GADD45B (growth arrest and DNA damage inducible beta)

Gene

• Entrez ID: 4616
• Gene name: Growth arrest and DNA damage inducible beta
• Gene symbol: GADD45B
• Synonyms (NCBI Gene): GADD45BETA, MYD118
• Chromosome: 19
• Chromosome location: 19p13.3
• Summary: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1010219	hsa-miR-127-3p	CLIP-seq
MIRT1010220	hsa-miR-130a	CLIP-seq
MIRT1010221	hsa-miR-130b	CLIP-seq
MIRT1010222	hsa-miR-136	CLIP-seq
MIRT1010223	hsa-miR-140-5p	CLIP-seq
MIRT1010224	hsa-miR-219-5p	CLIP-seq
MIRT1010225	hsa-miR-301a	CLIP-seq
MIRT1010226	hsa-miR-301b	CLIP-seq
MIRT1010227	hsa-miR-3121-3p	CLIP-seq
MIRT1010228	hsa-miR-3166	CLIP-seq
MIRT1010229	hsa-miR-3666	CLIP-seq
MIRT1010230	hsa-miR-3925-3p	CLIP-seq
MIRT1010231	hsa-miR-4258	CLIP-seq
MIRT1010232	hsa-miR-4267	CLIP-seq
MIRT1010233	hsa-miR-4295	CLIP-seq
MIRT1010234	hsa-miR-454	CLIP-seq
MIRT1010235	hsa-miR-4771	CLIP-seq
MIRT1010236	hsa-miR-4782-3p	CLIP-seq
MIRT1010237	hsa-miR-495	CLIP-seq
MIRT1010238	hsa-miR-513c	CLIP-seq
MIRT1010239	hsa-miR-514b-5p	CLIP-seq
MIRT1010240	hsa-miR-515-5p	CLIP-seq
MIRT1010241	hsa-miR-519a	CLIP-seq
MIRT1010242	hsa-miR-519b-3p	CLIP-seq
MIRT1010243	hsa-miR-519c-3p	CLIP-seq
MIRT1010244	hsa-miR-767-3p	CLIP-seq
MIRT1010245	hsa-miR-802	CLIP-seq
MIRT1999207	hsa-miR-3940-5p	CLIP-seq
MIRT1010231	hsa-miR-4258	CLIP-seq
MIRT1999208	hsa-miR-4507	CLIP-seq
MIRT1010244	hsa-miR-767-3p	CLIP-seq
MIRT1999209	hsa-miR-891b	CLIP-seq
MIRT2232897	hsa-miR-1225-5p	CLIP-seq
MIRT1010220	hsa-miR-130a	CLIP-seq
MIRT1010221	hsa-miR-130b	CLIP-seq
MIRT1010223	hsa-miR-140-5p	CLIP-seq
MIRT2232898	hsa-miR-150	CLIP-seq
MIRT1010225	hsa-miR-301a	CLIP-seq
MIRT1010226	hsa-miR-301b	CLIP-seq
MIRT2232899	hsa-miR-3157-5p	CLIP-seq
MIRT1010229	hsa-miR-3666	CLIP-seq
MIRT2232900	hsa-miR-3691-3p	CLIP-seq
MIRT1010231	hsa-miR-4258	CLIP-seq
MIRT2232901	hsa-miR-4264	CLIP-seq
MIRT1010232	hsa-miR-4267	CLIP-seq
MIRT1010233	hsa-miR-4295	CLIP-seq
MIRT2232902	hsa-miR-4323	CLIP-seq
MIRT1010234	hsa-miR-454	CLIP-seq
MIRT2232903	hsa-miR-4690-3p	CLIP-seq
MIRT2232904	hsa-miR-4797-3p	CLIP-seq
MIRT2232905	hsa-miR-4797-5p	CLIP-seq
MIRT1010237	hsa-miR-495	CLIP-seq
MIRT1010241	hsa-miR-519a	CLIP-seq
MIRT1010242	hsa-miR-519b-3p	CLIP-seq
MIRT1010243	hsa-miR-519c-3p	CLIP-seq
MIRT2232906	hsa-miR-622	CLIP-seq
MIRT2232907	hsa-miR-720	CLIP-seq
MIRT1010245	hsa-miR-802	CLIP-seq
MIRT1999209	hsa-miR-891b	CLIP-seq
MIRT1010231	hsa-miR-4258	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12052864, 16256071, 25314077, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	9827804
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	9827804
GO:0006915	Process	Apoptotic process	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IDA	9827804
GO:0043410	Process	Positive regulation of MAPK cascade	IEA
GO:0046330	Process	Positive regulation of JNK cascade	IDA	9827804
GO:0046330	Process	Positive regulation of JNK cascade	IEA
GO:0051726	Process	Regulation of cell cycle	IBA
GO:0051726	Process	Regulation of cell cycle	IEA
GO:0051726	Process	Regulation of cell cycle	IEA
GO:1900745	Process	Positive regulation of p38MAPK cascade	IDA	9827804
GO:1900745	Process	Positive regulation of p38MAPK cascade	IEA

Other IDs

• MIM: 604948
• HGNC: 4096
• e!Ensembl: ENSG00000099860

Protein

• UniProt ID: O75293
• Protein name: Growth arrest and DNA damage-inducible protein GADD45 beta (Myeloid differentiation primary response protein MyD118) (Negative growth regulatory protein MyD118)
• Protein function: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01248	Ribosomal_L7Ae	21 → 121	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family	Domain

• Sequence:

  MTLEELVACDNAAQKMQTVTAAVEELLVAAQRQDRLTVGVYESAKLMNVDPDSVVLCLLA
  IDEEEEDDIALQIHFTLIQSFCCDNDINIVRVSGMQRLAQLLGEPAETQGTTEARDLHCL
  LVTNPHTDAWKSHGLVEVASYCEESRGNNQWVPYISLQER

• Sequence length: 160

Pathways

KEGG:

MAPK signaling pathway
NF-kappa B signaling pathway
FoxO signaling pathway
Cell cycle
p53 signaling pathway
Apoptosis
Cellular senescence
Epstein-Barr virus infection
Pathways in cancer
Transcriptional misregulation in cancer
Colorectal cancer
Pancreatic cancer
Endometrial cancer
Glioma
Thyroid cancer
Basal cell carcinoma
Melanoma
Chronic myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer

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