Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4600
Gene name Gene Name - the full gene name approved by the HGNC.	MX dynamin like GTPase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MX2
Synonyms (NCBI Gene) Gene synonyms aliases	MXB
Chromosome Chromosome number	21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	21q22.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelop

Show/Hide all(231)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021267	hsa-miR-146a-5p	Microarray	18057241
MIRT628763	hsa-miR-148a-5p	HITS-CLIP	19536157
MIRT710678	hsa-miR-511-3p	HITS-CLIP	19536157
MIRT628762	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT628761	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT628759	hsa-miR-567	HITS-CLIP	19536157
MIRT628758	hsa-miR-223-5p	HITS-CLIP	19536157
MIRT628757	hsa-miR-2117	HITS-CLIP	19536157
MIRT628756	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT628755	hsa-miR-297	HITS-CLIP	19536157
MIRT628754	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT628753	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT628763	hsa-miR-148a-5p	HITS-CLIP	23824327
MIRT628762	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT628761	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT628760	hsa-miR-4670-3p	HITS-CLIP	23824327
MIRT628759	hsa-miR-567	HITS-CLIP	23824327
MIRT628758	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT628757	hsa-miR-2117	HITS-CLIP	23824327
MIRT628756	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT628755	hsa-miR-297	HITS-CLIP	23824327
MIRT633708	hsa-miR-3611	HITS-CLIP	23824327
MIRT628754	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT628753	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT628763	hsa-miR-148a-5p	HITS-CLIP	23824327
MIRT628762	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT628761	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT628760	hsa-miR-4670-3p	HITS-CLIP	23824327
MIRT628759	hsa-miR-567	HITS-CLIP	23824327
MIRT628758	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT628757	hsa-miR-2117	HITS-CLIP	23824327
MIRT628756	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT628755	hsa-miR-297	HITS-CLIP	23824327
MIRT633708	hsa-miR-3611	HITS-CLIP	23824327
MIRT628754	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT628753	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT628763	hsa-miR-148a-5p	HITS-CLIP	23824327
MIRT628762	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT628761	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT628760	hsa-miR-4670-3p	HITS-CLIP	23824327
MIRT628759	hsa-miR-567	HITS-CLIP	23824327
MIRT628758	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT628757	hsa-miR-2117	HITS-CLIP	23824327
MIRT628756	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT628755	hsa-miR-297	HITS-CLIP	23824327
MIRT628754	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT628753	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT628758	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT628755	hsa-miR-297	HITS-CLIP	27418678
MIRT710678	hsa-miR-511-3p	HITS-CLIP	27418678
MIRT628759	hsa-miR-567	HITS-CLIP	27418678
MIRT628761	hsa-miR-6817-3p	HITS-CLIP	27418678
MIRT628756	hsa-miR-6873-3p	HITS-CLIP	27418678
MIRT628762	hsa-miR-7110-3p	HITS-CLIP	27418678
MIRT628763	hsa-miR-148a-5p	HITS-CLIP	19536157
MIRT710678	hsa-miR-511-3p	HITS-CLIP	19536157
