Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	466
Gene name Gene Name - the full gene name approved by the HGNC.	Activating transcription factor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ATF1
Synonyms (NCBI Gene) Gene synonyms aliases	EWS-ATF1, FUS/ATF-1, TREB36
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q13.12
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related

Show/Hide all(170)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024634	hsa-miR-215-5p	Microarray	19074876
MIRT026443	hsa-miR-192-5p	Microarray	19074876
MIRT038958	hsa-miR-23a-5p	CLASH	23622248
MIRT437453	hsa-miR-182-5p	Luciferase reporter assay	23249749
MIRT732363	hsa-miR-30a-5p	Luciferase reporter assay, qRT-PCR, Western blot	28259977
MIRT732363	hsa-miR-30a-5p	Luciferase reporter assay, qRT-PCR, Western blot	28259977
MIRT756142	hsa-miR-340-5p	Luciferase reporter assay, Western blotting, qRT-PCR	33530829
MIRT804159	hsa-miR-1273f	CLIP-seq
MIRT804160	hsa-miR-1283	CLIP-seq
MIRT804161	hsa-miR-1297	CLIP-seq
MIRT804162	hsa-miR-142-5p	CLIP-seq
MIRT804163	hsa-miR-143	CLIP-seq
MIRT804164	hsa-miR-144	CLIP-seq
MIRT804165	hsa-miR-145	CLIP-seq
MIRT804166	hsa-miR-2054	CLIP-seq
MIRT804167	hsa-miR-2115	CLIP-seq
MIRT804168	hsa-miR-217	CLIP-seq
MIRT804169	hsa-miR-26a	CLIP-seq
MIRT804170	hsa-miR-26b	CLIP-seq
MIRT804171	hsa-miR-2861	CLIP-seq
MIRT804172	hsa-miR-30a	CLIP-seq
MIRT804173	hsa-miR-30b	CLIP-seq
MIRT804174	hsa-miR-30c	CLIP-seq
MIRT804175	hsa-miR-30d	CLIP-seq
MIRT804176	hsa-miR-30e	CLIP-seq
MIRT804177	hsa-miR-3117-5p	CLIP-seq
MIRT804178	hsa-miR-3129-3p	CLIP-seq
MIRT804179	hsa-miR-3163	CLIP-seq
MIRT804180	hsa-miR-323b-3p	CLIP-seq
MIRT804181	hsa-miR-329	CLIP-seq
MIRT804182	hsa-miR-340	CLIP-seq
MIRT804183	hsa-miR-3607-3p	CLIP-seq
MIRT804184	hsa-miR-362-3p	CLIP-seq
MIRT804185	hsa-miR-3662	CLIP-seq
MIRT804186	hsa-miR-3692	CLIP-seq
MIRT804187	hsa-miR-3941	CLIP-seq
MIRT804188	hsa-miR-410	CLIP-seq
MIRT804189	hsa-miR-4282	CLIP-seq
MIRT804190	hsa-miR-4436b-5p	CLIP-seq
MIRT804191	hsa-miR-4452	CLIP-seq
MIRT804192	hsa-miR-4464	CLIP-seq
MIRT804193	hsa-miR-4465	CLIP-seq
MIRT804194	hsa-miR-4477b	CLIP-seq
MIRT804195	hsa-miR-4496	CLIP-seq
MIRT804196	hsa-miR-4512	CLIP-seq
MIRT804197	hsa-miR-4645-3p	CLIP-seq
MIRT804198	hsa-miR-466	CLIP-seq
MIRT804199	hsa-miR-4662a-5p	CLIP-seq
MIRT804200	hsa-miR-4668-3p	CLIP-seq
MIRT804201	hsa-miR-4672	CLIP-seq
MIRT804202	hsa-miR-4704-5p	CLIP-seq
MIRT804203	hsa-miR-4708-5p	CLIP-seq
MIRT804204	hsa-miR-4724-3p	CLIP-seq
MIRT804205	hsa-miR-4748	CLIP-seq
MIRT804206	hsa-miR-4753-3p	CLIP-seq
MIRT804207	hsa-miR-4760-5p	CLIP-seq
MIRT804208	hsa-miR-4766-5p	CLIP-seq
MIRT804209	hsa-miR-4768-5p	CLIP-seq
MIRT804210	hsa-miR-4770	CLIP-seq
MIRT804211	hsa-miR-4773	CLIP-seq
MIRT804212	hsa-miR-4775	CLIP-seq
MIRT804213	hsa-miR-4789-3p	CLIP-seq
MIRT804214	hsa-miR-491-3p	CLIP-seq
MIRT804215	hsa-miR-495	CLIP-seq
MIRT804216	hsa-miR-502-5p	CLIP-seq
MIRT804217	hsa-miR-514	CLIP-seq
MIRT804218	hsa-miR-514b-3p	CLIP-seq
MIRT804219	hsa-miR-516a-3p	CLIP-seq
MIRT804220	hsa-miR-520d-5p	CLIP-seq
MIRT804221	hsa-miR-524-5p	CLIP-seq
MIRT804222	hsa-miR-543	CLIP-seq
MIRT804223	hsa-miR-548ac	CLIP-seq
MIRT804224	hsa-miR-548ae	CLIP-seq
MIRT804225	hsa-miR-548aj	CLIP-seq
MIRT804226	hsa-miR-548am	CLIP-seq
MIRT804227	hsa-miR-548c-3p	CLIP-seq
MIRT804228	hsa-miR-548d-3p	CLIP-seq
