Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4831
Gene name Gene Name - the full gene name approved by the HGNC.
NME/NM23 nucleoside diphosphate kinase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NME2
Synonyms (NCBI Gene) Gene synonyms aliases
NDKB, NDPK-B, NDPKB, NM23-H2, NM23B, PUF
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.33
Summary Summary of gene provided in NCBI Entrez Gene.
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of `A` (encoded by NME1) and `B` (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighb
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT050036 hsa-miR-27a-3p CLASH 23622248
MIRT048132 hsa-miR-197-3p CLASH 23622248
MIRT046894 hsa-miR-221-3p CLASH 23622248
MIRT046082 hsa-miR-125b-5p CLASH 23622248
MIRT045749 hsa-miR-125a-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001726 Component Ruffle IDA 11919189
GO:0002762 Process Negative regulation of myeloid leukocyte differentiation IEA
GO:0003677 Function DNA binding IDA 19435876
GO:0003713 Function Transcription coactivator activity IDA 8392752
GO:0004550 Function Nucleoside diphosphate kinase activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
156491 7850 ENSG00000243678
Protein
UniProt ID P22392
Protein name Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2)
Protein function Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regul
PDB 1NSK , 1NUE , 3BBB , 3BBC , 3BBF , 7KPF , 8PIE , 8PYW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00334 NDK 5 139 Nucleoside diphosphate kinase Domain
Tissue specificity TISSUE SPECIFICITY: [Isoform 1]: Ubiquitously expressed. {ECO:0000269|PubMed:16442775}.; TISSUE SPECIFICITY: [Isoform 3]: Ubiquitously expressed. {ECO:0000269|PubMed:16442775}.
Sequence
Sequence length 152
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Purine metabolism
Pyrimidine metabolism
Drug metabolism - other enzymes
Metabolic pathways
Nucleotide metabolism
Biosynthesis of cofactors
  Interconversion of nucleotide di- and triphosphates
Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Arthritis Degenerative polyarthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 18784066
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
15814641
Colorectal neoplasms Colorectal Neoplasms rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
15814641
Mesothelioma Mesothelioma rs121907908, rs387906350, rs387906351 15920167
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 29522283
Atherosclerosis Inhibit 17272673
Breast Neoplasms Associate 19544670, 21738817, 29475390
Burkitt Lymphoma Associate 7768941
Carcinoma Hepatocellular Associate 39207047
Carcinoma Non Small Cell Lung Associate 32386284
Carcinoma Renal Cell Associate 7614395
Choroidal Neovascularization Inhibit 37598400
Colorectal Neoplasms Associate 28717007, 29475390, 8549951
Helicobacter Infections Associate 11302954