Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4685
Gene name	Neural cell adhesion molecule 2
Gene symbol	NCAM2
Synonyms (NCBI Gene)	NCAM21
Chromosome	21
Chromosome location	21q21.1
Summary	The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]

201

Show/Hide all (201)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018062	hsa-miR-335-5p	Microarray	18185580
MIRT029650	hsa-miR-26b-5p	Microarray	19088304
MIRT503840	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT503839	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT503838	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT503836	hsa-miR-3924	HITS-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT503839	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT503838	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT503836	hsa-miR-3924	PAR-CLIP	20371350
MIRT563183	hsa-miR-6507-5p	PAR-CLIP	20371350
MIRT563182	hsa-miR-4790-3p	PAR-CLIP	20371350
MIRT563181	hsa-miR-3653-3p	PAR-CLIP	20371350
MIRT563180	hsa-miR-6505-5p	PAR-CLIP	20371350
MIRT563179	hsa-miR-3658	PAR-CLIP	20371350
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT503839	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT503838	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT503836	hsa-miR-3924	PAR-CLIP	20371350
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503839	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503838	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503836	hsa-miR-3924	PAR-CLIP	21572407
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503839	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503838	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503836	hsa-miR-3924	PAR-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503839	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503838	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503836	hsa-miR-3924	PAR-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT527323	hsa-miR-495-3p	PAR-CLIP	22012620
MIRT527322	hsa-miR-5688	PAR-CLIP	22012620
MIRT527321	hsa-miR-3529-3p	PAR-CLIP	22012620
MIRT527320	hsa-miR-3065-5p	PAR-CLIP	22012620
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503839	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503838	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503839	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503838	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503836	hsa-miR-3924	PAR-CLIP	23446348
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503839	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503838	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503836	hsa-miR-3924	PAR-CLIP	23446348
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT444930	hsa-miR-21-3p	PAR-CLIP	22100165
MIRT444929	hsa-miR-3591-3p	PAR-CLIP	22100165
MIRT444928	hsa-miR-1273e	PAR-CLIP	22100165
MIRT444927	hsa-miR-6885-3p	PAR-CLIP	22100165
MIRT503840	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT503839	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT503838	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT503836	hsa-miR-3924	HITS-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT503839	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT503838	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT503836	hsa-miR-3924	PAR-CLIP	20371350
MIRT563183	hsa-miR-6507-5p	PAR-CLIP	20371350
MIRT563182	hsa-miR-4790-3p	PAR-CLIP	20371350
MIRT563181	hsa-miR-3653-3p	PAR-CLIP	20371350
MIRT563180	hsa-miR-6505-5p	PAR-CLIP	20371350
MIRT563179	hsa-miR-3658	PAR-CLIP	20371350
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT503839	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT503838	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT503836	hsa-miR-3924	PAR-CLIP	20371350
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503839	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503838	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503836	hsa-miR-3924	PAR-CLIP	21572407
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503839	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503838	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503836	hsa-miR-3924	PAR-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT503839	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503838	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT503836	hsa-miR-3924	PAR-CLIP	21572407
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT527323	hsa-miR-495-3p	PAR-CLIP	22012620
MIRT527322	hsa-miR-5688	PAR-CLIP	22012620
MIRT527321	hsa-miR-3529-3p	PAR-CLIP	22012620
MIRT527320	hsa-miR-3065-5p	PAR-CLIP	22012620
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503839	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503838	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503839	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503838	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503836	hsa-miR-3924	PAR-CLIP	23446348
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT503840	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT503839	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503838	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT503837	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT503836	hsa-miR-3924	PAR-CLIP	23446348
MIRT503835	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT444930	hsa-miR-21-3p	PAR-CLIP	22100165
MIRT444929	hsa-miR-3591-3p	PAR-CLIP	22100165
MIRT444928	hsa-miR-1273e	PAR-CLIP	22100165
MIRT444927	hsa-miR-6885-3p	PAR-CLIP	22100165
MIRT1175679	hsa-miR-1182	CLIP-seq
MIRT1175680	hsa-miR-1324	CLIP-seq
MIRT1175681	hsa-miR-133a	CLIP-seq
MIRT1175682	hsa-miR-133b	CLIP-seq
MIRT1175683	hsa-miR-203	CLIP-seq
MIRT1175684	hsa-miR-2278	CLIP-seq
MIRT1175685	hsa-miR-3120-3p	CLIP-seq
MIRT1175686	hsa-miR-3121-3p	CLIP-seq
MIRT1175687	hsa-miR-3130-3p	CLIP-seq
MIRT1175688	hsa-miR-340	CLIP-seq
MIRT1175689	hsa-miR-34b	CLIP-seq
MIRT1175690	hsa-miR-3616-5p	CLIP-seq
MIRT1175691	hsa-miR-3646	CLIP-seq
MIRT1175692	hsa-miR-3647-5p	CLIP-seq
MIRT1175693	hsa-miR-369-3p	CLIP-seq
MIRT1175694	hsa-miR-374a	CLIP-seq
MIRT1175695	hsa-miR-374b	CLIP-seq
MIRT1175696	hsa-miR-3974	CLIP-seq
MIRT1175697	hsa-miR-4264	CLIP-seq
MIRT1175698	hsa-miR-4421	CLIP-seq
MIRT1175699	hsa-miR-4422	CLIP-seq
MIRT1175700	hsa-miR-4517	CLIP-seq
MIRT1175701	hsa-miR-4635	CLIP-seq
MIRT1175702	hsa-miR-4662a-5p	CLIP-seq
MIRT1175703	hsa-miR-4704-3p	CLIP-seq
MIRT1175704	hsa-miR-4793-3p	CLIP-seq
MIRT1175705	hsa-miR-4797-3p	CLIP-seq
MIRT1175706	hsa-miR-4803	CLIP-seq
MIRT1175707	hsa-miR-515-5p	CLIP-seq
MIRT1175708	hsa-miR-545	CLIP-seq
MIRT1175709	hsa-miR-548p	CLIP-seq
MIRT1175710	hsa-miR-561	CLIP-seq
MIRT1175711	hsa-miR-573	CLIP-seq
MIRT1175712	hsa-miR-610	CLIP-seq
MIRT1175713	hsa-miR-668	CLIP-seq
MIRT2050850	hsa-miR-2116	CLIP-seq
MIRT2050851	hsa-miR-3613-3p	CLIP-seq
MIRT1175690	hsa-miR-3616-5p	CLIP-seq
MIRT1175692	hsa-miR-3647-5p	CLIP-seq
MIRT2050852	hsa-miR-3662	CLIP-seq
MIRT1175701	hsa-miR-4635	CLIP-seq
MIRT2050853	hsa-miR-4659a-3p	CLIP-seq
MIRT2050854	hsa-miR-4659b-3p	CLIP-seq
MIRT2050855	hsa-miR-548c-3p	CLIP-seq
MIRT1175710	hsa-miR-561	CLIP-seq
MIRT1175711	hsa-miR-573	CLIP-seq
MIRT2050856	hsa-miR-622	CLIP-seq
MIRT2279957	hsa-miR-1243	CLIP-seq
MIRT2279958	hsa-miR-1255a	CLIP-seq
MIRT2279959	hsa-miR-1255b	CLIP-seq
MIRT2279960	hsa-miR-127-5p	CLIP-seq
MIRT2279961	hsa-miR-197	CLIP-seq
MIRT1175685	hsa-miR-3120-3p	CLIP-seq
MIRT1175693	hsa-miR-369-3p	CLIP-seq
MIRT1175694	hsa-miR-374a	CLIP-seq
MIRT1175695	hsa-miR-374b	CLIP-seq
MIRT2279962	hsa-miR-383	CLIP-seq
MIRT1175698	hsa-miR-4421	CLIP-seq
MIRT1175699	hsa-miR-4422	CLIP-seq
MIRT2279963	hsa-miR-4699-3p	CLIP-seq
MIRT2279964	hsa-miR-4772-5p	CLIP-seq
MIRT2279965	hsa-miR-495	CLIP-seq
MIRT2279966	hsa-miR-5096	CLIP-seq
MIRT2279967	hsa-miR-520g	CLIP-seq
MIRT2279968	hsa-miR-520h	CLIP-seq
MIRT1175712	hsa-miR-610	CLIP-seq
MIRT1175713	hsa-miR-668	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9226371
GO:0007155	Process	Cell adhesion	IEA
GO:0007158	Process	Neuron cell-cell adhesion	TAS	9226371
GO:0007413	Process	Axonal fasciculation	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9226371
GO:0016604	Component	Nuclear body	IDA
GO:0030424	Component	Axon	IEA
GO:0042802	Function	Identical protein binding	IPI	21300289
GO:0043005	Component	Neuron projection	IBA
GO:0097060	Component	Synaptic membrane	IEA

