Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4733
Gene name Gene Name - the full gene name approved by the HGNC.	Developmentally regulated GTP binding protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DRG1
Synonyms (NCBI Gene) Gene synonyms aliases	NEDD3, TANALS
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q12.2

Show/Hide all(1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs1391978939	C>G,T	Likely-pathogenic	Stop gained, coding sequence variant, missense variant

Show/Hide all(100)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025534	hsa-miR-34a-5p	Proteomics	21566225
MIRT040743	hsa-miR-455-5p	CLASH	23622248
MIRT040480	hsa-miR-605-5p	CLASH	23622248
MIRT040302	hsa-miR-615-3p	CLASH	23622248
MIRT945375	hsa-miR-1273e	CLIP-seq
MIRT945376	hsa-miR-1273g	CLIP-seq
MIRT945377	hsa-miR-1292	CLIP-seq
MIRT945378	hsa-miR-2110	CLIP-seq
MIRT945379	hsa-miR-2681	CLIP-seq
MIRT945380	hsa-miR-3133	CLIP-seq
MIRT945381	hsa-miR-3153	CLIP-seq
MIRT945382	hsa-miR-4271	CLIP-seq
MIRT945383	hsa-miR-4511	CLIP-seq
MIRT945384	hsa-miR-4668-5p	CLIP-seq
MIRT945385	hsa-miR-4725-3p	CLIP-seq
MIRT945386	hsa-miR-491-3p	CLIP-seq
MIRT945387	hsa-miR-548aa	CLIP-seq
MIRT945388	hsa-miR-636	CLIP-seq
MIRT1979860	hsa-miR-3617	CLIP-seq
MIRT1979861	hsa-miR-3646	CLIP-seq
MIRT1979862	hsa-miR-4670-3p	CLIP-seq
MIRT1979863	hsa-miR-548ag	CLIP-seq
MIRT1979864	hsa-miR-548ai	CLIP-seq
MIRT1979865	hsa-miR-641	CLIP-seq
MIRT2215057	hsa-miR-1262	CLIP-seq
MIRT2215058	hsa-miR-145	CLIP-seq
MIRT2215059	hsa-miR-1470	CLIP-seq
MIRT2215060	hsa-miR-4287	CLIP-seq
MIRT2215061	hsa-miR-4469	CLIP-seq
MIRT2215062	hsa-miR-4667-3p	CLIP-seq
MIRT2215063	hsa-miR-4685-3p	CLIP-seq
MIRT2215064	hsa-miR-4701-3p	CLIP-seq
MIRT2215057	hsa-miR-1262	CLIP-seq
MIRT945375	hsa-miR-1273e	CLIP-seq
MIRT945376	hsa-miR-1273g	CLIP-seq
MIRT945377	hsa-miR-1292	CLIP-seq
MIRT2215058	hsa-miR-145	CLIP-seq
MIRT2215059	hsa-miR-1470	CLIP-seq
MIRT2519508	hsa-miR-1825	CLIP-seq
MIRT2519509	hsa-miR-199a-5p	CLIP-seq
MIRT2519510	hsa-miR-199b-5p	CLIP-seq
MIRT945378	hsa-miR-2110	CLIP-seq
MIRT945379	hsa-miR-2681	CLIP-seq
MIRT945380	hsa-miR-3133	CLIP-seq
MIRT945381	hsa-miR-3153	CLIP-seq
MIRT2519511	hsa-miR-331-3p	CLIP-seq
MIRT1979860	hsa-miR-3617	CLIP-seq
MIRT1979861	hsa-miR-3646	CLIP-seq
MIRT945382	hsa-miR-4271	CLIP-seq
MIRT2215060	hsa-miR-4287	CLIP-seq
MIRT2519512	hsa-miR-4308	CLIP-seq
MIRT2215061	hsa-miR-4469	CLIP-seq
MIRT945383	hsa-miR-4511	CLIP-seq
MIRT2215062	hsa-miR-4667-3p	CLIP-seq
MIRT945384	hsa-miR-4668-5p	CLIP-seq
MIRT1979862	hsa-miR-4670-3p	CLIP-seq
MIRT2215063	hsa-miR-4685-3p	CLIP-seq
MIRT2215064	hsa-miR-4701-3p	CLIP-seq
MIRT945385	hsa-miR-4725-3p	CLIP-seq
MIRT945387	hsa-miR-548aa	CLIP-seq
MIRT1979863	hsa-miR-548ag	CLIP-seq
MIRT1979864	hsa-miR-548ai	CLIP-seq
MIRT945388	hsa-miR-636	CLIP-seq
MIRT2519513	hsa-miR-640	CLIP-seq
MIRT1979865	hsa-miR-641	CLIP-seq
MIRT2215057	hsa-miR-1262	CLIP-seq
MIRT945375	hsa-miR-1273e	CLIP-seq
MIRT945376	hsa-miR-1273g	CLIP-seq
MIRT945377	hsa-miR-1292	CLIP-seq
MIRT2679514	hsa-miR-134	CLIP-seq
MIRT2215058	hsa-miR-145	CLIP-seq
MIRT2215059	hsa-miR-1470	CLIP-seq
MIRT2519508	hsa-miR-1825	CLIP-seq
MIRT2519509	hsa-miR-199a-5p	CLIP-seq
MIRT2519510	hsa-miR-199b-5p	CLIP-seq
MIRT945378	hsa-miR-2110	CLIP-seq
MIRT945379	hsa-miR-2681	CLIP-seq
MIRT2679515	hsa-miR-3118	CLIP-seq
MIRT945380	hsa-miR-3133	CLIP-seq
MIRT945381	hsa-miR-3153	CLIP-seq
MIRT2519511	hsa-miR-331-3p	CLIP-seq
MIRT1979860	hsa-miR-3617	CLIP-seq
MIRT1979861	hsa-miR-3646	CLIP-seq
MIRT945382	hsa-miR-4271	CLIP-seq
MIRT2215060	hsa-miR-4287	CLIP-seq
MIRT2519512	hsa-miR-4308	CLIP-seq
MIRT2215061	hsa-miR-4469	CLIP-seq
MIRT945383	hsa-miR-4511	CLIP-seq
MIRT2215062	hsa-miR-4667-3p	CLIP-seq
MIRT945384	hsa-miR-4668-5p	CLIP-seq
MIRT1979862	hsa-miR-4670-3p	CLIP-seq
MIRT2215063	hsa-miR-4685-3p	CLIP-seq
MIRT2215064	hsa-miR-4701-3p	CLIP-seq
MIRT945385	hsa-miR-4725-3p	CLIP-seq
MIRT945387	hsa-miR-548aa	CLIP-seq
MIRT1979863	hsa-miR-548ag	CLIP-seq
MIRT1979864	hsa-miR-548ai	CLIP-seq
MIRT945388	hsa-miR-636	CLIP-seq
MIRT2519513	hsa-miR-640	CLIP-seq
MIRT1979865	hsa-miR-641	CLIP-seq

