ACLY (ATP citrate lyase)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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47 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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ATP citrate lyase |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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ACLY |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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ACL, ATPCL, CLATP |
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Chromosome
Chromosome number
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17 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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17q21.2 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acety |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||||||||||||
| UniProt ID | P53396 | |||||||||||||||||||||||||
| Protein name | ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme) | |||||||||||||||||||||||||
| Protein function | Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism. {ECO:0000269|PubMed:10653665, ECO:0000269|PubMed:1371749, | |||||||||||||||||||||||||
| PDB | 3MWD , 3MWE , 3PFF , 5TDE , 5TDF , 5TDM , 5TDZ , 5TE1 , 5TEQ , 5TES , 5TET , 6HXH , 6HXK , 6HXL , 6HXM , 6O0H , 6POE , 6POF , 6QFB , 6UI9 , 6UIA , 6UUW , 6UUZ , 6UV5 , 6Z2H , 7LIW , 7LJ9 , 7LLA , 7RIG , 7RKZ , 7RMP , 8G1E , 8G1F , 8G5C , 8G5D | |||||||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence | ||||||||||||||||||||||||||
| Sequence length | 1101 | |||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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