MYBPC1 (myosin binding protein C1)

Gene

• Entrez ID: 4604
• Gene name: Myosin binding protein C1
• Gene symbol: MYBPC1
• Synonyms (NCBI Gene): CMYO16, CMYP16, LCCS4, MYBPCC, MYBPCS, MYOTREM, ssMyBP-C
• Disease Acronyms (UniProt): CMYO16, LCCS4
• Chromosome: 12
• Chromosome location: 12q23.2
• Summary: This gene encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skel

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs199628742	C>A,T	Likely-benign, conflicting-interpretations-of-pathogenicity	Intron variant
rs387906657	T>C	Pathogenic	Missense variant, coding sequence variant
rs397515422	C>T	Pathogenic	Stop gained, coding sequence variant
rs564856283	G>A,C	Pathogenic	Coding sequence variant, missense variant
rs1421405659	T>C,G	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs1565943228	T>G	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs1593846841	T>C	Pathogenic	Missense variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028918	hsa-miR-26b-5p	Microarray	19088304
MIRT038283	hsa-miR-130b-5p	CLASH	23622248
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610063	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT610062	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT610061	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT610060	hsa-miR-612	HITS-CLIP	23824327
MIRT610059	hsa-miR-6860	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610054	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT644601	hsa-miR-1298-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610063	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT610062	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT610061	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT610060	hsa-miR-612	HITS-CLIP	23824327
MIRT610059	hsa-miR-6860	HITS-CLIP	23824327
MIRT610058	hsa-miR-4486	HITS-CLIP	23824327
MIRT610057	hsa-miR-378g	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610054	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610063	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT610062	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT610061	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT610060	hsa-miR-612	HITS-CLIP	23824327
MIRT610059	hsa-miR-6860	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610054	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610054	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610063	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT610062	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT610061	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT610060	hsa-miR-612	HITS-CLIP	23824327
MIRT610059	hsa-miR-6860	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610054	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610054	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610054	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610054	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610063	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT610062	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT610061	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT610060	hsa-miR-612	HITS-CLIP	23824327
MIRT610059	hsa-miR-6860	HITS-CLIP	23824327
MIRT610058	hsa-miR-4486	HITS-CLIP	23824327
MIRT610057	hsa-miR-378g	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610054	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT570998	hsa-miR-3662	HITS-CLIP	24906430
MIRT570997	hsa-miR-8084	HITS-CLIP	24906430
MIRT608290	hsa-miR-7153-3p	HITS-CLIP	24906430
MIRT570996	hsa-miR-1272	HITS-CLIP	24906430
MIRT608289	hsa-miR-4789-5p	HITS-CLIP	24906430
MIRT570993	hsa-miR-7156-3p	HITS-CLIP	24906430
MIRT608288	hsa-miR-6505-5p	HITS-CLIP	24906430
MIRT570998	hsa-miR-3662	PAR-CLIP	20371350
MIRT570997	hsa-miR-8084	PAR-CLIP	20371350
MIRT570996	hsa-miR-1272	PAR-CLIP	20371350
MIRT570995	hsa-miR-1206	PAR-CLIP	20371350
MIRT570994	hsa-miR-6516-3p	PAR-CLIP	20371350
MIRT570993	hsa-miR-7156-3p	PAR-CLIP	20371350
MIRT543938	hsa-miR-3646	PAR-CLIP	21572407
MIRT527639	hsa-miR-1252-3p	PAR-CLIP	21572407
MIRT527638	hsa-miR-4506	PAR-CLIP	21572407
MIRT527637	hsa-miR-875-5p	PAR-CLIP	21572407
MIRT527636	hsa-miR-4495	PAR-CLIP	21572407
