Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4838
Gene name Gene Name - the full gene name approved by the HGNC.	Nodal growth differentiation factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NODAL
Synonyms (NCBI Gene) Gene synonyms aliases	HTX5
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q22.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate

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SNP ID	Visualize variation	Clinical significance	Consequence
rs104894169	C>T	Pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs121909283	C>A,T	Pathogenic, likely-benign, likely-pathogenic	Stop gained, missense variant, coding sequence variant
rs150819707	G>A	Not-provided, conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, missense variant
rs555563029	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs878855044	C>T	Likely-pathogenic	Splice donor variant
rs1564667180	GGTGCCTC>-	Likely-pathogenic	Frameshift variant, coding sequence variant
rs1564667617	C>A	Likely-pathogenic	Splice acceptor variant
rs1589152470	C>-	Pathogenic	Frameshift variant, coding sequence variant

Show/Hide all(398)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023342	hsa-miR-122-5p	Microarray	17612493
MIRT054063	hsa-miR-378a-5p	Luciferase reporter assay, Western blot	22454525
MIRT054063	hsa-miR-378a-5p	Luciferase reporter assay, Western blot	22454525
MIRT611697	hsa-miR-4438	HITS-CLIP	23824327
MIRT667198	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT667197	hsa-miR-3943	HITS-CLIP	23824327
MIRT667196	hsa-miR-5586-5p	HITS-CLIP	23824327
MIRT667195	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT667194	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT611698	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611696	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT611695	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT611694	hsa-miR-4469	HITS-CLIP	23824327
MIRT611693	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611692	hsa-miR-3660	HITS-CLIP	23824327
MIRT611691	hsa-miR-4526	HITS-CLIP	23824327
MIRT611690	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT667193	hsa-miR-3194-5p	HITS-CLIP	23824327
MIRT667192	hsa-miR-4313	HITS-CLIP	23824327
MIRT611689	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT611688	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT667191	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT667190	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT611687	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT611686	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611685	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611684	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT054063	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT611683	hsa-miR-1200	HITS-CLIP	23824327
MIRT611682	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT611697	hsa-miR-4438	HITS-CLIP	23824327
MIRT611698	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611696	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT611695	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT611694	hsa-miR-4469	HITS-CLIP	23824327
MIRT611693	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611692	hsa-miR-3660	HITS-CLIP	23824327
MIRT611691	hsa-miR-4526	HITS-CLIP	23824327
MIRT611690	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT641352	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT611689	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT611688	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT611687	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT611686	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611685	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611684	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT054063	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT611683	hsa-miR-1200	HITS-CLIP	23824327
MIRT611682	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT611697	hsa-miR-4438	HITS-CLIP	23824327
MIRT611698	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611696	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT611695	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT611694	hsa-miR-4469	HITS-CLIP	23824327
MIRT611693	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611692	hsa-miR-3660	HITS-CLIP	23824327
MIRT611691	hsa-miR-4526	HITS-CLIP	23824327
MIRT611690	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT611689	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT611688	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT611687	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT611686	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611685	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611684	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT054063	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT611683	hsa-miR-1200	HITS-CLIP	23824327
MIRT611682	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT611697	hsa-miR-4438	HITS-CLIP	23824327
MIRT611698	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611696	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT611695	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT611694	hsa-miR-4469	HITS-CLIP	23824327
MIRT611693	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611692	hsa-miR-3660	HITS-CLIP	23824327
MIRT611691	hsa-miR-4526	HITS-CLIP	23824327
