Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4603
Gene name Gene Name - the full gene name approved by the HGNC.
MYB proto-oncogene like 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MYBL1
Synonyms (NCBI Gene) Gene synonyms aliases
A-MYB, AMYB
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q13.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016526 hsa-miR-193b-3p Microarray 20304954
MIRT020041 hsa-miR-375 Microarray 20215506
MIRT002505 hsa-miR-373-3p Microarray 15685193
MIRT021060 hsa-miR-155-5p Reporter assay;Other 20584899
MIRT021060 hsa-miR-155-5p Reporter assay;Other 18668040
Transcription factors
Transcription factor Regulation Reference
SP1 Unknown 10951586
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000278 Process Mitotic cell cycle IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 7987850
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
159405 7547 ENSG00000185697
Protein
UniProt ID P10243
Protein name Myb-related protein A (A-Myb) (Myb-like protein 1)
Protein function Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:7987850, PubMed:8058310). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13921 Myb_DNA-bind_6 38 98 Domain
PF07988 LMSTEN 240 286 LMSTEN motif Motif
PF09316 Cmyb_C 486 648 C-myb, C-terminal Family
Tissue specificity TISSUE SPECIFICITY: Expressed in a variety of lymphoid and solid tumor lines cultured in vitro.
Sequence
MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDDKLKKLVEQHGTDDWTL
IASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRV
IELVQKYGPKRWSLIAKHLKGR
IGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHW
NSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCAAMDHMQTQNQFYIPVQIPGYQYVSPEG
NCIEHVQPTSAFIQQPFIDEDPDKEKKIKELEMLLMSAENEVRRKR
IPSQPGSFSSWSGS
FLMDDNMSNTLNSLDEHTSEFYSMDENQPVSAQQNSPTKFLAVEANAVLSSLQTIPEFAE
TLELIESDPVAWSDVTSFDISDAAASPIKSTPVKLMRIQHNEGAMECQFNVSLVLEGKKN
TCNGGNSEAVPLTSPNIAKFSTPPAILRKKRKMRVGHSPGSELRDGSLNDGGNMALKHTP
LKTLPFSPSQFFNTCPGNEQLNIENPSFTSTPICGQKALITTPLHKETTPKDQKENVGFR
TPTIRRSILGTTPRTPTPFKNALAAQEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDLF
LKEEDEPAYKSCKQENTASGKKVRKSLVLDNWEKEESGTQLLTEDISD
MQSENRFTTSLL
MIPLLEIHDNRCNLIPEKQDINSTNKTYTLTKKKPNPNTSKVVKLEKNLQSNCEWETVVY
GKTEDQLIMTEQARRYLSTYTATSSTSRALIL
Sequence length 752
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Prostate cancer Prostate cancer (early onset) N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Aicardi Syndrome Associate 26631609, 34011559
Ameloblastoma Associate 32124419
Astrocytoma Associate 23881924, 31563982, 36074655
Brain Neoplasms Associate 36074655
Breast Neoplasms Associate 39796135
Burkitt Lymphoma Associate 8634438
Carcinogenesis Associate 31483290
Carcinoma Adenoid Cystic Associate 26631609, 29149504, 29410490, 29467480, 29496310, 30926674, 31028361, 32124419, 33878706, 34599282, 38010473, 40184085
Carcinoma Hepatocellular Associate 35987690
Carcinoma Mucoepidermoid Associate 39549430