Gene Gene information from NCBI Gene database.
Entrez ID 4660
Gene name Protein phosphatase 1 regulatory subunit 12B
Gene symbol PPP1R12B
Synonyms (NCBI Gene)
MYPT2PP1bp55
Chromosome 1
Chromosome location 1q32.1
Summary Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two
miRNA miRNA information provided by mirtarbase database.
956
miRTarBase ID miRNA Experiments Reference
MIRT046147 hsa-miR-30b-5p CLASH 23622248
MIRT666858 hsa-miR-92a-1-5p HITS-CLIP 23824327
MIRT666857 hsa-miR-659-3p HITS-CLIP 23824327
MIRT666856 hsa-miR-29a-5p HITS-CLIP 23824327
MIRT132403 hsa-miR-106b-5p HITS-CLIP 22473208
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
GO ID Ontology Definition Evidence Reference
GO:0001725 Component Stress fiber IEA
GO:0004857 Function Enzyme inhibitor activity IBA
GO:0005515 Function Protein binding IPI 11067852, 25814554, 32814053
GO:0005654 Component Nucleoplasm TAS
GO:0005737 Component Cytoplasm IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603768 7619 ENSG00000077157
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O60237
Protein name Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2)
Protein function Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13637 Ank_4 59 100 Repeat
PF00023 Ank 123 155 Ankyrin repeat Repeat
PF00023 Ank 216 248 Ankyrin repeat Repeat
PF15898 PRKG1_interact 881 982 cGMP-dependent protein kinase interacting domain Coiled-coil
Tissue specificity TISSUE SPECIFICITY: Detected in skeletal muscle, fetal and adult heart, brain, placenta, kidney, spleen, thymus, pancreas and lung. Isoform 3 and isoform 4 are heart specific. {ECO:0000269|PubMed:11067852, ECO:0000269|PubMed:9570949}.
Sequence
MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGA
VFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACI
DENLDMVKFLVENRANVNQQ
DNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQ
GVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAG
YELNVQDY
DGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLEL
LQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSS
SSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPAQNTFSASSARRFS
SGLFNKPEEPKDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRGSSIYRSSSSPRISAL
LDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGSYTRQLWRDEAKGNEI
PQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITNRPLPSTANGVTATPV
LSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRSTQGVTLTDLQEAERT
FSRSRAERQAQEQPREKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGRSLDEEPICHR
LRCPAQPDKPTTPASPSTSRPSLYTSSHLLWTNRFSVPDSESSETTTNTTTAKEMDKNEN
EEADLDEQSSKRLSIRERRRPKERRRGTGINFWTKDEDETDGSEEVKETWHERLSRLESG
GSNPTTSDSYGDRASARARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKL
QEAQLELADIKSKLEKVAQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTELK
SDNQRLKDENGALIRVISKLSK
Sequence length 982
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Vascular smooth muscle contraction
Focal adhesion
Regulation of actin cytoskeleton
Oxytocin signaling pathway
Proteoglycans in cancer
  Regulation of PLK1 Activity at G2/M Transition
RHO GTPases activate PKNs
RHO GTPases activate PAKs
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Congenital lactic acidosis Uncertain significance rs2148861501 RCV001844392
Lung cancer Likely benign rs376793967 RCV005932891
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Celiac Disease Associate 26123480
Endometrial Neoplasms Associate 34180758
Neoplasms Inhibit 34397405
Precancerous Conditions Associate 34334530
Wilms Tumor Associate 34334530