MIRT611690	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT611689	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT611688	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT611687	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT611686	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611685	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611684	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT054063	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT611683	hsa-miR-1200	HITS-CLIP	23824327
MIRT611682	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT611697	hsa-miR-4438	HITS-CLIP	23824327
MIRT611698	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611696	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT611695	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT611694	hsa-miR-4469	HITS-CLIP	23824327
MIRT611693	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611692	hsa-miR-3660	HITS-CLIP	23824327
MIRT611691	hsa-miR-4526	HITS-CLIP	23824327
MIRT611690	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT611689	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT611688	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT611687	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT611686	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611685	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611684	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT054063	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT611683	hsa-miR-1200	HITS-CLIP	23824327
MIRT611682	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT611697	hsa-miR-4438	HITS-CLIP	23824327
MIRT611698	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611696	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT611695	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT611694	hsa-miR-4469	HITS-CLIP	23824327
MIRT611693	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611692	hsa-miR-3660	HITS-CLIP	23824327
MIRT611691	hsa-miR-4526	HITS-CLIP	23824327
MIRT611690	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT611689	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT611688	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT611687	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT611686	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611685	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611684	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT054063	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT611683	hsa-miR-1200	HITS-CLIP	23824327
MIRT611682	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT611697	hsa-miR-4438	HITS-CLIP	23824327
MIRT611698	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611696	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT611695	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT611694	hsa-miR-4469	HITS-CLIP	23824327
MIRT611693	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611692	hsa-miR-3660	HITS-CLIP	23824327
MIRT611691	hsa-miR-4526	HITS-CLIP	23824327
MIRT611690	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT611689	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT611688	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT611687	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT611686	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611685	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611684	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT054063	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT611683	hsa-miR-1200	HITS-CLIP	23824327
MIRT611682	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT611697	hsa-miR-4438	HITS-CLIP	23824327
MIRT611698	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611696	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT611695	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT611694	hsa-miR-4469	HITS-CLIP	23824327
MIRT611693	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611692	hsa-miR-3660	HITS-CLIP	23824327
MIRT611691	hsa-miR-4526	HITS-CLIP	23824327
MIRT611690	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT611689	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT611688	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT611687	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT611686	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611685	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611684	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT054063	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT611683	hsa-miR-1200	HITS-CLIP	23824327
MIRT611682	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT611697	hsa-miR-4438	HITS-CLIP	23824327
MIRT611698	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611696	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT611695	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT611694	hsa-miR-4469	HITS-CLIP	23824327
MIRT611693	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611692	hsa-miR-3660	HITS-CLIP	23824327
MIRT611691	hsa-miR-4526	HITS-CLIP	23824327
MIRT611690	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT611689	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT611688	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT611687	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT611686	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611685	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611684	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT054063	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT611683	hsa-miR-1200	HITS-CLIP	23824327
MIRT611682	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT611697	hsa-miR-4438	HITS-CLIP	23824327
MIRT667198	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT667197	hsa-miR-3943	HITS-CLIP	23824327
MIRT667196	hsa-miR-5586-5p	HITS-CLIP	23824327
