Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	4600
Gene name	MX dynamin like GTPase 2
Gene symbol	MX2
Synonyms (NCBI Gene)	MXB
Chromosome	21
Chromosome location	21q22.3
Summary	The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelop

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021267	hsa-miR-146a-5p	Microarray	18057241
MIRT628763	hsa-miR-148a-5p	HITS-CLIP	19536157
MIRT710678	hsa-miR-511-3p	HITS-CLIP	19536157
MIRT628762	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT628761	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT628759	hsa-miR-567	HITS-CLIP	19536157
MIRT628758	hsa-miR-223-5p	HITS-CLIP	19536157
MIRT628757	hsa-miR-2117	HITS-CLIP	19536157
MIRT628756	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT628755	hsa-miR-297	HITS-CLIP	19536157
MIRT628754	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT628753	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT628763	hsa-miR-148a-5p	HITS-CLIP	23824327
MIRT628762	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT628761	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT628760	hsa-miR-4670-3p	HITS-CLIP	23824327
MIRT628759	hsa-miR-567	HITS-CLIP	23824327
MIRT628758	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT628757	hsa-miR-2117	HITS-CLIP	23824327
MIRT628756	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT628755	hsa-miR-297	HITS-CLIP	23824327
MIRT633708	hsa-miR-3611	HITS-CLIP	23824327
MIRT628754	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT628753	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT628763	hsa-miR-148a-5p	HITS-CLIP	23824327
MIRT628762	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT628761	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT628760	hsa-miR-4670-3p	HITS-CLIP	23824327
MIRT628759	hsa-miR-567	HITS-CLIP	23824327
MIRT628758	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT628757	hsa-miR-2117	HITS-CLIP	23824327
MIRT628756	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT628755	hsa-miR-297	HITS-CLIP	23824327
MIRT633708	hsa-miR-3611	HITS-CLIP	23824327
MIRT628754	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT628753	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT628763	hsa-miR-148a-5p	HITS-CLIP	23824327
MIRT628762	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT628761	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT628760	hsa-miR-4670-3p	HITS-CLIP	23824327
MIRT628759	hsa-miR-567	HITS-CLIP	23824327
MIRT628758	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT628757	hsa-miR-2117	HITS-CLIP	23824327
MIRT628756	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT628755	hsa-miR-297	HITS-CLIP	23824327
MIRT628754	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT628753	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT628758	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT628755	hsa-miR-297	HITS-CLIP	27418678
MIRT710678	hsa-miR-511-3p	HITS-CLIP	27418678
MIRT628759	hsa-miR-567	HITS-CLIP	27418678
MIRT628761	hsa-miR-6817-3p	HITS-CLIP	27418678
MIRT628756	hsa-miR-6873-3p	HITS-CLIP	27418678
MIRT628762	hsa-miR-7110-3p	HITS-CLIP	27418678
MIRT628763	hsa-miR-148a-5p	HITS-CLIP	19536157
MIRT710678	hsa-miR-511-3p	HITS-CLIP	19536157
MIRT628762	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT628761	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT628759	hsa-miR-567	HITS-CLIP	19536157
MIRT628758	hsa-miR-223-5p	HITS-CLIP	19536157
MIRT628757	hsa-miR-2117	HITS-CLIP	19536157
MIRT628756	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT628755	hsa-miR-297	HITS-CLIP	19536157
MIRT628754	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT628753	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT628763	hsa-miR-148a-5p	HITS-CLIP	23824327
MIRT628762	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT628761	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT628760	hsa-miR-4670-3p	HITS-CLIP	23824327
MIRT628759	hsa-miR-567	HITS-CLIP	23824327
MIRT628758	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT628757	hsa-miR-2117	HITS-CLIP	23824327
MIRT628756	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT628755	hsa-miR-297	HITS-CLIP	23824327
MIRT633708	hsa-miR-3611	HITS-CLIP	23824327
MIRT628754	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT628753	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT628763	hsa-miR-148a-5p	HITS-CLIP	23824327
MIRT628762	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT628761	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT628760	hsa-miR-4670-3p	HITS-CLIP	23824327
MIRT628759	hsa-miR-567	HITS-CLIP	23824327
MIRT628758	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT628757	hsa-miR-2117	HITS-CLIP	23824327
MIRT628756	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT628755	hsa-miR-297	HITS-CLIP	23824327
MIRT633708	hsa-miR-3611	HITS-CLIP	23824327
MIRT628754	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT628753	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT628763	hsa-miR-148a-5p	HITS-CLIP	23824327
