ATOX1 (antioxidant 1 copper chaperone)

Gene

• Entrez ID: 475
• Gene name: Antioxidant 1 copper chaperone
• Gene symbol: ATOX1
• Synonyms (NCBI Gene): ATX1, HAH1
• Chromosome: 5
• Chromosome location: 5q33.1
• Summary: This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028597	hsa-miR-30a-5p	Proteomics	18668040
MIRT031845	hsa-miR-16-5p	Sequencing	20371350
MIRT051900	hsa-let-7b-5p	CLASH	23622248
MIRT572382	hsa-miR-4476	PAR-CLIP	20371350
MIRT572381	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT572380	hsa-miR-9500	PAR-CLIP	20371350
MIRT572379	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT572378	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT572377	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT572376	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT572375	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT572374	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT572373	hsa-miR-6132	PAR-CLIP	20371350
MIRT572372	hsa-miR-6836-5p	PAR-CLIP	20371350
MIRT572371	hsa-miR-1909-3p	PAR-CLIP	20371350
MIRT572370	hsa-miR-6722-3p	PAR-CLIP	20371350
MIRT572368	hsa-miR-4533	PAR-CLIP	20371350
MIRT572369	hsa-miR-137	PAR-CLIP	20371350
MIRT572367	hsa-miR-6511b-5p	PAR-CLIP	20371350
MIRT572366	hsa-miR-6811-5p	PAR-CLIP	20371350
MIRT444268	hsa-miR-4635	PAR-CLIP	22100165
MIRT444267	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT444268	hsa-miR-4635	PAR-CLIP	22100165
MIRT444267	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT572382	hsa-miR-4476	PAR-CLIP	20371350
MIRT572381	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT572380	hsa-miR-9500	PAR-CLIP	20371350
MIRT572379	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT572378	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT572377	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT572376	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT572375	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT572374	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT572373	hsa-miR-6132	PAR-CLIP	20371350
MIRT572372	hsa-miR-6836-5p	PAR-CLIP	20371350
MIRT572371	hsa-miR-1909-3p	PAR-CLIP	20371350
MIRT572370	hsa-miR-6722-3p	PAR-CLIP	20371350
MIRT572368	hsa-miR-4533	PAR-CLIP	20371350
MIRT572369	hsa-miR-137	PAR-CLIP	20371350
MIRT572367	hsa-miR-6511b-5p	PAR-CLIP	20371350
MIRT572366	hsa-miR-6811-5p	PAR-CLIP	20371350
MIRT444268	hsa-miR-4635	PAR-CLIP	22100165
MIRT444267	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT444268	hsa-miR-4635	PAR-CLIP	22100165
MIRT444267	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT806236	hsa-miR-1913	CLIP-seq
MIRT806237	hsa-miR-25	CLIP-seq
MIRT806238	hsa-miR-3065-5p	CLIP-seq
MIRT806239	hsa-miR-32	CLIP-seq
MIRT806240	hsa-miR-324-3p	CLIP-seq
MIRT806241	hsa-miR-363	CLIP-seq
MIRT806242	hsa-miR-367	CLIP-seq
MIRT806243	hsa-miR-4310	CLIP-seq
MIRT806244	hsa-miR-4313	CLIP-seq
MIRT806245	hsa-miR-4722-3p	CLIP-seq
MIRT806246	hsa-miR-4793-5p	CLIP-seq
MIRT806247	hsa-miR-646	CLIP-seq
MIRT806248	hsa-miR-9	CLIP-seq
MIRT806249	hsa-miR-92a	CLIP-seq
MIRT806250	hsa-miR-92b	CLIP-seq
MIRT2177572	hsa-miR-1182	CLIP-seq
MIRT2177573	hsa-miR-3591-3p	CLIP-seq
MIRT2177574	hsa-miR-3691-3p	CLIP-seq
MIRT2177575	hsa-miR-4304	CLIP-seq
MIRT806243	hsa-miR-4310	CLIP-seq
MIRT2177576	hsa-miR-4480	CLIP-seq
MIRT806246	hsa-miR-4793-5p	CLIP-seq
MIRT2177577	hsa-miR-549	CLIP-seq
MIRT2177578	hsa-miR-873	CLIP-seq
MIRT2177579	hsa-miR-941	CLIP-seq
MIRT2480967	hsa-miR-1231	CLIP-seq
MIRT2480968	hsa-miR-1299	CLIP-seq
MIRT2480969	hsa-miR-133a	CLIP-seq
MIRT2480970	hsa-miR-133b	CLIP-seq
MIRT2480971	hsa-miR-1587	CLIP-seq
MIRT806236	hsa-miR-1913	CLIP-seq
MIRT2480972	hsa-miR-1914	CLIP-seq
MIRT2480973	hsa-miR-1915	CLIP-seq
MIRT2480974	hsa-miR-3120-5p	CLIP-seq
MIRT2480975	hsa-miR-3144-5p	CLIP-seq
MIRT2480976	hsa-miR-3151	CLIP-seq
MIRT2480977	hsa-miR-3191	CLIP-seq
MIRT806240	hsa-miR-324-3p	CLIP-seq
MIRT2177574	hsa-miR-3691-3p	CLIP-seq
MIRT2480978	hsa-miR-4265	CLIP-seq
MIRT2480979	hsa-miR-4296	CLIP-seq
MIRT806243	hsa-miR-4310	CLIP-seq
