Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4670
Gene name	Heterogeneous nuclear ribonucleoprotein M
Gene symbol	HNRNPM
Synonyms (NCBI Gene)	CEARHNRNPM4HNRPMHNRPM4HTGR1NAGR1hnRNP M
Chromosome	19
Chromosome location	19p13.2
Summary	This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in th

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005120	hsa-miR-30a-5p	pSILAC	18668040
MIRT005120	hsa-miR-30a-5p	Proteomics;Other	18668040
MIRT029321	hsa-miR-26b-5p	Microarray	19088304
MIRT049986	hsa-miR-29a-3p	CLASH	23622248
MIRT049361	hsa-miR-92a-3p	CLASH	23622248
MIRT048765	hsa-miR-93-5p	CLASH	23622248
MIRT047057	hsa-miR-183-5p	CLASH	23622248
MIRT046439	hsa-miR-15b-5p	CLASH	23622248
MIRT045805	hsa-miR-191-5p	CLASH	23622248
MIRT043473	hsa-miR-331-3p	CLASH	23622248
MIRT042112	hsa-miR-484	CLASH	23622248
MIRT041425	hsa-miR-193b-3p	CLASH	23622248
MIRT040906	hsa-miR-18a-3p	CLASH	23622248
MIRT039993	hsa-miR-615-3p	CLASH	23622248
MIRT038991	hsa-let-7f-1-3p	CLASH	23622248
MIRT038991	hsa-let-7f-1-3p	CLASH	23622248
MIRT1051866	hsa-miR-105	CLIP-seq
MIRT1051867	hsa-miR-132	CLIP-seq
MIRT1051868	hsa-miR-212	CLIP-seq
MIRT1051869	hsa-miR-216a	CLIP-seq
MIRT1051870	hsa-miR-3613-3p	CLIP-seq
MIRT1051871	hsa-miR-4694-3p	CLIP-seq
MIRT1051866	hsa-miR-105	CLIP-seq
MIRT1051872	hsa-miR-1279	CLIP-seq
MIRT1051867	hsa-miR-132	CLIP-seq
MIRT1051868	hsa-miR-212	CLIP-seq
MIRT1051873	hsa-miR-3065-5p	CLIP-seq
MIRT1051874	hsa-miR-3914	CLIP-seq
MIRT1051875	hsa-miR-3973	CLIP-seq
MIRT1051876	hsa-miR-4680-3p	CLIP-seq
MIRT1051871	hsa-miR-4694-3p	CLIP-seq
MIRT1051877	hsa-miR-4789-5p	CLIP-seq
MIRT1051878	hsa-miR-4795-3p	CLIP-seq
MIRT1051879	hsa-miR-505	CLIP-seq
MIRT1051880	hsa-miR-520g	CLIP-seq
MIRT1051881	hsa-miR-520h	CLIP-seq
MIRT1051882	hsa-miR-873	CLIP-seq
MIRT1051872	hsa-miR-1279	CLIP-seq
MIRT2244059	hsa-miR-1283	CLIP-seq
MIRT1051867	hsa-miR-132	CLIP-seq
MIRT1051868	hsa-miR-212	CLIP-seq
MIRT1051869	hsa-miR-216a	CLIP-seq
MIRT2244060	hsa-miR-3064-3p	CLIP-seq
MIRT1051873	hsa-miR-3065-5p	CLIP-seq
MIRT1051870	hsa-miR-3613-3p	CLIP-seq
MIRT2244061	hsa-miR-3662	CLIP-seq
MIRT1051875	hsa-miR-3973	CLIP-seq
MIRT2244062	hsa-miR-4257	CLIP-seq
MIRT1051878	hsa-miR-4795-3p	CLIP-seq
MIRT1051879	hsa-miR-505	CLIP-seq
MIRT1051880	hsa-miR-520g	CLIP-seq
MIRT1051881	hsa-miR-520h	CLIP-seq
MIRT2244063	hsa-miR-522	CLIP-seq
MIRT1051866	hsa-miR-105	CLIP-seq
MIRT2244059	hsa-miR-1283	CLIP-seq
MIRT1051867	hsa-miR-132	CLIP-seq
MIRT1051868	hsa-miR-212	CLIP-seq
MIRT1051869	hsa-miR-216a	CLIP-seq
MIRT2244060	hsa-miR-3064-3p	CLIP-seq
MIRT1051870	hsa-miR-3613-3p	CLIP-seq
MIRT2547093	hsa-miR-3671	CLIP-seq
MIRT1051876	hsa-miR-4680-3p	CLIP-seq
MIRT1051871	hsa-miR-4694-3p	CLIP-seq
MIRT2547094	hsa-miR-4760-3p	CLIP-seq
MIRT1051877	hsa-miR-4789-5p	CLIP-seq
MIRT2547095	hsa-miR-548a-5p	CLIP-seq
MIRT2547096	hsa-miR-548ab	CLIP-seq
MIRT2547097	hsa-miR-548ak	CLIP-seq
MIRT2547098	hsa-miR-548b-5p	CLIP-seq
MIRT2547099	hsa-miR-548c-5p	CLIP-seq
MIRT2547100	hsa-miR-548d-5p	CLIP-seq
MIRT2547101	hsa-miR-548h	CLIP-seq
MIRT2547102	hsa-miR-548i	CLIP-seq
MIRT2547103	hsa-miR-548j	CLIP-seq
MIRT2547104	hsa-miR-548n	CLIP-seq
MIRT2547105	hsa-miR-548w	CLIP-seq
MIRT2547106	hsa-miR-548y	CLIP-seq
MIRT2547107	hsa-miR-559	CLIP-seq
MIRT2547108	hsa-miR-607	CLIP-seq
MIRT1051866	hsa-miR-105	CLIP-seq
MIRT2244059	hsa-miR-1283	CLIP-seq
MIRT1051867	hsa-miR-132	CLIP-seq
MIRT1051868	hsa-miR-212	CLIP-seq
MIRT1051869	hsa-miR-216a	CLIP-seq
MIRT2244060	hsa-miR-3064-3p	CLIP-seq
MIRT1051870	hsa-miR-3613-3p	CLIP-seq
MIRT2547093	hsa-miR-3671	CLIP-seq
MIRT1051871	hsa-miR-4694-3p	CLIP-seq
MIRT2547094	hsa-miR-4760-3p	CLIP-seq
MIRT2547095	hsa-miR-548a-5p	CLIP-seq
MIRT2547096	hsa-miR-548ab	CLIP-seq
MIRT2547097	hsa-miR-548ak	CLIP-seq
MIRT2547098	hsa-miR-548b-5p	CLIP-seq
MIRT2547099	hsa-miR-548c-5p	CLIP-seq
MIRT2547100	hsa-miR-548d-5p	CLIP-seq
MIRT2547101	hsa-miR-548h	CLIP-seq
MIRT2547102	hsa-miR-548i	CLIP-seq
MIRT2547103	hsa-miR-548j	CLIP-seq
MIRT2547104	hsa-miR-548n	CLIP-seq
MIRT2547105	hsa-miR-548w	CLIP-seq
MIRT2547106	hsa-miR-548y	CLIP-seq
MIRT2547107	hsa-miR-559	CLIP-seq
MIRT2547108	hsa-miR-607	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000380	Process	Alternative mRNA splicing, via spliceosome	IMP	19874820
GO:0000398	Process	MRNA splicing, via spliceosome	IC	9731529, 11991638
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	NAS	9731529
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	17435768, 18457437, 19874820, 20467437, 21988832, 24965446, 25416956, 25678563, 30021884, 32296183, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	19874820
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IDA	9731529
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005730	Component	Nucleolus	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016363	Component	Nuclear matrix	IDA	19874820
GO:0019904	Function	Protein domain specific binding	IPI	11984006
GO:0042382	Component	Paraspeckles	IDA	19874820
GO:0045202	Component	Synapse	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
160994	5046	ENSG00000099783

