Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4719
Gene name Gene Name - the full gene name approved by the HGNC.	NADH:ubiquinone oxidoreductase core subunit S1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NDUFS1
Synonyms (NCBI Gene) Gene synonyms aliases	CI-75Kd, CI-75k, MC1DN5, PRO1304
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q33.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase acti

Show/Hide all(30)

SNP ID	Visualize variation	Clinical significance	Consequence
rs78042826	G>A,C	Conflicting-interpretations-of-pathogenicity, benign, likely-benign	Coding sequence variant, missense variant
rs149271416	G>A	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs151279101	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs199422224	T>C	Pathogenic	Coding sequence variant, missense variant
rs199422225	G>A	Pathogenic	Coding sequence variant, missense variant
rs199422226	G>A,C	Pathogenic	Coding sequence variant, synonymous variant, missense variant
rs201034481	C>T	Likely-pathogenic	Coding sequence variant, intron variant, missense variant
rs370009373	T>G	Pathogenic	Splice acceptor variant
rs370411488	A>G	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs372691318	G>A,C	Pathogenic	Stop gained, coding sequence variant, missense variant
rs387907199	T>C	Pathogenic	Coding sequence variant, missense variant
rs397515383	GAT>-	Pathogenic	Coding sequence variant, inframe deletion
rs397515447	C>T	Pathogenic	Coding sequence variant, missense variant
rs747249702	A>C,G	Likely-pathogenic	Missense variant, coding sequence variant
rs750971390	G>A	Pathogenic	Intron variant, coding sequence variant, stop gained
rs767122069	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs776114731	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs786205666	A>C	Likely-pathogenic	Coding sequence variant, missense variant
rs863224097	T>A	Likely-pathogenic	Coding sequence variant, missense variant
rs863224099	C>G	Likely-pathogenic	Coding sequence variant, missense variant
rs863224100	GTT>-	Likely-pathogenic	Coding sequence variant, inframe deletion
rs863224103	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1131692032	T>A	Likely-pathogenic	Missense variant, coding sequence variant
rs1321888585	C>A,T	Likely-pathogenic	Missense variant, coding sequence variant
rs1485032272	T>A,C	Likely-pathogenic	Missense variant, coding sequence variant
rs1553503175	->CG	Likely-pathogenic	Frameshift variant, coding sequence variant
rs1553503177	GCTTATAG>-	Likely-pathogenic	Frameshift variant, coding sequence variant
rs1553506655	TA>-	Pathogenic	Frameshift variant, coding sequence variant
rs1559047521	TTTAA>-	Likely-pathogenic	Intron variant
rs1575944638	GA>-	Likely-pathogenic	Frameshift variant, coding sequence variant

Show/Hide all(456)