MIRT806244	hsa-miR-4313	CLIP-seq
MIRT2480980	hsa-miR-4322	CLIP-seq
MIRT2480981	hsa-miR-4417	CLIP-seq
MIRT2480982	hsa-miR-4447	CLIP-seq
MIRT2480983	hsa-miR-4472	CLIP-seq
MIRT2177576	hsa-miR-4480	CLIP-seq
MIRT2480984	hsa-miR-4492	CLIP-seq
MIRT2480985	hsa-miR-4498	CLIP-seq
MIRT2480986	hsa-miR-4652-5p	CLIP-seq
MIRT2480987	hsa-miR-4656	CLIP-seq
MIRT2480988	hsa-miR-4675	CLIP-seq
MIRT806245	hsa-miR-4722-3p	CLIP-seq
MIRT2480989	hsa-miR-4726-3p	CLIP-seq
MIRT2480990	hsa-miR-4741	CLIP-seq
MIRT2480991	hsa-miR-4786-3p	CLIP-seq
MIRT806246	hsa-miR-4793-5p	CLIP-seq
MIRT2480992	hsa-miR-491-5p	CLIP-seq
MIRT2480993	hsa-miR-671-5p	CLIP-seq
MIRT2480994	hsa-miR-762	CLIP-seq
MIRT2480995	hsa-miR-875-3p	CLIP-seq
MIRT806248	hsa-miR-9	CLIP-seq
MIRT2480967	hsa-miR-1231	CLIP-seq
MIRT2480968	hsa-miR-1299	CLIP-seq
MIRT2480969	hsa-miR-133a	CLIP-seq
MIRT2480970	hsa-miR-133b	CLIP-seq
MIRT2480971	hsa-miR-1587	CLIP-seq
MIRT806236	hsa-miR-1913	CLIP-seq
MIRT2480972	hsa-miR-1914	CLIP-seq
MIRT2480973	hsa-miR-1915	CLIP-seq
MIRT2480974	hsa-miR-3120-5p	CLIP-seq
MIRT2480975	hsa-miR-3144-5p	CLIP-seq
MIRT2480976	hsa-miR-3151	CLIP-seq
MIRT2480977	hsa-miR-3191	CLIP-seq
MIRT806240	hsa-miR-324-3p	CLIP-seq
MIRT2177574	hsa-miR-3691-3p	CLIP-seq
MIRT2480978	hsa-miR-4265	CLIP-seq
MIRT2480979	hsa-miR-4296	CLIP-seq
MIRT806243	hsa-miR-4310	CLIP-seq
MIRT806244	hsa-miR-4313	CLIP-seq
MIRT2480980	hsa-miR-4322	CLIP-seq
MIRT2480981	hsa-miR-4417	CLIP-seq
MIRT2480982	hsa-miR-4447	CLIP-seq
MIRT2480983	hsa-miR-4472	CLIP-seq
MIRT2177576	hsa-miR-4480	CLIP-seq
MIRT2480984	hsa-miR-4492	CLIP-seq
MIRT2480985	hsa-miR-4498	CLIP-seq
MIRT2480986	hsa-miR-4652-5p	CLIP-seq
MIRT2480987	hsa-miR-4656	CLIP-seq
MIRT2480988	hsa-miR-4675	CLIP-seq
MIRT806245	hsa-miR-4722-3p	CLIP-seq
MIRT2480989	hsa-miR-4726-3p	CLIP-seq
MIRT2480990	hsa-miR-4741	CLIP-seq
MIRT2480991	hsa-miR-4786-3p	CLIP-seq
MIRT806246	hsa-miR-4793-5p	CLIP-seq
MIRT2480992	hsa-miR-491-5p	CLIP-seq
MIRT2480993	hsa-miR-671-5p	CLIP-seq
MIRT2480994	hsa-miR-762	CLIP-seq
MIRT2480995	hsa-miR-875-3p	CLIP-seq
MIRT806248	hsa-miR-9	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005507	Function	Copper ion binding	IDA	12029094
GO:0005515	Function	Protein binding	IPI	12968035, 21667063, 24837030, 25416956, 26745413, 32296183
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS	12029094
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006825	Process	Copper ion transport	IBA
GO:0006825	Process	Copper ion transport	IEA
GO:0006825	Process	Copper ion transport	IEA
GO:0006825	Process	Copper ion transport	TAS	15670166
GO:0006878	Process	Intracellular copper ion homeostasis	IEA
GO:0006878	Process	Intracellular copper ion homeostasis	TAS	9430722
GO:0006979	Process	Response to oxidative stress	IEA
GO:0006979	Process	Response to oxidative stress	TAS	9430722
GO:0016530	Function	Metallochaperone activity	TAS	15670166
GO:0016531	Function	Copper chaperone activity	IBA
GO:0016531	Function	Copper chaperone activity	IDA	12029094
GO:0032767	Function	Copper-dependent protein binding	IDA	31283225
GO:0032767	Function	Copper-dependent protein binding	IPI	10497213
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051117	Function	ATPase binding	IEA
GO:0060003	Process	Copper ion export	IEA
GO:1903136	Function	Cuprous ion binding	IDA	31283225

Other IDs

• MIM: 602270
• HGNC: 798
• e!Ensembl: ENSG00000177556

Protein

• UniProt ID: O00244
• Protein name: Copper transport protein ATOX1 (Metal transport protein ATX1)
• Protein function: Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
• PDB: 1FE0, 1FE4, 1FEE, 1TL4, 1TL5, 2K1R, 2LQ9, 3CJK, 3IWL, 3IWX, 4QOT, 4YDX, 4YEA, 5F0W, 5T7L, 7DC1, 7ZC3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00403	HMA	5 → 61	Heavy-metal-associated domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous.
• Sequence:

  MPKHEFSVDMTCGGCAEAVSRVLNKLGGVKYDIDLPNKKVCIESEHSMDTLLATLKKTGK
  TVSYLGLE

• Sequence length: 68

Pathways

KEGG:

Mineral absorption

Reactome:

Ion influx/efflux at host-pathogen interface