Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4680
Gene name Gene Name - the full gene name approved by the HGNC.	CEA cell adhesion molecule 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CEACAM6
Synonyms (NCBI Gene) Gene synonyms aliases	CD66c, CEAL, NCA, NCA-50/90
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tu

Show/Hide all(175)

miRTarBase ID	miRNA	Experiments	Reference
MIRT038060	hsa-miR-423-5p	CLASH	23622248
MIRT438274	hsa-miR-29a-3p	Luciferase reporter assay, Western blot	25171863
MIRT438274	hsa-miR-29a-3p	Luciferase reporter assay, Western blot	25171863
MIRT736081	hsa-miR-765	Microarray	31498480
MIRT736555	hsa-miR-26a-1-3p	Luciferase reporter assay, Western blotting, qRT-PCR	32648688
MIRT736593	hsa-miR-146a-3p	Luciferase reporter assay, Western blotting, qRT-PCR	32648688
MIRT883038	hsa-miR-1179	CLIP-seq
MIRT883039	hsa-miR-1229	CLIP-seq
MIRT883040	hsa-miR-140-5p	CLIP-seq
MIRT883041	hsa-miR-1914	CLIP-seq
MIRT883042	hsa-miR-1976	CLIP-seq
MIRT883043	hsa-miR-2116	CLIP-seq
MIRT883044	hsa-miR-2278	CLIP-seq
MIRT883045	hsa-miR-29a	CLIP-seq
MIRT883046	hsa-miR-29b	CLIP-seq
MIRT883047	hsa-miR-29c	CLIP-seq
MIRT883048	hsa-miR-3143	CLIP-seq
MIRT883049	hsa-miR-3158-3p	CLIP-seq
MIRT883050	hsa-miR-3198	CLIP-seq
MIRT883051	hsa-miR-338-3p	CLIP-seq
MIRT883052	hsa-miR-3545-5p	CLIP-seq
MIRT883053	hsa-miR-3591-5p	CLIP-seq
MIRT883054	hsa-miR-3611	CLIP-seq
MIRT883055	hsa-miR-3668	CLIP-seq
MIRT883056	hsa-miR-380	CLIP-seq
MIRT883057	hsa-miR-3924	CLIP-seq
MIRT883058	hsa-miR-3925-3p	CLIP-seq
MIRT883059	hsa-miR-4309	CLIP-seq
MIRT883060	hsa-miR-4425	CLIP-seq
MIRT883061	hsa-miR-4433	CLIP-seq
MIRT883062	hsa-miR-4446-3p	CLIP-seq
MIRT883063	hsa-miR-4459	CLIP-seq
MIRT883064	hsa-miR-4460	CLIP-seq
MIRT883065	hsa-miR-4468	CLIP-seq
MIRT883066	hsa-miR-4495	CLIP-seq
MIRT883067	hsa-miR-4509	CLIP-seq
MIRT883068	hsa-miR-450b-3p	CLIP-seq
MIRT883069	hsa-miR-4530	CLIP-seq
MIRT883070	hsa-miR-4677-5p	CLIP-seq
MIRT883071	hsa-miR-4727-3p	CLIP-seq
MIRT883072	hsa-miR-4768-3p	CLIP-seq
MIRT883073	hsa-miR-4778-3p	CLIP-seq
MIRT883074	hsa-miR-543	CLIP-seq
MIRT883075	hsa-miR-548ad	CLIP-seq
MIRT883076	hsa-miR-766	CLIP-seq
MIRT883077	hsa-miR-769-3p	CLIP-seq
MIRT883078	hsa-miR-892b	CLIP-seq
MIRT1961823	hsa-miR-1245b-3p	CLIP-seq
MIRT1961824	hsa-miR-1283	CLIP-seq
MIRT1961825	hsa-miR-1285	CLIP-seq
MIRT1961826	hsa-miR-15a	CLIP-seq
MIRT1961827	hsa-miR-15b	CLIP-seq
MIRT1961828	hsa-miR-16	CLIP-seq
MIRT1961829	hsa-miR-195	CLIP-seq
MIRT1961830	hsa-miR-2052	CLIP-seq
MIRT1961831	hsa-miR-2054	CLIP-seq
MIRT1961832	hsa-miR-2277-3p	CLIP-seq
MIRT883045	hsa-miR-29a	CLIP-seq
MIRT883046	hsa-miR-29b	CLIP-seq
MIRT883047	hsa-miR-29c	CLIP-seq
MIRT1961833	hsa-miR-3065-3p	CLIP-seq
MIRT883048	hsa-miR-3143	CLIP-seq
MIRT1961834	hsa-miR-3153	CLIP-seq
MIRT1961835	hsa-miR-3187-5p	CLIP-seq
MIRT1961836	hsa-miR-331-3p	CLIP-seq
MIRT1961837	hsa-miR-338-5p	CLIP-seq
MIRT1961838	hsa-miR-3659	CLIP-seq
MIRT1961839	hsa-miR-3913-3p	CLIP-seq
MIRT1961840	hsa-miR-3921	CLIP-seq
MIRT1961841	hsa-miR-424	CLIP-seq
MIRT1961842	hsa-miR-4280	CLIP-seq
MIRT1961843	hsa-miR-4292	CLIP-seq
MIRT1961844	hsa-miR-4311	CLIP-seq
MIRT1961845	hsa-miR-4422	CLIP-seq
MIRT1961846	hsa-miR-4480	CLIP-seq
MIRT1961847	hsa-miR-4653-5p	CLIP-seq
MIRT1961848	hsa-miR-4658	CLIP-seq
MIRT1961849	hsa-miR-4666-3p	CLIP-seq
MIRT1961850	hsa-miR-4668-5p	CLIP-seq
MIRT1961851	hsa-miR-4682	CLIP-seq
