Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	460
Gene name	Astrotactin 1
Gene symbol	ASTN1
Synonyms (NCBI Gene)	ASTN
Chromosome	1
Chromosome location	1q25.2
Summary	Astrotactin is a neuronal adhesion molecule required for glial-guided migration of young postmitotic neuroblasts in cortical regions of developing brain, including cerebrum, hippocampus, cerebellum, and olfactory bulb (Fink et al., 1995).[supplied by OMIM

Show/Hide all (1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs138686233	C>G,T	Likely-pathogenic	Non coding transcript variant, missense variant, coding sequence variant

174

Show/Hide all (174)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019216	hsa-miR-335-5p	Microarray	18185580
MIRT446124	hsa-miR-4324	PAR-CLIP	22100165
MIRT446123	hsa-miR-544b	PAR-CLIP	22100165
MIRT446122	hsa-miR-3928-3p	PAR-CLIP	22100165
MIRT446121	hsa-miR-6804-5p	PAR-CLIP	22100165
MIRT446120	hsa-miR-516a-3p	PAR-CLIP	22100165
MIRT446119	hsa-miR-516b-3p	PAR-CLIP	22100165
MIRT446117	hsa-miR-7162-5p	PAR-CLIP	22100165
MIRT446118	hsa-miR-378a-5p	PAR-CLIP	22100165
MIRT446116	hsa-miR-1200	PAR-CLIP	22100165
MIRT446115	hsa-miR-3915	PAR-CLIP	22100165
MIRT446114	hsa-miR-6834-5p	PAR-CLIP	22100165
MIRT446113	hsa-miR-1226-5p	PAR-CLIP	22100165
MIRT446112	hsa-miR-6734-5p	PAR-CLIP	22100165
MIRT446111	hsa-miR-1273e	PAR-CLIP	22100165
MIRT446124	hsa-miR-4324	PAR-CLIP	22100165
MIRT446123	hsa-miR-544b	PAR-CLIP	22100165
MIRT446122	hsa-miR-3928-3p	PAR-CLIP	22100165
MIRT446121	hsa-miR-6804-5p	PAR-CLIP	22100165
MIRT446120	hsa-miR-516a-3p	PAR-CLIP	22100165
MIRT446119	hsa-miR-516b-3p	PAR-CLIP	22100165
MIRT446117	hsa-miR-7162-5p	PAR-CLIP	22100165
MIRT446118	hsa-miR-378a-5p	PAR-CLIP	22100165
MIRT446116	hsa-miR-1200	PAR-CLIP	22100165
MIRT446115	hsa-miR-3915	PAR-CLIP	22100165
MIRT446114	hsa-miR-6834-5p	PAR-CLIP	22100165
MIRT446113	hsa-miR-1226-5p	PAR-CLIP	22100165
MIRT446112	hsa-miR-6734-5p	PAR-CLIP	22100165
MIRT446111	hsa-miR-1273e	PAR-CLIP	22100165
MIRT446124	hsa-miR-4324	PAR-CLIP	22100165
MIRT446123	hsa-miR-544b	PAR-CLIP	22100165
MIRT446122	hsa-miR-3928-3p	PAR-CLIP	22100165
MIRT446121	hsa-miR-6804-5p	PAR-CLIP	22100165
MIRT446120	hsa-miR-516a-3p	PAR-CLIP	22100165
MIRT446119	hsa-miR-516b-3p	PAR-CLIP	22100165
MIRT446117	hsa-miR-7162-5p	PAR-CLIP	22100165
MIRT446118	hsa-miR-378a-5p	PAR-CLIP	22100165
MIRT446116	hsa-miR-1200	PAR-CLIP	22100165
MIRT446115	hsa-miR-3915	PAR-CLIP	22100165
MIRT446114	hsa-miR-6834-5p	PAR-CLIP	22100165
MIRT446113	hsa-miR-1226-5p	PAR-CLIP	22100165
MIRT446112	hsa-miR-6734-5p	PAR-CLIP	22100165
MIRT446111	hsa-miR-1273e	PAR-CLIP	22100165
MIRT446124	hsa-miR-4324	PAR-CLIP	22100165
MIRT446123	hsa-miR-544b	PAR-CLIP	22100165
MIRT446122	hsa-miR-3928-3p	PAR-CLIP	22100165
MIRT446121	hsa-miR-6804-5p	PAR-CLIP	22100165
MIRT446120	hsa-miR-516a-3p	PAR-CLIP	22100165
MIRT446119	hsa-miR-516b-3p	PAR-CLIP	22100165
MIRT446117	hsa-miR-7162-5p	PAR-CLIP	22100165
MIRT446118	hsa-miR-378a-5p	PAR-CLIP	22100165
MIRT446116	hsa-miR-1200	PAR-CLIP	22100165
MIRT446115	hsa-miR-3915	PAR-CLIP	22100165
MIRT446114	hsa-miR-6834-5p	PAR-CLIP	22100165