MIRT804229	hsa-miR-548g	CLIP-seq
MIRT804230	hsa-miR-548u	CLIP-seq
MIRT804231	hsa-miR-548x	CLIP-seq
MIRT804232	hsa-miR-548z	CLIP-seq
MIRT804233	hsa-miR-570	CLIP-seq
MIRT804234	hsa-miR-577	CLIP-seq
MIRT804235	hsa-miR-590-3p	CLIP-seq
MIRT804236	hsa-miR-603	CLIP-seq
MIRT804237	hsa-miR-892a	CLIP-seq
MIRT1937498	hsa-miR-105	CLIP-seq
MIRT804166	hsa-miR-2054	CLIP-seq
MIRT804177	hsa-miR-3117-5p	CLIP-seq
MIRT1937499	hsa-miR-3201	CLIP-seq
MIRT804186	hsa-miR-3692	CLIP-seq
MIRT1937500	hsa-miR-4272	CLIP-seq
MIRT1937501	hsa-miR-4277	CLIP-seq
MIRT1937502	hsa-miR-4279	CLIP-seq
MIRT804190	hsa-miR-4436b-5p	CLIP-seq
MIRT804202	hsa-miR-4704-5p	CLIP-seq
MIRT804204	hsa-miR-4724-3p	CLIP-seq
MIRT804206	hsa-miR-4753-3p	CLIP-seq
MIRT804207	hsa-miR-4760-5p	CLIP-seq
MIRT1937503	hsa-miR-4762-3p	CLIP-seq
MIRT804209	hsa-miR-4768-5p	CLIP-seq
MIRT804211	hsa-miR-4773	CLIP-seq
MIRT804212	hsa-miR-4775	CLIP-seq
MIRT1937504	hsa-miR-4791	CLIP-seq
MIRT804229	hsa-miR-548g	CLIP-seq
MIRT804234	hsa-miR-577	CLIP-seq
MIRT1937505	hsa-miR-587	CLIP-seq
MIRT804235	hsa-miR-590-3p	CLIP-seq
MIRT1937506	hsa-miR-922	CLIP-seq
MIRT804165	hsa-miR-145	CLIP-seq
MIRT804166	hsa-miR-2054	CLIP-seq
MIRT2177145	hsa-miR-28-3p	CLIP-seq
MIRT2177146	hsa-miR-300	CLIP-seq
MIRT804177	hsa-miR-3117-5p	CLIP-seq
MIRT804186	hsa-miR-3692	CLIP-seq
MIRT2177147	hsa-miR-381	CLIP-seq
MIRT1937501	hsa-miR-4277	CLIP-seq
MIRT1937502	hsa-miR-4279	CLIP-seq
MIRT804190	hsa-miR-4436b-5p	CLIP-seq
MIRT2177148	hsa-miR-4666-3p	CLIP-seq
MIRT804202	hsa-miR-4704-5p	CLIP-seq
MIRT804204	hsa-miR-4724-3p	CLIP-seq
MIRT804206	hsa-miR-4753-3p	CLIP-seq
MIRT1937503	hsa-miR-4762-3p	CLIP-seq
MIRT804209	hsa-miR-4768-5p	CLIP-seq
MIRT804211	hsa-miR-4773	CLIP-seq
MIRT804216	hsa-miR-502-5p	CLIP-seq
MIRT804219	hsa-miR-516a-3p	CLIP-seq
MIRT804229	hsa-miR-548g	CLIP-seq
MIRT1937505	hsa-miR-587	CLIP-seq
MIRT804235	hsa-miR-590-3p	CLIP-seq
MIRT2177149	hsa-miR-668	CLIP-seq
MIRT1937506	hsa-miR-922	CLIP-seq
MIRT804166	hsa-miR-2054	CLIP-seq
MIRT804204	hsa-miR-4724-3p	CLIP-seq
MIRT804206	hsa-miR-4753-3p	CLIP-seq
MIRT804209	hsa-miR-4768-5p	CLIP-seq
MIRT2480436	hsa-miR-3148	CLIP-seq
MIRT804179	hsa-miR-3163	CLIP-seq
MIRT2480437	hsa-miR-3978	CLIP-seq
MIRT804189	hsa-miR-4282	CLIP-seq
MIRT2480438	hsa-miR-432	CLIP-seq
MIRT804200	hsa-miR-4668-3p	CLIP-seq
MIRT2480439	hsa-miR-4778-3p	CLIP-seq
MIRT804224	hsa-miR-548ae	CLIP-seq
MIRT804225	hsa-miR-548aj	CLIP-seq
MIRT804226	hsa-miR-548am	CLIP-seq
MIRT804231	hsa-miR-548x	CLIP-seq
MIRT804164	hsa-miR-144	CLIP-seq
MIRT804168	hsa-miR-217	CLIP-seq
MIRT2480436	hsa-miR-3148	CLIP-seq
MIRT804179	hsa-miR-3163	CLIP-seq
MIRT2480437	hsa-miR-3978	CLIP-seq
MIRT804189	hsa-miR-4282	CLIP-seq
MIRT2480438	hsa-miR-432	CLIP-seq
MIRT804191	hsa-miR-4452	CLIP-seq
MIRT804197	hsa-miR-4645-3p	CLIP-seq
MIRT804199	hsa-miR-4662a-5p	CLIP-seq
MIRT804200	hsa-miR-4668-3p	CLIP-seq
MIRT804207	hsa-miR-4760-5p	CLIP-seq
MIRT804208	hsa-miR-4766-5p	CLIP-seq
MIRT2480439	hsa-miR-4778-3p	CLIP-seq
MIRT804224	hsa-miR-548ae	CLIP-seq
MIRT804225	hsa-miR-548aj	CLIP-seq
MIRT804226	hsa-miR-548am	CLIP-seq
MIRT804229	hsa-miR-548g	CLIP-seq
MIRT804231	hsa-miR-548x	CLIP-seq
MIRT804233	hsa-miR-570	CLIP-seq
MIRT804234	hsa-miR-577	CLIP-seq
MIRT804235	hsa-miR-590-3p	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
EWSR1	Unknown	9569031
PIAS3	Activation	17565989

