Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4842
Gene name	Nitric oxide synthase 1
Gene symbol	NOS1
Synonyms (NCBI Gene)	IHPS1N-NOSNC-NOSNOSbNOSnNOS
Chromosome	12
Chromosome location	12q24.22
Summary	The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission,

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miRTarBase ID	miRNA	Experiments	Reference
MIRT736673	hsa-miR-146a-3p	Northern blottingRNA-seqqRT-PCR	32758035
MIRT1189360	hsa-miR-103a	CLIP-seq
MIRT1189361	hsa-miR-107	CLIP-seq
MIRT1189362	hsa-miR-1183	CLIP-seq
MIRT1189363	hsa-miR-1184	CLIP-seq
MIRT1189364	hsa-miR-1200	CLIP-seq
MIRT1189365	hsa-miR-122	CLIP-seq
MIRT1189366	hsa-miR-1285	CLIP-seq
MIRT1189367	hsa-miR-1292	CLIP-seq
MIRT1189368	hsa-miR-1307	CLIP-seq
MIRT1189369	hsa-miR-1324	CLIP-seq
MIRT1189370	hsa-miR-1343	CLIP-seq
MIRT1189371	hsa-miR-2114	CLIP-seq
MIRT1189372	hsa-miR-3117-5p	CLIP-seq
MIRT1189373	hsa-miR-3122	CLIP-seq
MIRT1189374	hsa-miR-3135b	CLIP-seq
MIRT1189375	hsa-miR-3155	CLIP-seq
MIRT1189376	hsa-miR-3155b	CLIP-seq
MIRT1189377	hsa-miR-3187-5p	CLIP-seq
MIRT1189378	hsa-miR-3192	CLIP-seq
MIRT1189379	hsa-miR-3199	CLIP-seq
MIRT1189380	hsa-miR-338-3p	CLIP-seq
MIRT1189381	hsa-miR-3652	CLIP-seq
MIRT1189382	hsa-miR-3664-3p	CLIP-seq
MIRT1189383	hsa-miR-3689a-3p	CLIP-seq
MIRT1189384	hsa-miR-3689c	CLIP-seq
MIRT1189385	hsa-miR-377	CLIP-seq
MIRT1189386	hsa-miR-3913-5p	CLIP-seq
MIRT1189387	hsa-miR-3945	CLIP-seq
MIRT1189388	hsa-miR-4253	CLIP-seq
MIRT1189389	hsa-miR-4284	CLIP-seq
MIRT1189390	hsa-miR-4314	CLIP-seq
MIRT1189391	hsa-miR-4329	CLIP-seq
MIRT1189392	hsa-miR-4418	CLIP-seq
MIRT1189393	hsa-miR-4430	CLIP-seq
MIRT1189394	hsa-miR-4433	CLIP-seq
MIRT1189395	hsa-miR-4459	CLIP-seq
MIRT1189396	hsa-miR-4466	CLIP-seq
MIRT1189397	hsa-miR-4471	CLIP-seq
MIRT1189398	hsa-miR-4530	CLIP-seq
MIRT1189399	hsa-miR-4638-5p	CLIP-seq
MIRT1189400	hsa-miR-4646-5p	CLIP-seq
MIRT1189401	hsa-miR-4652-5p	CLIP-seq
MIRT1189402	hsa-miR-4695-5p	CLIP-seq
MIRT1189403	hsa-miR-4728-5p	CLIP-seq
MIRT1189404	hsa-miR-4735-5p	CLIP-seq
MIRT1189405	hsa-miR-4740-5p	CLIP-seq
MIRT1189406	hsa-miR-4761-5p	CLIP-seq
MIRT1189407	hsa-miR-4768-3p	CLIP-seq
MIRT1189408	hsa-miR-4786-5p	CLIP-seq
MIRT1189409	hsa-miR-4799-5p	CLIP-seq
MIRT1189410	hsa-miR-484	CLIP-seq
MIRT1189411	hsa-miR-509-3-5p	CLIP-seq
MIRT1189412	hsa-miR-509-5p	CLIP-seq
MIRT1189413	hsa-miR-510	CLIP-seq
MIRT1189414	hsa-miR-512-5p	CLIP-seq
MIRT1189415	hsa-miR-545	CLIP-seq
MIRT1189416	hsa-miR-582-3p	CLIP-seq
MIRT1189417	hsa-miR-612	CLIP-seq
MIRT1189418	hsa-miR-668	CLIP-seq
