Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	462
Gene name	Serpin family C member 1
Gene symbol	SERPINC1
Synonyms (NCBI Gene)	AT3AT3DATIIIATIII-R2ATIII-T1ATIII-T2THPH7
Chromosome	1
Chromosome location	1q25.1
Summary	The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coa

Show/Hide all (42)

SNP ID	Visualize variation	Clinical significance	Consequence
rs2227624	A>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	5 prime UTR variant, coding sequence variant, missense variant
rs28929469	G>A	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs121909547	G>A,T	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs121909551	G>A	Pathogenic-likely-pathogenic, likely-benign	Missense variant, coding sequence variant
rs121909552	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign	Missense variant, coding sequence variant
rs121909558	A>T	Pathogenic	5 prime UTR variant, missense variant, coding sequence variant
rs121909560	CT>-	Pathogenic	Frameshift variant, coding sequence variant
rs121909561	TCCA>-	Pathogenic	Frameshift variant, coding sequence variant
rs121909562	G>A	Pathogenic	Stop gained, coding sequence variant
rs121909563	C>A,T	Pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs121909565	A>G	Pathogenic	Missense variant, coding sequence variant
rs121909567	G>A	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs121909569	A>G	Pathogenic	Missense variant, coding sequence variant
rs121909570	T>C,G	Pathogenic	Missense variant, coding sequence variant
rs121909571	T>C	Pathogenic	Missense variant, coding sequence variant
rs121909572	A>G	Pathogenic	Missense variant, coding sequence variant
rs121909573	A>G	Pathogenic	Missense variant, coding sequence variant
rs387906575	A>G	Pathogenic	Coding sequence variant, 5 prime UTR variant, missense variant
rs542881762	C>G,T	Likely-pathogenic	Intron variant
rs786204063	AAG>-	Pathogenic	Coding sequence variant, inframe deletion
rs863224495	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1131691435	T>C	Likely-pathogenic	Missense variant, coding sequence variant
rs1460568494	G>A	Likely-pathogenic	Missense variant, coding sequence variant
rs1557904209	C>A	Likely-pathogenic	Stop gained, coding sequence variant
rs1572086894	TTCATGCATCTCCTTTCTGTACCCTAAGAGAGTGGGGAAGGTGTACTCACCTCAAGAAATGCCTTATGGAATGCATCTGAGACATAGAGGTCATCTCGGCCTTCTGCAACAATACCTGGAAGGAAGACCGGAGAAGTCTTTGTGAGATGGGAGAAAGTTGGCTTC>-	Likely-pathogenic	Splice donor variant, intron variant, splice acceptor variant, coding sequence variant
rs1572088348	C>A	Likely-pathogenic	Intron variant
rs1572088775	T>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1572088823	CTTCC>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1572088837	->T	Pathogenic	Coding sequence variant, frameshift variant
rs1572088853	C>-	Likely-pathogenic	Coding sequence variant, stop gained
rs1572088865	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1572090079	C>T	Pathogenic	Splice donor variant
rs1572090114	A>G	Likely-pathogenic	Coding sequence variant, missense variant
rs1572090173	G>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1572090305	->G	Pathogenic	Coding sequence variant, frameshift variant
rs1572090368	CTTAAA>-	Pathogenic	Coding sequence variant, inframe deletion
rs1572091783	G>-	Likely-pathogenic	Coding sequence variant, stop gained
rs1572091831	AAAATG>-	Likely-pathogenic	Coding sequence variant, inframe deletion
rs1572092076	->G	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1572092099	G>T	Pathogenic	Coding sequence variant, stop gained
rs1572092103	A>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1572092195	C>G	Likely-pathogenic	Splice acceptor variant

Show/Hide all (89)