Show/Hide all(26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0002181	Process	Cytoplasmic translation	IBA
GO:0003924	Function	GTPase activity	IDA	23711155, 29915238
GO:0003924	Function	GTPase activity	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 18184589, 19819225, 21516116, 25416956, 25944354, 28514442, 29915238, 31324722, 32296183, 33961781, 35156780, 35271311, 36012204
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IEA
GO:0005634	Component	Nucleus	IDA	29915238
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	19819225, 29915238
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0008017	Function	Microtubule binding	IDA	28855639
GO:0008017	Function	Microtubule binding	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016604	Component	Nuclear body	IDA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030955	Function	Potassium ion binding	IDA	23711155
GO:0031116	Process	Positive regulation of microtubule polymerization	IEA
GO:0031116	Process	Positive regulation of microtubule polymerization	IMP	28855639
GO:0042802	Function	Identical protein binding	IPI	23711155
GO:0046872	Function	Metal ion binding	IEA
GO:1901673	Process	Regulation of mitotic spindle assembly	IMP	28855639

MIM	HGNC	e!Ensembl
603952	3029	ENSG00000185721

Protein

UniProt ID

Q9Y295

Protein name

Developmentally-regulated GTP-binding protein 1 (DRG-1) (Neural precursor cell expressed developmentally down-regulated protein 3) (NEDD-3) (Translation factor GTPase DRG1) (TRAFAC GTPase DRG1) (EC 3.6.5.-)

Protein function

Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:23711155, PubMed:29915238, PubMed:37179472). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by i

PDB

2EKI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01926	MMR_HSR1	66 → 183	50S ribosome-binding GTPase	Family
PF16897	MMR_HSR1_Xtn	186 → 291	C-terminal region of MMR_HSR1 domain	Family
PF02824	TGS	292 → 366	TGS domain	Domain

Tissue specificity

TISSUE SPECIFICITY: High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes. {ECO:0000269|PubMed:10760581}.

Sequence

MSSTLAKIAEIEAEMARTQKNKATAHHLGLLKARLAKLRRELITPKGGGGGGPGEGFDVA
KTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVIRYKGAKIQLLDLPG
IIEGAKDGKGRGRQVIAVARTCNLILIVLDVLKPLGHKKIIENELEGFGIRLNSKPPNIG
FKKKDKGGINLTATCPQSELDAETVKSILAEYKIHNADVTLRSDATADDLIDVVEGNRVY
IPCIYVLNKIDQISIEELDIIYKVPHCVPISAHHRWNFDDLLEKIWDYLKLVRIYTKPKG
QLPDYTSPVVLPYSRTTVEDFCMKIHKNLIKEFKYALVWGLSVKHNPQKVGKDHTLEDED
VIQIVKK

Sequence length

367

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Congenital finger flexion contractures	Flexion contracture	rs1391978939	N/A

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Colorectal Cancer	Colorectal cancer	N/A	N/A	GWAS
Neurodevelopmental Disorders	complex neurodevelopmental disorder	N/A	N/A	GenCC

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Stimulate	27626498
Carcinogenesis	Associate	27626498
Cell Transformation Neoplastic	Associate	32266933
Melanoma	Associate	25993655
Neoplasms	Associate	18288642, 19622774, 27626498
Neoplasms	Stimulate	32266933
Neoplastic Syndromes Hereditary	Associate	15247272
Obesity	Associate	25379721
Osteosarcoma	Associate	32266933
Prostatic Neoplasms	Associate	15247272, 19622774
Prostatitis	Inhibit	10428464
Urinary Bladder Neoplasms	Associate	18288642

DRG1 (developmentally regulated GTP binding protein 1)