MIRT1189419	hsa-miR-675	CLIP-seq
MIRT1189420	hsa-miR-769-5p	CLIP-seq
MIRT1189421	hsa-miR-935	CLIP-seq
MIRT1189367	hsa-miR-1292	CLIP-seq
MIRT1189422	hsa-miR-1321	CLIP-seq
MIRT1189423	hsa-miR-2355-5p	CLIP-seq
MIRT1189372	hsa-miR-3117-5p	CLIP-seq
MIRT1189424	hsa-miR-3162-5p	CLIP-seq
MIRT1189378	hsa-miR-3192	CLIP-seq
MIRT1189379	hsa-miR-3199	CLIP-seq
MIRT1189383	hsa-miR-3689a-3p	CLIP-seq
MIRT1189384	hsa-miR-3689c	CLIP-seq
MIRT1189425	hsa-miR-3940-3p	CLIP-seq
MIRT1189390	hsa-miR-4314	CLIP-seq
MIRT1189391	hsa-miR-4329	CLIP-seq
MIRT1189397	hsa-miR-4471	CLIP-seq
MIRT1189400	hsa-miR-4646-5p	CLIP-seq
MIRT1189401	hsa-miR-4652-5p	CLIP-seq
MIRT1189403	hsa-miR-4728-5p	CLIP-seq
MIRT1189404	hsa-miR-4735-5p	CLIP-seq
MIRT1189426	hsa-miR-4739	CLIP-seq
MIRT1189405	hsa-miR-4740-5p	CLIP-seq
MIRT1189427	hsa-miR-4756-5p	CLIP-seq
MIRT1189408	hsa-miR-4786-5p	CLIP-seq
MIRT1189420	hsa-miR-769-5p	CLIP-seq
MIRT1189428	hsa-miR-1268	CLIP-seq
MIRT1189429	hsa-miR-1268b	CLIP-seq
MIRT1189430	hsa-miR-1273g	CLIP-seq
MIRT1189367	hsa-miR-1292	CLIP-seq
MIRT1189431	hsa-miR-129-5p	CLIP-seq
MIRT1189432	hsa-miR-132	CLIP-seq
MIRT1189433	hsa-miR-1976	CLIP-seq
MIRT1189434	hsa-miR-212	CLIP-seq
MIRT1189435	hsa-miR-24	CLIP-seq
MIRT1189372	hsa-miR-3117-5p	CLIP-seq
MIRT1189436	hsa-miR-3176	CLIP-seq
MIRT1189378	hsa-miR-3192	CLIP-seq
MIRT1189380	hsa-miR-338-3p	CLIP-seq
MIRT1189437	hsa-miR-3686	CLIP-seq
MIRT1189383	hsa-miR-3689a-3p	CLIP-seq
MIRT1189384	hsa-miR-3689c	CLIP-seq
MIRT1189438	hsa-miR-3922-3p	CLIP-seq
MIRT1189389	hsa-miR-4284	CLIP-seq
MIRT1189390	hsa-miR-4314	CLIP-seq
MIRT1189439	hsa-miR-4438	CLIP-seq
MIRT1189397	hsa-miR-4471	CLIP-seq
MIRT1189440	hsa-miR-451b	CLIP-seq
MIRT1189398	hsa-miR-4530	CLIP-seq
MIRT1189400	hsa-miR-4646-5p	CLIP-seq
MIRT1189441	hsa-miR-4652-3p	CLIP-seq
MIRT1189442	hsa-miR-4696	CLIP-seq
MIRT1189443	hsa-miR-4715-3p	CLIP-seq
MIRT1189403	hsa-miR-4728-5p	CLIP-seq
MIRT1189404	hsa-miR-4735-5p	CLIP-seq
MIRT1189444	hsa-miR-4742-3p	CLIP-seq
MIRT1189445	hsa-miR-5095	CLIP-seq
MIRT1189446	hsa-miR-5096	CLIP-seq
MIRT1189447	hsa-miR-585	CLIP-seq
MIRT1189448	hsa-miR-661	CLIP-seq
MIRT1189367	hsa-miR-1292	CLIP-seq
MIRT1189372	hsa-miR-3117-5p	CLIP-seq
MIRT1551802	hsa-miR-3149	CLIP-seq
MIRT1189378	hsa-miR-3192	CLIP-seq
MIRT1189390	hsa-miR-4314	CLIP-seq
MIRT1189397	hsa-miR-4471	CLIP-seq
MIRT1189400	hsa-miR-4646-5p	CLIP-seq
MIRT1189404	hsa-miR-4735-5p	CLIP-seq
MIRT1189439	hsa-miR-4438	CLIP-seq
MIRT1189445	hsa-miR-5095	CLIP-seq
MIRT2283869	hsa-miR-1182	CLIP-seq