MIRT1961852	hsa-miR-4714-5p	CLIP-seq
MIRT1961853	hsa-miR-4722-3p	CLIP-seq
MIRT1961854	hsa-miR-4766-5p	CLIP-seq
MIRT1961855	hsa-miR-4768-5p	CLIP-seq
MIRT883073	hsa-miR-4778-3p	CLIP-seq
MIRT1961856	hsa-miR-4786-5p	CLIP-seq
MIRT1961857	hsa-miR-4793-5p	CLIP-seq
MIRT1961858	hsa-miR-489	CLIP-seq
MIRT1961859	hsa-miR-497	CLIP-seq
MIRT1961860	hsa-miR-514	CLIP-seq
MIRT1961861	hsa-miR-514b-3p	CLIP-seq
MIRT883074	hsa-miR-543	CLIP-seq
MIRT1961862	hsa-miR-574-5p	CLIP-seq
MIRT1961863	hsa-miR-612	CLIP-seq
MIRT1961864	hsa-miR-635	CLIP-seq
MIRT1961865	hsa-miR-642b	CLIP-seq
MIRT2198363	hsa-miR-1207-3p	CLIP-seq
MIRT2198364	hsa-miR-1272	CLIP-seq
MIRT2198365	hsa-miR-127-5p	CLIP-seq
MIRT1961824	hsa-miR-1283	CLIP-seq
MIRT1961825	hsa-miR-1285	CLIP-seq
MIRT2198366	hsa-miR-1321	CLIP-seq
MIRT2198367	hsa-miR-1322	CLIP-seq
MIRT1961826	hsa-miR-15a	CLIP-seq
MIRT1961827	hsa-miR-15b	CLIP-seq
MIRT1961828	hsa-miR-16	CLIP-seq
MIRT1961829	hsa-miR-195	CLIP-seq
MIRT883042	hsa-miR-1976	CLIP-seq
MIRT2198368	hsa-miR-205	CLIP-seq
MIRT2198369	hsa-miR-219-1-3p	CLIP-seq
MIRT1961832	hsa-miR-2277-3p	CLIP-seq
MIRT883044	hsa-miR-2278	CLIP-seq
MIRT2198370	hsa-miR-3119	CLIP-seq
MIRT2198371	hsa-miR-3123	CLIP-seq
MIRT883049	hsa-miR-3158-3p	CLIP-seq
MIRT2198372	hsa-miR-3162-5p	CLIP-seq
MIRT2198373	hsa-miR-3163	CLIP-seq
MIRT1961835	hsa-miR-3187-5p	CLIP-seq
MIRT1961836	hsa-miR-331-3p	CLIP-seq
MIRT883051	hsa-miR-338-3p	CLIP-seq
MIRT1961837	hsa-miR-338-5p	CLIP-seq
MIRT2198374	hsa-miR-339-5p	CLIP-seq
MIRT883054	hsa-miR-3611	CLIP-seq
MIRT2198375	hsa-miR-361-5p	CLIP-seq
MIRT2198376	hsa-miR-362-5p	CLIP-seq
MIRT2198377	hsa-miR-3662	CLIP-seq
MIRT2198378	hsa-miR-3664-5p	CLIP-seq
MIRT2198379	hsa-miR-3682-5p	CLIP-seq
MIRT883058	hsa-miR-3925-3p	CLIP-seq
MIRT1961841	hsa-miR-424	CLIP-seq
MIRT2198380	hsa-miR-4260	CLIP-seq
MIRT2198381	hsa-miR-4266	CLIP-seq
MIRT2198382	hsa-miR-4270	CLIP-seq
MIRT2198383	hsa-miR-4283	CLIP-seq
MIRT1961843	hsa-miR-4292	CLIP-seq
MIRT1961844	hsa-miR-4311	CLIP-seq
MIRT1961845	hsa-miR-4422	CLIP-seq
MIRT883060	hsa-miR-4425	CLIP-seq
MIRT883061	hsa-miR-4433	CLIP-seq
MIRT2198384	hsa-miR-4441	CLIP-seq
MIRT883062	hsa-miR-4446-3p	CLIP-seq
MIRT883063	hsa-miR-4459	CLIP-seq
MIRT883065	hsa-miR-4468	CLIP-seq
MIRT2198385	hsa-miR-4473	CLIP-seq
MIRT1961846	hsa-miR-4480	CLIP-seq
MIRT2198386	hsa-miR-4489	CLIP-seq
MIRT883068	hsa-miR-450b-3p	CLIP-seq
MIRT883069	hsa-miR-4530	CLIP-seq
MIRT1961849	hsa-miR-4666-3p	CLIP-seq
MIRT2198387	hsa-miR-4671-3p	CLIP-seq
MIRT2198388	hsa-miR-4695-5p	CLIP-seq
MIRT2198389	hsa-miR-4704-5p	CLIP-seq
MIRT1961852	hsa-miR-4714-5p	CLIP-seq
MIRT1961853	hsa-miR-4722-3p	CLIP-seq
MIRT2198390	hsa-miR-4733-3p	CLIP-seq
MIRT2198391	hsa-miR-4739	CLIP-seq
MIRT2198392	hsa-miR-4756-5p	CLIP-seq
MIRT883072	hsa-miR-4768-3p	CLIP-seq
MIRT2198393	hsa-miR-4773	CLIP-seq
MIRT2198394	hsa-miR-4779	CLIP-seq
MIRT1961856	hsa-miR-4786-5p	CLIP-seq
MIRT1961857	hsa-miR-4793-5p	CLIP-seq
MIRT1961859	hsa-miR-497	CLIP-seq
MIRT2198395	hsa-miR-500b	CLIP-seq
MIRT2198396	hsa-miR-501-5p	CLIP-seq
MIRT2198397	hsa-miR-512-3p	CLIP-seq
MIRT2198398	hsa-miR-520f	CLIP-seq
MIRT2198399	hsa-miR-571	CLIP-seq
MIRT2198400	hsa-miR-578	CLIP-seq
MIRT2198401	hsa-miR-581	CLIP-seq
MIRT2198402	hsa-miR-583	CLIP-seq
MIRT1961863	hsa-miR-612	CLIP-seq
MIRT883076	hsa-miR-766	CLIP-seq
MIRT883077	hsa-miR-769-3p	CLIP-seq
MIRT2198403	hsa-miR-935	CLIP-seq

