Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4641
Gene name Gene Name - the full gene name approved by the HGNC.
Myosin IC
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MYO1C
Synonyms (NCBI Gene) Gene synonyms aliases
MMI-beta, MMIb, MyoIC, NMI, myr2
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates wi
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025523 hsa-miR-34a-5p Proteomics 21566225
MIRT052105 hsa-let-7b-5p CLASH 23622248
MIRT052105 hsa-let-7b-5p CLASH 23622248
MIRT050021 hsa-miR-27a-3p CLASH 23622248
MIRT049220 hsa-miR-92a-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000146 Function Microfilament motor activity IBA
GO:0000166 Function Nucleotide binding IEA
GO:0001725 Component Stress fiber IDA
GO:0003774 Function Cytoskeletal motor activity IEA
GO:0003779 Function Actin binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606538 7597 ENSG00000197879
Protein
UniProt ID O00159
Protein name Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb)
Protein function Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments
PDB 4BYF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00063 Myosin_head 48 718 Myosin head (motor domain) Domain
PF00612 IQ 735 755 IQ calmodulin-binding motif Motif
PF00612 IQ 758 777 IQ calmodulin-binding motif Motif
PF06017 Myosin_TH1 874 1055 Unconventional myosin tail, actin- and lipid-binding Domain
Sequence
MALQVELVPTGEIIRVVHPHRPCKLALGSDGVRVTMESALTARDRVGVQDFVLLENFTSE
AAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVA
DTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPV
LEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIF
YQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDE
VEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIA
KGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLL
DIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIIC
DLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRG
EFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDRSELSDKKRPETV
ATQFKMSLLQLVEILQSKEPAYVRCIKPNDAKQPGRFDEVLIRHQVKYLGLLENLRVRRA
GFAYRRKYEAFLQRYKSLCPETWPTWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIR
FP
KTLFATEDALEVRRQSLATKIQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKR
KWAAQTIRRLIRGFVLRHAPRCPENAFFLDHVRTSFLLNLRRQLPQNVLDTSWPTPPPAL
REASELLRELCIKNMVWKYCRSISPEWKQQLQQKAVASEIFKGKKDNYPQSVPRLFISTR
LGTDEISPRVLQALGSEPIQYAVPVVKYDRKGYKPRSRQLLLTPNAVVIVEDAKVKQRID
YANLTGISVSSLSDSLFVLHVQRADNKQKGDVVLQSDHVIETLTKTALSANRVNSININQ
GSITFAGGPGRDGTIDFTPGSELLITKAKNGHLAV
VAPRLNSR
Sequence length 1063
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Motor proteins
Pathogenic Escherichia coli infection
  Regulation of actin dynamics for phagocytic cup formation
B-WICH complex positively regulates rRNA expression
FCGR3A-mediated phagocytosis
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome Anophthalmia-microphthalmia syndrome N/A N/A ClinVar
Deafness autosomal dominant nonsyndromic hearing loss N/A N/A GenCC
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Amebiasis Associate 24468784
Breast Neoplasms Associate 31699152
Carcinoma Pancreatic Ductal Associate 36781839
Cysts Associate 24468784
Endometrial Neoplasms Inhibit 27716847
Glioma Associate 37953466
Hearing Loss Associate 19027848
Hearing Loss Sensorineural Associate 19027848
Lung Neoplasms Associate 36101745
Malocclusion Associate 24698832