MIRT628762	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT628761	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT628759	hsa-miR-567	HITS-CLIP	19536157
MIRT628758	hsa-miR-223-5p	HITS-CLIP	19536157
MIRT628757	hsa-miR-2117	HITS-CLIP	19536157
MIRT628756	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT628755	hsa-miR-297	HITS-CLIP	19536157
MIRT628754	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT628753	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT628763	hsa-miR-148a-5p	HITS-CLIP	23824327
MIRT628762	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT628761	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT628760	hsa-miR-4670-3p	HITS-CLIP	23824327
MIRT628759	hsa-miR-567	HITS-CLIP	23824327
MIRT628758	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT628757	hsa-miR-2117	HITS-CLIP	23824327
MIRT628756	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT628755	hsa-miR-297	HITS-CLIP	23824327
MIRT633708	hsa-miR-3611	HITS-CLIP	23824327
MIRT628754	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT628753	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT628763	hsa-miR-148a-5p	HITS-CLIP	23824327
MIRT628762	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT628761	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT628760	hsa-miR-4670-3p	HITS-CLIP	23824327
MIRT628759	hsa-miR-567	HITS-CLIP	23824327
MIRT628758	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT628757	hsa-miR-2117	HITS-CLIP	23824327
MIRT628756	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT628755	hsa-miR-297	HITS-CLIP	23824327
MIRT633708	hsa-miR-3611	HITS-CLIP	23824327
MIRT628754	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT628753	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT628763	hsa-miR-148a-5p	HITS-CLIP	23824327
MIRT628762	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT628761	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT628760	hsa-miR-4670-3p	HITS-CLIP	23824327
MIRT628759	hsa-miR-567	HITS-CLIP	23824327
MIRT628758	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT628757	hsa-miR-2117	HITS-CLIP	23824327
MIRT628756	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT628755	hsa-miR-297	HITS-CLIP	23824327
MIRT628754	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT628753	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT1166697	hsa-miR-140-3p	CLIP-seq
MIRT1166698	hsa-miR-185	CLIP-seq
MIRT1166699	hsa-miR-188-5p	CLIP-seq
MIRT1166700	hsa-miR-3169	CLIP-seq
MIRT1166701	hsa-miR-4306	CLIP-seq
MIRT1166702	hsa-miR-4477a	CLIP-seq
MIRT1166703	hsa-miR-4503	CLIP-seq
MIRT1166704	hsa-miR-4515	CLIP-seq
MIRT1166705	hsa-miR-4644	CLIP-seq
MIRT1166706	hsa-miR-4729	CLIP-seq
MIRT1166707	hsa-miR-521	CLIP-seq
MIRT1166708	hsa-miR-570	CLIP-seq
MIRT1166709	hsa-miR-711	CLIP-seq
MIRT1166710	hsa-miR-935	CLIP-seq
MIRT2048209	hsa-miR-1243	CLIP-seq
MIRT2048210	hsa-miR-132	CLIP-seq
MIRT2048211	hsa-miR-212	CLIP-seq
MIRT2048212	hsa-miR-3622b-5p	CLIP-seq
MIRT2048213	hsa-miR-4252	CLIP-seq
MIRT2048214	hsa-miR-4475	CLIP-seq
MIRT2048215	hsa-miR-4701-5p	CLIP-seq
MIRT2048216	hsa-miR-4704-3p	CLIP-seq
MIRT2048217	hsa-miR-4747-5p	CLIP-seq
MIRT2048218	hsa-miR-4766-5p	CLIP-seq
MIRT2048219	hsa-miR-488	CLIP-seq
MIRT2048220	hsa-miR-588	CLIP-seq
MIRT2277096	hsa-miR-4261	CLIP-seq
MIRT2575888	hsa-miR-1205	CLIP-seq
MIRT2575889	hsa-miR-1273f	CLIP-seq
MIRT2575890	hsa-miR-1286	CLIP-seq
MIRT2575891	hsa-miR-1298	CLIP-seq
MIRT1166697	hsa-miR-140-3p	CLIP-seq
MIRT2575892	hsa-miR-143	CLIP-seq