miRTarBase ID	miRNA	Experiments	Reference
MIRT046974	hsa-miR-221-3p	CLASH	23622248
MIRT043105	hsa-miR-324-5p	CLASH	23622248
MIRT040441	hsa-miR-615-3p	CLASH	23622248
MIRT545646	hsa-miR-8485	HITS-CLIP	21572407
MIRT545645	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT545644	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT545643	hsa-miR-603	HITS-CLIP	21572407
MIRT545642	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT545640	hsa-miR-3941	HITS-CLIP	21572407
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT612201	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT612200	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT612199	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT612198	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT612201	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT612200	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT612199	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT612198	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT612201	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT612200	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT612199	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT612198	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT612201	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT612200	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT612199	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT612198	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT616120	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT616119	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT616118	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616115	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT612201	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT612200	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT612199	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT612198	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT616120	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT616119	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT616118	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616115	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT612201	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT612200	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT612199	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT612198	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT616120	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT616119	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT616118	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616117	hsa-miR-548ao-5p	HITS-CLIP	23824327
MIRT616116	hsa-miR-548ax	HITS-CLIP	23824327
MIRT616115	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT612201	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT612200	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT612199	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT612198	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT612201	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT612200	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT612199	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT612198	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT552225	hsa-miR-4428	PAR-CLIP	21572407
MIRT552224	hsa-miR-3653-5p	PAR-CLIP	21572407
MIRT552223	hsa-miR-1976	PAR-CLIP	21572407
MIRT236271	hsa-miR-3682-5p	PAR-CLIP	21572407
MIRT552222	hsa-miR-4279	PAR-CLIP	21572407
MIRT545646	hsa-miR-8485	PAR-CLIP	21572407
MIRT545645	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT545644	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT545643	hsa-miR-603	PAR-CLIP	21572407
MIRT545642	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT545641	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT545640	hsa-miR-3941	PAR-CLIP	21572407
MIRT545639	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT545646	hsa-miR-8485	PAR-CLIP	21572407
MIRT545645	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT545644	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT545643	hsa-miR-603	PAR-CLIP	21572407
MIRT545642	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT545641	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT545640	hsa-miR-3941	PAR-CLIP	21572407
MIRT545639	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT462199	hsa-miR-1252-3p	PAR-CLIP	23592263
MIRT462198	hsa-miR-3688-3p	PAR-CLIP	23592263
MIRT462197	hsa-miR-4330	PAR-CLIP	23592263
MIRT462196	hsa-miR-4670-3p	PAR-CLIP	23592263
MIRT462195	hsa-miR-3928-3p	PAR-CLIP	23592263
MIRT462194	hsa-miR-5093	PAR-CLIP	23592263
MIRT462193	hsa-miR-3915	PAR-CLIP	23592263
MIRT440126	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440126	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT733103	hsa-miR-3130-5p	Immunohistochemistry (IHC), Luciferase reporter assay, qRT-PCR, Western blotting	33978320
MIRT733103	hsa-miR-3130-5p	Immunohistochemistry (IHC), Luciferase reporter assay, qRT-PCR, Western blotting	33978320
MIRT733103	hsa-miR-3130-5p	Immunohistochemistry (IHC), Luciferase reporter assay, qRT-PCR, Western blotting	33978320
MIRT545646	hsa-miR-8485	HITS-CLIP	21572407
MIRT545645	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT545644	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT545643	hsa-miR-603	HITS-CLIP	21572407
MIRT545642	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT545640	hsa-miR-3941	HITS-CLIP	21572407
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT612201	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT612200	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT612199	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT612198	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT612201	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT612200	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT612199	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT612198	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT612201	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT612200	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT612199	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT612198	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT612201	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT612200	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT612199	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT612198	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT616120	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT616119	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT616118	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616115	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT612201	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT612200	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT612199	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT612198	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT616120	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT616119	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT616118	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616115	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT612201	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT612200	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT612199	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT612198	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT616120	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT616119	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT616118	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT616117	hsa-miR-548ao-5p	HITS-CLIP	23824327
