NQO2 (N-ribosyldihydronicotinamide:quinone dehydrogenase 2)

Gene

• Entrez ID: 4835
• Gene name: N-ribosyldihydronicotinamide:quinone dehydrogenase 2
• Gene symbol: NQO2
• Synonyms (NCBI Gene): DHQV, DIA6, NMOR2, QR2
• Chromosome: 6
• Chromosome location: 6p25.2
• Summary: This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutati

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044829	hsa-miR-320a	CLASH	23622248
MIRT044829	hsa-miR-320a	HITS-CLIP	19536157
MIRT723160	hsa-miR-320b	HITS-CLIP	19536157
MIRT723159	hsa-miR-320c	HITS-CLIP	19536157
MIRT723158	hsa-miR-320d	HITS-CLIP	19536157
MIRT723157	hsa-miR-4429	HITS-CLIP	19536157
MIRT723156	hsa-miR-193a-3p	HITS-CLIP	19536157
MIRT723155	hsa-miR-193b-3p	HITS-CLIP	19536157
MIRT723154	hsa-miR-892b	HITS-CLIP	19536157
MIRT723153	hsa-miR-1278	HITS-CLIP	19536157
MIRT723152	hsa-miR-3190-5p	HITS-CLIP	19536157
MIRT723151	hsa-miR-4268	HITS-CLIP	19536157
MIRT723150	hsa-miR-4448	HITS-CLIP	19536157
MIRT723149	hsa-miR-4529-5p	HITS-CLIP	19536157
MIRT723148	hsa-miR-9-3p	HITS-CLIP	19536157
MIRT723147	hsa-miR-6772-3p	HITS-CLIP	19536157
MIRT723146	hsa-miR-3187-3p	HITS-CLIP	19536157
MIRT694062	hsa-miR-576-3p	HITS-CLIP	23313552
MIRT694061	hsa-miR-1228-3p	HITS-CLIP	23313552
MIRT694060	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT694059	hsa-miR-4735-5p	HITS-CLIP	23313552
MIRT694058	hsa-miR-4794	HITS-CLIP	23313552
MIRT694057	hsa-miR-664a-5p	HITS-CLIP	23313552
MIRT694056	hsa-miR-1227-3p	HITS-CLIP	23313552
MIRT694055	hsa-miR-4775	HITS-CLIP	23313552
MIRT694054	hsa-miR-4715-3p	HITS-CLIP	23313552
MIRT694053	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT631695	hsa-miR-6796-3p	HITS-CLIP	23824327
MIRT631694	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT631693	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT631692	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT631691	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT631690	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT631689	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT631688	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT631687	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT631686	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT631685	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT631684	hsa-miR-4284	HITS-CLIP	23824327
MIRT631683	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631682	hsa-miR-4267	HITS-CLIP	23824327
MIRT631681	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631680	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT631679	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT631678	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT631677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT631676	hsa-miR-7977	HITS-CLIP	23824327
MIRT631675	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT631674	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT647028	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT647027	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT647026	hsa-miR-4532	HITS-CLIP	23824327
MIRT647025	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT647024	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT647023	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT647022	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT647021	hsa-miR-1976	HITS-CLIP	23824327
MIRT631679	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT647020	hsa-miR-4279	HITS-CLIP	23824327
MIRT631695	hsa-miR-6796-3p	HITS-CLIP	23824327
MIRT631683	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631694	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT631681	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631693	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT631692	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT631691	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT631690	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT631689	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT631688	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT631687	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT631686	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT631685	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT631684	hsa-miR-4284	HITS-CLIP	23824327
MIRT631676	hsa-miR-7977	HITS-CLIP	23824327
MIRT631682	hsa-miR-4267	HITS-CLIP	23824327
MIRT631680	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT631679	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT631678	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT631677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT631676	hsa-miR-7977	HITS-CLIP	23824327
MIRT631675	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT631674	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT631695	hsa-miR-6796-3p	HITS-CLIP	23824327
MIRT631694	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT631693	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT631692	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT631691	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT631690	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT631689	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT631688	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT631687	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT631686	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT631685	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT631684	hsa-miR-4284	HITS-CLIP	23824327
MIRT631683	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631682	hsa-miR-4267	HITS-CLIP	23824327
MIRT631681	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631680	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT631679	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT631678	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT631677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT631676	hsa-miR-7977	HITS-CLIP	23824327
MIRT631675	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT631674	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT457801	hsa-miR-941	PAR-CLIP	23592263
MIRT457800	hsa-miR-4258	PAR-CLIP	23592263
MIRT457799	hsa-miR-4707-3p	PAR-CLIP	23592263
MIRT457798	hsa-miR-6789-3p	PAR-CLIP	23592263
MIRT457800	hsa-miR-4258	PAR-CLIP	27292025
MIRT457799	hsa-miR-4707-3p	PAR-CLIP	27292025
MIRT457798	hsa-miR-6789-3p	PAR-CLIP	27292025
MIRT457801	hsa-miR-941	PAR-CLIP	27292025
MIRT044829	hsa-miR-320a	HITS-CLIP	19536157
MIRT723160	hsa-miR-320b	HITS-CLIP	19536157
MIRT723159	hsa-miR-320c	HITS-CLIP	19536157
MIRT723158	hsa-miR-320d	HITS-CLIP	19536157
MIRT723157	hsa-miR-4429	HITS-CLIP	19536157
MIRT723156	hsa-miR-193a-3p	HITS-CLIP	19536157