MIRT2575893	hsa-miR-1911	CLIP-seq
MIRT2575894	hsa-miR-1912	CLIP-seq
MIRT2575895	hsa-miR-298	CLIP-seq
MIRT2575896	hsa-miR-3127-3p	CLIP-seq
MIRT2575897	hsa-miR-3130-3p	CLIP-seq
MIRT2575898	hsa-miR-3202	CLIP-seq
MIRT2575899	hsa-miR-326	CLIP-seq
MIRT2575900	hsa-miR-328	CLIP-seq
MIRT2575901	hsa-miR-330-3p	CLIP-seq
MIRT2575902	hsa-miR-330-5p	CLIP-seq
MIRT2575903	hsa-miR-3654	CLIP-seq
MIRT2575904	hsa-miR-3665	CLIP-seq
MIRT2575905	hsa-miR-3679-3p	CLIP-seq
MIRT2575906	hsa-miR-3941	CLIP-seq
MIRT2575907	hsa-miR-3944-5p	CLIP-seq
MIRT2575908	hsa-miR-4271	CLIP-seq
MIRT2575909	hsa-miR-4276	CLIP-seq
MIRT2575910	hsa-miR-4278	CLIP-seq
MIRT2575911	hsa-miR-4463	CLIP-seq
MIRT1166702	hsa-miR-4477a	CLIP-seq
MIRT1166703	hsa-miR-4503	CLIP-seq
MIRT2575912	hsa-miR-4638-3p	CLIP-seq
MIRT2575913	hsa-miR-466	CLIP-seq
MIRT2575914	hsa-miR-4667-5p	CLIP-seq
MIRT2575915	hsa-miR-4672	CLIP-seq
MIRT2575916	hsa-miR-4700-5p	CLIP-seq
MIRT2575917	hsa-miR-4708-5p	CLIP-seq
MIRT2575918	hsa-miR-4716-3p	CLIP-seq
MIRT2575919	hsa-miR-4722-5p	CLIP-seq
MIRT2575920	hsa-miR-4725-3p	CLIP-seq
MIRT1166706	hsa-miR-4729	CLIP-seq
MIRT2048217	hsa-miR-4747-5p	CLIP-seq
MIRT2575921	hsa-miR-4768-3p	CLIP-seq
MIRT2575922	hsa-miR-4770	CLIP-seq
MIRT2575923	hsa-miR-4793-5p	CLIP-seq
MIRT1166707	hsa-miR-521	CLIP-seq
MIRT2575924	hsa-miR-542-3p	CLIP-seq
MIRT1166708	hsa-miR-570	CLIP-seq
MIRT2575925	hsa-miR-615-5p	CLIP-seq
MIRT2575926	hsa-miR-616	CLIP-seq
MIRT2575927	hsa-miR-625	CLIP-seq
MIRT2575928	hsa-miR-637	CLIP-seq
MIRT2575929	hsa-miR-643	CLIP-seq
MIRT2575930	hsa-miR-657	CLIP-seq
MIRT2575931	hsa-miR-764	CLIP-seq
MIRT1166710	hsa-miR-935	CLIP-seq
MIRT2575888	hsa-miR-1205	CLIP-seq
MIRT2575889	hsa-miR-1273f	CLIP-seq
MIRT2575890	hsa-miR-1286	CLIP-seq
MIRT2575891	hsa-miR-1298	CLIP-seq
MIRT1166697	hsa-miR-140-3p	CLIP-seq
MIRT2575892	hsa-miR-143	CLIP-seq
MIRT2575893	hsa-miR-1911	CLIP-seq
MIRT2575894	hsa-miR-1912	CLIP-seq
MIRT2575895	hsa-miR-298	CLIP-seq
MIRT2575896	hsa-miR-3127-3p	CLIP-seq
MIRT2575897	hsa-miR-3130-3p	CLIP-seq
MIRT2575898	hsa-miR-3202	CLIP-seq
MIRT2575899	hsa-miR-326	CLIP-seq
MIRT2575900	hsa-miR-328	CLIP-seq
MIRT2575901	hsa-miR-330-3p	CLIP-seq
MIRT2575902	hsa-miR-330-5p	CLIP-seq
MIRT2575903	hsa-miR-3654	CLIP-seq
MIRT2575904	hsa-miR-3665	CLIP-seq
MIRT2575905	hsa-miR-3679-3p	CLIP-seq
MIRT2575906	hsa-miR-3941	CLIP-seq
MIRT2575907	hsa-miR-3944-5p	CLIP-seq
MIRT2575908	hsa-miR-4271	CLIP-seq
MIRT2575909	hsa-miR-4276	CLIP-seq
MIRT2575910	hsa-miR-4278	CLIP-seq
MIRT2575911	hsa-miR-4463	CLIP-seq
MIRT1166702	hsa-miR-4477a	CLIP-seq
MIRT1166703	hsa-miR-4503	CLIP-seq
MIRT2575912	hsa-miR-4638-3p	CLIP-seq
MIRT2575913	hsa-miR-466	CLIP-seq
MIRT2575914	hsa-miR-4667-5p	CLIP-seq
MIRT2575915	hsa-miR-4672	CLIP-seq
MIRT2575916	hsa-miR-4700-5p	CLIP-seq
MIRT2575917	hsa-miR-4708-5p	CLIP-seq
MIRT2575918	hsa-miR-4716-3p	CLIP-seq
MIRT2575919	hsa-miR-4722-5p	CLIP-seq
MIRT2575920	hsa-miR-4725-3p	CLIP-seq
MIRT1166706	hsa-miR-4729	CLIP-seq
MIRT2048217	hsa-miR-4747-5p	CLIP-seq
MIRT2575921	hsa-miR-4768-3p	CLIP-seq
MIRT2575922	hsa-miR-4770	CLIP-seq
MIRT2575923	hsa-miR-4793-5p	CLIP-seq
MIRT1166707	hsa-miR-521	CLIP-seq
MIRT2575924	hsa-miR-542-3p	CLIP-seq
MIRT1166708	hsa-miR-570	CLIP-seq
MIRT2575925	hsa-miR-615-5p	CLIP-seq
MIRT2575926	hsa-miR-616	CLIP-seq
MIRT2575927	hsa-miR-625	CLIP-seq
MIRT2575928	hsa-miR-637	CLIP-seq
MIRT2575929	hsa-miR-643	CLIP-seq
MIRT2575930	hsa-miR-657	CLIP-seq
MIRT2575931	hsa-miR-764	CLIP-seq
MIRT1166710	hsa-miR-935	CLIP-seq