MIM	HGNC	e!Ensembl
602040	7657	ENSG00000154654

O15394

Protein name

Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2)

Protein function

May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.

PDB

2DOC , 2JLL , 2KBG , 2V5T , 2VAJ , 2WIM , 2XY1 , 2XY2 , 2XYC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07679	I-set	21 → 111	Immunoglobulin I-set domain	Domain
PF07679	I-set	115 → 198	Immunoglobulin I-set domain	Domain
PF07679	I-set	211 → 298	Immunoglobulin I-set domain	Domain
PF07679	I-set	302 → 397	Immunoglobulin I-set domain	Domain
PF13927	Ig_3	401 → 479		Domain
PF00041	fn3	497 → 581	Fibronectin type III domain	Domain
PF00041	fn3	593 → 678	Fibronectin type III domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed most strongly in adult and fetal brain.

Sequence

MSLLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEK
IISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREV
VSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSD
EGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEP
AISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV
QPHIIQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQH
GSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINI
SCDVKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNH
IGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVDVKEVASE
IWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIH
GQPSSGKSFKLSITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTM
GYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAVIGLGVAALLLILVVTD
VSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRTEDERVT
NHEDGSPVNEPNETTPLTEPEKLPLKEEDGKEALNPETIEIKVSNDIIQSKEDDSKA

Sequence length

837

Interactions

View interactions

	KEGG
	Virion - Ebolavirus, Lyssavirus and Morbillivirus Cell adhesion molecules Prion disease

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Gastric cancer	Benign	rs75625065	RCV005933217
NCAM2-related disorder	Benign; Likely benign; Uncertain significance	rs35654962, rs2017705, rs232518, rs116546079, rs182642680, rs75625065, rs150466591, rs868203661, rs143579715, rs986371, rs556299601, rs145537614, rs201600701	RCV003929675 RCV003979583 RCV003979600 RCV003909536 RCV003933834 RCV003941963 RCV003917046 RCV003931500 RCV003961465 RCV003922307 RCV003934242 RCV003944668 RCV003978962
See cases	Uncertain significance	rs2516987658	RCV002467407

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	20932310
Asthma	Associate	25335167
Autistic Disorder	Associate	20034085
Cognition Disorders	Associate	38238328
Neurobehavioral Manifestations	Associate	20034085
Prostatic Neoplasms	Associate	15583692

NCAM2 (neural cell adhesion molecule 2)