202098132, rs201758824, rs750641734, rs149623743, rs7223110, rs3729662, rs3729720, rs200387756 RCV003980959
RCV003984371
RCV003980960
RCV003980962
RCV003980963
RCV003934558
RCV003944071
RCV003947009
RCV003967158
RCV003943151
RCV003920549
RCV003920550
RCV003926005
Show/Hide Text Mining Associations (365)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Aberrant Crypt Foci Associate 12800233
Abortion Habitual Associate 19217092
Abortion Spontaneous Associate 19217092
Acrodermatitis Associate 17324275
Acute malaria Associate 28793894
Adenocarcinoma Associate 10970689, 12800233, 7531687
Adenocarcinoma Follicular Stimulate 17179688
Adenoma Stimulate 17179688
Adenoma Oxyphilic Associate 17179688
Aggressive Periodontitis Associate 27737359