MIRT616116	hsa-miR-548ax	HITS-CLIP	23824327
MIRT616115	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT612201	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT612200	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT612199	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT612198	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT545646	hsa-miR-8485	HITS-CLIP	23824327
MIRT545645	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT545644	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT545643	hsa-miR-603	HITS-CLIP	23824327
MIRT545641	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT545640	hsa-miR-3941	HITS-CLIP	23824327
MIRT545639	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT612202	hsa-miR-5701	HITS-CLIP	23824327
MIRT612201	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT612200	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT612199	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT612198	hsa-miR-493-5p	HITS-CLIP	23824327
MIRT552225	hsa-miR-4428	PAR-CLIP	21572407
MIRT552224	hsa-miR-3653-5p	PAR-CLIP	21572407
MIRT552223	hsa-miR-1976	PAR-CLIP	21572407
MIRT236271	hsa-miR-3682-5p	PAR-CLIP	21572407
MIRT552222	hsa-miR-4279	PAR-CLIP	21572407
MIRT545646	hsa-miR-8485	PAR-CLIP	21572407
MIRT545645	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT545644	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT545643	hsa-miR-603	PAR-CLIP	21572407
MIRT545642	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT545641	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT545640	hsa-miR-3941	PAR-CLIP	21572407
MIRT545639	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT545646	hsa-miR-8485	PAR-CLIP	21572407
MIRT545645	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT545644	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT545643	hsa-miR-603	PAR-CLIP	21572407
MIRT545642	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT545641	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT545640	hsa-miR-3941	PAR-CLIP	21572407
MIRT545639	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT462199	hsa-miR-1252-3p	PAR-CLIP	23592263
MIRT462198	hsa-miR-3688-3p	PAR-CLIP	23592263
MIRT462197	hsa-miR-4330	PAR-CLIP	23592263
MIRT462196	hsa-miR-4670-3p	PAR-CLIP	23592263
MIRT462195	hsa-miR-3928-3p	PAR-CLIP	23592263
MIRT462194	hsa-miR-5093	PAR-CLIP	23592263
MIRT462193	hsa-miR-3915	PAR-CLIP	23592263
MIRT1179154	hsa-miR-1305	CLIP-seq
MIRT1179155	hsa-miR-329	CLIP-seq
MIRT1179156	hsa-miR-4307	CLIP-seq
MIRT1179157	hsa-miR-466	CLIP-seq
MIRT1179158	hsa-miR-4666-5p	CLIP-seq
MIRT1179159	hsa-miR-4672	CLIP-seq
MIRT1179160	hsa-miR-607	CLIP-seq
MIRT1179161	hsa-miR-139-3p	CLIP-seq
MIRT1179162	hsa-miR-147	CLIP-seq
MIRT1179163	hsa-miR-219-1-3p	CLIP-seq
MIRT1179164	hsa-miR-3164	CLIP-seq
MIRT1179165	hsa-miR-3653	CLIP-seq
MIRT1179166	hsa-miR-3658	CLIP-seq
MIRT1179167	hsa-miR-3911	CLIP-seq
MIRT1179168	hsa-miR-4438	CLIP-seq
MIRT1179169	hsa-miR-4511	CLIP-seq
MIRT1179170	hsa-miR-4517	CLIP-seq
MIRT1179171	hsa-miR-4528	CLIP-seq
MIRT1179172	hsa-miR-4684-3p	CLIP-seq
MIRT1179173	hsa-miR-4781-3p	CLIP-seq
MIRT1179174	hsa-miR-548b-3p	CLIP-seq
MIRT1179175	hsa-miR-571	CLIP-seq
MIRT1179176	hsa-miR-644	CLIP-seq
MIRT1179154	hsa-miR-1305	CLIP-seq
MIRT1179177	hsa-miR-153	CLIP-seq
MIRT1179178	hsa-miR-18a	CLIP-seq
MIRT1179179	hsa-miR-18b	CLIP-seq
MIRT1179180	hsa-miR-2052	CLIP-seq
MIRT1179181	hsa-miR-320a	CLIP-seq
MIRT1179182	hsa-miR-320b	CLIP-seq
MIRT1179183	hsa-miR-320c	CLIP-seq
MIRT1179184	hsa-miR-320d	CLIP-seq
MIRT1179185	hsa-miR-320e	CLIP-seq
MIRT1179186	hsa-miR-323b-5p	CLIP-seq
MIRT1179155	hsa-miR-329	CLIP-seq
MIRT1179187	hsa-miR-3607-3p	CLIP-seq
MIRT1179165	hsa-miR-3653	CLIP-seq
MIRT1179166	hsa-miR-3658	CLIP-seq
MIRT1179156	hsa-miR-4307	CLIP-seq
MIRT1179188	hsa-miR-4429	CLIP-seq
MIRT1179168	hsa-miR-4438	CLIP-seq
MIRT1179169	hsa-miR-4511	CLIP-seq
MIRT1179189	hsa-miR-451b	CLIP-seq
MIRT1179171	hsa-miR-4528	CLIP-seq
MIRT1179157	hsa-miR-466	CLIP-seq
MIRT1179158	hsa-miR-4666-5p	CLIP-seq
MIRT1179159	hsa-miR-4672	CLIP-seq
MIRT1179172	hsa-miR-4684-3p	CLIP-seq
MIRT1179190	hsa-miR-4720-3p	CLIP-seq
MIRT1179191	hsa-miR-4735-3p	CLIP-seq
MIRT1179192	hsa-miR-4761-5p	CLIP-seq
MIRT1179193	hsa-miR-4793-3p	CLIP-seq
MIRT1179194	hsa-miR-4804-3p	CLIP-seq
MIRT1179195	hsa-miR-518a-5p	CLIP-seq
MIRT1179196	hsa-miR-520d-5p	CLIP-seq
MIRT1179197	hsa-miR-524-5p	CLIP-seq
MIRT1179198	hsa-miR-527	CLIP-seq
MIRT1179174	hsa-miR-548b-3p	CLIP-seq
MIRT1179160	hsa-miR-607	CLIP-seq
MIRT1179199	hsa-miR-649	CLIP-seq
MIRT1179154	hsa-miR-1305	CLIP-seq
MIRT2280927	hsa-miR-1321	CLIP-seq
MIRT2280928	hsa-miR-1323	CLIP-seq
MIRT2280929	hsa-miR-139-5p	CLIP-seq
MIRT2280930	hsa-miR-3189-3p	CLIP-seq
MIRT2280931	hsa-miR-3672	CLIP-seq
MIRT2280932	hsa-miR-369-3p	CLIP-seq
MIRT2280933	hsa-miR-374a	CLIP-seq
MIRT2280934	hsa-miR-374b	CLIP-seq
MIRT2280935	hsa-miR-4495	CLIP-seq
MIRT1179158	hsa-miR-4666-5p	CLIP-seq
MIRT2280936	hsa-miR-4686	CLIP-seq
MIRT2280937	hsa-miR-4734	CLIP-seq
MIRT2280938	hsa-miR-4739	CLIP-seq
MIRT2280939	hsa-miR-4756-5p	CLIP-seq
MIRT2280940	hsa-miR-4786-5p	CLIP-seq
MIRT1179193	hsa-miR-4793-3p	CLIP-seq
MIRT2280941	hsa-miR-520f	CLIP-seq
MIRT2280942	hsa-miR-526b	CLIP-seq
MIRT2280943	hsa-miR-548a-3p	CLIP-seq
MIRT2280944	hsa-miR-548aa	CLIP-seq
MIRT2280945	hsa-miR-548e	CLIP-seq
MIRT2280946	hsa-miR-548f	CLIP-seq
MIRT2280947	hsa-miR-548o	CLIP-seq
MIRT2280948	hsa-miR-568	CLIP-seq
MIRT2280949	hsa-miR-582-5p	CLIP-seq
MIRT1179160	hsa-miR-607	CLIP-seq
MIRT2280950	hsa-miR-635	CLIP-seq
MIRT1179176	hsa-miR-644	CLIP-seq
MIRT2280951	hsa-miR-663b	CLIP-seq
MIRT2280952	hsa-miR-759	CLIP-seq
MIRT2280953	hsa-miR-769-5p	CLIP-seq
MIRT2280954	hsa-miR-885-5p	CLIP-seq
MIRT2280955	hsa-miR-889	CLIP-seq
MIRT2280956	hsa-miR-944	CLIP-seq
MIRT1179154	hsa-miR-1305	CLIP-seq
MIRT1179156	hsa-miR-4307	CLIP-seq
MIRT1179158	hsa-miR-4666-5p	CLIP-seq
MIRT1179195	hsa-miR-518a-5p	CLIP-seq
MIRT1179198	hsa-miR-527	CLIP-seq
MIRT1179160	hsa-miR-607	CLIP-seq
MIRT1179161	hsa-miR-139-3p	CLIP-seq
MIRT1179165	hsa-miR-3653	CLIP-seq
MIRT1179166	hsa-miR-3658	CLIP-seq
MIRT2579352	hsa-miR-4477b	CLIP-seq
MIRT1179169	hsa-miR-4511	CLIP-seq
MIRT1179170	hsa-miR-4517	CLIP-seq
MIRT1179172	hsa-miR-4684-3p	CLIP-seq
MIRT2579353	hsa-miR-4699-5p	CLIP-seq
MIRT2579354	hsa-miR-4753-3p	CLIP-seq
MIRT1179173	hsa-miR-4781-3p	CLIP-seq
MIRT1179174	hsa-miR-548b-3p	CLIP-seq
MIRT2280956	hsa-miR-944	CLIP-seq
MIRT1179161	hsa-miR-139-3p	CLIP-seq
MIRT2686133	hsa-miR-3198	CLIP-seq
MIRT1179165	hsa-miR-3653	CLIP-seq
MIRT1179166	hsa-miR-3658	CLIP-seq
MIRT2686134	hsa-miR-4309	CLIP-seq
MIRT1179168	hsa-miR-4438	CLIP-seq
MIRT1179169	hsa-miR-4511	CLIP-seq
MIRT1179170	hsa-miR-4517	CLIP-seq
MIRT1179172	hsa-miR-4684-3p	CLIP-seq
MIRT1179173	hsa-miR-4781-3p	CLIP-seq
MIRT1179174	hsa-miR-548b-3p	CLIP-seq