MIRT628762	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT628761	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT628760	hsa-miR-4670-3p	HITS-CLIP	23824327
MIRT628759	hsa-miR-567	HITS-CLIP	23824327
MIRT628758	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT628757	hsa-miR-2117	HITS-CLIP	23824327
MIRT628756	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT628755	hsa-miR-297	HITS-CLIP	23824327
MIRT628754	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT628753	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT1166697	hsa-miR-140-3p	CLIP-seq
MIRT1166698	hsa-miR-185	CLIP-seq
MIRT1166699	hsa-miR-188-5p	CLIP-seq
MIRT1166700	hsa-miR-3169	CLIP-seq
MIRT1166701	hsa-miR-4306	CLIP-seq
MIRT1166702	hsa-miR-4477a	CLIP-seq
MIRT1166703	hsa-miR-4503	CLIP-seq
MIRT1166704	hsa-miR-4515	CLIP-seq
MIRT1166705	hsa-miR-4644	CLIP-seq
MIRT1166706	hsa-miR-4729	CLIP-seq
MIRT1166707	hsa-miR-521	CLIP-seq
MIRT1166708	hsa-miR-570	CLIP-seq
MIRT1166709	hsa-miR-711	CLIP-seq
MIRT1166710	hsa-miR-935	CLIP-seq
MIRT2048209	hsa-miR-1243	CLIP-seq
MIRT2048210	hsa-miR-132	CLIP-seq
MIRT2048211	hsa-miR-212	CLIP-seq
MIRT2048212	hsa-miR-3622b-5p	CLIP-seq
MIRT2048213	hsa-miR-4252	CLIP-seq
MIRT2048214	hsa-miR-4475	CLIP-seq
MIRT2048215	hsa-miR-4701-5p	CLIP-seq
MIRT2048216	hsa-miR-4704-3p	CLIP-seq
MIRT2048217	hsa-miR-4747-5p	CLIP-seq
MIRT2048218	hsa-miR-4766-5p	CLIP-seq
MIRT2048219	hsa-miR-488	CLIP-seq
MIRT2048220	hsa-miR-588	CLIP-seq
MIRT2277096	hsa-miR-4261	CLIP-seq
MIRT2575888	hsa-miR-1205	CLIP-seq
MIRT2575889	hsa-miR-1273f	CLIP-seq
MIRT2575890	hsa-miR-1286	CLIP-seq
MIRT2575891	hsa-miR-1298	CLIP-seq
MIRT1166697	hsa-miR-140-3p	CLIP-seq
MIRT2575892	hsa-miR-143	CLIP-seq
MIRT2575893	hsa-miR-1911	CLIP-seq
MIRT2575894	hsa-miR-1912	CLIP-seq
MIRT2575895	hsa-miR-298	CLIP-seq
MIRT2575896	hsa-miR-3127-3p	CLIP-seq
MIRT2575897	hsa-miR-3130-3p	CLIP-seq
MIRT2575898	hsa-miR-3202	CLIP-seq
MIRT2575899	hsa-miR-326	CLIP-seq
MIRT2575900	hsa-miR-328	CLIP-seq
MIRT2575901	hsa-miR-330-3p	CLIP-seq
MIRT2575902	hsa-miR-330-5p	CLIP-seq
MIRT2575903	hsa-miR-3654	CLIP-seq
MIRT2575904	hsa-miR-3665	CLIP-seq
MIRT2575905	hsa-miR-3679-3p	CLIP-seq
MIRT2575906	hsa-miR-3941	CLIP-seq
MIRT2575907	hsa-miR-3944-5p	CLIP-seq
MIRT2575908	hsa-miR-4271	CLIP-seq
MIRT2575909	hsa-miR-4276	CLIP-seq
MIRT2575910	hsa-miR-4278	CLIP-seq
MIRT2575911	hsa-miR-4463	CLIP-seq
MIRT1166702	hsa-miR-4477a	CLIP-seq
MIRT1166703	hsa-miR-4503	CLIP-seq
MIRT2575912	hsa-miR-4638-3p	CLIP-seq
MIRT2575913	hsa-miR-466	CLIP-seq
MIRT2575914	hsa-miR-4667-5p	CLIP-seq
MIRT2575915	hsa-miR-4672	CLIP-seq
MIRT2575916	hsa-miR-4700-5p	CLIP-seq
MIRT2575917	hsa-miR-4708-5p	CLIP-seq
MIRT2575918	hsa-miR-4716-3p	CLIP-seq
MIRT2575919	hsa-miR-4722-5p	CLIP-seq
MIRT2575920	hsa-miR-4725-3p	CLIP-seq
MIRT1166706	hsa-miR-4729	CLIP-seq
MIRT2048217	hsa-miR-4747-5p	CLIP-seq
MIRT2575921	hsa-miR-4768-3p	CLIP-seq
MIRT2575922	hsa-miR-4770	CLIP-seq
MIRT2575923	hsa-miR-4793-5p	CLIP-seq
MIRT1166707	hsa-miR-521	CLIP-seq
MIRT2575924	hsa-miR-542-3p	CLIP-seq
MIRT1166708	hsa-miR-570	CLIP-seq
MIRT2575925	hsa-miR-615-5p	CLIP-seq
MIRT2575926	hsa-miR-616	CLIP-seq
MIRT2575927	hsa-miR-625	CLIP-seq
MIRT2575928	hsa-miR-637	CLIP-seq
MIRT2575929	hsa-miR-643	CLIP-seq
MIRT2575930	hsa-miR-657	CLIP-seq
MIRT2575931	hsa-miR-764	CLIP-seq
MIRT1166710	hsa-miR-935	CLIP-seq
MIRT2575888	hsa-miR-1205	CLIP-seq
MIRT2575889	hsa-miR-1273f	CLIP-seq
MIRT2575890	hsa-miR-1286	CLIP-seq
MIRT2575891	hsa-miR-1298	CLIP-seq
MIRT1166697	hsa-miR-140-3p	CLIP-seq
MIRT2575892	hsa-miR-143	CLIP-seq
MIRT2575893	hsa-miR-1911	CLIP-seq
MIRT2575894	hsa-miR-1912	CLIP-seq
MIRT2575895	hsa-miR-298	CLIP-seq
MIRT2575896	hsa-miR-3127-3p	CLIP-seq
MIRT2575897	hsa-miR-3130-3p	CLIP-seq
MIRT2575898	hsa-miR-3202	CLIP-seq
MIRT2575899	hsa-miR-326	CLIP-seq
MIRT2575900	hsa-miR-328	CLIP-seq
MIRT2575901	hsa-miR-330-3p	CLIP-seq
MIRT2575902	hsa-miR-330-5p	CLIP-seq
MIRT2575903	hsa-miR-3654	CLIP-seq
MIRT2575904	hsa-miR-3665	CLIP-seq
MIRT2575905	hsa-miR-3679-3p	CLIP-seq
MIRT2575906	hsa-miR-3941	CLIP-seq
MIRT2575907	hsa-miR-3944-5p	CLIP-seq
MIRT2575908	hsa-miR-4271	CLIP-seq
MIRT2575909	hsa-miR-4276	CLIP-seq
MIRT2575910	hsa-miR-4278	CLIP-seq
MIRT2575911	hsa-miR-4463	CLIP-seq
MIRT1166702	hsa-miR-4477a	CLIP-seq
MIRT1166703	hsa-miR-4503	CLIP-seq
MIRT2575912	hsa-miR-4638-3p	CLIP-seq
MIRT2575913	hsa-miR-466	CLIP-seq
MIRT2575914	hsa-miR-4667-5p	CLIP-seq
MIRT2575915	hsa-miR-4672	CLIP-seq
MIRT2575916	hsa-miR-4700-5p	CLIP-seq
MIRT2575917	hsa-miR-4708-5p	CLIP-seq
MIRT2575918	hsa-miR-4716-3p	CLIP-seq
MIRT2575919	hsa-miR-4722-5p	CLIP-seq
MIRT2575920	hsa-miR-4725-3p	CLIP-seq
MIRT1166706	hsa-miR-4729	CLIP-seq
MIRT2048217	hsa-miR-4747-5p	CLIP-seq
MIRT2575921	hsa-miR-4768-3p	CLIP-seq
MIRT2575922	hsa-miR-4770	CLIP-seq
MIRT2575923	hsa-miR-4793-5p	CLIP-seq
MIRT1166707	hsa-miR-521	CLIP-seq
MIRT2575924	hsa-miR-542-3p	CLIP-seq
MIRT1166708	hsa-miR-570	CLIP-seq
MIRT2575925	hsa-miR-615-5p	CLIP-seq
MIRT2575926	hsa-miR-616	CLIP-seq
MIRT2575927	hsa-miR-625	CLIP-seq
MIRT2575928	hsa-miR-637	CLIP-seq
MIRT2575929	hsa-miR-643	CLIP-seq
MIRT2575930	hsa-miR-657	CLIP-seq
MIRT2575931	hsa-miR-764	CLIP-seq
MIRT1166710	hsa-miR-935	CLIP-seq