MIRT527635	hsa-miR-4424	PAR-CLIP	21572407
MIRT527634	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT527633	hsa-miR-107	PAR-CLIP	21572407
MIRT527632	hsa-miR-3944-5p	PAR-CLIP	21572407
MIRT527631	hsa-miR-569	PAR-CLIP	21572407
MIRT527630	hsa-miR-3144-3p	PAR-CLIP	21572407
MIRT527629	hsa-miR-6741-5p	PAR-CLIP	21572407
MIRT527639	hsa-miR-1252-3p	PAR-CLIP	22012620
MIRT527638	hsa-miR-4506	PAR-CLIP	22012620
MIRT527637	hsa-miR-875-5p	PAR-CLIP	22012620
MIRT527636	hsa-miR-4495	PAR-CLIP	22012620
MIRT527635	hsa-miR-4424	PAR-CLIP	22012620
MIRT527634	hsa-miR-103a-3p	PAR-CLIP	22012620
MIRT527633	hsa-miR-107	PAR-CLIP	22012620
MIRT527632	hsa-miR-3944-5p	PAR-CLIP	22012620
MIRT527631	hsa-miR-569	PAR-CLIP	22012620
MIRT527630	hsa-miR-3144-3p	PAR-CLIP	22012620
MIRT527629	hsa-miR-6741-5p	PAR-CLIP	22012620
MIRT515657	hsa-miR-548ac	PAR-CLIP	23446348
MIRT515656	hsa-miR-548bb-3p	PAR-CLIP	23446348
MIRT515655	hsa-miR-548d-3p	PAR-CLIP	23446348
MIRT515654	hsa-miR-548h-3p	PAR-CLIP	23446348
MIRT515653	hsa-miR-548z	PAR-CLIP	23446348
MIRT515652	hsa-miR-548ae-3p	PAR-CLIP	23446348
MIRT515651	hsa-miR-548ah-3p	PAR-CLIP	23446348
MIRT515650	hsa-miR-548aj-3p	PAR-CLIP	23446348
MIRT515649	hsa-miR-548am-3p	PAR-CLIP	23446348
MIRT515648	hsa-miR-548aq-3p	PAR-CLIP	23446348
MIRT515647	hsa-miR-548j-3p	PAR-CLIP	23446348
MIRT515646	hsa-miR-548x-3p	PAR-CLIP	23446348
MIRT515645	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT515644	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT515643	hsa-miR-3163	PAR-CLIP	23446348
MIRT515642	hsa-miR-369-3p	PAR-CLIP	23446348
MIRT515641	hsa-miR-5692b	PAR-CLIP	23446348
MIRT515640	hsa-miR-5692c	PAR-CLIP	23446348
MIRT515639	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT515638	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT515637	hsa-miR-374a-5p	PAR-CLIP	23446348
MIRT515636	hsa-miR-374b-5p	PAR-CLIP	23446348
MIRT515635	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	28735896
MIRT610052	hsa-miR-421	HITS-CLIP	28735896
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	28735896
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	28735896
MIRT610053	hsa-miR-505-3p	HITS-CLIP	28735896
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	28735896
MIRT610056	hsa-miR-676-5p	HITS-CLIP	28735896
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	28735896
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	28735896
MIRT610054	hsa-miR-7159-5p	HITS-CLIP	28735896
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610063	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT610062	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT610061	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT610060	hsa-miR-612	HITS-CLIP	23824327
MIRT610059	hsa-miR-6860	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610054	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT644601	hsa-miR-1298-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610063	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT610062	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT610061	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT610060	hsa-miR-612	HITS-CLIP	23824327
MIRT610059	hsa-miR-6860	HITS-CLIP	23824327
MIRT610058	hsa-miR-4486	HITS-CLIP	23824327
MIRT610057	hsa-miR-378g	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610054	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610063	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT610062	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT610061	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT610060	hsa-miR-612	HITS-CLIP	23824327
MIRT610059	hsa-miR-6860	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610054	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610054	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610063	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT610062	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT610061	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT610060	hsa-miR-612	HITS-CLIP	23824327