MIRT1189363	hsa-miR-1184	CLIP-seq
MIRT1189365	hsa-miR-122	CLIP-seq
MIRT2283870	hsa-miR-1245	CLIP-seq
MIRT2283871	hsa-miR-1254	CLIP-seq
MIRT1189428	hsa-miR-1268	CLIP-seq
MIRT1189429	hsa-miR-1268b	CLIP-seq
MIRT1189367	hsa-miR-1292	CLIP-seq
MIRT2283872	hsa-miR-1297	CLIP-seq
MIRT2283873	hsa-miR-1303	CLIP-seq
MIRT1189368	hsa-miR-1307	CLIP-seq
MIRT1189370	hsa-miR-1343	CLIP-seq
MIRT2283874	hsa-miR-140-3p	CLIP-seq
MIRT2283875	hsa-miR-150	CLIP-seq
MIRT2283876	hsa-miR-1827	CLIP-seq
MIRT2283877	hsa-miR-193a-5p	CLIP-seq
MIRT1189433	hsa-miR-1976	CLIP-seq
MIRT2283878	hsa-miR-204	CLIP-seq
MIRT2283879	hsa-miR-211	CLIP-seq
MIRT1189435	hsa-miR-24	CLIP-seq
MIRT2283880	hsa-miR-26a	CLIP-seq
MIRT2283881	hsa-miR-26b	CLIP-seq
MIRT2283882	hsa-miR-3116	CLIP-seq
MIRT1189372	hsa-miR-3117-5p	CLIP-seq
MIRT1189374	hsa-miR-3135b	CLIP-seq
MIRT2283883	hsa-miR-3136-3p	CLIP-seq
MIRT1189375	hsa-miR-3155	CLIP-seq
MIRT1189376	hsa-miR-3155b	CLIP-seq
MIRT2283884	hsa-miR-3159	CLIP-seq
MIRT1189378	hsa-miR-3192	CLIP-seq
MIRT2283885	hsa-miR-3194-3p	CLIP-seq
MIRT2283886	hsa-miR-3649	CLIP-seq
MIRT1189381	hsa-miR-3652	CLIP-seq
MIRT2283887	hsa-miR-3672	CLIP-seq
MIRT2283888	hsa-miR-371-5p	CLIP-seq
MIRT1189385	hsa-miR-377	CLIP-seq
MIRT2283889	hsa-miR-4258	CLIP-seq
MIRT2283890	hsa-miR-4279	CLIP-seq
MIRT1189389	hsa-miR-4284	CLIP-seq
MIRT2283891	hsa-miR-431	CLIP-seq
MIRT1189390	hsa-miR-4314	CLIP-seq
MIRT1189391	hsa-miR-4329	CLIP-seq
MIRT1189392	hsa-miR-4418	CLIP-seq
MIRT1189393	hsa-miR-4430	CLIP-seq
MIRT1189439	hsa-miR-4438	CLIP-seq
MIRT2283892	hsa-miR-4465	CLIP-seq
MIRT1189397	hsa-miR-4471	CLIP-seq
MIRT2283893	hsa-miR-4486	CLIP-seq
MIRT2283894	hsa-miR-4494	CLIP-seq
MIRT2283895	hsa-miR-4505	CLIP-seq
MIRT1189399	hsa-miR-4638-5p	CLIP-seq
MIRT1189400	hsa-miR-4646-5p	CLIP-seq
MIRT2283896	hsa-miR-4707-3p	CLIP-seq
MIRT1189443	hsa-miR-4715-3p	CLIP-seq
MIRT2283897	hsa-miR-4722-3p	CLIP-seq
MIRT1189404	hsa-miR-4735-5p	CLIP-seq
MIRT2283898	hsa-miR-4755-5p	CLIP-seq
MIRT2283899	hsa-miR-4775	CLIP-seq
MIRT1189410	hsa-miR-484	CLIP-seq
MIRT1189411	hsa-miR-509-3-5p	CLIP-seq
MIRT1189445	hsa-miR-5095	CLIP-seq
MIRT1189412	hsa-miR-509-5p	CLIP-seq
MIRT1189413	hsa-miR-510	CLIP-seq
MIRT2283900	hsa-miR-562	CLIP-seq
MIRT1189447	hsa-miR-585	CLIP-seq
MIRT2283901	hsa-miR-590-3p	CLIP-seq
MIRT2283902	hsa-miR-623	CLIP-seq
MIRT2283903	hsa-miR-647	CLIP-seq
MIRT1189448	hsa-miR-661	CLIP-seq
MIRT1189418	hsa-miR-668	CLIP-seq
MIRT1189363	hsa-miR-1184	CLIP-seq
MIRT1189365	hsa-miR-122	CLIP-seq
MIRT1189367	hsa-miR-1292	CLIP-seq
MIRT1189370	hsa-miR-1343	CLIP-seq