MIRT667195	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT667194	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT611698	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611696	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT611695	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT611694	hsa-miR-4469	HITS-CLIP	23824327
MIRT611693	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611692	hsa-miR-3660	HITS-CLIP	23824327
MIRT611691	hsa-miR-4526	HITS-CLIP	23824327
MIRT611690	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT667193	hsa-miR-3194-5p	HITS-CLIP	23824327
MIRT667192	hsa-miR-4313	HITS-CLIP	23824327
MIRT611689	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT611688	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT667191	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT667190	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT611687	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT611686	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611685	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611684	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT054063	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT611683	hsa-miR-1200	HITS-CLIP	23824327
MIRT611682	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT611697	hsa-miR-4438	HITS-CLIP	23824327
MIRT611698	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611696	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT611695	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT611694	hsa-miR-4469	HITS-CLIP	23824327
MIRT611693	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611692	hsa-miR-3660	HITS-CLIP	23824327
MIRT611691	hsa-miR-4526	HITS-CLIP	23824327
MIRT611690	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT641352	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT611689	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT611688	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT611687	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT611686	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611685	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611684	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT054063	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT611683	hsa-miR-1200	HITS-CLIP	23824327
MIRT611682	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT611697	hsa-miR-4438	HITS-CLIP	23824327
MIRT611698	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611696	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT611695	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT611694	hsa-miR-4469	HITS-CLIP	23824327
MIRT611693	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611692	hsa-miR-3660	HITS-CLIP	23824327
MIRT611691	hsa-miR-4526	HITS-CLIP	23824327
MIRT611690	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT611689	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT611688	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT611687	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT611686	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611685	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611684	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT054063	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT611683	hsa-miR-1200	HITS-CLIP	23824327
MIRT611682	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT611697	hsa-miR-4438	HITS-CLIP	23824327
MIRT611698	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611696	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT611695	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT611694	hsa-miR-4469	HITS-CLIP	23824327
MIRT611693	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611692	hsa-miR-3660	HITS-CLIP	23824327
MIRT611691	hsa-miR-4526	HITS-CLIP	23824327
MIRT611690	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT611689	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT611688	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT611687	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT611686	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611685	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611684	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT054063	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT611683	hsa-miR-1200	HITS-CLIP	23824327
MIRT611682	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT611697	hsa-miR-4438	HITS-CLIP	23824327
MIRT611698	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611696	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT611695	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT611694	hsa-miR-4469	HITS-CLIP	23824327
MIRT611693	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611692	hsa-miR-3660	HITS-CLIP	23824327
MIRT611691	hsa-miR-4526	HITS-CLIP	23824327
MIRT611690	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT611689	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT611688	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT611687	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT611686	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611685	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611684	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT054063	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT611683	hsa-miR-1200	HITS-CLIP	23824327
MIRT611682	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT611697	hsa-miR-4438	HITS-CLIP	23824327
MIRT611698	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611696	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT611695	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT611694	hsa-miR-4469	HITS-CLIP	23824327
