PPP1R12A (protein phosphatase 1 regulatory subunit 12A)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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4659 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Protein phosphatase 1 regulatory subunit 12A |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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PPP1R12A |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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GUBS, M130, MBS, MYPT1 |
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Chromosome
Chromosome number
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12 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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12q21.2-q21.31 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosp |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||||||||||||
| UniProt ID | O14974 | ||||||||||||||||||||||||||||||
| Protein name | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | ||||||||||||||||||||||||||||||
| Protein function | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, | ||||||||||||||||||||||||||||||
| PDB | 2KJY , 5HUZ | ||||||||||||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in striated muscles, specifically in type 2a fibers (at protein level). {ECO:0000269|PubMed:20634291}. | ||||||||||||||||||||||||||||||
| Sequence |
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| Sequence length | 1030 | ||||||||||||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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