MIRT2391652	hsa-miR-2276	CLIP-seq
MIRT1189435	hsa-miR-24	CLIP-seq
MIRT1189372	hsa-miR-3117-5p	CLIP-seq
MIRT1189374	hsa-miR-3135b	CLIP-seq
MIRT1189378	hsa-miR-3192	CLIP-seq
MIRT2391653	hsa-miR-3614-5p	CLIP-seq
MIRT1189381	hsa-miR-3652	CLIP-seq
MIRT1189383	hsa-miR-3689a-3p	CLIP-seq
MIRT1189384	hsa-miR-3689c	CLIP-seq
MIRT2391654	hsa-miR-378g	CLIP-seq
MIRT1189389	hsa-miR-4284	CLIP-seq
MIRT1189390	hsa-miR-4314	CLIP-seq
MIRT1189392	hsa-miR-4418	CLIP-seq
MIRT1189393	hsa-miR-4430	CLIP-seq
MIRT2391655	hsa-miR-4437	CLIP-seq
MIRT1189397	hsa-miR-4471	CLIP-seq
MIRT1189400	hsa-miR-4646-5p	CLIP-seq
MIRT2391656	hsa-miR-4674	CLIP-seq
MIRT1189442	hsa-miR-4696	CLIP-seq
MIRT1189403	hsa-miR-4728-5p	CLIP-seq
MIRT1189404	hsa-miR-4735-5p	CLIP-seq
MIRT1189411	hsa-miR-509-3-5p	CLIP-seq
MIRT1189412	hsa-miR-509-5p	CLIP-seq
MIRT2391657	hsa-miR-596	CLIP-seq
MIRT2283871	hsa-miR-1254	CLIP-seq
MIRT1189422	hsa-miR-1321	CLIP-seq
MIRT2455312	hsa-miR-298	CLIP-seq
MIRT2283882	hsa-miR-3116	CLIP-seq
MIRT1189373	hsa-miR-3122	CLIP-seq
MIRT1551802	hsa-miR-3149	CLIP-seq
MIRT2455313	hsa-miR-3152-5p	CLIP-seq
MIRT1189424	hsa-miR-3162-5p	CLIP-seq
MIRT2455314	hsa-miR-3173-3p	CLIP-seq
MIRT1189380	hsa-miR-338-3p	CLIP-seq
MIRT1189381	hsa-miR-3652	CLIP-seq
MIRT1189383	hsa-miR-3689a-3p	CLIP-seq
MIRT1189384	hsa-miR-3689c	CLIP-seq
MIRT2455315	hsa-miR-3689d	CLIP-seq
MIRT1189385	hsa-miR-377	CLIP-seq
MIRT1189386	hsa-miR-3913-5p	CLIP-seq
MIRT2455316	hsa-miR-3929	CLIP-seq
MIRT2455317	hsa-miR-411	CLIP-seq
MIRT2455318	hsa-miR-4419b	CLIP-seq
MIRT2455319	hsa-miR-4423-5p	CLIP-seq
MIRT1189393	hsa-miR-4430	CLIP-seq
MIRT2455320	hsa-miR-4478	CLIP-seq
MIRT1189398	hsa-miR-4530	CLIP-seq
MIRT2455321	hsa-miR-4656	CLIP-seq
MIRT1189403	hsa-miR-4728-5p	CLIP-seq
MIRT1189426	hsa-miR-4739	CLIP-seq
MIRT1189427	hsa-miR-4756-5p	CLIP-seq
MIRT2455322	hsa-miR-485-5p	CLIP-seq
MIRT2455323	hsa-miR-550a	CLIP-seq
MIRT1189448	hsa-miR-661	CLIP-seq
MIRT1189365	hsa-miR-122	CLIP-seq
MIRT2283872	hsa-miR-1297	CLIP-seq
MIRT1189370	hsa-miR-1343	CLIP-seq
MIRT2283877	hsa-miR-193a-5p	CLIP-seq
MIRT1189435	hsa-miR-24	CLIP-seq
MIRT2283880	hsa-miR-26a	CLIP-seq
MIRT2283881	hsa-miR-26b	CLIP-seq
MIRT2582054	hsa-miR-296-5p	CLIP-seq
MIRT1189373	hsa-miR-3122	CLIP-seq
MIRT1189374	hsa-miR-3135b	CLIP-seq
MIRT1551802	hsa-miR-3149	CLIP-seq
MIRT2582055	hsa-miR-3170	CLIP-seq
MIRT1189380	hsa-miR-338-3p	CLIP-seq
MIRT2582056	hsa-miR-3613-3p	CLIP-seq
MIRT1189381	hsa-miR-3652	CLIP-seq
MIRT2582057	hsa-miR-3664-5p	CLIP-seq
MIRT2283887	hsa-miR-3672	CLIP-seq