Show/Hide all(37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15186778, 30879903, 32807793, 32814053
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	30879903
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IDA	28844695
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005758	Component	Mitochondrial intermembrane space	IDA	15186778
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006120	Process	Mitochondrial electron transport, NADH to ubiquinone	IMP	31557978
GO:0006120	Process	Mitochondrial electron transport, NADH to ubiquinone	NAS	9878551
GO:0008137	Function	NADH dehydrogenase (ubiquinone) activity	IBA
GO:0008137	Function	NADH dehydrogenase (ubiquinone) activity	IEA
GO:0008137	Function	NADH dehydrogenase (ubiquinone) activity	IMP	15824269, 16478720, 16870178
GO:0008137	Function	NADH dehydrogenase (ubiquinone) activity	IMP	30879903, 31557978
GO:0008137	Function	NADH dehydrogenase (ubiquinone) activity	NAS	9878551
GO:0009055	Function	Electron transfer activity	IEA
GO:0009055	Function	Electron transfer activity	NAS	1935949
GO:0009060	Process	Aerobic respiration	NAS	30030361
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016651	Function	Oxidoreductase activity, acting on NAD(P)H	IEA
GO:0032981	Process	Mitochondrial respiratory chain complex I assembly	IBA
GO:0032981	Process	Mitochondrial respiratory chain complex I assembly	IEA
GO:0032981	Process	Mitochondrial respiratory chain complex I assembly	IMP	16478720, 30879903, 31557978
GO:0042773	Process	ATP synthesis coupled electron transport	IEA
GO:0042776	Process	Proton motive force-driven mitochondrial ATP synthesis	NAS	30030361
GO:0045271	Component	Respiratory chain complex I	IDA	12611891
GO:0045271	Component	Respiratory chain complex I	IEA
GO:0045271	Component	Respiratory chain complex I	IMP	16478720
GO:0045271	Component	Respiratory chain complex I	NAS	9878551
GO:0045333	Process	Cellular respiration	IMP	15186778
GO:0046872	Function	Metal ion binding	IEA
GO:0051536	Function	Iron-sulfur cluster binding	IEA
GO:0051537	Function	2 iron, 2 sulfur cluster binding	IEA
GO:0051539	Function	4 iron, 4 sulfur cluster binding	IEA
GO:1902600	Process	Proton transmembrane transport	IEA

