NINJ1 (ninjurin 1)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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4814 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Ninjurin 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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NINJ1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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NIN1, NINJURIN, hNINJ1 |
Chromosome
Chromosome number
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9 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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9q22.31 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||
UniProt ID | Q92982 | ||||||||||
Protein name | Ninjurin-1 (hNINJ1) (Nerve injury-induced protein 1) [Cleaved into: Secreted ninjurin-1 (Soluble ninjurin-1)] | ||||||||||
Protein function | [Ninjurin-1]: Effector of various programmed cell death, such as pyroptosis and necroptosis, which mediates plasma membrane rupture (cytolysis) (PubMed:33472215, PubMed:36468682, PubMed:37196676, PubMed:37198476, PubMed:38614101, PubMed:39667936 | ||||||||||
PDB | 8CQR , 8SZA , 8UIP | ||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin. {ECO:0000269|PubMed:8780658}. | ||||||||||
Sequence |
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Sequence length | 152 | ||||||||||
Interactions | View interactions |
Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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