MIRT611693	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611692	hsa-miR-3660	HITS-CLIP	23824327
MIRT611691	hsa-miR-4526	HITS-CLIP	23824327
MIRT611690	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT611689	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT611688	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT611687	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT611686	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611685	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611684	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT054063	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT611683	hsa-miR-1200	HITS-CLIP	23824327
MIRT611682	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT611697	hsa-miR-4438	HITS-CLIP	23824327
MIRT611698	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611696	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT611695	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT611694	hsa-miR-4469	HITS-CLIP	23824327
MIRT611693	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611692	hsa-miR-3660	HITS-CLIP	23824327
MIRT611691	hsa-miR-4526	HITS-CLIP	23824327
MIRT611690	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT611689	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT611688	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT611687	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT611686	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611685	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611684	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT054063	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT611683	hsa-miR-1200	HITS-CLIP	23824327
MIRT611682	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT611697	hsa-miR-4438	HITS-CLIP	23824327
MIRT611698	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611696	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT611695	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT611694	hsa-miR-4469	HITS-CLIP	23824327
MIRT611693	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611692	hsa-miR-3660	HITS-CLIP	23824327
MIRT611691	hsa-miR-4526	HITS-CLIP	23824327
MIRT611690	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT611689	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT611688	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT611687	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT611686	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611685	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611684	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT054063	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT611683	hsa-miR-1200	HITS-CLIP	23824327
MIRT611682	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT611697	hsa-miR-4438	HITS-CLIP	23824327
MIRT611698	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT611696	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT611695	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT611694	hsa-miR-4469	HITS-CLIP	23824327
MIRT611693	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611692	hsa-miR-3660	HITS-CLIP	23824327
MIRT611691	hsa-miR-4526	HITS-CLIP	23824327
MIRT611690	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT611689	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT611688	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT611687	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT611686	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611685	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611684	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT054063	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT611683	hsa-miR-1200	HITS-CLIP	23824327
MIRT611682	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT1188358	hsa-miR-145	CLIP-seq
MIRT1188359	hsa-miR-1825	CLIP-seq
MIRT1188360	hsa-miR-199a-5p	CLIP-seq
MIRT1188361	hsa-miR-199b-5p	CLIP-seq
MIRT1188362	hsa-miR-2110	CLIP-seq
MIRT1188363	hsa-miR-2115	CLIP-seq
MIRT1188364	hsa-miR-3150a-3p	CLIP-seq
MIRT1188365	hsa-miR-3160-3p	CLIP-seq
MIRT1188366	hsa-miR-3175	CLIP-seq
MIRT1188367	hsa-miR-377	CLIP-seq
MIRT1188368	hsa-miR-4260	CLIP-seq
MIRT1188369	hsa-miR-4487	CLIP-seq
MIRT1188370	hsa-miR-4663	CLIP-seq
MIRT1188371	hsa-miR-4716-3p	CLIP-seq
MIRT1188372	hsa-miR-4728-5p	CLIP-seq
MIRT1188373	hsa-miR-558	CLIP-seq
MIRT1188374	hsa-miR-591	CLIP-seq
MIRT1188375	hsa-miR-9	CLIP-seq
MIRT1188376	hsa-miR-939	CLIP-seq
MIRT2054554	hsa-miR-3654	CLIP-seq
MIRT2054555	hsa-miR-4433	CLIP-seq
MIRT2054556	hsa-miR-665	CLIP-seq
MIRT2283669	hsa-miR-1236	CLIP-seq
MIRT2283670	hsa-miR-642a	CLIP-seq
MIRT1188358	hsa-miR-145	CLIP-seq
MIRT1188359	hsa-miR-1825	CLIP-seq
MIRT1188360	hsa-miR-199a-5p	CLIP-seq
MIRT1188361	hsa-miR-199b-5p	CLIP-seq
MIRT1188363	hsa-miR-2115	CLIP-seq
MIRT1188365	hsa-miR-3160-3p	CLIP-seq
MIRT1188369	hsa-miR-4487	CLIP-seq
MIRT1188370	hsa-miR-4663	CLIP-seq
MIRT1188373	hsa-miR-558	CLIP-seq
MIRT2455285	hsa-miR-135a	CLIP-seq
MIRT2455286	hsa-miR-135b	CLIP-seq
MIRT2455287	hsa-miR-146a	CLIP-seq
MIRT2455288	hsa-miR-146b-5p	CLIP-seq
MIRT2455289	hsa-miR-3119	CLIP-seq
MIRT2455290	hsa-miR-3136-3p	CLIP-seq
MIRT2054554	hsa-miR-3654	CLIP-seq
MIRT2455291	hsa-miR-4305	CLIP-seq
MIRT2455292	hsa-miR-4463	CLIP-seq
MIRT2455293	hsa-miR-4520a-3p	CLIP-seq
MIRT2455294	hsa-miR-4638-3p	CLIP-seq
MIRT2455295	hsa-miR-4768-3p	CLIP-seq
MIRT2054556	hsa-miR-665	CLIP-seq
MIRT2054556	hsa-miR-665	CLIP-seq
MIRT2054554	hsa-miR-3654	CLIP-seq
MIRT2455292	hsa-miR-4463	CLIP-seq
MIRT2455293	hsa-miR-4520a-3p	CLIP-seq
MIRT2455294	hsa-miR-4638-3p	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
NANOG	Unknown	23474366

