Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4736
Gene name Gene Name - the full gene name approved by the HGNC.	Ribosomal protein L10a
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RPL10A
Synonyms (NCBI Gene) Gene synonyms aliases	CSA19, Csa-19, L10A, NEDD6, uL1
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p21.31
Summary Summary of gene provided in NCBI Entrez Gene.	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT048513	hsa-miR-100-5p	CLASH	23622248
MIRT042813	hsa-miR-324-3p	CLASH	23622248
MIRT038179	hsa-miR-339-3p	CLASH	23622248
MIRT052719	hsa-miR-1260b	CLASH	23622248
MIRT714264	hsa-miR-497-3p	HITS-CLIP	19536157
MIRT714263	hsa-miR-6776-3p	HITS-CLIP	19536157
MIRT714262	hsa-miR-6715a-3p	HITS-CLIP	19536157
MIRT714261	hsa-miR-4705	HITS-CLIP	19536157
MIRT714259	hsa-miR-6865-3p	HITS-CLIP	19536157
MIRT714260	hsa-miR-4433a-5p	HITS-CLIP	19536157
MIRT684999	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT684998	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT684997	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT684996	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT684995	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT684994	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT684993	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT684992	hsa-miR-7844-5p	HITS-CLIP	23313552
MIRT684991	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT714264	hsa-miR-497-3p	HITS-CLIP	19536157
MIRT714263	hsa-miR-6776-3p	HITS-CLIP	19536157
MIRT714262	hsa-miR-6715a-3p	HITS-CLIP	19536157
MIRT714261	hsa-miR-4705	HITS-CLIP	19536157
MIRT714259	hsa-miR-6865-3p	HITS-CLIP	19536157
MIRT714260	hsa-miR-4433a-5p	HITS-CLIP	19536157
MIRT684999	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT684998	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT684997	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT684996	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT684995	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT684994	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT684993	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT684992	hsa-miR-7844-5p	HITS-CLIP	23313552
MIRT684991	hsa-miR-3613-3p	HITS-CLIP	23313552

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	IDA	25957688
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399, 32669547
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0005515	Function	Protein binding	IPI	24725412, 25416956, 30021884, 31046837, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	12962325
GO:0014069	Component	Postsynaptic density	IEA
GO:0015934	Component	Large ribosomal subunit	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	25957688, 32669547
GO:0022625	Component	Cytosolic large ribosomal subunit	IEA
GO:0022625	Component	Cytosolic large ribosomal subunit	IPI	25901680
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0045471	Process	Response to ethanol	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
615660	10299	ENSG00000198755

Protein

UniProt ID

P62906

Protein name

Large ribosomal subunit protein uL1 (60S ribosomal protein L10a) (CSA-19) (Neural precursor cell expressed developmentally down-regulated protein 6) (NEDD-6)

Protein function

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6LQM , 6LSR , 6LU8 , 6OLG , 6QZP , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FL2 , 8FL3 , 8FL4 , 8G5Y , 8G60 , 8G61 , 8G6J , 8IDY , 8IFD , 8IFE , 8INF , 8K2C , 8OHD , 8OJ0 , 8OJ5 , 8OJ8 , 8QFC , 8UKB , 8XSX , 8XSY , 8Y0W , 8YOP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00687	Ribosomal_L1	18 → 212	Ribosomal protein L1p/L10e family	Domain

Sequence

MSSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPR
PKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQI
PRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKKVLCLAVAVGHVKMTDDELV
YNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY

Sequence length

217

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Insomnia	Insomnia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alzheimer Disease	Associate	35766008
Anemia Diamond Blackfan	Associate	20116044
Breast Neoplasms	Associate	29081411
Glaucoma	Associate	36450729
Lymphoma Large B Cell Diffuse	Associate	36812125
Neoplasm Metastasis	Associate	34434692
Uveal melanoma	Associate	34434692

RPL10A (ribosomal protein L10a)