Show/Hide all(27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21982860, 26483485, 32296183
GO:0005615	Component	Extracellular space	IDA	25645918
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IMP	2803308, 11590190
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP	2803308, 8776764, 11590190
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	25171863
GO:0009986	Component	Cell surface	IBA
GO:0009986	Component	Cell surface	IC	2803308
GO:0009986	Component	Cell surface	IDA	2317824, 8776764, 16204051
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IDA	2317824
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IDA	10436421
GO:0016324	Component	Apical plasma membrane	IEA
GO:0030335	Process	Positive regulation of cell migration	IMP	16204051, 25171863
GO:0034116	Process	Positive regulation of heterotypic cell-cell adhesion	IMP	16204051
GO:0035577	Component	Azurophil granule membrane	TAS
GO:0042802	Function	Identical protein binding	IDA	26483485
GO:0042802	Function	Identical protein binding	IPI	21982860, 26483485, 32296183
GO:0046982	Function	Protein heterodimerization activity	IDA	26483485
GO:0098552	Component	Side of membrane	IEA
GO:1904906	Process	Positive regulation of endothelial cell-matrix adhesion via fibronectin	IMP	16204051
GO:2000811	Process	Negative regulation of anoikis	IMP	10910050

MIM	HGNC	e!Ensembl
163980	1818	ENSG00000086548

Protein

UniProt ID

P40199

Protein name

Cell adhesion molecule CEACAM6 (Carcinoembryonic antigen-related cell adhesion molecule 6) (CEA cell adhesion molecule 6) (Non-specific crossreacting antigen) (Normal cross-reacting antigen) (CD antigen CD66c)

Protein function

Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:10910050, PubMed:11590190, PubMed:1378450, PubMed:16204051, PubMed:2022629, PubMed:2803308, PubMed:8776764). Intercellular adhesion occurs in a calcium- a

