Gene Gene information from NCBI Gene database.
Entrez ID 4782
Gene name Nuclear factor I C
Gene symbol NFIC
Synonyms (NCBI Gene)
CTFCTF5NF-INFI
Chromosome 19
Chromosome location 19p13.3
Summary The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants en
miRNA miRNA information provided by mirtarbase database.
413
miRTarBase ID miRNA Experiments Reference
MIRT002601 hsa-miR-124-3p Proteomics 18668037
MIRT002601 hsa-miR-124-3p Microarray 15685193
MIRT042760 hsa-miR-339-5p CLASH 23622248
MIRT040932 hsa-miR-18a-3p CLASH 23622248
MIRT522314 hsa-miR-3651 HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
30
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 19706729
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IGI 1524678
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 1524678
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600729 7786 ENSG00000141905
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P08651
Protein name Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein)
Protein function Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replicatio
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10524 NfI_DNAbd_pre-N 8 47 Nuclear factor I protein pre-N-terminus Family
PF03165 MH1 69 173 MH1 domain Domain
PF00859 CTF_NFI 217 507 CTF/NF-I family transcription modulation region Family
Sequence
Sequence length 508
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Thyroid cancer, nonmedullary, 1 Uncertain significance rs143519997 RCV005927198
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 1953710
Breast Neoplasms Associate 16980581, 19589785, 25879941
Carcinogenesis Associate 25070814, 25879941
Carcinoma Small Cell Associate 1953710
Carcinoma Squamous Cell Inhibit 34985387
Cardiomyopathies Associate 35741813
Developmental Disabilities Associate 31067457
Diabetes Mellitus Type 2 Associate 32041280
Diabetic Foot Inhibit 37710299
Glioblastoma Associate 30195713