P52272

Protein name

Heterogeneous nuclear ribonucleoprotein M (hnRNP M)

Protein function

Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosin

PDB

2DGV , 2DH9 , 2DO0 , 2OT8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11532	HnRNP_M	41 → 70	Heterogeneous nuclear ribonucleoprotein M	Family
PF00076	RRM_1	73 → 143	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF00076	RRM_1	206 → 275	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF00076	RRM_1	655 → 723	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

Sequence

MAAGVEAAAEVAATEIKMEEESGAPGVPSGNGAPGPKGEGERPAQNEKRKEKNIKRGGNR
FEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFK
MEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTGGMGMGPGGPGMITIP
PSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKD
GKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHG
LGGIGMGLGPGGQPIDANHLNKGIGMGNIGPAGMGMEGIGFGINKMGGMEGPFGGGMENM
GRFGSGMNMGRINEILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMG
AGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIG
SGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAG
LERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPAL
GAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNL
PFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGR
EIDVRIDRNA

Sequence length

730

Interactions

View interactions

	KEGG		Reactome
	Spliceosome		FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Long QT syndrome	Likely benign	rs773444733	RCV000190204

Show/Hide Text Mining Associations (22)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adrenocortical Carcinoma	Associate	32915499
Breast Neoplasms	Associate	30042172
Carcinogenesis	Associate	24381081, 35158098
Carcinoma Hepatocellular	Associate	32915499, 35158098
Colorectal Neoplasms	Associate	24381081
Coronary Disease	Associate	38105623
Endometrial Neoplasms	Associate	32915499
Hypoxia	Associate	38105623
Leukemia Promyelocytic Acute	Associate	35544458
Lymphatic Metastasis	Stimulate	24381081
Myocardial Ischemia	Associate	38105623
Nasopharyngeal Carcinoma	Associate	34274258
Neoplasm Metastasis	Associate	24381081
Neoplasms	Associate	24381081, 34145290, 35158098
Neuralgia	Associate	37012681
Non alcoholic Fatty Liver Disease	Associate	25684943
Poisoning	Associate	32023846
Prader Willi Syndrome	Associate	27871485
Precancerous Conditions	Associate	24381081
Sarcoma	Associate	29036465
Sarcoma Ewing	Associate	29036465, 32023846
Thymoma	Associate	32915499

HNRNPM (heterogeneous nuclear ribonucleoprotein M)