Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	4680
Gene name	CEA cell adhesion molecule 6
Gene symbol	CEACAM6
Synonyms (NCBI Gene)	CD66cCEALNCANCA-50/90
Chromosome	19
Chromosome location	19q13.2
Summary	This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tu

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miRTarBase ID	miRNA	Experiments	Reference
MIRT038060	hsa-miR-423-5p	CLASH	23622248
MIRT438274	hsa-miR-29a-3p	Luciferase reporter assayWestern blot	25171863
MIRT438274	hsa-miR-29a-3p	Luciferase reporter assayWestern blot	25171863
MIRT736081	hsa-miR-765	Microarray	31498480
MIRT736555	hsa-miR-26a-1-3p	Luciferase reporter assayWestern blottingqRT-PCR	32648688
MIRT736593	hsa-miR-146a-3p	Luciferase reporter assayWestern blottingqRT-PCR	32648688
MIRT883038	hsa-miR-1179	CLIP-seq
MIRT883039	hsa-miR-1229	CLIP-seq
MIRT883040	hsa-miR-140-5p	CLIP-seq
MIRT883041	hsa-miR-1914	CLIP-seq
MIRT883042	hsa-miR-1976	CLIP-seq
MIRT883043	hsa-miR-2116	CLIP-seq
MIRT883044	hsa-miR-2278	CLIP-seq
MIRT883045	hsa-miR-29a	CLIP-seq
MIRT883046	hsa-miR-29b	CLIP-seq
MIRT883047	hsa-miR-29c	CLIP-seq
MIRT883048	hsa-miR-3143	CLIP-seq
MIRT883049	hsa-miR-3158-3p	CLIP-seq
MIRT883050	hsa-miR-3198	CLIP-seq
MIRT883051	hsa-miR-338-3p	CLIP-seq
MIRT883052	hsa-miR-3545-5p	CLIP-seq
MIRT883053	hsa-miR-3591-5p	CLIP-seq
MIRT883054	hsa-miR-3611	CLIP-seq
MIRT883055	hsa-miR-3668	CLIP-seq
MIRT883056	hsa-miR-380	CLIP-seq
MIRT883057	hsa-miR-3924	CLIP-seq
MIRT883058	hsa-miR-3925-3p	CLIP-seq
MIRT883059	hsa-miR-4309	CLIP-seq
MIRT883060	hsa-miR-4425	CLIP-seq
MIRT883061	hsa-miR-4433	CLIP-seq
MIRT883062	hsa-miR-4446-3p	CLIP-seq
MIRT883063	hsa-miR-4459	CLIP-seq
MIRT883064	hsa-miR-4460	CLIP-seq
MIRT883065	hsa-miR-4468	CLIP-seq
MIRT883066	hsa-miR-4495	CLIP-seq
MIRT883067	hsa-miR-4509	CLIP-seq
MIRT883068	hsa-miR-450b-3p	CLIP-seq
MIRT883069	hsa-miR-4530	CLIP-seq
MIRT883070	hsa-miR-4677-5p	CLIP-seq
MIRT883071	hsa-miR-4727-3p	CLIP-seq
MIRT883072	hsa-miR-4768-3p	CLIP-seq
MIRT883073	hsa-miR-4778-3p	CLIP-seq
MIRT883074	hsa-miR-543	CLIP-seq
MIRT883075	hsa-miR-548ad	CLIP-seq
MIRT883076	hsa-miR-766	CLIP-seq
MIRT883077	hsa-miR-769-3p	CLIP-seq
MIRT883078	hsa-miR-892b	CLIP-seq
MIRT1961823	hsa-miR-1245b-3p	CLIP-seq
MIRT1961824	hsa-miR-1283	CLIP-seq
MIRT1961825	hsa-miR-1285	CLIP-seq
MIRT1961826	hsa-miR-15a	CLIP-seq
MIRT1961827	hsa-miR-15b	CLIP-seq
MIRT1961828	hsa-miR-16	CLIP-seq
MIRT1961829	hsa-miR-195	CLIP-seq
MIRT1961830	hsa-miR-2052	CLIP-seq
MIRT1961831	hsa-miR-2054	CLIP-seq
MIRT1961832	hsa-miR-2277-3p	CLIP-seq
MIRT883045	hsa-miR-29a	CLIP-seq
MIRT883046	hsa-miR-29b	CLIP-seq
MIRT883047	hsa-miR-29c	CLIP-seq
MIRT1961833	hsa-miR-3065-3p	CLIP-seq
MIRT883048	hsa-miR-3143	CLIP-seq
MIRT1961834	hsa-miR-3153	CLIP-seq
MIRT1961835	hsa-miR-3187-5p	CLIP-seq
MIRT1961836	hsa-miR-331-3p	CLIP-seq
MIRT1961837	hsa-miR-338-5p	CLIP-seq
MIRT1961838	hsa-miR-3659	CLIP-seq
MIRT1961839	hsa-miR-3913-3p	CLIP-seq
MIRT1961840	hsa-miR-3921	CLIP-seq
MIRT1961841	hsa-miR-424	CLIP-seq
MIRT1961842	hsa-miR-4280	CLIP-seq
MIRT1961843	hsa-miR-4292	CLIP-seq
MIRT1961844	hsa-miR-4311	CLIP-seq
MIRT1961845	hsa-miR-4422	CLIP-seq
MIRT1961846	hsa-miR-4480	CLIP-seq
MIRT1961847	hsa-miR-4653-5p	CLIP-seq
MIRT1961848	hsa-miR-4658	CLIP-seq
MIRT1961849	hsa-miR-4666-3p	CLIP-seq
MIRT1961850	hsa-miR-4668-5p	CLIP-seq
MIRT1961851	hsa-miR-4682	CLIP-seq
MIRT1961852	hsa-miR-4714-5p	CLIP-seq
MIRT1961853	hsa-miR-4722-3p	CLIP-seq
MIRT1961854	hsa-miR-4766-5p	CLIP-seq
MIRT1961855	hsa-miR-4768-5p	CLIP-seq
MIRT883073	hsa-miR-4778-3p	CLIP-seq
MIRT1961856	hsa-miR-4786-5p	CLIP-seq
MIRT1961857	hsa-miR-4793-5p	CLIP-seq
MIRT1961858	hsa-miR-489	CLIP-seq
MIRT1961859	hsa-miR-497	CLIP-seq
MIRT1961860	hsa-miR-514	CLIP-seq
MIRT1961861	hsa-miR-514b-3p	CLIP-seq
MIRT883074	hsa-miR-543	CLIP-seq
MIRT1961862	hsa-miR-574-5p	CLIP-seq
MIRT1961863	hsa-miR-612	CLIP-seq
MIRT1961864	hsa-miR-635	CLIP-seq
MIRT1961865	hsa-miR-642b	CLIP-seq
MIRT2198363	hsa-miR-1207-3p	CLIP-seq
MIRT2198364	hsa-miR-1272	CLIP-seq
MIRT2198365	hsa-miR-127-5p	CLIP-seq
