Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	462
Gene name Gene Name - the full gene name approved by the HGNC.	Serpin family C member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SERPINC1
Synonyms (NCBI Gene) Gene synonyms aliases	AT3, AT3D, ATIII, ATIII-R2, ATIII-T1, ATIII-T2, THPH7
Disease Acronyms (UniProt) Disease acronyms from UniProt database	AT3D
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q25.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coa

Show/Hide all(42)

SNP ID	Visualize variation	Clinical significance	Consequence
rs2227624	A>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	5 prime UTR variant, coding sequence variant, missense variant
rs28929469	G>A	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs121909547	G>A,T	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs121909551	G>A	Pathogenic-likely-pathogenic, likely-benign	Missense variant, coding sequence variant
rs121909552	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign	Missense variant, coding sequence variant
rs121909558	A>T	Pathogenic	5 prime UTR variant, missense variant, coding sequence variant
rs121909560	CT>-	Pathogenic	Frameshift variant, coding sequence variant
rs121909561	TCCA>-	Pathogenic	Frameshift variant, coding sequence variant
rs121909562	G>A	Pathogenic	Stop gained, coding sequence variant
rs121909563	C>A,T	Pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs121909565	A>G	Pathogenic	Missense variant, coding sequence variant
rs121909567	G>A	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs121909569	A>G	Pathogenic	Missense variant, coding sequence variant
rs121909570	T>C,G	Pathogenic	Missense variant, coding sequence variant
rs121909571	T>C	Pathogenic	Missense variant, coding sequence variant
rs121909572	A>G	Pathogenic	Missense variant, coding sequence variant
rs121909573	A>G	Pathogenic	Missense variant, coding sequence variant
rs387906575	A>G	Pathogenic	Coding sequence variant, 5 prime UTR variant, missense variant
rs542881762	C>G,T	Likely-pathogenic	Intron variant
rs786204063	AAG>-	Pathogenic	Coding sequence variant, inframe deletion
rs863224495	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1131691435	T>C	Likely-pathogenic	Missense variant, coding sequence variant
rs1460568494	G>A	Likely-pathogenic	Missense variant, coding sequence variant
rs1557904209	C>A	Likely-pathogenic	Stop gained, coding sequence variant
rs1572086894	TTCATGCATCTCCTTTCTGTACCCTAAGAGAGTGGGGAAGGTGTACTCACCTCAAGAAATGCCTTATGGAATGCATCTGAGACATAGAGGTCATCTCGGCCTTCTGCAACAATACCTGGAAGGAAGACCGGAGAAGTCTTTGTGAGATGGGAGAAAGTTGGCTTC>-	Likely-pathogenic	Splice donor variant, intron variant, splice acceptor variant, coding sequence variant
rs1572088348	C>A	Likely-pathogenic	Intron variant
rs1572088775	T>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1572088823	CTTCC>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1572088837	->T	Pathogenic	Coding sequence variant, frameshift variant
rs1572088853	C>-	Likely-pathogenic	Coding sequence variant, stop gained
rs1572088865	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1572090079	C>T	Pathogenic	Splice donor variant
rs1572090114	A>G	Likely-pathogenic	Coding sequence variant, missense variant
rs1572090173	G>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1572090305	->G	Pathogenic	Coding sequence variant, frameshift variant
rs1572090368	CTTAAA>-	Pathogenic	Coding sequence variant, inframe deletion
rs1572091783	G>-	Likely-pathogenic	Coding sequence variant, stop gained
rs1572091831	AAAATG>-	Likely-pathogenic	Coding sequence variant, inframe deletion
rs1572092076	->G	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1572092099	G>T	Pathogenic	Coding sequence variant, stop gained
rs1572092103	A>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1572092195	C>G	Likely-pathogenic	Splice acceptor variant