Show/Hide all(40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	1655749
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	1655749
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003700	Function	DNA-binding transcription factor activity	TAS	2196176, 8401579
GO:0005515	Function	Protein binding	IPI	10722738, 20102225, 21217774, 25609649, 28514442, 29983246, 31527615
GO:0005634	Component	Nucleus	IDA	8798441
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	1655749, 12871976
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	1655749
GO:0006357	Process	Regulation of transcription by RNA polymerase II	NAS	1655749
GO:0010976	Process	Positive regulation of neuron projection development	IEA
GO:0014074	Process	Response to purine-containing compound	IDA	25644539
GO:0032025	Process	Response to cobalt ion	IEA
GO:0042802	Function	Identical protein binding	IPI	20102225, 21045134
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045740	Process	Positive regulation of DNA replication	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	1655749
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISO
GO:0065003	Process	Protein-containing complex assembly	IEA
GO:0090575	Component	RNA polymerase II transcription regulator complex	IEA
GO:0090575	Component	RNA polymerase II transcription regulator complex	IPI	20102225
GO:0090575	Component	RNA polymerase II transcription regulator complex	ISO
GO:0141156	Process	CAMP/PKA signal transduction	IBA
GO:0141156	Process	CAMP/PKA signal transduction	IDA	25644539
GO:1990589	Component	ATF4-CREB1 transcription factor complex	IBA
GO:1990590	Component	ATF1-ATF4 transcription factor complex	IDA	12871976
GO:1990590	Component	ATF1-ATF4 transcription factor complex	IEA