miRTarBase ID	miRNA	Experiments	Reference
MIRT653922	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT653921	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT653920	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT653919	hsa-miR-30a-5p	HITS-CLIP	23824327
MIRT653918	hsa-miR-30b-5p	HITS-CLIP	23824327
MIRT653917	hsa-miR-30c-5p	HITS-CLIP	23824327
MIRT653916	hsa-miR-30d-5p	HITS-CLIP	23824327
MIRT653915	hsa-miR-30e-5p	HITS-CLIP	23824327
MIRT653914	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT653913	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT653912	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT653910	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT653942	hsa-miR-181c-3p	HITS-CLIP	23824327
MIRT653941	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT653940	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT653939	hsa-miR-6812-3p	HITS-CLIP	23824327
MIRT653938	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT653937	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT653936	hsa-miR-4794	HITS-CLIP	23824327
MIRT653935	hsa-miR-664a-5p	HITS-CLIP	23824327
MIRT653934	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT653933	hsa-miR-3064-5p	HITS-CLIP	23824327
MIRT653932	hsa-miR-6504-5p	HITS-CLIP	23824327
MIRT653931	hsa-miR-626	HITS-CLIP	23824327
MIRT653930	hsa-miR-6876-3p	HITS-CLIP	23824327
MIRT653929	hsa-miR-7974	HITS-CLIP	23824327
MIRT653928	hsa-miR-4687-3p	HITS-CLIP	23824327
MIRT653927	hsa-miR-3618	HITS-CLIP	23824327
MIRT653926	hsa-miR-934	HITS-CLIP	23824327
MIRT653925	hsa-miR-526b-5p	HITS-CLIP	23824327
MIRT653924	hsa-miR-578	HITS-CLIP	23824327
MIRT653923	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT653922	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT653921	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT653920	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT653919	hsa-miR-30a-5p	HITS-CLIP	23824327
MIRT653918	hsa-miR-30b-5p	HITS-CLIP	23824327
MIRT653917	hsa-miR-30c-5p	HITS-CLIP	23824327
MIRT653916	hsa-miR-30d-5p	HITS-CLIP	23824327
MIRT653915	hsa-miR-30e-5p	HITS-CLIP	23824327
MIRT653914	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT653913	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT653912	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT653910	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT653922	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT653921	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT653920	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT653919	hsa-miR-30a-5p	HITS-CLIP	23824327
MIRT653918	hsa-miR-30b-5p	HITS-CLIP	23824327
MIRT653917	hsa-miR-30c-5p	HITS-CLIP	23824327
MIRT653916	hsa-miR-30d-5p	HITS-CLIP	23824327
MIRT653915	hsa-miR-30e-5p	HITS-CLIP	23824327
MIRT653914	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT653913	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT653912	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT653910	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT653942	hsa-miR-181c-3p	HITS-CLIP	23824327
MIRT653941	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT653940	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT653939	hsa-miR-6812-3p	HITS-CLIP	23824327
MIRT653938	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT653937	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT653936	hsa-miR-4794	HITS-CLIP	23824327
MIRT653935	hsa-miR-664a-5p	HITS-CLIP	23824327
MIRT653934	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT653933	hsa-miR-3064-5p	HITS-CLIP	23824327
MIRT653932	hsa-miR-6504-5p	HITS-CLIP	23824327
MIRT653931	hsa-miR-626	HITS-CLIP	23824327
MIRT653930	hsa-miR-6876-3p	HITS-CLIP	23824327
MIRT653929	hsa-miR-7974	HITS-CLIP	23824327
MIRT653928	hsa-miR-4687-3p	HITS-CLIP	23824327
MIRT653927	hsa-miR-3618	HITS-CLIP	23824327
MIRT653926	hsa-miR-934	HITS-CLIP	23824327
MIRT653925	hsa-miR-526b-5p	HITS-CLIP	23824327
MIRT653924	hsa-miR-578	HITS-CLIP	23824327
MIRT653923	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT653922	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT653921	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT653920	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT653919	hsa-miR-30a-5p	HITS-CLIP	23824327
MIRT653918	hsa-miR-30b-5p	HITS-CLIP	23824327
MIRT653917	hsa-miR-30c-5p	HITS-CLIP	23824327
MIRT653916	hsa-miR-30d-5p	HITS-CLIP	23824327
MIRT653915	hsa-miR-30e-5p	HITS-CLIP	23824327
MIRT653914	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT653913	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT653912	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT653910	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT755332	hsa-miR-200c-3p	Luciferase reporter assayWestern blottingqRT-PCRELISAin vivo gain/loss-of-function experiments	34783290

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Transcription factor	Regulation	Reference
CEBPA	Activation	8910619
FOXA1	Repression	8910619
FOXA2	Repression	8910619
HNF4A	Activation	8910619
NR2F1	Repression	8910619
RXRA	Activation	8910619
THRA	Repression	8910619

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002020	Function	Protease binding	IPI	15853774
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IBA
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IEA
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	NAS	12878203
GO:0005515	Function	Protein binding	IPI	2013320, 12878203, 22582013, 28743742
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	NAS	14718574
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	1695900
GO:0005615	Component	Extracellular space	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0007596	Process	Blood coagulation	IEA
GO:0007599	Process	Hemostasis	IEA
GO:0008201	Function	Heparin binding	IEA
GO:0030193	Process	Regulation of blood coagulation	IEA
GO:0030414	Function	Peptidase inhibitor activity	IEA
GO:0031012	Component	Extracellular matrix	HDA	25037231, 28675934
GO:0042802	Function	Identical protein binding	IPI	18923394, 28743742
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0072562	Component	Blood microparticle	HDA	22516433

