Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	466
Gene name	Activating transcription factor 1
Gene symbol	ATF1
Synonyms (NCBI Gene)	EWS-ATF1FUS/ATF-1TREB36
Chromosome	12
Chromosome location	12q13.12
Summary	This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related

170

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024634	hsa-miR-215-5p	Microarray	19074876
MIRT026443	hsa-miR-192-5p	Microarray	19074876
MIRT038958	hsa-miR-23a-5p	CLASH	23622248
MIRT437453	hsa-miR-182-5p	Luciferase reporter assay	23249749
MIRT732363	hsa-miR-30a-5p	Luciferase reporter assayqRT-PCRWestern blot	28259977
MIRT732363	hsa-miR-30a-5p	Luciferase reporter assayqRT-PCRWestern blot	28259977
MIRT756142	hsa-miR-340-5p	Luciferase reporter assayWestern blottingqRT-PCR	33530829
MIRT804159	hsa-miR-1273f	CLIP-seq
MIRT804160	hsa-miR-1283	CLIP-seq
MIRT804161	hsa-miR-1297	CLIP-seq
MIRT804162	hsa-miR-142-5p	CLIP-seq
MIRT804163	hsa-miR-143	CLIP-seq
MIRT804164	hsa-miR-144	CLIP-seq
MIRT804165	hsa-miR-145	CLIP-seq
MIRT804166	hsa-miR-2054	CLIP-seq
MIRT804167	hsa-miR-2115	CLIP-seq
MIRT804168	hsa-miR-217	CLIP-seq
MIRT804169	hsa-miR-26a	CLIP-seq
MIRT804170	hsa-miR-26b	CLIP-seq
MIRT804171	hsa-miR-2861	CLIP-seq
MIRT804172	hsa-miR-30a	CLIP-seq
MIRT804173	hsa-miR-30b	CLIP-seq
MIRT804174	hsa-miR-30c	CLIP-seq
MIRT804175	hsa-miR-30d	CLIP-seq
MIRT804176	hsa-miR-30e	CLIP-seq
MIRT804177	hsa-miR-3117-5p	CLIP-seq
MIRT804178	hsa-miR-3129-3p	CLIP-seq
MIRT804179	hsa-miR-3163	CLIP-seq
MIRT804180	hsa-miR-323b-3p	CLIP-seq
MIRT804181	hsa-miR-329	CLIP-seq
MIRT804182	hsa-miR-340	CLIP-seq
MIRT804183	hsa-miR-3607-3p	CLIP-seq
MIRT804184	hsa-miR-362-3p	CLIP-seq
MIRT804185	hsa-miR-3662	CLIP-seq
MIRT804186	hsa-miR-3692	CLIP-seq
MIRT804187	hsa-miR-3941	CLIP-seq
MIRT804188	hsa-miR-410	CLIP-seq
MIRT804189	hsa-miR-4282	CLIP-seq
MIRT804190	hsa-miR-4436b-5p	CLIP-seq
MIRT804191	hsa-miR-4452	CLIP-seq
MIRT804192	hsa-miR-4464	CLIP-seq
MIRT804193	hsa-miR-4465	CLIP-seq
MIRT804194	hsa-miR-4477b	CLIP-seq
MIRT804195	hsa-miR-4496	CLIP-seq
MIRT804196	hsa-miR-4512	CLIP-seq
MIRT804197	hsa-miR-4645-3p	CLIP-seq
MIRT804198	hsa-miR-466	CLIP-seq
MIRT804199	hsa-miR-4662a-5p	CLIP-seq
MIRT804200	hsa-miR-4668-3p	CLIP-seq
MIRT804201	hsa-miR-4672	CLIP-seq
MIRT804202	hsa-miR-4704-5p	CLIP-seq
MIRT804203	hsa-miR-4708-5p	CLIP-seq
MIRT804204	hsa-miR-4724-3p	CLIP-seq
MIRT804205	hsa-miR-4748	CLIP-seq
MIRT804206	hsa-miR-4753-3p	CLIP-seq
MIRT804207	hsa-miR-4760-5p	CLIP-seq
MIRT804208	hsa-miR-4766-5p	CLIP-seq
MIRT804209	hsa-miR-4768-5p	CLIP-seq
MIRT804210	hsa-miR-4770	CLIP-seq
MIRT804211	hsa-miR-4773	CLIP-seq
MIRT804212	hsa-miR-4775	CLIP-seq
MIRT804213	hsa-miR-4789-3p	CLIP-seq
MIRT804214	hsa-miR-491-3p	CLIP-seq
MIRT804215	hsa-miR-495	CLIP-seq
MIRT804216	hsa-miR-502-5p	CLIP-seq
MIRT804217	hsa-miR-514	CLIP-seq
MIRT804218	hsa-miR-514b-3p	CLIP-seq
MIRT804219	hsa-miR-516a-3p	CLIP-seq
MIRT804220	hsa-miR-520d-5p	CLIP-seq
MIRT804221	hsa-miR-524-5p	CLIP-seq
MIRT804222	hsa-miR-543	CLIP-seq
MIRT804223	hsa-miR-548ac	CLIP-seq
MIRT804224	hsa-miR-548ae	CLIP-seq
MIRT804225	hsa-miR-548aj	CLIP-seq
MIRT804226	hsa-miR-548am	CLIP-seq
MIRT804227	hsa-miR-548c-3p	CLIP-seq
MIRT804228	hsa-miR-548d-3p	CLIP-seq
MIRT804229	hsa-miR-548g	CLIP-seq