MIRT723155	hsa-miR-193b-3p	HITS-CLIP	19536157
MIRT723154	hsa-miR-892b	HITS-CLIP	19536157
MIRT723153	hsa-miR-1278	HITS-CLIP	19536157
MIRT723152	hsa-miR-3190-5p	HITS-CLIP	19536157
MIRT723151	hsa-miR-4268	HITS-CLIP	19536157
MIRT723150	hsa-miR-4448	HITS-CLIP	19536157
MIRT723149	hsa-miR-4529-5p	HITS-CLIP	19536157
MIRT723148	hsa-miR-9-3p	HITS-CLIP	19536157
MIRT723147	hsa-miR-6772-3p	HITS-CLIP	19536157
MIRT723146	hsa-miR-3187-3p	HITS-CLIP	19536157
MIRT694062	hsa-miR-576-3p	HITS-CLIP	23313552
MIRT694061	hsa-miR-1228-3p	HITS-CLIP	23313552
MIRT694060	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT694059	hsa-miR-4735-5p	HITS-CLIP	23313552
MIRT694058	hsa-miR-4794	HITS-CLIP	23313552
MIRT694057	hsa-miR-664a-5p	HITS-CLIP	23313552
MIRT694056	hsa-miR-1227-3p	HITS-CLIP	23313552
MIRT694055	hsa-miR-4775	HITS-CLIP	23313552
MIRT694054	hsa-miR-4715-3p	HITS-CLIP	23313552
MIRT694053	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT631695	hsa-miR-6796-3p	HITS-CLIP	23824327
MIRT631694	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT631693	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT631692	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT631691	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT631690	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT631689	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT631688	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT631687	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT631686	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT631685	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT631684	hsa-miR-4284	HITS-CLIP	23824327
MIRT631683	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631682	hsa-miR-4267	HITS-CLIP	23824327
MIRT631681	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631680	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT631679	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT631678	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT631677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT631676	hsa-miR-7977	HITS-CLIP	23824327
MIRT631675	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT631674	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT647028	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT647027	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT647026	hsa-miR-4532	HITS-CLIP	23824327
MIRT647025	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT647024	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT647023	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT647022	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT647021	hsa-miR-1976	HITS-CLIP	23824327
MIRT631679	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT647020	hsa-miR-4279	HITS-CLIP	23824327
MIRT631695	hsa-miR-6796-3p	HITS-CLIP	23824327
MIRT631683	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631694	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT631681	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631693	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT631692	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT631691	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT631690	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT631689	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT631688	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT631687	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT631686	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT631685	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT631684	hsa-miR-4284	HITS-CLIP	23824327
MIRT631676	hsa-miR-7977	HITS-CLIP	23824327
MIRT631682	hsa-miR-4267	HITS-CLIP	23824327
MIRT631680	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT631679	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT631678	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT631677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT631676	hsa-miR-7977	HITS-CLIP	23824327
MIRT631675	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT631674	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT631695	hsa-miR-6796-3p	HITS-CLIP	23824327
MIRT631694	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT631693	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT631692	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT631691	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT631690	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT631689	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT631688	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT631687	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT631686	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT631685	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT631684	hsa-miR-4284	HITS-CLIP	23824327
MIRT631683	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT631682	hsa-miR-4267	HITS-CLIP	23824327
MIRT631681	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT631680	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT631679	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT631678	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT631677	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT631676	hsa-miR-7977	HITS-CLIP	23824327
MIRT631675	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT631674	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT457801	hsa-miR-941	PAR-CLIP	23592263
MIRT457800	hsa-miR-4258	PAR-CLIP	23592263
MIRT457799	hsa-miR-4707-3p	PAR-CLIP	23592263
MIRT457798	hsa-miR-6789-3p	PAR-CLIP	23592263
MIRT2582381	hsa-miR-1539	CLIP-seq
MIRT2582382	hsa-miR-2277-3p	CLIP-seq
MIRT2582383	hsa-miR-2861	CLIP-seq
MIRT2582384	hsa-miR-29a	CLIP-seq
MIRT2582385	hsa-miR-29b	CLIP-seq
MIRT2582386	hsa-miR-29c	CLIP-seq
MIRT2582387	hsa-miR-3065-3p	CLIP-seq
MIRT2582388	hsa-miR-3152-5p	CLIP-seq
MIRT2582389	hsa-miR-4753-3p	CLIP-seq
MIRT2582390	hsa-miR-4763-5p	CLIP-seq
MIRT2582391	hsa-miR-4774-3p	CLIP-seq
MIRT2582392	hsa-miR-648	CLIP-seq
MIRT2582393	hsa-miR-661	CLIP-seq
MIRT2582394	hsa-miR-767-5p	CLIP-seq
MIRT2582395	hsa-miR-942	CLIP-seq
MIRT2582381	hsa-miR-1539	CLIP-seq
MIRT2582382	hsa-miR-2277-3p	CLIP-seq
MIRT2582383	hsa-miR-2861	CLIP-seq
MIRT2582384	hsa-miR-29a	CLIP-seq
MIRT2582385	hsa-miR-29b	CLIP-seq
MIRT2582386	hsa-miR-29c	CLIP-seq
MIRT2582387	hsa-miR-3065-3p	CLIP-seq
MIRT2582388	hsa-miR-3152-5p	CLIP-seq
MIRT2582389	hsa-miR-4753-3p	CLIP-seq
MIRT2582390	hsa-miR-4763-5p	CLIP-seq
MIRT2582391	hsa-miR-4774-3p	CLIP-seq
MIRT2582392	hsa-miR-648	CLIP-seq
MIRT2582393	hsa-miR-661	CLIP-seq
MIRT2582394	hsa-miR-767-5p	CLIP-seq
MIRT2582395	hsa-miR-942	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
JUND	Unknown	16545679
SP1	Unknown	11154737;15451063