MIM	HGNC	e!Ensembl
107300	775	ENSG00000117601

P01008

Protein name

Antithrombin-III (ATIII) (Serpin C1)

Protein function

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade (PubMed:15140129, PubMed:15853774). AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa (PubMed:15140129). Its inhibit

PDB

1ANT , 1ATH , 1AZX , 1BR8 , 1DZG , 1DZH , 1E03 , 1E04 , 1E05 , 1JVQ , 1LK6 , 1NQ9 , 1OYH , 1R1L , 1SR5 , 1T1F , 1TB6 , 2ANT , 2B4X , 2B5T , 2BEH , 2GD4 , 2HIJ , 2ZNH , 3EVJ , 3KCG , 4EB1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00079	Serpin	85 → 461	Serpin (serine protease inhibitor)	Domain

Tissue specificity

TISSUE SPECIFICITY: Found in plasma.

Sequence

MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEK
KATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFA
MTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFG
DKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAIN
ELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQ
VLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDG
FSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAV
VIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK

Sequence length

464

Interactions

View interactions

	KEGG		Reactome
	Complement and coagulation cascades		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation

354

Show/Hide Causal Diseases (8)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Abnormal thrombosis	Pathogenic	rs1487411568	RCV000852017
Coloboma of optic nerve	Pathogenic	rs2526582621	RCV006259483
Deep venous thrombosis	Pathogenic	rs2227624, rs121909567, rs1572092099	RCV000852240 RCV000851769 RCV000852038
Hepatocellular carcinoma	Likely pathogenic	rs1572090079	RCV005906946
Hereditary antithrombin deficiency	Likely pathogenic; Pathogenic	rs2102782517, rs2102778910, rs483352856, rs483352854, rs2227606, rs2102782435, rs2102778641, rs2102778169, rs768704768, rs2102783199, rs1170430756, rs121909550, rs2102785788, rs1657743081, rs2102789590 View all (87 more)	RCV001377779 RCV001380042 RCV001857426 RCV002514538 RCV001523260 RCV001779986 RCV001779988 RCV001779989 RCV001801304 RCV001801312 RCV001801322 RCV001908898 RCV001951154 RCV001958585 RCV001984533 RCV002074468 RCV002074473 RCV002245317 RCV002245318 RCV002245320 RCV002245321 RCV002285196 RCV000167937 RCV002664191 RCV002648222 RCV002648224 RCV002572012 RCV000197842 RCV003126293 RCV003330339 RCV003330340 RCV003389113 RCV003447799 RCV003447801 RCV003484563 RCV003484574 RCV003484578 RCV003526964 RCV003527184 RCV003527185 RCV003527186 RCV003527187 RCV003527189 RCV003527190 RCV003527191 RCV003527192 RCV003527193 RCV003527194 RCV003638986 RCV003639540 RCV003638133 RCV003639154 RCV003877717 RCV003872232 RCV000019619 RCV000019620 RCV000019623 RCV000019625 RCV000019626 RCV000019627 RCV000019628 RCV000019630 RCV000019631 RCV000019632 RCV000019633 RCV000019635 RCV000019636 RCV000019637 RCV000019638 RCV000019642 RCV000019643 RCV000019644 RCV000019645 RCV000019646 RCV000019647 RCV000019650 RCV000019651 RCV000019652 RCV000019653 RCV000019655 RCV000019656 RCV000019657 RCV000019658 RCV000019659 RCV000019660 RCV000019661 RCV000019662 RCV004577660 RCV000456535 RCV003330321 RCV000851915 RCV000851895 RCV000851891 RCV000852207 RCV000852159 RCV000851776 RCV000852112 RCV000851716 RCV000852036 RCV000852262 RCV000799362 RCV000810125 RCV000819059 RCV000818759 RCV000799445 RCV000856668 RCV001070670 RCV001045955 RCV001231167 RCV001235412
SERPINC1-related disorder	Likely pathogenic; Pathogenic	rs2227606, rs199469508, rs2526594866, rs2526595830, rs2526572412, rs121909552, rs765445413	RCV003956212 RCV003399991 RCV003400140 RCV003944099 RCV003959075 RCV004754265 RCV004754569
Thromboembolism	Pathogenic	rs2227624	RCV000852239
Tuberous sclerosis 2	Pathogenic; Likely pathogenic	rs483352856, rs483352854	RCV000087276 RCV000087290