MIM	HGNC	e!Ensembl
123803	783	ENSG00000123268

Protein

UniProt ID

P18846

Protein name

Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (Protein TREB36)

Protein function

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02173	pKID	43 → 83	pKID domain	Family
PF00170	bZIP_1	211 → 270	bZIP transcription factor	Coiled-coil

Sequence

MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR
RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL
ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ
IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC
LENRVAVLENQNKTLIEELKTLKDLYSNKSV

Sequence length

271

Interactions

View interactions

	KEGG		Reactome
	Aldosterone synthesis and secretion Transcriptional misregulation in cancer		CREB phosphorylation NGF-stimulated transcription

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Colorectal Cancer	Colorectal cancer	N/A	N/A	GWAS
Heart Failure	Heart failure	N/A	N/A	GWAS
Multiple Sclerosis	Multiple sclerosis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (40)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
3C syndrome	Associate	35165059
Adenocarcinoma of Lung	Associate	37158648
Carcinogenesis	Associate	36041632
Carcinoma Renal Cell	Associate	29076874, 29434341, 30047065, 31782119, 32720034, 33827033, 34251595, 35165059, 37479138
Colorectal Neoplasms	Associate	22631637, 26553438, 29727690
COVID 19	Associate	38301615
Epstein Barr Virus Infections	Stimulate	36154610
Esophageal Neoplasms	Associate	28912415
Essential Hypertension	Associate	26149214
Glomerulonephritis IGA	Associate	38301615
Hemolytic Uremic Syndrome	Stimulate	35245485
Hemorrhage	Associate	22052915
Histiocytoma Angiomatoid Fibrous	Associate	19801966, 21822206, 30642852, 34193943, 34228212
Inflammation	Associate	26536102, 35245485
Leukemia Myeloid Acute	Stimulate	11238126
Leukemia Myeloid Acute	Associate	23474756, 31537905
Lymphatic Metastasis	Associate	35397606
Malignant mesenchymal tumor	Associate	28009602, 33141488, 34821426
Melanoma	Associate	20087159
Mesothelioma	Associate	34193943, 35665561
Mesothelioma Malignant	Associate	28505004, 34121509
Myoepithelioma	Associate	23588365
Nasopharyngeal Carcinoma	Associate	30905073
Neoplasm Metastasis	Associate	35397606, 36701842
Neoplasms	Associate	10574952, 17409099, 19561568, 28505004, 28946910, 29434341, 31537905, 32770123, 33141488, 33827033, 34193943, 34821426, 35347249, 35397606, 35476996 View all (4 more)
Neoplasms	Inhibit	22631637
Neuroblastoma	Associate	19633294
Neurocytoma	Associate	30642852
Neuroectodermal Tumors	Associate	36934861
Obesity	Associate	26119994
Peritonitis	Associate	35665561
Renal Insufficiency Chronic	Associate	35245485
Salivary Gland Neoplasms	Associate	29076874
Sarcoma	Associate	31232935, 34193943
Sarcoma Clear Cell	Associate	10574952, 11826187, 12966428, 16867224, 19561568, 20087159, 25880253, 30219084, 31232935, 33478436, 34193943, 34228212, 35476996, 35477713, 36041632, 36959380, 37405123 View all (2 more)
Sarcoma Ewing	Associate	12966428, 30642852, 36041632, 8223458
Soft Tissue Neoplasms	Associate	38460673
Stomach Neoplasms	Associate	35397606
Thyroid Neoplasms	Associate	17409099
Vascular Diseases	Associate	35245485

ATF1 (activating transcription factor 1)