NQO2 (N-ribosyldihydronicotinamide:quinone dehydrogenase 2)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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4835 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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N-ribosyldihydronicotinamide:quinone dehydrogenase 2 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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NQO2 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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DHQV, DIA6, NMOR2, QR2 |
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Chromosome
Chromosome number
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6 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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6p25.2 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutati |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | P16083 | ||||||||||
| Protein name | Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.5.1) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2) | ||||||||||
| Protein function | The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutama | ||||||||||
| PDB | 1QR2 , 1SG0 , 1XI2 , 1ZX1 , 2BZS , 2QMY , 2QMZ , 2QR2 , 2QWX , 2QX4 , 2QX6 , 2QX8 , 2QX9 , 3FW1 , 3G5M , 3GAM , 3NFR , 3NHF , 3NHJ , 3NHK , 3NHL , 3NHP , 3NHR , 3NHS , 3NHU , 3NHW , 3NHY , 3O2N , 3O73 , 3OVM , 3OWH , 3OWX , 3OX1 , 3OX2 , 3OX3 , 3TE7 , 3TEM , 3TZB , 3UXE , 3UXH , 4FGJ , 4FGK , 4FGL , 4GQI , 4GR9 , 4QOD , 4QOE , 4QOF , 4QOG , 4QOH , 4QOI | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 231 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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