MIRT610059	hsa-miR-6860	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610054	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610054	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610054	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610054	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT610065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT610064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT610063	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT610062	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT610061	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT610060	hsa-miR-612	HITS-CLIP	23824327
MIRT610059	hsa-miR-6860	HITS-CLIP	23824327
MIRT610058	hsa-miR-4486	HITS-CLIP	23824327
MIRT610057	hsa-miR-378g	HITS-CLIP	23824327
MIRT610056	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610055	hsa-miR-4470	HITS-CLIP	23824327
MIRT610054	hsa-miR-7159-5p	HITS-CLIP	23824327
MIRT610053	hsa-miR-505-3p	HITS-CLIP	23824327
MIRT610052	hsa-miR-421	HITS-CLIP	23824327
MIRT610051	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT610050	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT610049	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT610048	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT570998	hsa-miR-3662	PAR-CLIP	20371350
MIRT570997	hsa-miR-8084	PAR-CLIP	20371350
MIRT570996	hsa-miR-1272	PAR-CLIP	20371350
MIRT570995	hsa-miR-1206	PAR-CLIP	20371350
MIRT570994	hsa-miR-6516-3p	PAR-CLIP	20371350
MIRT570993	hsa-miR-7156-3p	PAR-CLIP	20371350
MIRT543938	hsa-miR-3646	PAR-CLIP	21572407
MIRT527639	hsa-miR-1252-3p	PAR-CLIP	21572407
MIRT527638	hsa-miR-4506	PAR-CLIP	21572407
MIRT527637	hsa-miR-875-5p	PAR-CLIP	21572407
MIRT527636	hsa-miR-4495	PAR-CLIP	21572407
MIRT527635	hsa-miR-4424	PAR-CLIP	21572407
MIRT527634	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT527633	hsa-miR-107	PAR-CLIP	21572407
MIRT527632	hsa-miR-3944-5p	PAR-CLIP	21572407
MIRT527631	hsa-miR-569	PAR-CLIP	21572407
MIRT527630	hsa-miR-3144-3p	PAR-CLIP	21572407
MIRT527629	hsa-miR-6741-5p	PAR-CLIP	21572407
MIRT527639	hsa-miR-1252-3p	PAR-CLIP	22012620
MIRT527638	hsa-miR-4506	PAR-CLIP	22012620
MIRT527637	hsa-miR-875-5p	PAR-CLIP	22012620
MIRT527636	hsa-miR-4495	PAR-CLIP	22012620
MIRT527635	hsa-miR-4424	PAR-CLIP	22012620
MIRT527634	hsa-miR-103a-3p	PAR-CLIP	22012620
MIRT527633	hsa-miR-107	PAR-CLIP	22012620
MIRT527632	hsa-miR-3944-5p	PAR-CLIP	22012620
MIRT527631	hsa-miR-569	PAR-CLIP	22012620
MIRT527630	hsa-miR-3144-3p	PAR-CLIP	22012620
MIRT527629	hsa-miR-6741-5p	PAR-CLIP	22012620
MIRT515657	hsa-miR-548ac	PAR-CLIP	23446348
MIRT515656	hsa-miR-548bb-3p	PAR-CLIP	23446348
MIRT515655	hsa-miR-548d-3p	PAR-CLIP	23446348
MIRT515654	hsa-miR-548h-3p	PAR-CLIP	23446348
MIRT515653	hsa-miR-548z	PAR-CLIP	23446348
MIRT515652	hsa-miR-548ae-3p	PAR-CLIP	23446348
MIRT515651	hsa-miR-548ah-3p	PAR-CLIP	23446348
MIRT515650	hsa-miR-548aj-3p	PAR-CLIP	23446348
MIRT515649	hsa-miR-548am-3p	PAR-CLIP	23446348
MIRT515648	hsa-miR-548aq-3p	PAR-CLIP	23446348
MIRT515647	hsa-miR-548j-3p	PAR-CLIP	23446348
MIRT515646	hsa-miR-548x-3p	PAR-CLIP	23446348
MIRT515645	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT515644	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT515643	hsa-miR-3163	PAR-CLIP	23446348
MIRT515642	hsa-miR-369-3p	PAR-CLIP	23446348
MIRT515641	hsa-miR-5692b	PAR-CLIP	23446348
MIRT515640	hsa-miR-5692c	PAR-CLIP	23446348
MIRT515639	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT515638	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT515637	hsa-miR-374a-5p	PAR-CLIP	23446348
MIRT515636	hsa-miR-374b-5p	PAR-CLIP	23446348
MIRT515635	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT1922856	hsa-miR-1236	CLIP-seq
MIRT2391238	hsa-miR-2467-3p	CLIP-seq
MIRT2391239	hsa-miR-3678-3p	CLIP-seq
MIRT2391240	hsa-miR-4645-3p	CLIP-seq
MIRT2391241	hsa-miR-4676-5p	CLIP-seq
MIRT2391242	hsa-miR-4755-3p	CLIP-seq
MIRT2391243	hsa-miR-575	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	23414517
GO:0005829	Component	Cytosol	TAS
GO:0007155	Process	Cell adhesion	IEA
GO:0008307	Function	Structural constituent of muscle	TAS	8375400
GO:0017022	Function	Myosin binding	IDA	31025394, 31264822
GO:0030016	Component	Myofibril	ISS	1429890
GO:0030049	Process	Muscle filament sliding	TAS
GO:0031432	Function	Titin binding	ISS	1429890
GO:0032982	Component	Myosin filament	IEA