MIM	HGNC	e!Ensembl
157655	7707	ENSG00000023228

Protein

UniProt ID

P28331

Protein name

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 7.1.1.2) (Complex I-75kD) (CI-75kD)

Protein function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:30879903, PubMed:31557978). E

PDB

5XTB , 5XTD , 5XTH , 5XTI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13510	Fer2_4	29 → 107		Domain
PF10588	NADH-G_4Fe-4S_3	113 → 152	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	Domain
PF00384	Molybdopterin	301 → 629	Molybdopterin oxidoreductase	Family
PF09326	NADH_dhqG_C	658 → 710	NADH-ubiquinone oxidoreductase subunit G, C-terminal	Family

Sequence

MLRIPVRKALVGLSKSPKGCVRTTATAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQI
PRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFL
LANHPLDCPICDQGGECDLQDQSMMFGNDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCT
RCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTA
RPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQ
RLTEPMVRNEKGLLTYTSWEDALSRVAGMLQSFQGKDVAAIAGGLVDAEALVALKDLLNR
VDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRK
SWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDIASGSHPFSQVLKEAKKPMVVLGSSA
LQRNDGAAILAAVSSIAQKIRMTSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKN
PPKVLFLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKSATYVNTE
GRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLVRYDDIE
GANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQA
VEEPSIC

Sequence length

727

Interactions

View interactions

	KEGG		Reactome
	Oxidative phosphorylation Metabolic pathways Thermogenesis Retrograde endocannabinoid signaling Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy		Respiratory electron transport Complex I biogenesis

Show/Hide Causal Diseases (2)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
leigh syndrome	Leigh syndrome	rs1559047521, rs747249702	N/A
Mitochondrial Complex Deficiency	Mitochondrial complex 1 deficiency, nuclear type 5, Mitochondrial complex I deficiency, nuclear type 1	rs370009373, rs370411488, rs151279101, rs1485032272, rs750971390, rs397515383, rs1321888585, rs199422224, rs387907199, rs397515447, rs372691318	N/A

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Leigh Syndrome With Leukodystrophy	Leigh syndrome with leukodystrophy	N/A	N/A	GenCC
Mitochondrial Diseases	mitochondrial disease	N/A	N/A	GenCC

Show/Hide Text Mining Associations (17)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	38017020
Breast Neoplasms	Associate	39684297
Carcinogenesis	Associate	36658121, 39684297
Colorectal Neoplasms	Associate	36658121
Cyanosis	Associate	36042640
Heart Failure	Inhibit	31863644
Leigh Disease	Associate	36042640, 36403546
Leukoencephalopathies	Associate	15576045, 33811136
Lung Neoplasms	Associate	27516145
Mitochondrial complex I deficiency	Associate	11349233, 18435906, 27516145, 31557978, 36042640
Mitochondrial Diseases	Associate	30764484, 31863644, 36042640
Neoplasms	Associate	27516145, 32942548, 39684297
Neuroblastoma	Associate	36675163
Ovarian Diseases	Associate	25298284
Schizophrenia	Associate	26053550
Testicular Neoplasms	Associate	30764484
Weight Gain	Associate	24196945

NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1)