PDB

4WHC , 4WTZ , 4Y8A , 4YIQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	38 → 141	Immunoglobulin V-set domain	Domain
PF13927	Ig_3	146 → 219		Domain
PF13895	Ig_2	239 → 318	Immunoglobulin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in neutrophils (PubMed:1378450). Expressed in columnar epithelial and goblet cells of the colon (PubMed:10436421). Expressed in numerous tumor cell lines (at protein level) (PubMed:16204051). {ECO:0000269|PubMed:10436421, ECO

Sequence

MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQ
NRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFY
TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWV
NGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDGP
TISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQ
AHNSATGLNRTTVTMITVSGSAPVLSAVATVGITIGVLARVALI

Sequence length

344

Interactions

View interactions

	Reactome
			Fibronectin matrix formation Cell surface interactions at the vascular wall Neutrophil degranulation

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Cystic Fibrosis	cystic fibrosis	N/A	N/A	GenCC

Show/Hide Text Mining Associations (62)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	23099808, 32648688
Adenoma	Associate	10666389, 37565794
Adenomatous Polyposis Coli	Associate	37565794
Asthma	Associate	28275137, 39239252
Bacterial Infections	Associate	31393983
Breast Neoplasms	Associate	18221536, 18614350, 23592399, 32235022, 33838601
Carcinogenesis	Associate	10666389, 15729073, 25299082, 31171910
Carcinoma	Associate	31171910
Carcinoma Non Small Cell Lung	Associate	24625834, 35141051
Carcinoma Pancreatic Ductal	Associate	24476519
Cardiovascular Diseases	Associate	34639156
Cholangiocarcinoma	Associate	16868542
Colitis Ulcerative	Stimulate	34394073
Colonic Neoplasms	Stimulate	17201906
Colonic Neoplasms	Associate	26673628
Colonic Polyps	Associate	10666389
Colorectal Neoplasms	Associate	10666389, 16755296, 26673628, 26993598, 34394073, 37535601, 37816733
Communicable Diseases	Associate	39239252
COVID 19	Associate	37302069
Crohn Disease	Associate	17525800, 20587550, 21559399, 25706391, 31393983
Crohn Disease	Stimulate	24326999, 34394073
Diabetes Mellitus	Associate	36360783
Duodenal Neoplasms	Associate	37565794
Fetal Alcohol Spectrum Disorders	Associate	31393983
Hereditary Breast and Ovarian Cancer Syndrome	Stimulate	18614350
Hypoxia	Stimulate	39674878
Idiopathic Pulmonary Fibrosis	Associate	22761659
Infections	Stimulate	17525800, 25706391
Inflammation	Associate	26673628, 27579896, 39239252
Inflammatory Bowel Diseases	Inhibit	19637360
Inflammatory Bowel Diseases	Associate	21559399, 34394073
Leukemia	Associate	20063526
Lung Diseases	Stimulate	22037359, 26374831
Lung Neoplasms	Associate	20090913, 24625834
Lymphatic Metastasis	Associate	15729073
Lymphatic Metastasis	Stimulate	16868542, 25299082
Mohr Tranebjaerg syndrome	Stimulate	32648688
Multiple Myeloma	Associate	23603913
Neoplasm Metastasis	Associate	15729073, 17406026, 18614350, 27993815, 33379338, 38433022
Neoplasms	Associate	16868542, 17201906, 18614350, 19411761, 20090913, 22037359, 23603913, 25299082, 27959387, 28604612, 28731711, 28883649, 32816956, 33838601, 35141051, 35302657, 37349126, 39239252 View all (3 more)
Ovarian Neoplasms	Associate	35302657
Pancreatic Neoplasms	Associate	15729073, 19411761, 34321959
Pancreatitis Chronic	Associate	24476519
Parkinson Disease	Associate	39239252
Philadelphia Chromosome	Associate	37819686
Philadelphia Chromosome	Stimulate	40076750
Polyps	Associate	10666389
Precancerous Conditions	Associate	31171910
Precursor B Cell Lymphoblastic Leukemia Lymphoma	Associate	20063526
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	20063526, 36629681, 37819686, 38037221, 40076750
Precursor Cell Lymphoblastic Leukemia Lymphoma	Stimulate	21365622
Premature Birth	Associate	26374831
Prostatic Neoplasms	Associate	17201906
Psoriasis	Associate	39239252
Pulmonary Disease Chronic Obstructive	Stimulate	26374831
Pyruvate Carboxylase Deficiency Disease	Associate	34321959
Respiratory Insufficiency	Associate	26374831
Respiratory Tract Neoplasms	Stimulate	26374831
Stomach Neoplasms	Associate	25299082, 28883649, 32816956
Stomach Neoplasms	Stimulate	39674878
Uterine Cervical Dysplasia	Associate	15729073, 31171910
Uterine Cervical Neoplasms	Stimulate	39346086

CEACAM6 (CEA cell adhesion molecule 6)