Other IDs

• MIM: 160794
• HGNC: 7549
• e!Ensembl: ENSG00000196091

Protein

• UniProt ID: Q00872
• Protein name: Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform)
• Protein function: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. Slow skeletal protein that binds to both myosin and actin (PubMed:31025394, PubMed:31264822). In vitro, binds to native thin filaments and
• PDB: 1X44, 2DAV, 2YUV, 2YUW, 2YUX, 2YUZ, 2YXM
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07679	I-set	59 → 159	Immunoglobulin I-set domain	Domain
  PF18362	THB	209 → 242	Tri-helix bundle domain	Domain
  PF07679	I-set	253 → 337	Immunoglobulin I-set domain	Domain
  PF07679	I-set	342 → 431	Immunoglobulin I-set domain	Domain
  PF07679	I-set	433 → 507	Immunoglobulin I-set domain	Domain
  PF07679	I-set	530 → 616	Immunoglobulin I-set domain	Domain
  PF00041	fn3	621 → 706	Fibronectin type III domain	Domain
  PF00041	fn3	719 → 822	Fibronectin type III domain	Domain
  PF07679	I-set	839 → 928	Immunoglobulin I-set domain	Domain
  PF00041	fn3	933 → 1016	Fibronectin type III domain	Domain
  PF07679	I-set	1047 → 1136	Immunoglobulin I-set domain	Domain

• Sequence:

  MPEPTKKEENEVPAPAPPPEEPSKEKEAGTTPAKDWTLVETPPGEEQAKQNANSQLSILF
  IEKPQGGTVKVGEDITFIAKVKAEDLLRKPTIKWFKGKWMDLASKAGKHLQLKETFERHS
  RVYTFEMQIIKAKDNFAGNYRCEVTYKDKFDSCSFDLEVHESTGTTPNIDIRSAFKRSGE
  GQEDAGELDFSGLLKRREVKQQEEEPQVDVWELLKNAKPSEYEKIAFQYGITDLRGMLKR
  LKRMRREEKKSAAFAKILDPAYQVDKGGRVRFVVELADPKLEVKWYKNGQEIRPSTKYIF
  EHKGCQRILFINNCQMTDDSEYYVTAGDEKCSTELFVREPPIMVTKQLEDTTAYCGERVE
  LECEVSEDDANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIEGATKADAAEYSVMTTGG
  QSSAKLSVDLKPLKILTPLTDQTVNLGKEICLKCEISENIPGKWTKNGLPVQESDRLKVV
  HKGRIHKLVIANALTEDEGDYVFAPDAYNVTLPAKVHVIDPPKIILDGLDADNTVTVIAG
  NKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTLVIDIAERDDSGVYHIN
  LKNEAGEAHASIKVKVVDFPDPPVAPTVTEVGDDWCIMNWEPPAYDGGSPILGYFIERKK
  KQSSRWMRLNFDLCKETTFEPKKMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPLAVTSP
  PTLLTVDSVTDTTVTMRWRPPDHIGAAGLDGYVLEYCFEGSTSAKQSDENGEAAYDLPAE
  DWIVANKDLIDKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYYSQPILVKEIIEPPKIR
  IPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQINIRNSETDTIIFIRK
  AERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVWGENVALTWTPPKDDGN
  AAITGYTIQKADKKSMEWFTVIEHYHRTSATITELVIGNEYYFRVFSENMCGLSEDATMT
  KESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNATLNCSVRGNPKPKITW
  MKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVNDLGTVEIECKLEVKVIA
  Q

