NOS2 (nitric oxide synthase 2)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4843
Gene name Gene Name - the full gene name approved by the HGNC.
Nitric oxide synthase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NOS2
Synonyms (NCBI Gene) Gene synonyms aliases
HEP-NOS, INOS, NOS, NOS2A
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q11.2
Summary Summary of gene provided in NCBI Entrez Gene.
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducibl
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(23)
miRTarBase ID miRNA Experiments Reference
MIRT007347 hsa-miR-26a-5p qRT-PCR, Western blot 23338972
MIRT007347 hsa-miR-26a-5p Luciferase reporter assay 26854724
MIRT007347 hsa-miR-26a-5p Luciferase reporter assay 26854724
MIRT732802 hsa-miR-155-5p Luciferase reporter assay, qRT-PCR, Western blotting 33318876
MIRT737162 hsa-miR-939-5p qRT-PCR 33368266
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(22)
Transcription factor Regulation Reference
APC Activation 11935128
FOS Activation 12788789
FOS Repression 9776360
FOSL2 Activation 12788789
IKBKB Repression 17478759
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(81)
GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IEA
GO:0001912 Process Positive regulation of leukocyte mediated cytotoxicity TAS 10450191
GO:0002227 Process Innate immune response in mucosa NAS 18390757
GO:0004517 Function Nitric-oxide synthase activity IBA
GO:0004517 Function Nitric-oxide synthase activity IDA 7504305, 7682706, 35772285
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
163730 7873 ENSG00000007171
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P35228
Protein name Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2)
Protein function Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7504305, PubMed:7531687, PubMed:7544004, PubMed:7682706). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitr
PDB 1NSI , 2LL6 , 2NSI , 3E7G , 3EJ8 , 3HR4 , 4CX7 , 4NOS , 5TP6 , 5XN3 , 6JWM , 6JWN , 6KEY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02898 NO_synthase 135 → 497 Nitric oxide synthase, oxygenase domain Domain
PF00258 Flavodoxin_1 541 → 672 Flavodoxin Domain
PF00667 FAD_binding_1 725 → 947 FAD binding domain Domain
PF00175 NAD_binding_1 979 → 1093 Oxidoreductase NAD-binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. Expressed in chondrocytes (PubMed:7504305). {ECO:0000269|PubMed:7504305}.
Sequence 
MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPL
VETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIM
TPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ
LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNI
RSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYG
RFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVG
GLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINI
AVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEM
LNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVT
ILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPG
NGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGD
ELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDL
SKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQ
PALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQ
LLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQL
PILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCF
VRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPD
EDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLY
VCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDR
VAVQPSSLEMSAL
Sequence length 1153
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Arginine biosynthesis
Arginine and proline metabolism
Metabolic pathways
Calcium signaling pathway
HIF-1 signaling pathway
Peroxisome
Apelin signaling pathway
Relaxin signaling pathway
Alzheimer disease
Amyotrophic lateral sclerosis
Pathways of neurodegeneration - multiple diseases
Pertussis
Leishmaniasis
Chagas disease
Toxoplasmosis
Amoebiasis
Tuberculosis
Pathways in cancer
Small cell lung cancer 		  ROS and RNS production in phagocytes
Nitric oxide stimulates guanylate cyclase
Interleukin-4 and Interleukin-13 signaling
Peroxisomal protein import
Inhibition of nitric oxide production
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (4)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Ankylosing Spondylitis Ankylosing spondylitis N/A N/A GWAS
Mental Depression Clinical depression N/A N/A GWAS
Psoriasis Psoriasis N/A N/A GWAS
Psoriasis vulgaris Psoriasis vulgaris N/A N/A GWAS
Show/Hide Text Mining Associations (365)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Aberrant Crypt Foci Associate 12800233
Abortion Habitual Associate 19217092
Abortion Spontaneous Associate 19217092
Acrodermatitis Associate 17324275
Acute malaria Associate 28793894
Adenocarcinoma Associate 10970689, 12800233, 7531687
Adenocarcinoma Follicular Stimulate 17179688
Adenoma Stimulate 17179688
Adenoma Oxyphilic Associate 17179688
Aggressive Periodontitis Associate 27737359