MIRT1961824	hsa-miR-1283	CLIP-seq
MIRT1961825	hsa-miR-1285	CLIP-seq
MIRT2198366	hsa-miR-1321	CLIP-seq
MIRT2198367	hsa-miR-1322	CLIP-seq
MIRT1961826	hsa-miR-15a	CLIP-seq
MIRT1961827	hsa-miR-15b	CLIP-seq
MIRT1961828	hsa-miR-16	CLIP-seq
MIRT1961829	hsa-miR-195	CLIP-seq
MIRT883042	hsa-miR-1976	CLIP-seq
MIRT2198368	hsa-miR-205	CLIP-seq
MIRT2198369	hsa-miR-219-1-3p	CLIP-seq
MIRT1961832	hsa-miR-2277-3p	CLIP-seq
MIRT883044	hsa-miR-2278	CLIP-seq
MIRT2198370	hsa-miR-3119	CLIP-seq
MIRT2198371	hsa-miR-3123	CLIP-seq
MIRT883049	hsa-miR-3158-3p	CLIP-seq
MIRT2198372	hsa-miR-3162-5p	CLIP-seq
MIRT2198373	hsa-miR-3163	CLIP-seq
MIRT1961835	hsa-miR-3187-5p	CLIP-seq
MIRT1961836	hsa-miR-331-3p	CLIP-seq
MIRT883051	hsa-miR-338-3p	CLIP-seq
MIRT1961837	hsa-miR-338-5p	CLIP-seq
MIRT2198374	hsa-miR-339-5p	CLIP-seq
MIRT883054	hsa-miR-3611	CLIP-seq
MIRT2198375	hsa-miR-361-5p	CLIP-seq
MIRT2198376	hsa-miR-362-5p	CLIP-seq
MIRT2198377	hsa-miR-3662	CLIP-seq
MIRT2198378	hsa-miR-3664-5p	CLIP-seq
MIRT2198379	hsa-miR-3682-5p	CLIP-seq
MIRT883058	hsa-miR-3925-3p	CLIP-seq
MIRT1961841	hsa-miR-424	CLIP-seq
MIRT2198380	hsa-miR-4260	CLIP-seq
MIRT2198381	hsa-miR-4266	CLIP-seq
MIRT2198382	hsa-miR-4270	CLIP-seq
MIRT2198383	hsa-miR-4283	CLIP-seq
MIRT1961843	hsa-miR-4292	CLIP-seq
MIRT1961844	hsa-miR-4311	CLIP-seq
MIRT1961845	hsa-miR-4422	CLIP-seq
MIRT883060	hsa-miR-4425	CLIP-seq
MIRT883061	hsa-miR-4433	CLIP-seq
MIRT2198384	hsa-miR-4441	CLIP-seq
MIRT883062	hsa-miR-4446-3p	CLIP-seq
MIRT883063	hsa-miR-4459	CLIP-seq
MIRT883065	hsa-miR-4468	CLIP-seq
MIRT2198385	hsa-miR-4473	CLIP-seq
MIRT1961846	hsa-miR-4480	CLIP-seq
MIRT2198386	hsa-miR-4489	CLIP-seq
MIRT883068	hsa-miR-450b-3p	CLIP-seq
MIRT883069	hsa-miR-4530	CLIP-seq
MIRT1961849	hsa-miR-4666-3p	CLIP-seq
MIRT2198387	hsa-miR-4671-3p	CLIP-seq
MIRT2198388	hsa-miR-4695-5p	CLIP-seq
MIRT2198389	hsa-miR-4704-5p	CLIP-seq
MIRT1961852	hsa-miR-4714-5p	CLIP-seq
MIRT1961853	hsa-miR-4722-3p	CLIP-seq
MIRT2198390	hsa-miR-4733-3p	CLIP-seq
MIRT2198391	hsa-miR-4739	CLIP-seq
MIRT2198392	hsa-miR-4756-5p	CLIP-seq
MIRT883072	hsa-miR-4768-3p	CLIP-seq
MIRT2198393	hsa-miR-4773	CLIP-seq
MIRT2198394	hsa-miR-4779	CLIP-seq
MIRT1961856	hsa-miR-4786-5p	CLIP-seq
MIRT1961857	hsa-miR-4793-5p	CLIP-seq
MIRT1961859	hsa-miR-497	CLIP-seq
MIRT2198395	hsa-miR-500b	CLIP-seq
MIRT2198396	hsa-miR-501-5p	CLIP-seq
MIRT2198397	hsa-miR-512-3p	CLIP-seq
MIRT2198398	hsa-miR-520f	CLIP-seq
MIRT2198399	hsa-miR-571	CLIP-seq
MIRT2198400	hsa-miR-578	CLIP-seq
MIRT2198401	hsa-miR-581	CLIP-seq
MIRT2198402	hsa-miR-583	CLIP-seq
MIRT1961863	hsa-miR-612	CLIP-seq
MIRT883076	hsa-miR-766	CLIP-seq
MIRT883077	hsa-miR-769-3p	CLIP-seq
MIRT2198403	hsa-miR-935	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21982860, 26483485, 32296183
GO:0005615	Component	Extracellular space	IDA	25645918
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IMP	2803308, 11590190
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP	2803308, 8776764, 11590190
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	25171863
GO:0009986	Component	Cell surface	IBA
GO:0009986	Component	Cell surface	IC	2803308
GO:0009986	Component	Cell surface	IDA	2317824, 8776764, 16204051
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IDA	2317824
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IDA	10436421
GO:0016324	Component	Apical plasma membrane	IEA
GO:0030335	Process	Positive regulation of cell migration	IMP	16204051, 25171863
GO:0034116	Process	Positive regulation of heterotypic cell-cell adhesion	IMP	16204051
GO:0035577	Component	Azurophil granule membrane	TAS
GO:0042802	Function	Identical protein binding	IDA	26483485
GO:0042802	Function	Identical protein binding	IPI	21982860, 26483485, 32296183
GO:0046982	Function	Protein heterodimerization activity	IDA	26483485
GO:0098552	Component	Side of membrane	IEA
GO:1904906	Process	Positive regulation of endothelial cell-matrix adhesion via fibronectin	IMP	16204051
GO:2000811	Process	Negative regulation of anoikis	IMP	10910050