Show/Hide all(89)

miRTarBase ID	miRNA	Experiments	Reference
MIRT653922	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT653921	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT653920	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT653919	hsa-miR-30a-5p	HITS-CLIP	23824327
MIRT653918	hsa-miR-30b-5p	HITS-CLIP	23824327
MIRT653917	hsa-miR-30c-5p	HITS-CLIP	23824327
MIRT653916	hsa-miR-30d-5p	HITS-CLIP	23824327
MIRT653915	hsa-miR-30e-5p	HITS-CLIP	23824327
MIRT653914	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT653913	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT653912	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT653910	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT653942	hsa-miR-181c-3p	HITS-CLIP	23824327
MIRT653941	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT653940	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT653939	hsa-miR-6812-3p	HITS-CLIP	23824327
MIRT653938	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT653937	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT653936	hsa-miR-4794	HITS-CLIP	23824327
MIRT653935	hsa-miR-664a-5p	HITS-CLIP	23824327
MIRT653934	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT653933	hsa-miR-3064-5p	HITS-CLIP	23824327
MIRT653932	hsa-miR-6504-5p	HITS-CLIP	23824327
MIRT653931	hsa-miR-626	HITS-CLIP	23824327
MIRT653930	hsa-miR-6876-3p	HITS-CLIP	23824327
MIRT653929	hsa-miR-7974	HITS-CLIP	23824327
MIRT653928	hsa-miR-4687-3p	HITS-CLIP	23824327
MIRT653927	hsa-miR-3618	HITS-CLIP	23824327
MIRT653926	hsa-miR-934	HITS-CLIP	23824327
MIRT653925	hsa-miR-526b-5p	HITS-CLIP	23824327
MIRT653924	hsa-miR-578	HITS-CLIP	23824327
MIRT653923	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT653922	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT653921	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT653920	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT653919	hsa-miR-30a-5p	HITS-CLIP	23824327
MIRT653918	hsa-miR-30b-5p	HITS-CLIP	23824327
MIRT653917	hsa-miR-30c-5p	HITS-CLIP	23824327
MIRT653916	hsa-miR-30d-5p	HITS-CLIP	23824327
MIRT653915	hsa-miR-30e-5p	HITS-CLIP	23824327
MIRT653914	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT653913	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT653912	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT653910	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT653922	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT653921	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT653920	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT653919	hsa-miR-30a-5p	HITS-CLIP	23824327
MIRT653918	hsa-miR-30b-5p	HITS-CLIP	23824327
MIRT653917	hsa-miR-30c-5p	HITS-CLIP	23824327
MIRT653916	hsa-miR-30d-5p	HITS-CLIP	23824327
MIRT653915	hsa-miR-30e-5p	HITS-CLIP	23824327
MIRT653914	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT653913	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT653912	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT653910	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT653942	hsa-miR-181c-3p	HITS-CLIP	23824327
MIRT653941	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT653940	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT653939	hsa-miR-6812-3p	HITS-CLIP	23824327
MIRT653938	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT653937	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT653936	hsa-miR-4794	HITS-CLIP	23824327
MIRT653935	hsa-miR-664a-5p	HITS-CLIP	23824327
MIRT653934	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT653933	hsa-miR-3064-5p	HITS-CLIP	23824327
MIRT653932	hsa-miR-6504-5p	HITS-CLIP	23824327
MIRT653931	hsa-miR-626	HITS-CLIP	23824327
MIRT653930	hsa-miR-6876-3p	HITS-CLIP	23824327
MIRT653929	hsa-miR-7974	HITS-CLIP	23824327
MIRT653928	hsa-miR-4687-3p	HITS-CLIP	23824327
MIRT653927	hsa-miR-3618	HITS-CLIP	23824327
MIRT653926	hsa-miR-934	HITS-CLIP	23824327
MIRT653925	hsa-miR-526b-5p	HITS-CLIP	23824327
MIRT653924	hsa-miR-578	HITS-CLIP	23824327
MIRT653923	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT653922	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT653921	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT653920	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT653919	hsa-miR-30a-5p	HITS-CLIP	23824327
MIRT653918	hsa-miR-30b-5p	HITS-CLIP	23824327
MIRT653917	hsa-miR-30c-5p	HITS-CLIP	23824327
MIRT653916	hsa-miR-30d-5p	HITS-CLIP	23824327
MIRT653915	hsa-miR-30e-5p	HITS-CLIP	23824327
MIRT653914	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT653913	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT653912	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT653910	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT755332	hsa-miR-200c-3p	Luciferase reporter assay, Western blotting, qRT-PCR, ELISA, in vivo gain/loss-of-function experiments	34783290