Show/Hide all(35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0002376	Process	Immune system process	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IEA
GO:0003924	Function	GTPase activity	TAS	8798556
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005525	Function	GTP binding	IEA
GO:0005525	Function	GTP binding	IMP	15184662
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	8798556
GO:0005635	Component	Nuclear envelope	IEA
GO:0005643	Component	Nuclear pore	IDA	15184662
GO:0005643	Component	Nuclear pore	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	8798556
GO:0005829	Component	Cytosol	TAS
GO:0005874	Component	Microtubule	IBA
GO:0005886	Component	Plasma membrane	IBA
GO:0006952	Process	Defense response	TAS	8798556
GO:0008017	Function	Microtubule binding	IBA
GO:0009615	Process	Response to virus	IDA	24048477
GO:0015031	Process	Protein transport	IEA
GO:0016185	Process	Synaptic vesicle budding from presynaptic endocytic zone membrane	IBA
GO:0035455	Process	Response to interferon-alpha	IDA	24121441
GO:0045087	Process	Innate immune response	IEA
GO:0045202	Component	Synapse	IBA
GO:0046822	Process	Regulation of nucleocytoplasmic transport	IMP	15184662
GO:0051028	Process	MRNA transport	IEA
GO:0051607	Process	Defense response to virus	IBA
GO:0051607	Process	Defense response to virus	IEA
GO:0051607	Process	Defense response to virus	IMP	24121441
GO:0051726	Process	Regulation of cell cycle	IMP	15184662
GO:0098793	Component	Presynapse	IEA