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001512	Function	Dihydronicotinamide riboside quinone reductase activity	IDA	18254726
GO:0003955	Function	NAD(P)H dehydrogenase (quinone) activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	16189514, 24606901, 25416956, 31515488, 32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA	10945627
GO:0005829	Component	Cytosol	TAS
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0007613	Process	Memory	IEA
GO:0008270	Function	Zinc ion binding	IDA	18254726
GO:0009055	Function	Electron transfer activity	IDA	10945627, 18254726
GO:0016491	Function	Oxidoreductase activity	IDA	10945627
GO:0016661	Function	Oxidoreductase activity, acting on other nitrogenous compounds as donors	IDA	10945627
GO:0022900	Process	Electron transport chain	IEA
GO:0031404	Function	Chloride ion binding	IDA	18254726
GO:0042803	Function	Protein homodimerization activity	IPI	18254726
GO:0043525	Process	Positive regulation of neuron apoptotic process	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IEA
GO:0071949	Function	FAD binding	IDA	18254726
GO:1904408	Function	Melatonin binding	IDA	18254726
GO:1904707	Process	Positive regulation of vascular associated smooth muscle cell proliferation	IEA
GO:1905594	Function	Resveratrol binding	IDA	18254726
GO:2000379	Process	Positive regulation of reactive oxygen species metabolic process	IEA