MIRT1189383	hsa-miR-3689a-3p	CLIP-seq
MIRT1189384	hsa-miR-3689c	CLIP-seq
MIRT1189386	hsa-miR-3913-5p	CLIP-seq
MIRT2455316	hsa-miR-3929	CLIP-seq
MIRT2455317	hsa-miR-411	CLIP-seq
MIRT2582058	hsa-miR-4260	CLIP-seq
MIRT1189389	hsa-miR-4284	CLIP-seq
MIRT2455318	hsa-miR-4419b	CLIP-seq
MIRT1189393	hsa-miR-4430	CLIP-seq
MIRT2582059	hsa-miR-4432	CLIP-seq
MIRT1189439	hsa-miR-4438	CLIP-seq
MIRT2283892	hsa-miR-4465	CLIP-seq
MIRT2455320	hsa-miR-4478	CLIP-seq
MIRT1189440	hsa-miR-451b	CLIP-seq
MIRT2582060	hsa-miR-4522	CLIP-seq
MIRT1189398	hsa-miR-4530	CLIP-seq
MIRT2455321	hsa-miR-4656	CLIP-seq
MIRT1189442	hsa-miR-4696	CLIP-seq
MIRT1189443	hsa-miR-4715-3p	CLIP-seq
MIRT1189403	hsa-miR-4728-5p	CLIP-seq
MIRT1189404	hsa-miR-4735-5p	CLIP-seq
MIRT2283899	hsa-miR-4775	CLIP-seq
MIRT2455322	hsa-miR-485-5p	CLIP-seq
MIRT1189445	hsa-miR-5095	CLIP-seq
MIRT2283901	hsa-miR-590-3p	CLIP-seq
MIRT2582061	hsa-miR-615-5p	CLIP-seq
MIRT1189365	hsa-miR-122	CLIP-seq
MIRT2283872	hsa-miR-1297	CLIP-seq
MIRT2686438	hsa-miR-1323	CLIP-seq
MIRT1189370	hsa-miR-1343	CLIP-seq
MIRT2283877	hsa-miR-193a-5p	CLIP-seq
MIRT2283880	hsa-miR-26a	CLIP-seq
MIRT2283881	hsa-miR-26b	CLIP-seq
MIRT2582054	hsa-miR-296-5p	CLIP-seq
MIRT1189373	hsa-miR-3122	CLIP-seq
MIRT1189374	hsa-miR-3135b	CLIP-seq
MIRT1551802	hsa-miR-3149	CLIP-seq
MIRT2582055	hsa-miR-3170	CLIP-seq
MIRT1189380	hsa-miR-338-3p	CLIP-seq
MIRT2686439	hsa-miR-345	CLIP-seq
MIRT2582056	hsa-miR-3613-3p	CLIP-seq
MIRT1189381	hsa-miR-3652	CLIP-seq
MIRT2582057	hsa-miR-3664-5p	CLIP-seq
MIRT2283887	hsa-miR-3672	CLIP-seq
MIRT1189383	hsa-miR-3689a-3p	CLIP-seq
MIRT1189384	hsa-miR-3689c	CLIP-seq
MIRT1189386	hsa-miR-3913-5p	CLIP-seq
MIRT2455316	hsa-miR-3929	CLIP-seq
MIRT2582058	hsa-miR-4260	CLIP-seq
MIRT2455318	hsa-miR-4419b	CLIP-seq
MIRT1189393	hsa-miR-4430	CLIP-seq
MIRT2582059	hsa-miR-4432	CLIP-seq
MIRT1189439	hsa-miR-4438	CLIP-seq
MIRT2283892	hsa-miR-4465	CLIP-seq
MIRT2455320	hsa-miR-4478	CLIP-seq
MIRT1189440	hsa-miR-451b	CLIP-seq
MIRT2582060	hsa-miR-4522	CLIP-seq
MIRT1189398	hsa-miR-4530	CLIP-seq
MIRT2455321	hsa-miR-4656	CLIP-seq
MIRT1189442	hsa-miR-4696	CLIP-seq
MIRT1189443	hsa-miR-4715-3p	CLIP-seq
MIRT1189403	hsa-miR-4728-5p	CLIP-seq
MIRT2686440	hsa-miR-4732-3p	CLIP-seq
MIRT1189404	hsa-miR-4735-5p	CLIP-seq
MIRT2283899	hsa-miR-4775	CLIP-seq
MIRT2455322	hsa-miR-485-5p	CLIP-seq
MIRT1189445	hsa-miR-5095	CLIP-seq
MIRT2686441	hsa-miR-548c-3p	CLIP-seq
MIRT2686442	hsa-miR-548o	CLIP-seq
MIRT2283901	hsa-miR-590-3p	CLIP-seq
MIRT2582061	hsa-miR-615-5p	CLIP-seq

