Gene Gene information from NCBI Gene database.
Entrez ID 4603
Gene name MYB proto-oncogene like 1
Gene symbol MYBL1
Synonyms (NCBI Gene)
A-MYBAMYB
Chromosome 8
Chromosome location 8q13.1
miRNA miRNA information provided by mirtarbase database.
419
miRTarBase ID miRNA Experiments Reference
MIRT016526 hsa-miR-193b-3p Microarray 20304954
MIRT020041 hsa-miR-375 Microarray 20215506
MIRT002505 hsa-miR-373-3p Microarray 15685193
MIRT021060 hsa-miR-155-5p Reporter assay;Other 20584899
MIRT021060 hsa-miR-155-5p Reporter assay;Other 18668040
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
SP1 Unknown 10951586
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
24
GO ID Ontology Definition Evidence Reference
GO:0000278 Process Mitotic cell cycle IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 7987850
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
159405 7547 ENSG00000185697
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P10243
Protein name Myb-related protein A (A-Myb) (Myb-like protein 1)
Protein function Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:7987850, PubMed:8058310). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13921 Myb_DNA-bind_6 38 98 Domain
PF07988 LMSTEN 240 286 LMSTEN motif Motif
PF09316 Cmyb_C 486 648 C-myb, C-terminal Family
Tissue specificity TISSUE SPECIFICITY: Expressed in a variety of lymphoid and solid tumor lines cultured in vitro.
Sequence
MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDDKLKKLVEQHGTDDWTL
IASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRV
IELVQKYGPKRWSLIAKHLKGR
IGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHW
NSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCAAMDHMQTQNQFYIPVQIPGYQYVSPEG
NCIEHVQPTSAFIQQPFIDEDPDKEKKIKELEMLLMSAENEVRRKR
IPSQPGSFSSWSGS
FLMDDNMSNTLNSLDEHTSEFYSMDENQPVSAQQNSPTKFLAVEANAVLSSLQTIPEFAE
TLELIESDPVAWSDVTSFDISDAAASPIKSTPVKLMRIQHNEGAMECQFNVSLVLEGKKN
TCNGGNSEAVPLTSPNIAKFSTPPAILRKKRKMRVGHSPGSELRDGSLNDGGNMALKHTP
LKTLPFSPSQFFNTCPGNEQLNIENPSFTSTPICGQKALITTPLHKETTPKDQKENVGFR
TPTIRRSILGTTPRTPTPFKNALAAQEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDLF
LKEEDEPAYKSCKQENTASGKKVRKSLVLDNWEKEESGTQLLTEDISD
MQSENRFTTSLL
MIPLLEIHDNRCNLIPEKQDINSTNKTYTLTKKKPNPNTSKVVKLEKNLQSNCEWETVVY
GKTEDQLIMTEQARRYLSTYTATSSTSRALIL
Sequence length 752
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Familial cancer of breast Benign rs148388060 RCV005910658
Lung cancer Benign rs148388060 RCV005910659
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Aicardi Syndrome Associate 26631609, 34011559
Ameloblastoma Associate 32124419
Astrocytoma Associate 23881924, 31563982, 36074655
Brain Neoplasms Associate 36074655
Breast Neoplasms Associate 39796135
Burkitt Lymphoma Associate 8634438
Carcinogenesis Associate 31483290
Carcinoma Adenoid Cystic Associate 26631609, 29149504, 29410490, 29467480, 29496310, 30926674, 31028361, 32124419, 33878706, 34599282, 38010473, 40184085
Carcinoma Hepatocellular Associate 35987690
Carcinoma Mucoepidermoid Associate 39549430