Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	4665
Gene name	NGFI-A binding protein 2
Gene symbol	NAB2
Synonyms (NCBI Gene)	MADER
Chromosome	12
Chromosome location	12q13.3
Summary	This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multim

118

Show/Hide all (118)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018637	hsa-miR-335-5p	Microarray	18185580
MIRT1172507	hsa-miR-1207-5p	CLIP-seq
MIRT1172508	hsa-miR-1275	CLIP-seq
MIRT1172509	hsa-miR-1280	CLIP-seq
MIRT1172510	hsa-miR-188-3p	CLIP-seq
MIRT1172511	hsa-miR-3179	CLIP-seq
MIRT1172512	hsa-miR-3668	CLIP-seq
MIRT1172513	hsa-miR-4436b-3p	CLIP-seq
MIRT1172514	hsa-miR-4640-5p	CLIP-seq
MIRT1172515	hsa-miR-4650-5p	CLIP-seq
MIRT1172516	hsa-miR-4665-5p	CLIP-seq
MIRT1172517	hsa-miR-4713-3p	CLIP-seq
MIRT1172518	hsa-miR-4726-5p	CLIP-seq
MIRT1172519	hsa-miR-4740-3p	CLIP-seq
MIRT1172520	hsa-miR-4761-3p	CLIP-seq
MIRT1172521	hsa-miR-4763-3p	CLIP-seq
MIRT1172522	hsa-miR-495	CLIP-seq
MIRT1172523	hsa-miR-518a-5p	CLIP-seq
MIRT1172524	hsa-miR-527	CLIP-seq
MIRT2049852	hsa-miR-134	CLIP-seq
MIRT2049853	hsa-miR-1915	CLIP-seq
MIRT2049854	hsa-miR-2467-3p	CLIP-seq
MIRT2049855	hsa-miR-28-3p	CLIP-seq
MIRT2049856	hsa-miR-296-3p	CLIP-seq
MIRT2049857	hsa-miR-3064-3p	CLIP-seq
MIRT2049858	hsa-miR-3118	CLIP-seq
MIRT2049859	hsa-miR-3125	CLIP-seq
MIRT2049860	hsa-miR-3164	CLIP-seq
MIRT2049861	hsa-miR-3916	CLIP-seq
MIRT2049862	hsa-miR-409-3p	CLIP-seq
MIRT2049863	hsa-miR-4252	CLIP-seq
MIRT2049864	hsa-miR-4423-5p	CLIP-seq
MIRT1172513	hsa-miR-4436b-3p	CLIP-seq
MIRT2049865	hsa-miR-4476	CLIP-seq
MIRT2049866	hsa-miR-4535	CLIP-seq
MIRT2049867	hsa-miR-4661-3p	CLIP-seq
MIRT2049868	hsa-miR-4685-5p	CLIP-seq
MIRT2049869	hsa-miR-4715-3p	CLIP-seq
MIRT2049870	hsa-miR-492	CLIP-seq
MIRT2049871	hsa-miR-758	CLIP-seq
MIRT2049872	hsa-miR-767-3p	CLIP-seq
MIRT2049852	hsa-miR-134	CLIP-seq
MIRT2049854	hsa-miR-2467-3p	CLIP-seq
MIRT2049856	hsa-miR-296-3p	CLIP-seq
MIRT2049858	hsa-miR-3118	CLIP-seq
MIRT2049859	hsa-miR-3125	CLIP-seq
MIRT2049860	hsa-miR-3164	CLIP-seq
MIRT2049861	hsa-miR-3916	CLIP-seq
MIRT2049865	hsa-miR-4476	CLIP-seq
MIRT2049867	hsa-miR-4661-3p	CLIP-seq
MIRT2049868	hsa-miR-4685-5p	CLIP-seq
MIRT2049871	hsa-miR-758	CLIP-seq
MIRT1172515	hsa-miR-4650-5p	CLIP-seq
MIRT1172519	hsa-miR-4740-3p	CLIP-seq
MIRT2577121	hsa-miR-122	CLIP-seq
MIRT2577122	hsa-miR-1228	CLIP-seq
MIRT2577123	hsa-miR-1276	CLIP-seq
MIRT2577124	hsa-miR-1294	CLIP-seq
MIRT2577125	hsa-miR-1321	CLIP-seq
MIRT2577126	hsa-miR-146b-3p	CLIP-seq
MIRT2577127	hsa-miR-147	CLIP-seq
MIRT2577128	hsa-miR-1827	CLIP-seq
MIRT2577129	hsa-miR-19a	CLIP-seq
MIRT2577130	hsa-miR-19b	CLIP-seq
MIRT2577131	hsa-miR-3123	CLIP-seq
MIRT2577132	hsa-miR-3126-5p	CLIP-seq
MIRT2577133	hsa-miR-3173-5p	CLIP-seq
MIRT2577134	hsa-miR-3612	CLIP-seq
MIRT2577135	hsa-miR-4254	CLIP-seq
MIRT2577136	hsa-miR-4308	CLIP-seq
MIRT2577137	hsa-miR-4311	CLIP-seq
MIRT2577138	hsa-miR-4313	CLIP-seq
MIRT2577139	hsa-miR-4316	CLIP-seq
MIRT2577140	hsa-miR-4419a	CLIP-seq
MIRT2577141	hsa-miR-4443	CLIP-seq
MIRT2577142	hsa-miR-4510	CLIP-seq
MIRT2577143	hsa-miR-4668-5p	CLIP-seq
MIRT2577144	hsa-miR-4728-5p	CLIP-seq
MIRT2577145	hsa-miR-4739	CLIP-seq
MIRT2577146	hsa-miR-4744	CLIP-seq
MIRT2577147	hsa-miR-4756-5p	CLIP-seq
MIRT2577148	hsa-miR-502-5p	CLIP-seq
MIRT2577149	hsa-miR-548q	CLIP-seq
MIRT2577150	hsa-miR-574-5p	CLIP-seq
MIRT2577151	hsa-miR-583	CLIP-seq
MIRT2577152	hsa-miR-650	CLIP-seq
MIRT2577153	hsa-miR-874	CLIP-seq
MIRT2577121	hsa-miR-122	CLIP-seq
MIRT2577122	hsa-miR-1228	CLIP-seq
MIRT2577123	hsa-miR-1276	CLIP-seq
MIRT2577124	hsa-miR-1294	CLIP-seq
MIRT2577125	hsa-miR-1321	CLIP-seq
MIRT2577126	hsa-miR-146b-3p	CLIP-seq
MIRT2577127	hsa-miR-147	CLIP-seq
MIRT2577128	hsa-miR-1827	CLIP-seq
MIRT2577129	hsa-miR-19a	CLIP-seq
MIRT2577130	hsa-miR-19b	CLIP-seq
MIRT2577131	hsa-miR-3123	CLIP-seq
MIRT2577132	hsa-miR-3126-5p	CLIP-seq
MIRT2577133	hsa-miR-3173-5p	CLIP-seq
MIRT2577134	hsa-miR-3612	CLIP-seq
MIRT2577135	hsa-miR-4254	CLIP-seq
MIRT2577136	hsa-miR-4308	CLIP-seq
MIRT2577137	hsa-miR-4311	CLIP-seq
MIRT2577139	hsa-miR-4316	CLIP-seq
MIRT2577140	hsa-miR-4419a	CLIP-seq
MIRT2577141	hsa-miR-4443	CLIP-seq
MIRT2577142	hsa-miR-4510	CLIP-seq
MIRT2577143	hsa-miR-4668-5p	CLIP-seq
MIRT2577144	hsa-miR-4728-5p	CLIP-seq
MIRT2577145	hsa-miR-4739	CLIP-seq
MIRT2577146	hsa-miR-4744	CLIP-seq
MIRT2577147	hsa-miR-4756-5p	CLIP-seq
MIRT2577149	hsa-miR-548q	CLIP-seq
MIRT2577150	hsa-miR-574-5p	CLIP-seq
MIRT2577151	hsa-miR-583	CLIP-seq
MIRT2577152	hsa-miR-650	CLIP-seq
MIRT2577153	hsa-miR-874	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
EGR1	Activation	16260776;20506119
EGR3	Activation	20506119

