SEPTIN2 (septin 2)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4735
Gene name Gene Name - the full gene name approved by the HGNC.
Septin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SEPTIN2
Synonyms (NCBI Gene) Gene synonyms aliases
DIFF6, NEDD-5, NEDD5, Pnutl3, SEPT2, Septin-2, hNedd5
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q37.3
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT735123 hsa-miR-223-3p Immunoprecipitaion (IP), qRT-PCR, Immunocytochemistry (ICC) 32838617
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(38)
GO ID Ontology Definition Evidence Reference
GO:0000145 Component Exocyst IEA
GO:0000777 Component Condensed chromosome kinetochore IEA
GO:0003924 Function GTPase activity IBA 21873635
GO:0005515 Function Protein binding IPI 10321247, 16189514, 17229681, 17685441, 17803907, 18330356, 25416956, 25588830, 28530676, 31515488
GO:0005525 Function GTP binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
601506 7729 ENSG00000168385
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q15019
Protein name Septin-2 (Neural precursor cell expressed developmentally down-regulated protein 5) (NEDD-5)
Protein function Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differ
PDB 2QA5 , 2QAG , 2QNR , 6UPA , 6UPQ , 6UPR , 7M6J
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00735 Septin 34 → 313 Septin Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Up-regulated in liver cancer. {ECO:0000269|PubMed:15915442, ECO:0000269|PubMed:19165576}.
Sequence
Sequence length 361
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Bacterial invasion of epithelial cells
Shigellosis 		  Anchoring of the basal body to the plasma membrane
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Lymphocytic Leukemia Lymphocytic Leukemia GWAS
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Show/Hide Text Mining Associations (17)
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 9811347
Astrocytoma Associate 15140406
Brain Neoplasms Associate 15140406
Breast Neoplasms Associate 27557506
Colorectal Neoplasms Associate 33200802
Diffuse Neurofibrillary Tangles with Calcification Associate 9811347
Glioblastoma Associate 17233837
Graves Ophthalmopathy Associate 34078122
Hereditary Breast and Ovarian Cancer Syndrome Associate 27557506
HIV Seropositivity Associate 31732191