• Sequence length: 1141

Pathways

KEGG:

Cytoskeleton in muscle cells

Reactome:

Striated Muscle Contraction

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Arthrogryposis multiplex congenita	Arthrogryposis	rs1586285494, rs80358233, rs137853305, rs1559154278, rs398124167, rs398124172, rs587780399, rs786204576, rs786204430, rs769345284, rs749355583, rs793888524, rs793888525, rs878854368, rs555445835, rs758105619, rs886041851, rs794727136, rs755239192, rs760715690, rs773952935, rs112610938, rs1057516676, rs1057516996, rs780022652, rs1057517399, rs1057517360, rs1057518353, rs1057517977, rs1064796311, rs779232987, rs775997446, rs1064797093, rs1064797094, rs1064797095, rs755500591, rs754272530, rs758247804, rs200731870, rs747179265, rs1553740233, rs776569219, rs375628303, rs775631800, rs781667543, rs1553548666, rs928945364, rs763364977, rs1458048713, rs1553883480, rs1472403020, rs1336053002, rs202048855, rs1197561990, rs755531536, rs1554112524, rs762133567, rs1553555882, rs934111355, rs1255744452, rs1366269616, rs1555734932, rs1553548207, rs752582527, rs1257495033, rs113525641, rs755863625, rs374929094, rs539819851, rs1366853918, rs1218073575, rs1553537512, rs1553552384, rs747564597, rs776059611, rs756726488, rs1357811155, rs1553939600, rs772009599, rs1255445731, rs1011425121, rs1553561697, rs1553551748, rs1553552413, rs760935667, rs1553603400, rs1302373559, rs1389892619, rs1553710982, rs757157808, rs1180339426, rs761964375, rs1235589246, rs1443738549, rs1553934586, rs1553934597, rs1553603437, rs749452641, rs1553904694, rs754369875, rs112517981, rs774495973, rs1428597732, rs746999970, rs113091511, rs1553603958, rs1553469502, rs770797137, rs1553608621, rs1159756073, rs776167256, rs778593702, rs1553601066, rs1553689774, rs760768475, rs1559296376, rs201636991, rs1559039815, rs748922882, rs772366030, rs1207534366, rs1259297878, rs762780413, rs1559360386, rs1559940778, rs760200697, rs1344099907, rs750900690, rs1559168230, rs746177326, rs761067911, rs1323364980, rs537560378, rs1319778592, rs1340063197, rs1577833924, rs750585238, rs1600470099, rs1575714905, rs1576203853, rs779909544, rs760124743, rs2096362304, rs1212374733, rs1490309743, rs767709270, rs1374971806, rs2096491549, rs2097886912, rs2099021112, rs2097758221, rs1474341248, rs925947627
Distal arthrogryposis	ARTHROGRYPOSIS, DISTAL, TYPE 1, Distal arthrogryposis syndrome, ARTHROGRYPOSIS, DISTAL, TYPE 1B, Distal arthrogryposis type 1	rs121434638, rs104894127, rs104894129, rs137853305, rs137853306, rs199476153, rs199476147, rs121913619, rs879255230, rs387906657, rs387906658, rs199474721, rs587776917, rs587776918, rs587776919, rs587776920, rs587777129, rs587777130, rs587777131, rs199476146, rs606231471, rs370167241, rs765430577, rs878853117, rs878853118, rs1555621138, rs149459910, rs1553566820, rs1553567411, rs1553567937, rs1341894581, rs201987709, rs1554658995, rs1554289078, rs762979130, rs1554659746, rs1555242493, rs1555769818, rs1567973091, rs1563929039, rs1563929143, rs1350968647, rs1356994386, rs1229171141, rs1567559027, rs1563929383, rs113612402, rs1465836003, rs1597490381, rs1190799930, rs767987856, rs1587956195, rs1281970248, rs1575076514, rs1597482824, rs1825151618	20045868, 22610851, 26661508
Lethal congenital contracture syndrome	LETHAL CONGENITAL CONTRACTURAL SYNDROME 3, LETHAL CONGENITAL CONTRACTURE SYNDROME 4, Lethal congenital contracture syndrome type 3	rs121908315, rs386833693, rs121434407, rs1565859132, rs786204798, rs786204799, rs786204800, rs749355583, rs793888524, rs793888525, rs751050956, rs1555642784, rs746361190, rs886041056, rs764239923, rs779432560, rs539703340, rs886041057, rs368085516, rs750803388, rs775011495, rs144659252, rs1595795343, rs1595795307, rs755420151	22610851, 26661508, 20045868
Myopathy	Myopathy	rs137854521, rs386834236, rs121908557, rs121909092, rs111033570, rs104894299, rs104894294, rs121909273, rs121909274, rs121909275, rs199474699, rs199476140, rs118192165, rs118192169, rs118192166, rs193922856, rs281865489, rs397514675, rs397514676, rs397514677, rs367543058, rs118192117, rs193922837, rs118192129, rs118192143, rs118192153, rs118192133, rs118192156, rs118192149, rs118192148, rs118192183, rs118192147, rs118192123, rs118192127, rs118192142, rs118192144, rs118192178, rs118192151, rs118192150, rs118192184, rs118192154, rs118192134, rs118192155, rs193922893, rs118192132, rs118192146, rs193922867, rs193922884, rs587777528, rs527236030, rs587777672, rs587777673, rs587777674, rs587777675, rs587783343, rs2754158, rs786204796, rs748277951, rs797046047, rs797046064, rs797046060, rs797045479, rs797045931, rs797045932, rs797045934, rs797045935, rs797045477, rs797045478, rs1057518851, rs1057518855, rs1057518773, rs1057518866, rs1555322610, rs1555806119, rs761483896, rs144071404, rs1198364572, rs1568614042, rs978984063, rs1568604308, rs1332371891, rs1601842249, rs777176261, rs1249621033, rs1278804520, rs1568613962, rs1568510406, rs1597512576, rs193922887, rs371455345, rs1603452200, rs1599634685, rs1575065895, rs1575201712, rs139715157, rs1974129338
Hypotonia	Neonatal Hypotonia	rs141138948, rs397517172, rs869312824, rs1583169151