Other IDs

• MIM: 160998
• HGNC: 7856
• e!Ensembl: ENSG00000124588

Protein

• UniProt ID: P16083
• Protein name: Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.5.1) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2)
• Protein function: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutama
• PDB: 1QR2, 1SG0, 1XI2, 1ZX1, 2BZS, 2QMY, 2QMZ, 2QR2, 2QWX, 2QX4, 2QX6, 2QX8, 2QX9, 3FW1, 3G5M, 3GAM, 3NFR, 3NHF, 3NHJ, 3NHK, 3NHL, 3NHP, 3NHR, 3NHS, 3NHU, 3NHW, 3NHY, 3O2N, 3O73, 3OVM, 3OWH, 3OWX, 3OX1, 3OX2, 3OX3, 3TE7, 3TEM, 3TZB, 3UXE, 3UXH, 4FGJ, 4FGK, 4FGL, 4GQI, 4GR9, 4QOD, 4QOE, 4QOF, 4QOG, 4QOH, 4QOI
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02525	Flavodoxin_2	4 → 212	Flavodoxin-like fold	Domain

• Sequence:

  MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTL
  SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV
  LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC
  GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ

• Sequence length: 231

Pathways

Reactome:

Phase I - Functionalization of compounds

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Bone marrow diseases	Bone Marrow Diseases	rs1557518298, rs1557507208, rs1569770360, rs1644867065	12351651
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038
Dermatitis	Contact Dermatitis	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	25724174
Marfan syndrome	Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465, rs137854466, rs137854467, rs387906547, rs387906548, rs137854469, rs137854473, rs1131692050, rs112989722, rs137854474, rs137854476, rs140593, rs1555395819, rs137854478, rs137854479, rs137854480, rs137854481, rs137854482, rs137854483, rs137854484, rs137854485, rs112289537, rs193922181, rs193922182, rs193922185, rs140603, rs193922187, rs193922188, rs193921256, rs112660651, rs193922193, rs193922194, rs193922197, rs193922198, rs193922199, rs193922203, rs193922204, rs193922205, rs193922206, rs111401431, rs193922207, rs113871094, rs111671429, rs193922216, rs193922219, rs193922220, rs193922223, rs193922224, rs193922225, rs193922226, rs193922227, rs193922228, rs193922230, rs193922235, rs147195031, rs193922236, rs193922239, rs193922240, rs193922241, rs193922246, rs397514558, rs398122934, rs397515753, rs397515754, rs397515755, rs397515756, rs397515757, rs113812345, rs397515758, rs397515759, rs397515762, rs25403, rs397515765, rs397515766, rs397515767, rs397515768, rs397515769, rs397515770, rs397515771, rs25404, rs397515773, rs397515774, rs397515775, rs397515776, rs397515778, rs397515779, rs397515781, rs112202622, rs397515782, rs397515784, rs397515785, rs397515786, rs397515788, rs397515789, rs397515790, rs397515791, rs397515792, rs397515793, rs397515794, rs397515797, rs397515798, rs397515799, rs397515801, rs397515802, rs397515803, rs397515804, rs397515805, rs397515808, rs397515810, rs397515811, rs397515812, rs111231312, rs267606798, rs397515814, rs113905529, rs397515816, rs397515817, rs397515818, rs397515819, rs397515820, rs363853, rs113249837, rs397515821, rs111929350, rs397515823, rs397515824, rs113086760, rs397515825, rs397515826, rs397515827, rs363807, rs397515828, rs397515829, rs397515830, rs397515831, rs397515833, rs111687884, rs113080385, rs397515834, rs397515836, rs113001196, rs397515840, rs397515845, rs397515846, rs397515847, rs397515848, rs397515851, rs397515852, rs397515853, rs397515854, rs111856492, rs397515859, rs397515861, rs397515863, rs397515864, rs397515865, rs397515866, rs397515867, rs137854855, rs199474693, rs587782944, rs587782947, rs587782948, rs672601352, rs876658120, rs727504651, rs727503054, rs727504315, rs727504411, rs727503057, rs727504454, rs200309328, rs363811, rs727504410, rs363821, rs727504347, rs727505006, rs727505110, rs730880356, rs727505269, rs727503058, rs727504421, rs730880107, rs730880104, rs730880103, rs730880102, rs730880101, rs730880106, rs730880100, rs730880105, rs730880099, rs112645512, rs730880108, rs730880098, rs730880097, rs794728321, rs794728283, rs794728280, rs794728336, rs794728272, rs794728160, rs794728271, rs794728270, rs794728319, rs794728262, rs794728251, rs76702162, rs794728335, rs794728334, rs794728246, rs763091520, rs794728333, rs794728237, rs761857514, rs794728234, rs140630, rs794728231, rs794728228, rs794728225, rs794728308, rs794728216, rs794728221, rs763449629, rs201058219, rs794728210, rs794728208, rs794728206, rs794728199, rs794728195, rs794728194, rs794728193, rs794728190, rs1555399381, rs794728176, rs1555399968, rs113422242, rs794728326, rs794728166, rs794728325, rs794728165, rs794728162, rs794728213, rs869025417, rs112642323, rs869025416, rs869025415, rs869025424, rs869025423, rs869025414, rs869025422, rs869025413, rs869025412, rs869025411, rs869025418, rs869025426, rs869025406, rs869025421, rs869025425, rs869025404, rs869025420, rs869025403, rs398122833, rs876657645, rs878853686, rs878853676, rs886038919, rs886038795, rs187553035, rs886038869, rs886038949, rs886038967, rs886038976, rs886038848, rs886038940, rs886038877, rs886039038, rs886038817, rs886038963, rs886039036, rs886038797, rs886039550, rs886041482, rs1057517855, rs1057518912, rs1057518973, rs1057519502, rs1057521100, rs1057521102, rs1057518881, rs1057520617, rs1057521101, rs1555394445, rs369058466, rs1060501069, rs1060501031, rs778966916, rs1060501043, rs1555397663, rs1060501017, rs1060501094, rs1060501065, rs1555393848, rs1555394151, rs1060501051, rs1060501013, rs1060501054, rs1060501048, rs1060501089, rs1060501039, rs1555398160, rs1060501022, rs1060501024, rs1060501086, rs1060501058, rs1060501036, rs1060501100, rs1060501042, rs1060501059, rs1555397743, rs1060501021, rs1060501027, rs1060501096, rs1060501038, rs1060501050, rs1064794130, rs112118237, rs1064793980, rs1064793118, rs1064793636, rs1064794282, rs1064793559, rs1085307921, rs1085308004, rs1085307468, rs112907302, rs1131691479, rs1131691373, rs1131691467, rs1131691938, rs1131691311, rs1131691806, rs1131691317, rs1555393827, rs363804, rs1555397738, rs1555399144, rs1555400274, rs1555394195, rs1555398836, rs113543334, rs1555399825, rs1555394626, rs1555395256, rs1555395257, rs1555396427, rs1555397548, rs1555398173, rs1555404803, rs1232880706, rs1555393825, rs1555394567, rs1555396998, rs1555394928, rs1555397203, rs112375043, rs1555397720, rs140599, rs1555399150, rs1555400373, rs1555405041, rs1555395229, rs1555397671, rs775417975, rs1555398774, rs1555399368, rs1555394904, rs1555395987, rs1555397424, rs1555398377, rs1555398835, rs1555401011, rs1555405043, rs1555394580, rs1555397404, rs1555398511, rs1555395826, rs1555399372, rs1555399821, rs1555399836, rs1555400063, rs363810, rs1555397655, rs1555395756, rs1555395742, rs1555393844, rs112550005, rs1555395002, rs1555395658, rs765387131, rs1555396429, rs1555396835, rs1555397014, rs1555397016, rs778710767, rs1555397557, rs1555397704, rs140648, rs1555398406, rs1555398681, rs1555399257, rs1555399361, rs1555399764, rs1555405056, rs1555393510, rs1555395980, rs1555396789, rs1555399094, rs1555399378, rs1555399816, rs1555395645, rs371097218, rs1555398278, rs1555394238, rs1555396418, rs1206813753, rs1555399271, rs1555405044, rs113544411, rs1555395663, rs1555397216, rs1555398989, rs1555399149, rs1555401670, rs1555395001, rs1445085747, rs1555393538, rs1555393565, rs1404133653, rs1555394450, rs1555394581, rs1555394633, rs1555394900, rs1555395189, rs1555395261, rs1052480459, rs1555395480, rs1555395670, rs363806, rs1555395820, rs1555396419, rs1555396765, rs1296209846, rs794728233, rs1555396853, rs1555396863, rs1555397197, rs1555397204, rs1555397212, rs1555397713, rs1555397736, rs1555398139, rs1555398144, rs1555398409