Show/Hide all (4)

Transcription factor	Regulation	Reference
NFKB1	Activation	17081374
NR0B1	Activation	19726747
RELA	Activation	17081374
SP1	Unknown	12237165

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Show/Hide all (124)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001666	Process	Response to hypoxia	IEP	16276418
GO:0001917	Component	Photoreceptor inner segment	ISS	17027776
GO:0002028	Process	Regulation of sodium ion transport	IEA
GO:0002028	Process	Regulation of sodium ion transport	ISS
GO:0004517	Function	Nitric-oxide synthase activity	IBA
GO:0004517	Function	Nitric-oxide synthase activity	IDA	1689048, 35772285
GO:0004517	Function	Nitric-oxide synthase activity	IEA
GO:0004517	Function	Nitric-oxide synthase activity	ISS	7545544, 23549614
GO:0004517	Function	Nitric-oxide synthase activity	TAS
GO:0005246	Function	Calcium channel regulator activity	TAS	18337493
GO:0005515	Function	Protein binding	IPI	11149895, 17161399, 27225184
GO:0005516	Function	Calmodulin binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS	23549614
GO:0005737	Component	Cytoplasm	TAS	17892502
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	ISS
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005856	Component	Cytoskeleton	ISS	7545544
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005901	Component	Caveola	IEA
GO:0006527	Process	L-arginine catabolic process	IBA
GO:0006527	Process	L-arginine catabolic process	TAS	7545544
GO:0006809	Process	Nitric oxide biosynthetic process	IBA
GO:0006809	Process	Nitric oxide biosynthetic process	IEA
GO:0006809	Process	Nitric oxide biosynthetic process	ISS	7545544
GO:0006813	Process	Potassium ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0006941	Process	Striated muscle contraction	IEA
GO:0006941	Process	Striated muscle contraction	ISS
GO:0007154	Process	Cell communication	IEA
GO:0007263	Process	Nitric oxide mediated signal transduction	IBA
GO:0007520	Process	Myoblast fusion	TAS	7545544
GO:0008015	Process	Blood circulation	IEA
GO:0009408	Process	Response to heat	IDA	18048451
GO:0009725	Process	Response to hormone	IBA
GO:0010181	Function	FMN binding	IBA
GO:0010181	Function	FMN binding	IEA
GO:0010181	Function	FMN binding	ISS
GO:0010523	Process	Negative regulation of calcium ion transport into cytosol	TAS	17568574
GO:0010882	Process	Regulation of cardiac muscle contraction by calcium ion signaling	TAS	18337493
GO:0010959	Process	Regulation of metal ion transport	IEA
GO:0012505	Component	Endomembrane system	IEA
GO:0014069	Component	Postsynaptic density	IBA
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016529	Component	Sarcoplasmic reticulum	IDA	9892689
GO:0017080	Function	Sodium channel regulator activity	ISS
GO:0020037	Function	Heme binding	IEA
GO:0020037	Function	Heme binding	ISS
GO:0023052	Process	Signaling	IEA
GO:0030018	Component	Z disc	IEA
GO:0030315	Component	T-tubule	IEA
GO:0032496	Process	Response to lipopolysaccharide	IBA
GO:0032991	Component	Protein-containing complex	ISS
GO:0033017	Component	Sarcoplasmic reticulum membrane	IEA
GO:0033555	Process	Multicellular organismal response to stress	IMP	18391107
GO:0034617	Function	Tetrahydrobiopterin binding	NAS	7488039
GO:0034618	Function	Arginine binding	IEA
GO:0034618	Function	Arginine binding	TAS	17029414
GO:0035605	Function	Peptidyl-cysteine S-nitrosylase activity	IMP	28089352
GO:0042178	Process	Xenobiotic catabolic process	IEA
GO:0042178	Process	Xenobiotic catabolic process	ISS
GO:0042311	Process	Vasodilation	IDA	18048451
GO:0042311	Process	Vasodilation	IMP	18391107
GO:0042383	Component	Sarcolemma	IDA	7545544, 27225184
GO:0042383	Component	Sarcolemma	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043197	Component	Dendritic spine	IEA
GO:0043267	Process	Negative regulation of potassium ion transport	IEA
GO:0043267	Process	Negative regulation of potassium ion transport	ISS
GO:0043271	Process	Negative regulation of monoatomic ion transport	IEA
GO:0043525	Process	Positive regulation of neuron apoptotic process	IMP	28089352
GO:0044305	Component	Calyx of Held	IEA
GO:0044325	Function	Transmembrane transporter binding	ISS
GO:0044325	Function	Transmembrane transporter binding	TAS	21536106
GO:0045121	Component	Membrane raft	IEA
GO:0045121	Component	Membrane raft	ISS
GO:0045202	Component	Synapse	IEA
GO:0045202	Component	Synapse	ISS
GO:0045454	Process	Cell redox homeostasis	IEA
GO:0045454	Process	Cell redox homeostasis	TAS
GO:0045776	Process	Negative regulation of blood pressure	IBA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0046870	Function	Cadmium ion binding	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048306	Function	Calcium-dependent protein binding	ISS	23549614
GO:0048471	Component	Perinuclear region of cytoplasm	ISS	17027776
GO:0050660	Function	Flavin adenine dinucleotide binding	IBA
GO:0050660	Function	Flavin adenine dinucleotide binding	IEA
GO:0050660	Function	Flavin adenine dinucleotide binding	ISS
GO:0050661	Function	NADP binding	IEA
GO:0050661	Function	NADP binding	ISS
GO:0050767	Process	Regulation of neurogenesis	IEA
GO:0051612	Process	Negative regulation of serotonin uptake	IEA
GO:0051612	Process	Negative regulation of serotonin uptake	ISS
GO:0051649	Process	Establishment of localization in cell	IEA
GO:0051926	Process	Negative regulation of calcium ion transport	IEA
GO:0051926	Process	Negative regulation of calcium ion transport	ISS
GO:0055117	Process	Regulation of cardiac muscle contraction	TAS	9892689
GO:0060078	Process	Regulation of postsynaptic membrane potential	IEA
GO:0065008	Process	Regulation of biological quality	IEA
GO:0071363	Process	Cellular response to growth factor stimulus	IEA
GO:0071363	Process	Cellular response to growth factor stimulus	ISS
GO:0071944	Component	Cell periphery	ISS	23549614
GO:0097110	Function	Scaffold protein binding	ISS
GO:0098735	Process	Positive regulation of the force of heart contraction	IEA
GO:0098735	Process	Positive regulation of the force of heart contraction	ISS
GO:0099163	Process	Synaptic signaling by nitric oxide	IEA
GO:0106071	Process	Positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0106071	Process	Positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS
GO:1902307	Process	Positive regulation of sodium ion transmembrane transport	ISS
GO:1902514	Process	Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	TAS	18337493, 21536106
GO:1903522	Process	Regulation of blood circulation	IEA
GO:1905026	Process	Positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential	TAS	18337493