MIRT804230	hsa-miR-548u	CLIP-seq
MIRT804231	hsa-miR-548x	CLIP-seq
MIRT804232	hsa-miR-548z	CLIP-seq
MIRT804233	hsa-miR-570	CLIP-seq
MIRT804234	hsa-miR-577	CLIP-seq
MIRT804235	hsa-miR-590-3p	CLIP-seq
MIRT804236	hsa-miR-603	CLIP-seq
MIRT804237	hsa-miR-892a	CLIP-seq
MIRT1937498	hsa-miR-105	CLIP-seq
MIRT804166	hsa-miR-2054	CLIP-seq
MIRT804177	hsa-miR-3117-5p	CLIP-seq
MIRT1937499	hsa-miR-3201	CLIP-seq
MIRT804186	hsa-miR-3692	CLIP-seq
MIRT1937500	hsa-miR-4272	CLIP-seq
MIRT1937501	hsa-miR-4277	CLIP-seq
MIRT1937502	hsa-miR-4279	CLIP-seq
MIRT804190	hsa-miR-4436b-5p	CLIP-seq
MIRT804202	hsa-miR-4704-5p	CLIP-seq
MIRT804204	hsa-miR-4724-3p	CLIP-seq
MIRT804206	hsa-miR-4753-3p	CLIP-seq
MIRT804207	hsa-miR-4760-5p	CLIP-seq
MIRT1937503	hsa-miR-4762-3p	CLIP-seq
MIRT804209	hsa-miR-4768-5p	CLIP-seq
MIRT804211	hsa-miR-4773	CLIP-seq
MIRT804212	hsa-miR-4775	CLIP-seq
MIRT1937504	hsa-miR-4791	CLIP-seq
MIRT804229	hsa-miR-548g	CLIP-seq
MIRT804234	hsa-miR-577	CLIP-seq
MIRT1937505	hsa-miR-587	CLIP-seq
MIRT804235	hsa-miR-590-3p	CLIP-seq
MIRT1937506	hsa-miR-922	CLIP-seq
MIRT804165	hsa-miR-145	CLIP-seq
MIRT804166	hsa-miR-2054	CLIP-seq
MIRT2177145	hsa-miR-28-3p	CLIP-seq
MIRT2177146	hsa-miR-300	CLIP-seq
MIRT804177	hsa-miR-3117-5p	CLIP-seq
MIRT804186	hsa-miR-3692	CLIP-seq
MIRT2177147	hsa-miR-381	CLIP-seq
MIRT1937501	hsa-miR-4277	CLIP-seq
MIRT1937502	hsa-miR-4279	CLIP-seq
MIRT804190	hsa-miR-4436b-5p	CLIP-seq
MIRT2177148	hsa-miR-4666-3p	CLIP-seq
MIRT804202	hsa-miR-4704-5p	CLIP-seq
MIRT804204	hsa-miR-4724-3p	CLIP-seq
MIRT804206	hsa-miR-4753-3p	CLIP-seq
MIRT1937503	hsa-miR-4762-3p	CLIP-seq
MIRT804209	hsa-miR-4768-5p	CLIP-seq
MIRT804211	hsa-miR-4773	CLIP-seq
MIRT804216	hsa-miR-502-5p	CLIP-seq
MIRT804219	hsa-miR-516a-3p	CLIP-seq
MIRT804229	hsa-miR-548g	CLIP-seq
MIRT1937505	hsa-miR-587	CLIP-seq
MIRT804235	hsa-miR-590-3p	CLIP-seq
MIRT2177149	hsa-miR-668	CLIP-seq
MIRT1937506	hsa-miR-922	CLIP-seq
MIRT804166	hsa-miR-2054	CLIP-seq
MIRT804204	hsa-miR-4724-3p	CLIP-seq
MIRT804206	hsa-miR-4753-3p	CLIP-seq
MIRT804209	hsa-miR-4768-5p	CLIP-seq
MIRT2480436	hsa-miR-3148	CLIP-seq
MIRT804179	hsa-miR-3163	CLIP-seq
MIRT2480437	hsa-miR-3978	CLIP-seq
MIRT804189	hsa-miR-4282	CLIP-seq
MIRT2480438	hsa-miR-432	CLIP-seq
MIRT804200	hsa-miR-4668-3p	CLIP-seq
MIRT2480439	hsa-miR-4778-3p	CLIP-seq
MIRT804224	hsa-miR-548ae	CLIP-seq
MIRT804225	hsa-miR-548aj	CLIP-seq
MIRT804226	hsa-miR-548am	CLIP-seq
MIRT804231	hsa-miR-548x	CLIP-seq
MIRT804164	hsa-miR-144	CLIP-seq
MIRT804168	hsa-miR-217	CLIP-seq
MIRT2480436	hsa-miR-3148	CLIP-seq
MIRT804179	hsa-miR-3163	CLIP-seq
MIRT2480437	hsa-miR-3978	CLIP-seq
MIRT804189	hsa-miR-4282	CLIP-seq
MIRT2480438	hsa-miR-432	CLIP-seq
MIRT804191	hsa-miR-4452	CLIP-seq
MIRT804197	hsa-miR-4645-3p	CLIP-seq
MIRT804199	hsa-miR-4662a-5p	CLIP-seq
MIRT804200	hsa-miR-4668-3p	CLIP-seq
MIRT804207	hsa-miR-4760-5p	CLIP-seq
MIRT804208	hsa-miR-4766-5p	CLIP-seq
MIRT2480439	hsa-miR-4778-3p	CLIP-seq
MIRT804224	hsa-miR-548ae	CLIP-seq
MIRT804225	hsa-miR-548aj	CLIP-seq
MIRT804226	hsa-miR-548am	CLIP-seq
MIRT804229	hsa-miR-548g	CLIP-seq
MIRT804231	hsa-miR-548x	CLIP-seq
MIRT804233	hsa-miR-570	CLIP-seq
MIRT804234	hsa-miR-577	CLIP-seq
MIRT804235	hsa-miR-590-3p	CLIP-seq