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Abnormal bleeding	Conflicting classifications of pathogenicity	rs121909548	RCV001270536
See cases	Uncertain significance	rs571861448, rs2526542046	RCV004584532 RCV004584563
Thrombocytopenia	Conflicting classifications of pathogenicity	rs121909548	RCV001270536

Show/Hide Text Mining Associations (132)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
18 Hydroxylase deficiency	Associate	36268972
Acquired Immunodeficiency Syndrome	Inhibit	37501065
alpha 1 Antitrypsin Deficiency	Associate	12595305
Alzheimer Disease	Stimulate	8362984
Amyloid angiopathy	Associate	8362984
Anemia Sickle Cell	Associate	23249216, 35822297
Antithrombin deficiency type 2	Associate	17492649, 18480576, 20435622, 23910795, 24162787, 24583439, 27708219, 28317092, 28743742, 30608445, 37201530, 8274732
Antithrombin deficiency type 2	Inhibit	24583439
Antithrombin deficiency type 2	Stimulate	39265995
Antithrombin III Deficiency	Associate	10997988, 12595305, 1469094, 1520874, 17244682, 17492649, 18480576, 20435622, 2066426, 23910795, 24824609, 25811371, 26748602, 27003919, 27279637 View all (27 more)
Antithrombin III Deficiency	Inhibit	1469094, 1868237, 32252658, 32422680, 37201530, 6305982, 9763552
Arteriovenous Fistula	Associate	23411429
Arthritis Infectious	Associate	12010802
beta Thalassemia	Associate	10606878, 17911195
Blood Coagulation Disorders	Associate	23722320, 24349325, 25119470, 28174134, 30594242, 35062299, 37501065, 8652818
Blood Coagulation Disorders	Inhibit	25811371, 8362984
Bronchopulmonary Dysplasia	Inhibit	25474412
Bronchopulmonary Dysplasia	Associate	37839510
Brugada Syndrome	Associate	23276942
Carcinoma Hepatocellular	Inhibit	23031791
Carcinoma Hepatocellular	Associate	26414287
Carcinoma Ovarian Epithelial	Associate	31718609
Carcinoma Squamous Cell	Inhibit	29851300
Cardiomyopathy Dilated	Associate	18480576
Cardiovascular Diseases	Associate	23411630, 29112333
Carotid Artery Thrombosis	Associate	11279641, 23910795
Cerebral Infarction	Associate	8443391
Chronic Limb Threatening Ischemia	Associate	19356951
Cognitive Dysfunction	Associate	3567355
Colorectal Neoplasms	Associate	30542696
Congenital Abnormalities	Associate	3179448
Congenital disorder of glycosylation type 1A	Associate	33583911
Congenital Hereditary and Neonatal Diseases and Abnormalities	Associate	39423957
Coronary Aneurysm	Associate	29207079
Coronary Artery Disease	Associate	10440909, 29207079
Coronary Restenosis	Associate	10440909
COVID 19	Associate	37371071
Critical Illness	Associate	19356951
Death	Associate	28174134
Diabetes Mellitus Type 1	Associate	1520874
Diffuse Neurofibrillary Tangles with Calcification	Associate	8362984
Disseminated Intravascular Coagulation	Inhibit	12010802, 18088351
Disseminated Intravascular Coagulation	Associate	29851300
Dysprothrombinemia	Associate	34256393
Endometrial Hyperplasia	Associate	21489304
Endometriosis	Associate	37572646
Exfoliation Syndrome	Stimulate	30842085
Fetal Death	Associate	20664396
Fever	Associate	9763552
Fibrosis	Associate	11773044
Fibrosis	Inhibit	23031791
Genetic Diseases Inborn	Associate	10556190
Gliosis	Associate	8362984
Glomerulonephritis IGA	Stimulate	30547763
Glucosephosphate Dehydrogenase Deficiency	Inhibit	35822297
Glycogen Storage Disease XIV	Associate	40225925
Hearing Loss Sensorineural	Associate	3567355
Heart Diseases	Inhibit	29366986
Hemophilia B	Associate	26023895
Hemorrhage	Associate	11238089, 19563500, 26023895
Heparin Cofactor II Deficiency	Associate	1469094
Hodgkin Disease	Associate	32235718
HTLV I Infections	Associate	35062299
Hyperhomocysteinemia	Associate	18612269
