Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
481
Gene name Gene Name - the full gene name approved by the HGNC.
ATPase Na+/K+ transporting subunit beta 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ATP1B1
Synonyms (NCBI Gene) Gene synonyms aliases
ATP1B
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q24.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemica
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT007176 hsa-miR-192-5p Luciferase reporter assay 23221637
MIRT007176 hsa-miR-192-5p Luciferase reporter assay 23221637
MIRT007176 hsa-miR-192-5p Luciferase reporter assay 23221637
MIRT441154 hsa-miR-218-5p HITS-CLIP 23212916
MIRT441154 hsa-miR-218-5p HITS-CLIP 23212916
Transcription factors
Transcription factor Regulation Reference
NR3C1 Repression 9694812
NR3C1 Unknown 11216640
NR3C2 Repression 9694812
NR3C2 Unknown 11216640
PGR Unknown 22330642
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IEA
GO:0001671 Function ATPase activator activity IBA 21873635
GO:0001671 Function ATPase activator activity IDA 10636900, 19542013, 23954377
GO:0001671 Function ATPase activator activity IGI 16861705, 18728015, 20100892
GO:0005515 Function Protein binding IPI 17947299, 22328087, 25012180, 25902260, 28298427, 30021884, 32814053
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
182330 804 ENSG00000143153
Protein
UniProt ID P05026
Protein name Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1)
Protein function This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers,
PDB 7E1Z , 7E20 , 7E21 , 8D3U , 8D3V , 8D3W , 8D3X , 8D3Y , 8ZYJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00287 Na_K-ATPase 3 297 Sodium / potassium ATPase beta chain Family
Tissue specificity TISSUE SPECIFICITY: Found in most tissues.
Sequence
Sequence length 303
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  cGMP-PKG signaling pathway
cAMP signaling pathway
Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Cytoskeleton in muscle cells
Insulin secretion
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Aldosterone synthesis and secretion
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Proximal tubule bicarbonate reclamation
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Carbohydrate digestion and absorption
Protein digestion and absorption
Bile secretion
Mineral absorption
  Basigin interactions
Ion homeostasis
Ion transport by P-type ATPases
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 29212778
Hypertension Essential Hypertension rs13306026
Leukemia Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2) rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 17330099
Unknown
Disease term Disease name Evidence References Source
Myocardial Infarction Myocardial Infarction GWAS
Endometriosis Endometriosis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 36094096
Asthma Associate 36835202
Atrial Fibrillation Associate 37967346
Breast Neoplasms Associate 22330642
Carcinoma Basal Cell Associate 25227856
Carcinoma Hepatocellular Stimulate 33868261
Carcinoma Renal Cell Associate 24452105
Death Sudden Cardiac Associate 19305409
Diabetes Mellitus Type 2 Associate 38014529
Essential Hypertension Associate 17236131