Gene Gene information from NCBI Gene database.
Entrez ID 4835
Gene name N-ribosyldihydronicotinamide:quinone dehydrogenase 2
Gene symbol NQO2
Synonyms (NCBI Gene)
DHQVDIA6NMOR2QR2
Chromosome 6
Chromosome location 6p25.2
Summary This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutati
miRNA miRNA information provided by mirtarbase database.
249
miRTarBase ID miRNA Experiments Reference
MIRT044829 hsa-miR-320a CLASH 23622248
MIRT044829 hsa-miR-320a HITS-CLIP 19536157
MIRT723160 hsa-miR-320b HITS-CLIP 19536157
MIRT723159 hsa-miR-320c HITS-CLIP 19536157
MIRT723158 hsa-miR-320d HITS-CLIP 19536157
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
JUND Unknown 16545679
SP1 Unknown 11154737;15451063
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
GO ID Ontology Definition Evidence Reference
GO:0001512 Function Dihydronicotinamide riboside quinone reductase activity IDA 18254726
GO:0001512 Function Dihydronicotinamide riboside quinone reductase activity IEA
GO:0003955 Function NAD(P)H dehydrogenase (quinone) activity IBA
GO:0005515 Function Protein binding IPI 16189514, 24606901, 25416956, 31515488, 32296183
GO:0005654 Component Nucleoplasm IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
160998 7856 ENSG00000124588
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P16083
Protein name Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.5.1) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2)
Protein function The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutama
PDB 1QR2 , 1SG0 , 1XI2 , 1ZX1 , 2BZS , 2QMY , 2QMZ , 2QR2 , 2QWX , 2QX4 , 2QX6 , 2QX8 , 2QX9 , 3FW1 , 3G5M , 3GAM , 3NFR , 3NHF , 3NHJ , 3NHK , 3NHL , 3NHP , 3NHR , 3NHS , 3NHU , 3NHW , 3NHY , 3O2N , 3O73 , 3OVM , 3OWH , 3OWX , 3OX1 , 3OX2 , 3OX3 , 3TE7 , 3TEM , 3TZB , 3UXE , 3UXH , 4FGJ , 4FGK , 4FGL , 4GQI , 4GR9 , 4QOD , 4QOE , 4QOF , 4QOG , 4QOH , 4QOI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02525 Flavodoxin_2 4 212 Flavodoxin-like fold Domain
Sequence
Sequence length 231
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Phase I - Functionalization of compounds
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Ovarian cancer Benign rs28383623 RCV003154675
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Agranulocytosis Associate 29281794, 40311769
Aphasia Broca Associate 36818472
Brain Ischemia Associate 31564827
Colorectal Neoplasms Associate 27165481
COVID 19 Associate 36770840, 36818472
Death Associate 37891619
Drug Related Side Effects and Adverse Reactions Associate 40311769
Glaucoma Associate 36770840
Lung Neoplasms Associate 37891619
Lymphatic Metastasis Associate 23918565