, rs1555398510, rs1555398520, rs1555398524, rs1555398667, rs1555399089, rs1555399482, rs1555399763, rs1555401002, rs794728323, rs1555393508, rs1555393514, rs1555393525, rs1555393532, rs1555393653, rs1555393657, rs1555393824, rs1555393831, rs112196241, rs1555393847, rs1555393862, rs1555393863, rs1555393866, rs113935744, rs1555393882, rs1555393886, rs1555393889, rs1555394138, rs1555394144, rs1555394146, rs1555394148, rs1555394149, rs1555394152, rs1555394153, rs1555394189, rs1555394197, rs1555394206, rs1555394212, rs1555394218, rs1555394220, rs1555394235, rs1555394245, rs1555394246, rs1057520728, rs1555394390, rs1555394391, rs537570299, rs1555394397, rs1555394398, rs1555394399, rs1555394402, rs1555394407, rs1555394412, rs1555394435, rs1555394436, rs1555394441, rs1555394556, rs1555394557, rs1555394559, rs1555394561, rs1555394570, rs397515844, rs1555394571, rs1555394574, rs1555394579, rs1555394582, rs534811966, rs111588631, rs1555394628, rs1555394629, rs1555394630, rs1555394631, rs1555394641, rs1555394644, rs1555394647, rs1555394756, rs886051245, rs1555394775, rs1555394776, rs1555394777, rs1555394779, rs1555394780, rs1555394783, rs1555394901, rs1555394906, rs1555394925, rs794728253, rs886039158, rs1555395013, rs1555395187, rs1555395188, rs1555395203, rs1555395205, rs363815, rs1246984265, rs794728245, rs1555395263, rs1555395267, rs1555395456, rs1555395475, rs1555395482, rs1555395638, rs1555395641, rs1555395648, rs1555395653, rs1555395659, rs111239111, rs1555395745, rs1555395747, rs1555395753, rs1555395757, rs1555395766, rs1555395767, rs1555395843, rs1555395846, rs1555395849, rs1555395978, rs1555395981, rs1555395984, rs1555395989, rs1555395990, rs1260109901, rs1555396186, rs1555396188, rs1555396198, rs1555396199, rs1555396201, rs1555396202, rs1555396205, rs1555396213, rs1555396424, rs1555396426, rs1555396428, rs1555396435, rs1555396630, rs1555396635, rs1555396636, rs1555396639, rs1555396757, rs1555396769, rs1555396838, rs1555396844, rs140627, rs1555396858, rs1555396990, rs1555396991, rs1555396993, rs769588424, rs1555397022, rs1555397024, rs1555397160, rs1555397174, rs1555397176, rs1555397193, rs1555397209, rs1555397210, rs1555397214, rs1060501076, rs113082854, rs113693945, rs111978932, rs1555397403, rs1555397419, rs1555397420, rs1555397421, rs1555397536, rs1555397537, rs1555397540, rs1555397542, rs1555397543, rs1555397545, rs1555397546, rs1555397670, rs1555397692, rs1555397718, rs1555397723, rs1555397744, rs113393517, rs1555398148, rs1555398152, rs1555398174, rs1555398176, rs1555398179, rs1555398282, rs1555398287, rs1555398380, rs1555398394, rs1555398397, rs1555398401, rs1555398404, rs1555398407, rs1555398413, rs1555398501, rs1555398508, rs1555398512, rs1555398513, rs1555398515, rs1555398521, rs794728205, rs1555398527, rs1555398551, rs1060501075, rs1555398566, rs1555398572, rs1555398580, rs1555398582, rs140597, rs1555398622, rs1555398624, rs1555398625, rs112547596, rs1555398627, rs1555398633, rs1555398637, rs1555398642, rs778867355, rs1555398648, rs1555398659, rs1293095681, rs1060501040, rs987202268, rs1555398672, rs1555398673, rs1555398677, rs1555398793, rs1555398803, rs1555398811, rs1555398826, rs1555398833, rs1555398974, rs1555398981, rs778900586, rs1555398988, rs1555398994, rs1555398995, rs1555398996, rs1555399093, rs869025405, rs1555399101, rs1555399146, rs1555399160, rs1555399162, rs1555399164, rs1555399165, rs1555399193, rs1555399195, rs1555399202, rs1555399204, rs1555399206, rs201778577, rs1555399210, rs1555399214, rs1555399270, rs1555399273, rs1555399281, rs1555399371, rs1555399385, rs1555399477, rs1555399484, rs1555399761, rs1555399775, rs1555399802, rs1555399804, rs1555399837, rs1555399840, rs1555399940, rs1555399944, rs1555399949, rs1555399953, rs1555399954, rs1555399955, rs1555399959, rs1555399962, rs1555399