MIM	HGNC	e!Ensembl
163731	7872	ENSG00000089250

P29475

Protein name

Nitric oxide synthase 1 (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Nitric oxide synthase, brain) (bNOS) (Peptidyl-cysteine S-nitrosylase NOS1)

Protein function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cy

PDB

4D1N , 4UCH , 4UH5 , 4UH6 , 4V3U , 5ADF , 5ADG , 5ADI , 5FVU , 5FVV , 5FVW , 5FVX , 5UO1 , 5UO2 , 5UO3 , 5UO4 , 5UO5 , 5UO6 , 5UO7 , 5VUV , 5VUW , 5VUX , 5VUY , 5VUZ , 5VV0 , 5VV1 , 5VV2 , 5VV3 , 5VV4 , 5VV5 , 6AUY , 6AUZ , 6AV0 , 6AV1 , 6AV2 , 6AV3 , 6AV4 , 6AV5 , 6CIC , 6CID , 6NG1 , 6NG2 , 6NG4 , 6NG5 , 6NG6 , 6NG7 , 6NG8 , 6NGA , 6NGB , 6NGC , 6NGD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00595	PDZ	17 → 96	PDZ domain	Domain
PF02898	NO_synthase	355 → 717	Nitric oxide synthase, oxygenase domain	Domain
PF00258	Flavodoxin_1	762 → 935	Flavodoxin	Domain
PF00667	FAD_binding_1	990 → 1219	FAD binding domain	Domain
PF00175	NAD_binding_1	1251 → 1365	Oxidoreductase NAD-binding domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Is

Sequence

MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA
GDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI
RVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAP
RPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGVKGGAPAKAEMKDMGIQV
DRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSPS
KCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLF
PLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRC
VGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVW
NSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQ
IPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGV
RDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSAT
ESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHV
WKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCE
IFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQ
EERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAF
GHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANN
SLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFV
RLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGV
ISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEY
EEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIV
SYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAP
FRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSRE
PDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAE
DAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS

Sequence length

1434

Interactions

View interactions

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Gastric cancer	Benign	rs2293044	RCV005937198
Malignant tumor of esophagus	Benign	rs2293044	RCV005937195
Melanoma	Benign	rs2293044	RCV005937200
Nonpapillary renal cell carcinoma	Benign	rs2293044	RCV005937196
NOS1-related disorder	Benign; Likely benign; Uncertain significance; Conflicting classifications of pathogenicity	rs201316068, rs200282713, rs41413747, rs11068428, rs1047735, rs3741475, rs2293054, rs9658557, rs368611180, rs149484022, rs541417685, rs372667819, rs199772308, rs74427117, rs755377258 View all (22 more)	RCV003906739 RCV003907178 RCV003909410 RCV003974572 RCV003984779 RCV003982529 RCV003977420 RCV003911405 RCV003952025 RCV003914647 RCV003947112 RCV003949550 RCV003959106 RCV003954389 RCV003964741 RCV003982027 RCV003976562 RCV003969167 RCV003962196 RCV003915842 RCV003970771 RCV003918446 RCV003936116 RCV003918513 RCV003928530 RCV003936037 RCV003906056 RCV003905974 RCV003926268 RCV003960773 RCV003910422 RCV003910570 RCV003955835 RCV003910505 RCV003960448 RCV003970584 RCV003915931
Ovarian serous cystadenocarcinoma	Benign	rs2293044	RCV005937199
Pyloric stenosis, infantile hypertrophic, 1	Uncertain significance	rs41279104	RCV000015050
Sarcoma	Benign; Likely benign	rs2293044, rs76090928	RCV005937197 RCV005910533

