Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4782
Gene name Gene Name - the full gene name approved by the HGNC.
Nuclear factor I C
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NFIC
Synonyms (NCBI Gene) Gene synonyms aliases
CTF, CTF5, NF-I, NFI
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants en
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002601 hsa-miR-124-3p Proteomics 18668037
MIRT002601 hsa-miR-124-3p Microarray 15685193
MIRT042760 hsa-miR-339-5p CLASH 23622248
MIRT040932 hsa-miR-18a-3p CLASH 23622248
MIRT522314 hsa-miR-3651 HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 19706729
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IGI 1524678
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 1524678
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600729 7786 ENSG00000141905
Protein
UniProt ID P08651
Protein name Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein)
Protein function Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replicatio
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10524 NfI_DNAbd_pre-N 8 47 Nuclear factor I protein pre-N-terminus Family
PF03165 MH1 69 173 MH1 domain Domain
PF00859 CTF_NFI 217 507 CTF/NF-I family transcription modulation region Family
Sequence
Sequence length 508
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Asthma Age of onset of childhood onset asthma N/A N/A GWAS
Diabetes Plasminogen activator inhibitor type 1 levels (PAI-1) in type 2 diabetes N/A N/A GWAS
Multiple myeloma Multiple myeloma N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 1953710
Breast Neoplasms Associate 16980581, 19589785, 25879941
Carcinogenesis Associate 25070814, 25879941
Carcinoma Small Cell Associate 1953710
Carcinoma Squamous Cell Inhibit 34985387
Cardiomyopathies Associate 35741813
Developmental Disabilities Associate 31067457
Diabetes Mellitus Type 2 Associate 32041280
Diabetic Foot Inhibit 37710299
Glioblastoma Associate 30195713