Transcription factors

Show/Hide all(7)

Transcription factor	Regulation	Reference
CEBPA	Activation	8910619
FOXA1	Repression	8910619
FOXA2	Repression	8910619
HNF4A	Activation	8910619
NR2F1	Repression	8910619
RXRA	Activation	8910619
THRA	Repression	8910619

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002020	Function	Protease binding	IPI	15853774
GO:0002438	Process	Acute inflammatory response to antigenic stimulus	IEA
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IBA	21873635
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	NAS	12878203
GO:0005515	Function	Protein binding	IPI	12878203, 22582013
GO:0005576	Component	Extracellular region	NAS	14718574
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IDA	1695900
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0007584	Process	Response to nutrient	IEA
GO:0007595	Process	Lactation	IEA
GO:0007596	Process	Blood coagulation	TAS
GO:0008201	Function	Heparin binding	IEA
GO:0010951	Process	Negative regulation of endopeptidase activity	IBA	21873635
GO:0042802	Function	Identical protein binding	IPI	18923394
GO:0043687	Process	Post-translational protein modification	TAS
GO:0044267	Process	Cellular protein metabolic process	TAS
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	25037231, 28675934
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:2000266	Process	Regulation of blood coagulation, intrinsic pathway	IEA

MIM	HGNC	e!Ensembl
107300	775	ENSG00000117601

Protein

UniProt ID

P01008

Protein name

Antithrombin-III (ATIII) (Serpin C1)

Protein function

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade (PubMed:15140129, PubMed:15853774). AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa (PubMed:15140129). Its inhibit

PDB

1ANT , 1ATH , 1AZX , 1BR8 , 1DZG , 1DZH , 1E03 , 1E04 , 1E05 , 1JVQ , 1LK6 , 1NQ9 , 1OYH , 1R1L , 1SR5 , 1T1F , 1TB6 , 2ANT , 2B4X , 2B5T , 2BEH , 2GD4 , 2HIJ , 2ZNH , 3EVJ , 3KCG , 4EB1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00079	Serpin	85 → 461	Serpin (serine protease inhibitor)	Domain

Tissue specificity

TISSUE SPECIFICITY: Found in plasma.

Sequence

MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEK
KATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFA
MTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFG
DKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAIN
ELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQ
VLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDG
FSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAV
VIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK

Sequence length

464

Interactions

View interactions

	KEGG		Reactome
	Complement and coagulation cascades		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Antithrombin deficiency	Antithrombin III Deficiency, Hereditary Antithrombin Deficiency	rs121909546, rs121909547, rs121909548, rs121909549, rs121909550, rs121909551, rs2227624, rs121909552, rs121909554, rs121909555, rs121909557, rs121909558, rs28929469, rs1572088837, rs121909560 View all (41 more)	7959685, 2013320, 1906811, 3179438, 16620552, 24956267, 26748602, 9845533, 6582486, 11794707, 10997988, 7832187, 16908819, 7994035, 12595305 View all (37 more)
Hereditary thrombophilia	Hereditary thrombophilia due to congenital antithrombin deficiency	rs121918146, rs121918122, rs761776963
Liver failure	Liver Failure, Acute	rs118203990, rs118203991, rs118203992, rs387907022, rs201861847, rs796065037, rs759315662, rs368196005, rs796052121, rs369437593, rs367683258, rs766314948, rs368085185, rs770446752, rs753039116 View all (10 more)	4089794
Nephrotic syndrome	Nephrotic Syndrome	rs876657369, rs121912601, rs121912602, rs876657370, rs121912603, rs121912604, rs121912605, rs121907900, rs121907901, rs28941778, rs587776576, rs28942089, rs587776577, rs28941777, rs121907910 View all (152 more)	11304663

Show/Hide Unknown Diseases (2)

Disease term	Disease name	References	Source
Unknown
Coronary syndrome	Acute Coronary Syndrome	7923645	ClinVar
Insomnia	Insomnia		GWAS

Show/Hide Text Mining Associations (132)