Show/Hide all (35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0002376	Process	Immune system process	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IEA
GO:0003924	Function	GTPase activity	TAS	8798556
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005525	Function	GTP binding	IEA
GO:0005525	Function	GTP binding	IMP	15184662
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	8798556
GO:0005635	Component	Nuclear envelope	IEA
GO:0005643	Component	Nuclear pore	IDA	15184662
GO:0005643	Component	Nuclear pore	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	8798556
GO:0005829	Component	Cytosol	TAS
GO:0005874	Component	Microtubule	IBA
GO:0005886	Component	Plasma membrane	IBA
GO:0006952	Process	Defense response	TAS	8798556
GO:0008017	Function	Microtubule binding	IBA
GO:0009615	Process	Response to virus	IDA	24048477
GO:0015031	Process	Protein transport	IEA
GO:0016185	Process	Synaptic vesicle budding from presynaptic endocytic zone membrane	IBA
GO:0035455	Process	Response to interferon-alpha	IDA	24121441
GO:0045087	Process	Innate immune response	IEA
GO:0045202	Component	Synapse	IBA
GO:0046822	Process	Regulation of nucleocytoplasmic transport	IMP	15184662
GO:0051028	Process	MRNA transport	IEA
GO:0051607	Process	Defense response to virus	IBA
GO:0051607	Process	Defense response to virus	IEA
GO:0051607	Process	Defense response to virus	IMP	24121441
GO:0051726	Process	Regulation of cell cycle	IMP	15184662
GO:0098793	Component	Presynapse	IEA