Unknown
Disease term	Disease name	Evidence	References	Source
Congenital contracture	lethal congenital contracture syndrome 3			GenCC
Digitotalar Dysmorphism	digitotalar dysmorphism			GenCC
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA

Associations from Text Mining
Disease Name	Relationship Type	References
Arnold Chiari Malformation	Associate	31227808
Arthrogryposis	Associate	25679999, 31264822, 38438057
Arthrogryposis multiplex congenita distal type 1	Associate	20045868, 38438057
Arthrogryposis multiplex congenita distal type 2	Associate	25679999
Breast Neoplasms	Associate	35132338
Cardiomyopathy Hypertrophic	Associate	20045868
Cognition Disorders	Associate	21061152
Contracture	Associate	31264822
Encephalitis	Associate	21061152
Inflammation	Associate	21061152
Muscle Hypotonia	Associate	31264822
Muscle Weakness	Associate	31264822
Muscular Diseases	Associate	25679999, 31025394, 31264822
Musculoskeletal Diseases	Associate	38438057
Myotonia Congenita	Associate	38438057
Neoplasm Metastasis	Associate	35132338
Neuromuscular Diseases	Associate	31264822
Osteoporosis	Associate	32930132
Pancreaticobiliary Maljunction	Associate	31365696
Sarcoma Ewing	Associate	36849756
Tremor	Associate	31025394, 31264822, 38438057