Show/Hide Text Mining Associations (121)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acute Kidney Injury	Associate	18971208
Agoraphobia	Associate	32361414
Alzheimer Disease	Inhibit	30704480
Amyotrophic Lateral Sclerosis	Associate	11344254
Anxiety	Associate	26746182, 32361414
Arthropathy progressive pseudorheumatoid of childhood	Associate	36599456
Asthma	Associate	22591701, 23517041, 26587832, 34762840
Atherosclerosis	Associate	24622112
Atrial Fibrillation	Associate	34428251
Attention Deficit Disorder with Hyperactivity	Associate	28589541, 33724699
Bipolar Disorder	Associate	18257968, 28195573
Bipolar Disorder	Stimulate	18392456
Bites Human	Associate	32672414
Carcinogenesis	Associate	27869735
Carcinoma Non Small Cell Lung	Associate	29517684
Carcinoma Renal Cell	Inhibit	15150612
Carcinoma Renal Cell	Associate	33221754
Cardiomyopathies	Associate	27041589
Cardiovascular Diseases	Associate	24622112
Cerebral Infarction	Associate	24082858
Cerebral Palsy	Associate	29940959
Cognition Disorders	Associate	21281558
Colorectal Neoplasms	Stimulate	29074106
Colorectal Neoplasms	Associate	36299603
Coronary Artery Disease	Associate	34814316
COVID 19	Stimulate	36334414
Coxa Magna	Associate	28770971
Cystic Fibrosis	Associate	14760158
Darier Disease	Associate	26440917
Death Sudden Cardiac	Associate	19204306
Dementia	Stimulate	36334414
Depressive Disorder	Associate	26746182
Diabetes Mellitus	Stimulate	21300066
Diabetes Mellitus Type 2	Associate	28076881
Diabetic Nephropathies	Associate	19415232
Disorders of Excessive Somnolence	Associate	30813952
Disruptive Impulse Control and Conduct Disorders	Associate	21922604, 28589541, 32710539
Epilepsy Temporal Lobe	Inhibit	12121328
Erectile Dysfunction	Associate	28076881, 28218896
Fatigue	Associate	27720787
Fatigue Syndrome Chronic	Associate	25853139
Fibrosis	Associate	34428251
Fractures Bone	Associate	15647821
Gastric Outlet Obstruction	Associate	14757827
Gastroparesis	Inhibit	21300066
Glioma	Associate	23259684, 23525950
Headache	Associate	36292708
Heredodegenerative Disorders Nervous System	Associate	29940959
Hip Fractures	Associate	15647821
Hippocampal Sclerosis	Stimulate	12121328
Holoprosencephaly	Associate	19234067
Hyperargininemia	Associate	9742507
Hypertension	Associate	36292708
Infant Newborn Diseases	Associate	29940959
Inflammation	Associate	14760158, 25904748, 26114387
Intracranial Aneurysm	Associate	29115560
Ischemia	Associate	11087833, 18971208, 30106246
Liver Neoplasms	Associate	12753090
Long QT Syndrome	Associate	23376825
Lung Injury	Associate	14760158
Lung Neoplasms	Inhibit	9683299
Lupus Erythematosus Systemic	Associate	23637325
Lymphoblastic Transformation Inhibition of	Associate	33724699
Lymphoma Follicular	Associate	19423521
Lymphoma Large B Cell Diffuse	Associate	19423521
Lymphoma Non Hodgkin	Associate	19423521
Macular Degeneration	Associate	19836390
Melanoma	Associate	24691438
Melanoma Cutaneous Malignant	Associate	17328085
Meningioma	Associate	20406964
Mental Disorders	Associate	18257968, 26440917
Mood Disorders	Associate	18392456, 26440917
Mucopolysaccharidosis III	Associate	29517684
Multiple Myeloma	Associate	28671047
Multiple Sclerosis	Associate	23826716
Muscle Neoplasms	Associate	29703249
Muscular Dystrophy Duchenne	Associate	11087833, 22086232, 26437761
Muscular Dystrophy Duchenne	Inhibit	29703249
Myalgia	Associate	25853139
Myocardial Ischemia	Associate	27041589
Myotilinopathy	Associate	17784878
Myotonia Congenita	Associate	22968481
Neoplasms	Inhibit	15150612, 36599456
Neoplasms	Associate	17328085, 19948239, 25972363, 29517684, 32305006, 9683299
Nerve Degeneration	Inhibit	19836390
Neuroblastoma	Associate	12753090, 17250678, 19726747, 9742507
Neurodegenerative Diseases	Associate	18663495
Neuroectodermal Tumors Primitive Peripheral	Associate	16413742
Neurologic Manifestations	Associate	17250678
Neurotoxicity Syndromes	Associate	25170949, 30953815, 9742507
Nevus	Associate	17328085
Nocturnal Enuresis	Associate	17365914
Obesity	Associate	22797309, 24063765
Osteosarcoma	Associate	32305006
Pancreatic Neoplasms	Associate	21467233
Panic Disorder	Associate	32361414
Paranoid Disorders	Associate	18544180
Parkinson Disease	Associate	18663495, 26383258, 32361414
Personality Disorders	Associate	21922604
Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy	Associate	21922604
Prostatitis	Associate	28218896
Psychotic Disorders	Associate	16380905
Pulmonary Arterial Hypertension	Associate	36292708
Pulmonary Disease Chronic Obstructive	Associate	19797159
Pyloric Stenosis	Associate	8571963
Pyloric Stenosis Hypertrophic	Associate	14757827, 20385275
Quadriplegia	Associate	29940959
Raynaud Disease	Associate	29698501
Respiratory Distress Syndrome	Associate	24602444
Respiratory Sounds	Associate	22591701
Rhabdomyosarcoma	Associate	24618610
Schizophrenia	Associate	16380905, 18257968, 18544180, 21281558, 26440917
Sleep Apnea Obstructive	Associate	24010499
Sleep Wake Disorders	Associate	30813952
Soft Tissue Injuries	Associate	19016740
Squamous Cell Carcinoma of Head and Neck	Associate	32756061
Stiff Person Syndrome	Associate	26746182
Tension Type Headache	Associate	36292708
Urinary Incontinence Stress	Associate	29900523
Vascular Diseases	Associate	24063765
Vitiligo	Associate	29186858

NOS1 (nitric oxide synthase 1)