Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4762
Gene name Gene Name - the full gene name approved by the HGNC.
Neurogenin 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NEUROG1
Synonyms (NCBI Gene) Gene synonyms aliases
AKA, CCDDRD, Math4C, NEUROD3, bHLHa6, ngn1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
CCDDRD
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q31.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017336 hsa-miR-335-5p Microarray 18185580
MIRT021004 hsa-miR-155-5p Proteomics 18668040
MIRT438550 hsa-let-7i-5p ChIP-seq, GFP reporter assay, Immunocytochemistry, Immunohistochemistry, Luciferase reporter assay, qRT-PCR 23884650
MIRT438550 hsa-let-7i-5p ChIP-seq, GFP reporter assay, Immunocytochemistry, Immunohistochemistry, Luciferase reporter assay, qRT-PCR 23884650
MIRT438550 hsa-let-7i-5p ChIP-seq, GFP reporter assay, Immunocytochemistry, Immunohistochemistry, Luciferase reporter assay, qRT-PCR 23884650
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0003682 Function Chromatin binding ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601726 7764 ENSG00000181965
Protein
UniProt ID Q92886
Protein name Neurogenin-1 (NGN-1) (Class A basic helix-loop-helix protein 6) (bHLHa6) (Neurogenic basic-helix-loop-helix protein) (Neurogenic differentiation factor 3) (NeuroD3)
Protein function Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcri
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00010 HLH 93 145 Helix-loop-helix DNA-binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Expression restricted to the embryonic nervous system.
Sequence
MPARLETCISDLDCASSSGSDLSGFLTDEEDCARLQQAASASGPPAPARRGAPNISRASE
VPGAQDDEQERRRRRGRTRVRSEALLHSLRRSRRVKANDRERNRMHNLNAALDALRSVLP
SFPDDTKLTKIETLRFAYNYIWALA
ETLRLADQGLPGGGARERLLPPQCVPCLPGPPSPA
SDAESWGSGAAAASPLSDPSSPAASEDFTYRPGDPVFSFPSLPKDLLHTTPCFIPYH
Sequence length 237
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Signaling pathways regulating pluripotency of stem cells  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
17044100, 18799289
Associations from Text Mining
Disease Name Relationship Type References
Adenoma Associate 30578081
Alzheimer Disease Associate 30201328
Cholangiocarcinoma Associate 17550320, 29484968
Cognition Disorders Associate 18799289
Colorectal Neoplasms Associate 17065427, 17474983, 18834226, 19002263, 25167802, 28469732, 29930328
Congenital Cranial Dysinnervation Disorders Associate 23419067
Congenital Hereditary and Neonatal Diseases and Abnormalities Associate 23419067
Cranial Nerve Diseases Associate 23419067
Deafness Associate 23419067
Down Syndrome Associate 25154785