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Transcription factor	Regulation	Reference
EWSR1	Unknown	9569031
PIAS3	Activation	17565989

Show/Hide all (40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	1655749
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	1655749
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003700	Function	DNA-binding transcription factor activity	TAS	2196176, 8401579
GO:0005515	Function	Protein binding	IPI	10722738, 20102225, 21217774, 25609649, 28514442, 29983246, 31527615
GO:0005634	Component	Nucleus	IDA	8798441
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	1655749, 12871976
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	1655749
GO:0006357	Process	Regulation of transcription by RNA polymerase II	NAS	1655749
GO:0010976	Process	Positive regulation of neuron projection development	IEA
GO:0014074	Process	Response to purine-containing compound	IDA	25644539
GO:0032025	Process	Response to cobalt ion	IEA
GO:0042802	Function	Identical protein binding	IPI	20102225, 21045134
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045740	Process	Positive regulation of DNA replication	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	1655749
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISO
GO:0065003	Process	Protein-containing complex assembly	IEA
GO:0090575	Component	RNA polymerase II transcription regulator complex	IEA
GO:0090575	Component	RNA polymerase II transcription regulator complex	IPI	20102225
GO:0090575	Component	RNA polymerase II transcription regulator complex	ISO
GO:0141156	Process	CAMP/PKA signal transduction	IBA
GO:0141156	Process	CAMP/PKA signal transduction	IDA	25644539
GO:1990589	Component	ATF4-CREB1 transcription factor complex	IBA
GO:1990590	Component	ATF1-ATF4 transcription factor complex	IDA	12871976
GO:1990590	Component	ATF1-ATF4 transcription factor complex	IEA

MIM	HGNC	e!Ensembl
123803	783	ENSG00000123268

P18846

Protein name

Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (Protein TREB36)

Protein function

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02173	pKID	43 → 83	pKID domain	Family
PF00170	bZIP_1	211 → 270	bZIP transcription factor	Coiled-coil

Sequence

MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR
RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL
ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ
IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC
LENRVAVLENQNKTLIEELKTLKDLYSNKSV

Sequence length

271

Interactions

View interactions

	KEGG		Reactome
	Aldosterone synthesis and secretion Transcriptional misregulation in cancer		CREB phosphorylation NGF-stimulated transcription

ATF1 (activating transcription factor 1)