MIM	HGNC	e!Ensembl
163980	1818	ENSG00000086548

P40199

Protein name

Cell adhesion molecule CEACAM6 (Carcinoembryonic antigen-related cell adhesion molecule 6) (CEA cell adhesion molecule 6) (Non-specific crossreacting antigen) (Normal cross-reacting antigen) (CD antigen CD66c)

Protein function

Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:10910050, PubMed:11590190, PubMed:1378450, PubMed:16204051, PubMed:2022629, PubMed:2803308, PubMed:8776764). Intercellular adhesion occurs in a calcium- a

PDB

4WHC , 4WTZ , 4Y8A , 4YIQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	38 → 141	Immunoglobulin V-set domain	Domain
PF13927	Ig_3	146 → 219		Domain
PF13895	Ig_2	239 → 318	Immunoglobulin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in neutrophils (PubMed:1378450). Expressed in columnar epithelial and goblet cells of the colon (PubMed:10436421). Expressed in numerous tumor cell lines (at protein level) (PubMed:16204051). {ECO:0000269|PubMed:10436421, ECO

Sequence

MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQ
NRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFY
TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWV
NGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDGP
TISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQ
AHNSATGLNRTTVTMITVSGSAPVLSAVATVGITIGVLARVALI

Sequence length

344

Interactions

View interactions

	Reactome
			Fibronectin matrix formation Cell surface interactions at the vascular wall Neutrophil degranulation

CEACAM6 (CEA cell adhesion molecule 6)