Disease Name	Relationship Type	References
Associations from Text Mining
18 Hydroxylase deficiency	Associate	36268972
Acquired Immunodeficiency Syndrome	Inhibit	37501065
alpha 1 Antitrypsin Deficiency	Associate	12595305
Alzheimer Disease	Stimulate	8362984
Amyloid angiopathy	Associate	8362984
Anemia Sickle Cell	Associate	23249216, 35822297
Antithrombin deficiency type 2	Associate	17492649, 18480576, 20435622, 23910795, 24162787, 24583439, 27708219, 28317092, 28743742, 30608445, 37201530, 8274732
Antithrombin deficiency type 2	Inhibit	24583439
Antithrombin deficiency type 2	Stimulate	39265995
Antithrombin III Deficiency	Associate	10997988, 12595305, 1469094, 1520874, 17244682, 17492649, 18480576, 20435622, 2066426, 23910795, 24824609, 25811371, 26748602, 27003919, 27279637 View all (27 more)
Antithrombin III Deficiency	Inhibit	1469094, 1868237, 32252658, 32422680, 37201530, 6305982, 9763552
Arteriovenous Fistula	Associate	23411429
Arthritis Infectious	Associate	12010802
beta Thalassemia	Associate	10606878, 17911195
Blood Coagulation Disorders	Associate	23722320, 24349325, 25119470, 28174134, 30594242, 35062299, 37501065, 8652818
Blood Coagulation Disorders	Inhibit	25811371, 8362984
Bronchopulmonary Dysplasia	Inhibit	25474412
Bronchopulmonary Dysplasia	Associate	37839510
Brugada Syndrome	Associate	23276942
Carcinoma Hepatocellular	Inhibit	23031791
Carcinoma Hepatocellular	Associate	26414287
Carcinoma Ovarian Epithelial	Associate	31718609
Carcinoma Squamous Cell	Inhibit	29851300
Cardiomyopathy Dilated	Associate	18480576
Cardiovascular Diseases	Associate	23411630, 29112333
Carotid Artery Thrombosis	Associate	11279641, 23910795
Cerebral Infarction	Associate	8443391
Chronic Limb Threatening Ischemia	Associate	19356951
Cognitive Dysfunction	Associate	3567355
Colorectal Neoplasms	Associate	30542696
Congenital Abnormalities	Associate	3179448
Congenital disorder of glycosylation type 1A	Associate	33583911
Congenital Hereditary and Neonatal Diseases and Abnormalities	Associate	39423957
Coronary Aneurysm	Associate	29207079
Coronary Artery Disease	Associate	10440909, 29207079
Coronary Restenosis	Associate	10440909
COVID 19	Associate	37371071
Critical Illness	Associate	19356951
Death	Associate	28174134
Diabetes Mellitus Type 1	Associate	1520874
Diffuse Neurofibrillary Tangles with Calcification	Associate	8362984
Disseminated Intravascular Coagulation	Inhibit	12010802, 18088351
Disseminated Intravascular Coagulation	Associate	29851300
Dysprothrombinemia	Associate	34256393
Endometrial Hyperplasia	Associate	21489304
Endometriosis	Associate	37572646
Exfoliation Syndrome	Stimulate	30842085
Fetal Death	Associate	20664396
Fever	Associate	9763552
Fibrosis	Associate	11773044
Fibrosis	Inhibit	23031791
Genetic Diseases Inborn	Associate	10556190
Gliosis	Associate	8362984
Glomerulonephritis IGA	Stimulate	30547763
Glucosephosphate Dehydrogenase Deficiency	Inhibit	35822297
Glycogen Storage Disease XIV	Associate	40225925
Hearing Loss Sensorineural	Associate	3567355
Heart Diseases	Inhibit	29366986
Hemophilia B	Associate	26023895
Hemorrhage	Associate	11238089, 19563500, 26023895
Heparin Cofactor II Deficiency	Associate	1469094
Hodgkin Disease	Associate	32235718
HTLV I Infections	Associate	35062299
Hyperhomocysteinemia	Associate	18612269
Hyperlipoproteinemia Type II	Associate	26748602
Hypersensitivity Immediate	Associate	10997988, 20435622, 32252658, 33419227, 36268972
Hypersensitivity Immediate	Inhibit	32252658