Show/Hide all(96)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0001701	Process	In utero embryonic development	IEA
GO:0001702	Process	Gastrulation with mouth forming second	IEA
GO:0001704	Process	Formation of primary germ layer	IEA
GO:0001707	Process	Mesoderm formation	IEA
GO:0001829	Process	Trophectodermal cell differentiation	IEA
GO:0001831	Process	Trophectodermal cellular morphogenesis	IEA
GO:0001842	Process	Neural fold formation	IEA
GO:0001889	Process	Liver development	IEA
GO:0001890	Process	Placenta development	IEA
GO:0001890	Process	Placenta development	IMP	21356369
GO:0001892	Process	Embryonic placenta development	IEA
GO:0001893	Process	Maternal placenta development	IEA
GO:0001944	Process	Vasculature development	IEA
GO:0001947	Process	Heart looping	IEA
GO:0002085	Process	Inhibition of neuroepithelial cell differentiation	IEA
GO:0003140	Process	Determination of left/right asymmetry in lateral mesoderm	IEA
GO:0003140	Process	Determination of left/right asymmetry in lateral mesoderm	ISS
GO:0005125	Function	Cytokine activity	IBA
GO:0005125	Function	Cytokine activity	IDA	21116837
GO:0005125	Function	Cytokine activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	21656830
GO:0005615	Component	Extracellular space	IEA
GO:0007178	Process	Cell surface receptor protein serine/threonine kinase signaling pathway	IBA
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IEA
GO:0007281	Process	Germ cell development	IEA
GO:0007368	Process	Determination of left/right symmetry	IEA
GO:0007369	Process	Gastrulation	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0007420	Process	Brain development	IEA
GO:0007492	Process	Endoderm development	IEA
GO:0007507	Process	Heart development	IEA
GO:0007565	Process	Female pregnancy	IEA
GO:0008083	Function	Growth factor activity	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0009880	Process	Embryonic pattern specification	IEA
GO:0009948	Process	Anterior/posterior axis specification	IEA
GO:0009952	Process	Anterior/posterior pattern specification	IEA
GO:0009966	Process	Regulation of signal transduction	IEA
GO:0010085	Process	Polarity specification of proximal/distal axis	IEA
GO:0010470	Process	Regulation of gastrulation	IEA
GO:0010575	Process	Positive regulation of vascular endothelial growth factor production	IMP	21116837
GO:0010721	Process	Negative regulation of cell development	IEA
GO:0016015	Function	Morphogen activity	NAS	21159651
GO:0016477	Process	Cell migration	IEA
GO:0019827	Process	Stem cell population maintenance	IEA
GO:0022409	Process	Positive regulation of cell-cell adhesion	IMP	21116837
GO:0030154	Process	Cell differentiation	IEA
GO:0030324	Process	Lung development	IEA
GO:0033505	Process	Floor plate morphogenesis	IEA
GO:0035019	Process	Somatic stem cell population maintenance	IEA
GO:0035050	Process	Embryonic heart tube development	IEA
GO:0035987	Process	Endodermal cell differentiation	IMP	21741376
GO:0038092	Process	Nodal signaling pathway	IDA	21116837
GO:0038092	Process	Nodal signaling pathway	IEA
GO:0038092	Process	Nodal signaling pathway	IGI	15150278
GO:0038092	Process	Nodal signaling pathway	ISS
GO:0042074	Process	Cell migration involved in gastrulation	IEA
GO:0045165	Process	Cell fate commitment	IEA
GO:0045596	Process	Negative regulation of cell differentiation	IEA
GO:0045766	Process	Positive regulation of angiogenesis	IEA
GO:0045766	Process	Positive regulation of angiogenesis	IMP	21116837
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	21116837
GO:0048018	Function	Receptor ligand activity	IEA
GO:0048327	Process	Axial mesodermal cell fate specification	IEA
GO:0048382	Process	Mesendoderm development	IEA
GO:0048382	Process	Mesendoderm development	IEA
GO:0048382	Process	Mesendoderm development	IMP	21741376
GO:0048546	Process	Digestive tract morphogenesis	IEA
GO:0048646	Process	Anatomical structure formation involved in morphogenesis	IEA
GO:0048701	Process	Embryonic cranial skeleton morphogenesis	IEA
GO:0048729	Process	Tissue morphogenesis	IEA
GO:0048859	Process	Formation of anatomical boundary	IEA
GO:0050679	Process	Positive regulation of epithelial cell proliferation	IDA	21656830
GO:0055123	Process	Digestive system development	IEA
GO:0060136	Process	Embryonic process involved in female pregnancy	IEA
GO:0060137	Process	Maternal process involved in parturition	IEA
GO:0060391	Process	Positive regulation of SMAD protein signal transduction	IMP	21741376
GO:0060460	Process	Left lung morphogenesis	IEA
GO:0060766	Process	Negative regulation of androgen receptor signaling pathway	IDA	21656830
GO:0060802	Process	Epiblast cell-extraembryonic ectoderm cell signaling	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IMP	21116837
GO:0070698	Function	Type I activin receptor binding	IDA	15150278
GO:0070698	Function	Type I activin receptor binding	IMP	21356369
GO:0090009	Process	Primitive streak formation	IEA
GO:0097190	Process	Apoptotic signaling pathway	IDA	15150278
GO:1901164	Process	Negative regulation of trophoblast cell migration	IDA	21356369
GO:1901383	Process	Negative regulation of chorionic trophoblast cell proliferation	IDA	15150278
GO:2000036	Process	Regulation of stem cell population maintenance	TAS	21630377
GO:2000242	Process	Negative regulation of reproductive process	IEA
GO:2000242	Process	Negative regulation of reproductive process	IEA