963, rs1060501041, rs1555399974, rs1555399976, rs1555399977, rs1555400049, rs794728172, rs1555400062, rs1555400064, rs1555400066, rs1555400267, rs1555400268, rs1555400278, rs794728168, rs1555400279, rs1156747241, rs1555400288, rs1555400371, rs1555400372, rs1555400379, rs1555400385, rs587782943, rs1555400387, rs1555400406, rs1439533354, rs746201757, rs1555400595, rs1555400603, rs1555400604, rs1555400606, rs1555400609, rs752010116, rs1555400612, rs1555400616, rs1555401004, rs1555401005, rs146348130, rs1555401667, rs1555401671, rs1555401676, rs1555401679, rs1555401687, rs1555401689, rs1555401695, rs1555401697, rs1555401701, rs1555404799, rs1555404800, rs200295020, rs1555404810, rs1555404820, rs1555405031, rs1555405039, rs1555405045, rs1555405530, rs794728292, rs1555405533, rs1555405536, rs1555405537, rs111764111, rs1555405658, rs1555405664, rs774371494, rs1555405673, rs1555407399, rs1555407414, rs1555407423, rs1555407429, rs886041536, rs1555404806, rs1566911709, rs1566913974, rs1566894226, rs1566895223, rs1566897376, rs1566902526, rs1566915277, rs1566897374, rs1566897420, rs1566891655, rs1346043320, rs1566922396, rs1566891706, rs1566894783, rs1566913670, rs1555394196, rs1566891454, rs1566891406, rs1566891404, rs1566895262, rs1566891645, rs1566895225, rs1566896114, rs1566898399, rs1566904011, rs1566906537, rs1566908956, rs1566909766, rs1566919599, rs1566937712, rs1566915335, rs1566891675, rs1566904526, rs1566906506, rs1566900540, rs1566894230, rs1555395206, rs1566891797, rs1597512576, rs1597523873, rs1597581001, rs1597516325, rs1057524757, rs1597506641, rs1597520781, rs1597593695, rs1597529829, rs1597520625, rs1597579923, rs1597531796, rs1008275504, rs1597567249, rs1597569265, rs1597652471, rs1597516347, rs1597577114, rs1597633163, rs1597519658, rs1597593852, rs1597516501, rs1566913982, rs1555393859, rs1597513708, rs368978109, rs1480832655, rs1597520683, rs1597522390, rs1597522553, rs1597529748, rs1597533707, rs1597537815, rs1597545309, rs1597545836, rs1597563234, rs1597563280, rs1597564359, rs772108557, rs1597568968, rs1597574236, rs1597574308, rs1597577975, rs193922179, rs1597581005, rs1597593736, rs1597623670, rs1597625734, rs1597631662, rs113604459, rs1597633183, rs1597633219, rs1597518951, rs1555394781, rs1597525871, rs1597526073, rs1597569159, rs1597569536, rs1597563934, rs1597545199, rs1364210063, rs1597552583, rs1597520619, rs1597540854, rs1597591602, rs1597569551, rs1597548716, rs1597553721, rs112728248, rs1597537858, rs1597517935, rs1597540907, rs1597552388, rs1597591643, rs1597529841, rs1597506547, rs1597509836, rs1597529686, rs1566897404, rs1597533713, rs1597543486, rs1597545257, rs1597545345, rs1597548672, rs1597562812, rs1597563287, rs1597571391, rs1555400052, rs1597583989, rs363852, rs1597547226, rs363808, rs974604498, rs2043595650, rs2043526284, rs2042997306, rs1555397195, rs886039054, rs1555397213, rs2042873946
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	14639047, 20861374

Unknown
Disease term	Disease name	Evidence	References	Source
Cleft Lip With Or Without Cleft Palate	Cleft Lip With Or Without Cleft Palate			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Agranulocytosis	Associate	29281794, 40311769
Aphasia Broca	Associate	36818472
Brain Ischemia	Associate	31564827
Colorectal Neoplasms	Associate	27165481
COVID 19	Associate	36770840, 36818472
Death	Associate	37891619
Drug Related Side Effects and Adverse Reactions	Associate	40311769
Glaucoma	Associate	36770840
Lung Neoplasms	Associate	37891619
Lymphatic Metastasis	Associate	23918565
Malaria	Associate	36770840
Neoplasms	Associate	23918565, 36770840, 39201396
Neuroblastoma	Associate	32295184
Neurodegenerative Diseases	Associate	36770840
Papillary Thyroid Microcarcinoma	Associate	23918565
Prostatic Neoplasms	Associate	15381063, 22266466