Ichthyosis prematurity syndrome	Associate	37839510
Idiopathic Noncirrhotic Portal Hypertension	Associate	34052252
Immunologic Deficiency Syndromes	Associate	15140129
Infant Newborn Diseases	Associate	8274732
Infections	Associate	15140129
Inflammation	Inhibit	12010802, 30896875
Inflammation	Associate	29207079
Inflammatory Bowel Diseases	Associate	25878173
Intracranial Thrombosis	Associate	12595305, 36351615
Ischemia	Associate	19356951
Kidney Failure Chronic	Associate	25887069
Leg Ulcer	Associate	11279641
Leukemia Lymphocytic Chronic B Cell	Stimulate	21812019
Lung Diseases	Associate	37839510
Lung Neoplasms	Associate	29851300
Lupus Erythematosus Systemic	Stimulate	15934123
Lymphoma	Associate	18056677
Membranous Obstruction of Inferior Vena Cava	Associate	34324211
Meningioma	Associate	25413266
Mucocutaneous Lymph Node Syndrome	Associate	29207079
Multiple Sclerosis	Stimulate	23762311
Nasopharyngeal Carcinoma	Associate	30896875
Neonatal hemochromatosis	Associate	11773044
Neoplasms	Associate	17503403, 18056677, 25413266
Neoplasms	Stimulate	30896875
Neoplasms by Site	Associate	10997988
Neoplastic Syndromes Hereditary	Associate	22716977, 2983542, 36268972
Neuralgia Postherpetic	Associate	37966014
Obstetric Labor Complications	Associate	34653293
Ovarian Hyperstimulation Syndrome	Associate	11872195
Paroxysmal ventricular fibrillation	Associate	18980758
Peripheral Arterial Disease	Associate	19356951
Plaque Amyloid	Associate	8362984
Prodromal Symptoms	Associate	19356951
Protein S Deficiency	Stimulate	11932669
Protein S Deficiency	Inhibit	28607330
Proteinuria	Associate	30547763
Pulmonary Disease Chronic Obstructive	Associate	10954247, 25329998
Pulmonary Embolism	Associate	28174134, 3169232, 9746774
Recurrence	Associate	1868237
Renal Insufficiency	Associate	15882280
Retinal Vein Occlusion	Inhibit	18160589
Retinal Vein Occlusion	Associate	29747524
Retroperitoneal liposarcoma	Associate	36438917
Schizophrenia	Associate	29249827
Schizophrenia	Stimulate	29249827
Stenosis Pulmonary Artery	Associate	10898281
Stroke	Associate	23910795, 34979665
Superior Mesenteric Artery Syndrome	Associate	29747524
Takayasu Arteritis	Associate	10072118
Thromboembolism	Associate	1541698, 1868237, 20824408, 25119470, 28607330, 29366986, 32252658, 37501065, 6305982, 7989582, 9763552
Thrombophilia	Associate	16607693, 19558686, 19903694, 23406614, 23411429, 27855570, 28075532, 29747524, 30637129, 35486842, 38309434
Thrombophilia	Inhibit	37501065
Thrombophilia hereditary	Associate	28075532, 34207366, 36902454, 9746774
Thrombophlebitis	Associate	6582486
Thrombosis	Associate	10072118, 10954247, 12591924, 12595305, 15140129, 1536946, 17244682, 18612269, 22498748, 22716977, 23910795, 24758255, 24824609, 25811371, 26748602 View all (15 more)
Tuberculosis	Stimulate	25187886
Tumor Lysis Syndrome	Associate	37201530
Upper Extremity Deep Vein Thrombosis	Associate	15262837
Uveal melanoma	Associate	33120861
Venous Thromboembolism	Associate	12239149, 1469094, 22581447, 22812604, 23150947, 25341889, 32457982, 34653293, 35112923, 36268972, 36764659, 39675565, 40339963
Venous Thrombosis	Associate	11279641, 15140129, 17244682, 18349091, 1906811, 19139080, 23910795, 25811371, 26982741, 27279637, 30608445, 34324211, 7742536, 9746774
Ventricular Dysfunction Left	Associate	35831174
Warfarin syndrome	Associate	24162787, 3663935
X Linked Combined Immunodeficiency Diseases	Associate	36343066

SERPINC1 (serpin family C member 1)