Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4814
Gene name Gene Name - the full gene name approved by the HGNC.
Ninjurin 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NINJ1
Synonyms (NCBI Gene) Gene synonyms aliases
NIN1, NINJURIN, hNINJ1
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q22.31
Summary Summary of gene provided in NCBI Entrez Gene.
The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT026972 hsa-miR-107 Microarray 20489155
MIRT709786 hsa-miR-27a-5p HITS-CLIP 19536157
MIRT709783 hsa-miR-4417 HITS-CLIP 19536157
MIRT709784 hsa-miR-1206 HITS-CLIP 19536157
MIRT709781 hsa-miR-6853-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0001530 Function Lipopolysaccharide binding IDA 26677008
GO:0002232 Process Leukocyte chemotaxis involved in inflammatory response IDA 22162058
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005576 Component Extracellular region IDA 32883094
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602062 7824 ENSG00000131669
Protein
UniProt ID Q92982
Protein name Ninjurin-1 (hNINJ1) (Nerve injury-induced protein 1) [Cleaved into: Secreted ninjurin-1 (Soluble ninjurin-1)]
Protein function [Ninjurin-1]: Effector of various programmed cell death, such as pyroptosis and necroptosis, which mediates plasma membrane rupture (cytolysis) (PubMed:33472215, PubMed:36468682, PubMed:37196676, PubMed:37198476, PubMed:38614101, PubMed:39667936
PDB 8CQR , 8SZA , 8UIP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04923 Ninjurin 38 139 Ninjurin Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin. {ECO:0000269|PubMed:8780658}.
Sequence
Sequence length 152
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Alzheimer disease Alzheimer's disease or family history of Alzheimer's disease N/A N/A GWAS
Gout Gout N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Colorectal Neoplasms Associate 31906747
Diabetic Nephropathies Associate 37986381
Inflammation Associate 37511311
Severe Acute Respiratory Syndrome Associate 37511311
Triple Negative Breast Neoplasms Associate 26792858