MIM	HGNC	e!Ensembl
147890	7533	ENSG00000183486

Protein

UniProt ID

P20592

Protein name

Interferon-induced GTP-binding protein Mx2 (Interferon-regulated resistance GTP-binding protein MxB) (Myxovirus resistance protein 2) (p78-related protein)

Protein function

Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and th

PDB

4WHJ , 4X0R , 5UOT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00350	Dynamin_N	121 → 296	Dynamin family	Domain
PF01031	Dynamin_M	307 → 594	Dynamin central region	Family
PF02212	GED	618 → 709	Dynamin GTPase effector domain	Family

Sequence

MSKAHKPWPYRRRSQFSSRKYLKKEMNSFQQQPPPFGTVPPQMMFPPNWQGAEKDAAFLA
KDFNFLTLNNQPPPGNRSQPRAMGPENNLYSQYEQKVRPCIDLIDSLRALGVEQDLALPA
IAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKQPCEAWAGRISYRNTELEL
QDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAVDNQPRD
IGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILTKPDLMD
RGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAEATKKEITFFQTHPYFRVLL
EEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQKATEELRRCGADIPSQEADKMF
FLIEKIKMFNQDIEKLVEGEEVVRENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEV
EKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPALSMLQKAMEIIQQAFINVAKKHFG
EFFNLNQTVQSTIEDIKVKHTAKAENMIQLQFRMEQMVFCQDQIYSVVLKKVREEIFNPL
GTPSQNMKLNSHFPSNESSVSSFTEIGIHLNAYFLETSKRLANQIPFIIQYFMLRENGDS
LQKAMMQILQEKNRYSWLLQEQSETATKRRILKERIYRLTQARHALCQFSSKEIH

Sequence length

715

Interactions

View interactions

	KEGG		Reactome
	Viral life cycle - HIV-1 Hepatitis C Measles Influenza A Human papillomavirus infection Coronavirus disease - COVID-19		ISG15 antiviral mechanism Interferon alpha/beta signaling

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Dementia	Dementia	N/A	N/A	GWAS
Melanoma	Melanoma	N/A	N/A	GWAS

Show/Hide Text Mining Associations (37)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Arthritis Psoriatic	Stimulate	25809693
Breast Neoplasms	Associate	37286092
Carcinogenesis	Associate	33734579
Carcinoma Squamous Cell	Associate	35779918
Colitis Ulcerative	Associate	36165492
Congenital heart block	Associate	28626076
COVID 19	Stimulate	34076249
COVID 19	Associate	34880855
Dermatomyositis	Associate	37353938
Diabetes Mellitus	Stimulate	34076249
Down Syndrome	Associate	10207158, 33933170, 38095646
Encephalitis	Associate	29950411
Glioblastoma	Associate	34707174
Heart Defects Congenital	Associate	10207158
Herpes Simplex	Associate	34552595
Herpes Zoster	Associate	29950411
Herpesviridae Infections	Associate	29950411
HIV Infections	Associate	24048477, 24930137, 29925663, 30520725, 31155311
HIV Infections	Inhibit	24121441, 25348155, 32217692
HTLV I Infections	Inhibit	24048477, 24139395, 26446602, 30496303
Infections	Associate	26446602, 29325426, 37219433
Leukemia Myeloid Acute	Associate	23696245
Leukemia Promyelocytic Acute	Associate	22123462
Lung Neoplasms	Stimulate	34076249
Lupus Erythematosus Systemic	Associate	29257335, 35757684, 37950194
Lupus Erythematosus Systemic	Stimulate	36059547
Melanoma	Associate	21983787, 24930137, 25837821, 27993549, 33734579, 34898573
Mucocutaneous Lymph Node Syndrome	Stimulate	24635044
Narcolepsy	Inhibit	17702266
Narcolepsy	Associate	18517045
Neoplasms	Associate	29950411, 33734579, 34707174, 37286092
pediatric multisystem inflammatory disease COVID 19 related	Associate	37255317
Pneumonia	Associate	29950411
Retroviridae Infections	Inhibit	29950411
Scleroderma Systemic	Associate	33253099
Tuberculosis Multidrug Resistant	Associate	29387293
Ulcer	Associate	35757684

MX2 (MX dynamin like GTPase 2)