PPP1R12B (protein phosphatase 1 regulatory subunit 12B)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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4660 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Protein phosphatase 1 regulatory subunit 12B |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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PPP1R12B |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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MYPT2, PP1bp55 |
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Chromosome
Chromosome number
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1 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1q32.1 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||||||||||||
| UniProt ID | O60237 | |||||||||||||||||||||||||
| Protein name | Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2) | |||||||||||||||||||||||||
| Protein function | Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. | |||||||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Detected in skeletal muscle, fetal and adult heart, brain, placenta, kidney, spleen, thymus, pancreas and lung. Isoform 3 and isoform 4 are heart specific. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}. | |||||||||||||||||||||||||
| Sequence |
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| Sequence length | 982 | |||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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