NFRKB (nuclear factor related to kappaB binding protein)

Gene

• Entrez ID: 4798
• Gene name: Nuclear factor related to kappaB binding protein
• Gene symbol: NFRKB
• Synonyms (NCBI Gene): INO80G
• Chromosome: 11
• Chromosome location: 11q24.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT670043	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT670042	hsa-miR-4438	HITS-CLIP	23824327
MIRT670041	hsa-miR-4258	HITS-CLIP	23824327
MIRT670040	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT670039	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT670038	hsa-miR-6789-3p	HITS-CLIP	23824327
MIRT670037	hsa-miR-4775	HITS-CLIP	23824327
MIRT670036	hsa-miR-5095	HITS-CLIP	23824327
MIRT670035	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT670034	hsa-miR-3149	HITS-CLIP	23824327
MIRT670033	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT670043	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT670042	hsa-miR-4438	HITS-CLIP	23824327
MIRT670041	hsa-miR-4258	HITS-CLIP	23824327
MIRT670040	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT670039	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT670038	hsa-miR-6789-3p	HITS-CLIP	23824327
MIRT670037	hsa-miR-4775	HITS-CLIP	23824327
MIRT670036	hsa-miR-5095	HITS-CLIP	23824327
MIRT670035	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT670034	hsa-miR-3149	HITS-CLIP	23824327
MIRT670033	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT2053225	hsa-miR-4796-3p	CLIP-seq
MIRT2053226	hsa-miR-520g	CLIP-seq
MIRT2053227	hsa-miR-520h	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000723	Process	Telomere maintenance	IEA
GO:0000723	Process	Telomere maintenance	ISO
GO:0002020	Function	Protease binding	IBA
GO:0002020	Function	Protease binding	IPI	18922472
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	18922472, 19615732, 25416956, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	18922472
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006275	Process	Regulation of DNA replication	IMP	25016522
GO:0006281	Process	DNA repair	IEA
GO:0006282	Process	Regulation of DNA repair	IEA
GO:0006282	Process	Regulation of DNA repair	ISO
GO:0006310	Process	DNA recombination	IEA
GO:0006338	Process	Chromatin remodeling	IDA	21303910
GO:0006974	Process	DNA damage response	IEA
GO:0010604	Process	Positive regulation of macromolecule metabolic process	IEA
GO:0031011	Component	Ino80 complex	IDA	18922472, 21303910
GO:0031011	Component	Ino80 complex	IEA
GO:0033044	Process	Regulation of chromosome organization	IEA
GO:0033044	Process	Regulation of chromosome organization	IMP	26340092
GO:0045739	Process	Positive regulation of DNA repair	IEA
GO:0045739	Process	Positive regulation of DNA repair	ISO
GO:0045893	Process	Positive regulation of DNA-templated transcription	IMP	27641337
GO:0045935	Process	Positive regulation of nucleobase-containing compound metabolic process	IEA
GO:0045995	Process	Regulation of embryonic development	IEA
GO:0045995	Process	Regulation of embryonic development	ISO
GO:0051052	Process	Regulation of DNA metabolic process	IEA
GO:0051726	Process	Regulation of cell cycle	IMP	26340092
GO:0060382	Process	Regulation of DNA strand elongation	IMP	25016522
GO:1904507	Process	Positive regulation of telomere maintenance in response to DNA damage	IEA
GO:1904507	Process	Positive regulation of telomere maintenance in response to DNA damage	ISO

Other IDs

• MIM: 164013
• HGNC: 7802
• e!Ensembl: ENSG00000170322

Protein

• UniProt ID: Q6P4R8
• Protein name: Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G)
• Protein function: Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. ; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probabl
• PDB: 3U21, 4UF5, 4UF6, 4WLP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14465	NFRKB_winged	379 → 478	NFRKB Winged Helix-like	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in thymus, brain, testes, spleen and liver. {ECO:0000269|PubMed:1777480}.
• Sequence:

  MDSLDHMLTDPLELGPCGDGHGTRIMEDCLLGGTRVSLPEDLLEDPEIFFDVVSLSTWQE
  VLSDSQREHLQQFLPQFPEDSAEQQNELILALFSGENFRFGNPLHIAQKLFRDGHFNPEV
  VKYRQLCFKSQYKRYLNSQQQYFHRLLKQILASRSDLLEMARRSGPALPFRQKRPSPSRT
  PEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSWLPSSPARSPSPAVPLRVVPTLS
  TTDMKTADKVELGDSDLKIMLKKHHEKRKHQPDHPDLLTGDLTLNDIMTRVNAGRKGSLA
  ALYDLAVLKKKVKEKEEKKKKKIKTIKSEAEDLAEPLSSTEGVAPLSQAPSPLAIPAIKE
  EPLEDLKPCLGINEISSSFFSLLLEILLLESQASLPMLEERVLDWQSSPASSLNSWFSAA
  PNWAELVLPALQYLAGESRAVPSSFSPFVEFKEKTQQWKLLGQSQDNEKELAALFQLWLE
  TKDQAFCKQENEDSSDATTPVPRVRTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRM
  HGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEI
  CELLKDSQFLAPDVTSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFE
  RIHQAQAAAAKARKALQQKPKPPSKVKSSSKESSIKVLSSGPSEQSQMSLSDSSMPPTPV
  TPVTPTTPALPAIPISPPPVSAVNKSGPSTVSEPAKSSSGVLLVSSPTMPHLGTMLSPAS
  SQTAPSSQAAARVVSHSGSAGLSQVRVVAQPSLPAVPQQSGGPAQTLPQMPAGPQIRVPA
  TATQTKVVPQTVMATVPVKAQTTAATVQRPGPGQTGLTVTSLPATASPVSKPATSSPGTS
  APSASTAAVIQNVTGQNIIKQVAITGQLGVKPQTGNSIPLTATNFRIQGKDVLRLPPSSI
  TTDAKGQTVLRITPDMMATLAKSQVTTVKLTQDLFGTGGNTTGKGISATLHVTSNPVHAA
  DSPAKASSASAPSSTPTGTTVVKVTPDLKPTEASSSAFRLMPALGVSVADQKGKSTVASS
  EAKPAATIRIVQGLGVMPPKAGQTITVATHAKQGASVASGSGTVHTSAVSLPSMNAAVSK
  TVAVASGAASTPISISTGAPTVRQVPVSTTVVSTSQAGKLPTRITVPLSVISQPMKGKSV
  VTAPIIKGNLGANLSGLGRNIILTTMPAGTKLIAGNKPVSFLTAQQLQQLQQQGQATQVR
  IQTVPASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ

• Sequence length: 1299

Pathways

KEGG:

ATP-dependent chromatin remodeling

Reactome:

UCH proteinases
DNA Damage Recognition in GG-NER