MIM	HGNC	e!Ensembl
601265	7865	ENSG00000156574

Protein

UniProt ID

Q96S42

Protein name

Nodal homolog

Protein function

Essential for mesoderm formation and axial patterning during embryonic development.

PDB

4N1D

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00019	TGF_beta	246 → 346	Transforming growth factor beta like domain	Domain

Sequence

MHAHCLPFLLHAWWALLQAGAATVATALLRTRGQPSSPSPLAYMLSLYRDPLPRADIIRS
LQAEDVAVDGQNWTFAFDFSFLSQQEDLAWAELRLQLSSPVDLPTEGSLAIEIFHQPKPD
TEQASDSCLERFQMDLFTVTLSQVTFSLGSMVLEVTRPLSKWLKHPGALEKQMSRVAGEC
WPRPPTPPATNVLLMLYSNLSQEQRQLGGSTLLWEAESSWRAQEGQLSWEWGKRHRRHHL
PDRSQLCRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLL
KRYQPHRVPSTCCAPVKTKPLSMLYVDNGRVLLDHHKDMIVEECGCL

Sequence length

347

Interactions

View interactions

	KEGG
	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells

Show/Hide Causal Diseases (1)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Heterotaxy, Visceral	heterotaxy, visceral, 5, autosomal	rs1564667617, rs1447874899, rs1564667078, rs1589152470, rs878855044, rs1564667180	N/A

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Holoprosencephaly	Holoprosencephaly sequence	N/A	N/A	ClinVar
Wolff-Parkinson-White Syndrome	Wolff-Parkinson-White pattern	N/A	N/A	ClinVar

Show/Hide Text Mining Associations (60)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Abnormalities Drug Induced	Associate	19553149
Azoospermia	Associate	26289399
Azoospermia Nonobstructive	Associate	26289399
Biliary Atresia	Associate	25765999
Breast Diseases	Associate	22643182
Breast Neoplasms	Associate	18334633, 22031289, 22577960, 22643182, 23680691, 26370966, 27007464, 32427827, 32636849, 33784590, 37870468
Calcinosis Cutis	Associate	22031289, 34769150
Carcinogenesis	Associate	24696849
Carcinoma Embryonal	Associate	17970049
Carcinoma Hepatocellular	Associate	24465741
Carcinoma in Situ	Inhibit	11127267
Carcinoma Ovarian Epithelial	Associate	16603637
Carcinoma Renal Cell	Associate	28775934, 30943930
Carcinoma Squamous Cell	Associate	31053522
Colorectal Neoplasms	Associate	24696849, 26358078, 31525256, 37002201
Colorectal Neoplasms	Stimulate	34257534
Congenital Abnormalities	Associate	19553149
Drug Related Side Effects and Adverse Reactions	Associate	32636849
Endometrial Neoplasms	Associate	19874624
Endometriosis	Associate	25228630
Endometriosis	Stimulate	30943930
Facial Asymmetry	Associate	25364968
Glioma	Associate	22643182, 23911596
Heart Defects Congenital	Associate	19553149, 23979609, 28738792
Heart Diseases	Associate	29928977
Hepatitis D	Associate	32636849
Heredodegenerative Disorders Nervous System	Associate	11391009
Heterotaxy Syndrome	Associate	36316122
Holoprosencephaly	Associate	19346217, 19431187, 19553149
Hypoxia	Stimulate	22031289, 35729773
Hypoxia	Associate	32427827
Hypoxia Brain	Stimulate	35729773
Laterality Defects Autosomal Dominant	Associate	28738792
Lymphatic Metastasis	Stimulate	34257534
Malocclusion	Associate	34257534
Melanoma	Associate	18334633, 18604175, 20495543, 20495621, 21159651, 21464823, 22031289, 22643182, 25204799, 25767211, 26239596, 26370966, 34769150, 39376672
Motor Neuron Disease	Associate	11391009
Mouth Diseases	Associate	30943930
Neoplasm Invasiveness	Associate	22643182
Neoplasm Metastasis	Associate	23680691, 24465741, 26358078, 26951550, 37002201
Neoplasm Metastasis	Stimulate	32636849, 33784590
Neoplasms	Associate	11127267, 11391009, 18334633, 21464823, 21557273, 21656830, 22031289, 22577960, 22643182, 24465741, 25204799, 25228630, 26358078, 26370966, 26951550 View all (8 more)
Neoplasms	Stimulate	19874624, 20495543, 33784590
Nevus Pigmented	Associate	20495543
Ovarian Diseases	Associate	30943930
Ovarian Neoplasms	Inhibit	18784254
Ovarian Neoplasms	Associate	30943930
Pancreatic Neoplasms	Associate	27632063
Paraneoplastic Syndromes	Associate	11391009
Penile Neoplasms	Associate	31053522
Personality Disorders	Associate	22643182
Pre Eclampsia	Associate	22723898, 30092105
Prostatic Neoplasms	Associate	21557273, 21656830, 22643182, 22843506, 25552920, 31210839
Prostatic Neoplasms	Stimulate	32366240
Retinoblastoma	Associate	30401983
Sertoli Cell Only Syndrome	Associate	26289399
Stomach Neoplasms	Associate	27325246
Tertiary Lymphoid Structures	Associate	22643182
Triple Negative Breast Neoplasms	Associate	27007464, 33784590
Uterine Cervical Dysplasia	Stimulate	34257534

NODAL (nodal growth differentiation factor)