Hyperlipoproteinemia Type II	Associate	26748602
Hypersensitivity Immediate	Associate	10997988, 20435622, 32252658, 33419227, 36268972
Hypersensitivity Immediate	Inhibit	32252658
Ichthyosis prematurity syndrome	Associate	37839510
Idiopathic Noncirrhotic Portal Hypertension	Associate	34052252
Immunologic Deficiency Syndromes	Associate	15140129
Infant Newborn Diseases	Associate	8274732
Infections	Associate	15140129
Inflammation	Inhibit	12010802, 30896875
Inflammation	Associate	29207079
Inflammatory Bowel Diseases	Associate	25878173
Intracranial Thrombosis	Associate	12595305, 36351615
Ischemia	Associate	19356951
Kidney Failure Chronic	Associate	25887069
Leg Ulcer	Associate	11279641
Leukemia Lymphocytic Chronic B Cell	Stimulate	21812019
Lung Diseases	Associate	37839510
Lung Neoplasms	Associate	29851300
Lupus Erythematosus Systemic	Stimulate	15934123
Lymphoma	Associate	18056677
Membranous Obstruction of Inferior Vena Cava	Associate	34324211
Meningioma	Associate	25413266
Mucocutaneous Lymph Node Syndrome	Associate	29207079
Multiple Sclerosis	Stimulate	23762311
Nasopharyngeal Carcinoma	Associate	30896875
Neonatal hemochromatosis	Associate	11773044
Neoplasms	Associate	17503403, 18056677, 25413266
Neoplasms	Stimulate	30896875
Neoplasms by Site	Associate	10997988
Neoplastic Syndromes Hereditary	Associate	22716977, 2983542, 36268972
Neuralgia Postherpetic	Associate	37966014
Obstetric Labor Complications	Associate	34653293
Ovarian Hyperstimulation Syndrome	Associate	11872195
Paroxysmal ventricular fibrillation	Associate	18980758
Peripheral Arterial Disease	Associate	19356951
Plaque Amyloid	Associate	8362984
Prodromal Symptoms	Associate	19356951
Protein S Deficiency	Stimulate	11932669
Protein S Deficiency	Inhibit	28607330
Proteinuria	Associate	30547763
Pulmonary Disease Chronic Obstructive	Associate	10954247, 25329998
Pulmonary Embolism	Associate	28174134, 3169232, 9746774
Recurrence	Associate	1868237
Renal Insufficiency	Associate	15882280
Retinal Vein Occlusion	Inhibit	18160589
Retinal Vein Occlusion	Associate	29747524
Retroperitoneal liposarcoma	Associate	36438917
Schizophrenia	Associate	29249827
Schizophrenia	Stimulate	29249827
Stenosis Pulmonary Artery	Associate	10898281
Stroke	Associate	23910795, 34979665
Superior Mesenteric Artery Syndrome	Associate	29747524
Takayasu Arteritis	Associate	10072118
Thromboembolism	Associate	1541698, 1868237, 20824408, 25119470, 28607330, 29366986, 32252658, 37501065, 6305982, 7989582, 9763552
Thrombophilia	Associate	16607693, 19558686, 19903694, 23406614, 23411429, 27855570, 28075532, 29747524, 30637129, 35486842, 38309434
Thrombophilia	Inhibit	37501065
Thrombophilia hereditary	Associate	28075532, 34207366, 36902454, 9746774
Thrombophlebitis	Associate	6582486
Thrombosis	Associate	10072118, 10954247, 12591924, 12595305, 15140129, 1536946, 17244682, 18612269, 22498748, 22716977, 23910795, 24758255, 24824609, 25811371, 26748602 View all (15 more)
Tuberculosis	Stimulate	25187886
Tumor Lysis Syndrome	Associate	37201530
Upper Extremity Deep Vein Thrombosis	Associate	15262837
Uveal melanoma	Associate	33120861
Venous Thromboembolism	Associate	12239149, 1469094, 22581447, 22812604, 23150947, 25341889, 32457982, 34653293, 35112923, 36268972, 36764659, 39675565, 40339963
Venous Thrombosis	Associate	11279641, 15140129, 17244682, 18349091, 1906811, 19139080, 23910795, 25811371, 26982741, 27279637, 30608445, 34324211, 7742536, 9746774
Ventricular Dysfunction Left	Associate	35831174
Warfarin syndrome	Associate	24162787, 3663935
X Linked Combined Immunodeficiency Diseases	Associate	36343066

SERPINC1 (serpin family C member 1)