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001958	Process	Endochondral ossification	IEA
GO:0003712	Function	Transcription coregulator activity	IBA
GO:0003712	Function	Transcription coregulator activity	IEA
GO:0003714	Function	Transcription corepressor activity	TAS	8668170
GO:0005515	Function	Protein binding	IPI	21516116, 25416956, 29892012, 31515488, 32296183, 32814053
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0014037	Process	Schwann cell differentiation	IEA
GO:0016480	Process	Negative regulation of transcription by RNA polymerase III	IDA	8668170
GO:0042552	Process	Myelination	IEA
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183
GO:0045682	Process	Regulation of epidermis development	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA

MIM	HGNC	e!Ensembl
602381	7627	ENSG00000166886

Q15742

Protein name

NGFI-A-binding protein 2 (EGR-1-binding protein 2) (Melanoma-associated delayed early response protein) (Protein MADER)

Protein function

Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04904	NCD1	36 → 114	NAB conserved region 1 (NCD1)	Domain
PF04905	NCD2	236 → 364	NAB conserved region 2 (NCD2)	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed at low levels. Highly expressed in melanoma cell lines.

Sequence

MHRAPSPTAEQPPGGGDSARRTLQPRLKPSARAMALPRTLGELQLYRVLQRANLLSYYET
FIQQGGDDVQQLCEAGEEEFLEIMALVGMATKPLHVRRLQKALREWATNPGLFSQPVPAV
PVSSIPLFKISETAGTRKGSMSNGHGSPGEKAGSARSFSPKSPLELGEKLSPLPGGPGAG
DPRIWPGRSTPESDVGAGGEEEAGSPPFSPPAGGGVPEGTGAGGLAAGGTGGGPDRLEPE
MVRMVVESVERIFRSFPRGDAGEVTSLLKLNKKLARSVGHIFEMDDNDSQKEEEIRKYSI
IYGRFDSKRREGKQLSLHELTINEAAAQFCMRDNTLLLRRVELFSLSRQVARESTYLSSL
KGSRLHPEELGGPPLKKLKQEVGEQSHPEIQQPPPGPESYVPPYRPSLEEDSASLSGESL
DGHLQAVGSCPRLTPPPADLPLALPAHGLWSRHILQQTLMDEGLRLARLVSHDRVGRLSP
CVPAKPPLAEFEEGLLDRCPAPGPHPALVEGRRSSVKVEAEASRQ

Sequence length

525

Interactions

View interactions

	Reactome
			NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination

NAB2 (NGFI-A binding protein 2)