Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4602
Gene name Gene Name - the full gene name approved by the HGNC.
MYB proto-oncogene, transcription factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MYB
Synonyms (NCBI Gene) Gene synonyms aliases
Cmyb, c-myb, c-myb_CDS, efg
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q23.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocati
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000935 hsa-miR-150-5p Western blot 18667440
MIRT000935 hsa-miR-150-5p Western blot 18667440
MIRT000935 hsa-miR-150-5p Western blot 18667440
MIRT000935 hsa-miR-150-5p Western blot 18667440
MIRT000935 hsa-miR-150-5p Luciferase reporter assay 18667440
Transcription factors
Transcription factor Regulation Reference
BCL3 Unknown 9694711
E2F1 Unknown 8137237
EGR1 Repression 7559553
ETS1 Activation 7848925
FOSL2 Activation 22493372
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000082 Process G1/S transition of mitotic cell cycle IEA
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 20531406
GO:0000278 Process Mitotic cell cycle IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 7987850, 25857263
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
189990 7545 ENSG00000118513
Protein
UniProt ID P10242
Protein name Transcriptional activator Myb (Proto-oncogene c-Myb)
Protein function Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00249 Myb_DNA-binding 92 138 Myb-like DNA-binding domain Domain
PF00249 Myb_DNA-binding 144 189 Myb-like DNA-binding domain Domain
PF07988 LMSTEN 267 313 LMSTEN motif Motif
PF09316 Cmyb_C 399 563 C-myb, C-terminal Family
Sequence
MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGT
DDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAK
HLKGRIGKQCRERWHNHL
NPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNA
IKNHWNSTM
RRKVEQEGYLQESSKASQPAVATSFQKNSHLMGFAQAPPTAQLPATGQPTV
NNDYSYYHISEAQNVSSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELEL
LLMSTENELKGQQ
VLPTQNHTCSYPGWHSTTIADHTRPHGDSAPVSCLGEHHSTPSLPAD
PGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSFLNTSSNHENSDLEMPSLT
STPLIGHKLTVTTPFHRDQTVKTQKENTVFRTPAIKRSILESSPRTPTPFKHALAAQEIK
YGPLKMLPQTPSHLVEDLQDVIKQESDESGIVAEFQENGPPLLKKIKQEVESPTDKSGNF
FCSHHWEGDSLNTQLFTQTSPVA
DAPNILTSSVLMAPASEDEDNVLKAFTVPKNRSLASP
LQPCSSTWEPASCGKMEEQMTSSSQARKYVNAFSARTLVM
Sequence length 640
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  PI3K-Akt signaling pathway   RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Hypothyroidism Hypothyroidism N/A N/A GWAS
Multiple Sclerosis Multiple sclerosis N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 28102292
Adenoma Associate 24472434
Adenoma Pleomorphic Associate 24302647
Adenomatous Polyposis Coli Associate 24472434
Aicardi Syndrome Associate 20702610, 24302647, 24893972, 26631609, 28085142, 28719465, 29978608, 31857685, 34011559
Aicardi Syndrome Stimulate 21785271
Anemia Hemolytic Associate 29879141
Anemia Sickle Cell Associate 18667698, 21068433, 21205891, 24614105, 24667352, 25084696, 25928412, 28332727, 29879141, 38339995
Asthma Associate 23606399
Astrocytoma Stimulate 21046410