MIM	HGNC	e!Ensembl
147890	7533	ENSG00000183486

P20592

Protein name

Interferon-induced GTP-binding protein Mx2 (Interferon-regulated resistance GTP-binding protein MxB) (Myxovirus resistance protein 2) (p78-related protein)

Protein function

Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and th

PDB

4WHJ , 4X0R , 5UOT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00350	Dynamin_N	121 → 296	Dynamin family	Domain
PF01031	Dynamin_M	307 → 594	Dynamin central region	Family
PF02212	GED	618 → 709	Dynamin GTPase effector domain	Family

Sequence

MSKAHKPWPYRRRSQFSSRKYLKKEMNSFQQQPPPFGTVPPQMMFPPNWQGAEKDAAFLA
KDFNFLTLNNQPPPGNRSQPRAMGPENNLYSQYEQKVRPCIDLIDSLRALGVEQDLALPA
IAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKQPCEAWAGRISYRNTELEL
QDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAVDNQPRD
IGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILTKPDLMD
RGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAEATKKEITFFQTHPYFRVLL
EEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQKATEELRRCGADIPSQEADKMF
FLIEKIKMFNQDIEKLVEGEEVVRENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEV
EKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPALSMLQKAMEIIQQAFINVAKKHFG
EFFNLNQTVQSTIEDIKVKHTAKAENMIQLQFRMEQMVFCQDQIYSVVLKKVREEIFNPL
GTPSQNMKLNSHFPSNESSVSSFTEIGIHLNAYFLETSKRLANQIPFIIQYFMLRENGDS
LQKAMMQILQEKNRYSWLLQEQSETATKRRILKERIYRLTQARHALCQFSSKEIH

Sequence length

715

Interactions

View interactions

	KEGG		Reactome
	Viral life cycle - HIV-1 Hepatitis C Measles Influenza A Human papillomavirus infection Coronavirus disease - COVID-19		ISG15 antiviral mechanism Interferon alpha/beta signaling

MX2 (MX dynamin like GTPase 2)