MIRT446113	hsa-miR-1226-5p	PAR-CLIP	22100165
MIRT446112	hsa-miR-6734-5p	PAR-CLIP	22100165
MIRT446111	hsa-miR-1273e	PAR-CLIP	22100165
MIRT803251	hsa-miR-1184	CLIP-seq
MIRT803252	hsa-miR-1205	CLIP-seq
MIRT803253	hsa-miR-129-5p	CLIP-seq
MIRT803254	hsa-miR-1302	CLIP-seq
MIRT803255	hsa-miR-150	CLIP-seq
MIRT803256	hsa-miR-1909	CLIP-seq
MIRT803257	hsa-miR-1915	CLIP-seq
MIRT803258	hsa-miR-2113	CLIP-seq
MIRT803259	hsa-miR-25	CLIP-seq
MIRT803260	hsa-miR-3064-3p	CLIP-seq
MIRT803261	hsa-miR-3150a-3p	CLIP-seq
MIRT803262	hsa-miR-3158-5p	CLIP-seq
MIRT803263	hsa-miR-3175	CLIP-seq
MIRT803264	hsa-miR-32	CLIP-seq
MIRT803265	hsa-miR-3529	CLIP-seq
MIRT803266	hsa-miR-363	CLIP-seq
MIRT803267	hsa-miR-367	CLIP-seq
MIRT803268	hsa-miR-379	CLIP-seq
MIRT803269	hsa-miR-3927	CLIP-seq
MIRT803270	hsa-miR-4270	CLIP-seq
MIRT803271	hsa-miR-4275	CLIP-seq
MIRT803272	hsa-miR-4298	CLIP-seq
MIRT803273	hsa-miR-4434	CLIP-seq
MIRT803274	hsa-miR-4441	CLIP-seq
MIRT803275	hsa-miR-4474-5p	CLIP-seq
MIRT803276	hsa-miR-4516	CLIP-seq
MIRT803277	hsa-miR-4531	CLIP-seq
MIRT803278	hsa-miR-4534	CLIP-seq
MIRT803279	hsa-miR-4648	CLIP-seq
MIRT803280	hsa-miR-4713-5p	CLIP-seq
MIRT803281	hsa-miR-4715-3p	CLIP-seq
MIRT803282	hsa-miR-4724-5p	CLIP-seq
MIRT803283	hsa-miR-4726-3p	CLIP-seq
MIRT803284	hsa-miR-4762-3p	CLIP-seq
MIRT803285	hsa-miR-4776-3p	CLIP-seq
MIRT803286	hsa-miR-487a	CLIP-seq
MIRT803287	hsa-miR-532-3p	CLIP-seq
MIRT803288	hsa-miR-544	CLIP-seq
MIRT803289	hsa-miR-548n	CLIP-seq
MIRT803290	hsa-miR-548t	CLIP-seq
MIRT803291	hsa-miR-552	CLIP-seq
MIRT803292	hsa-miR-633	CLIP-seq
MIRT803293	hsa-miR-758	CLIP-seq
MIRT803294	hsa-miR-92a	CLIP-seq
MIRT803295	hsa-miR-92b	CLIP-seq
MIRT803296	hsa-miR-939	CLIP-seq
MIRT1937226	hsa-miR-106a	CLIP-seq
MIRT1937227	hsa-miR-106b	CLIP-seq
MIRT803254	hsa-miR-1302	CLIP-seq
MIRT1937228	hsa-miR-1304	CLIP-seq
MIRT1937229	hsa-miR-17	CLIP-seq
MIRT1937230	hsa-miR-1827	CLIP-seq
MIRT1937231	hsa-miR-20a	CLIP-seq
MIRT1937232	hsa-miR-20b	CLIP-seq
MIRT1937233	hsa-miR-28-5p	CLIP-seq
MIRT1937234	hsa-miR-3120-3p	CLIP-seq
MIRT1937235	hsa-miR-3139	CLIP-seq
MIRT1937236	hsa-miR-3151	CLIP-seq
MIRT1937237	hsa-miR-3609	CLIP-seq
MIRT803272	hsa-miR-4298	CLIP-seq
MIRT803279	hsa-miR-4648	CLIP-seq
MIRT1937238	hsa-miR-4667-3p	CLIP-seq
MIRT1937239	hsa-miR-4796-3p	CLIP-seq
MIRT1937240	hsa-miR-519d	CLIP-seq
MIRT803288	hsa-miR-544	CLIP-seq
MIRT1937241	hsa-miR-548ah	CLIP-seq
MIRT803291	hsa-miR-552	CLIP-seq
MIRT1937242	hsa-miR-562	CLIP-seq
MIRT1937243	hsa-miR-708	CLIP-seq
MIRT1937244	hsa-miR-93	CLIP-seq
MIRT803251	hsa-miR-1184	CLIP-seq
MIRT803252	hsa-miR-1205	CLIP-seq
MIRT2176885	hsa-miR-147	CLIP-seq
MIRT2176886	hsa-miR-181a	CLIP-seq
MIRT2176887	hsa-miR-181b	CLIP-seq
MIRT2176888	hsa-miR-181c	CLIP-seq
MIRT2176889	hsa-miR-181d	CLIP-seq
MIRT1937234	hsa-miR-3120-3p	CLIP-seq
MIRT2176890	hsa-miR-3125	CLIP-seq
MIRT803261	hsa-miR-3150a-3p	CLIP-seq
MIRT803262	hsa-miR-3158-5p	CLIP-seq
MIRT2176891	hsa-miR-33a	CLIP-seq
MIRT2176892	hsa-miR-33b	CLIP-seq
MIRT2176893	hsa-miR-371-5p	CLIP-seq
MIRT2176894	hsa-miR-371b-5p	CLIP-seq
MIRT2176895	hsa-miR-3916	CLIP-seq
MIRT2176896	hsa-miR-3918	CLIP-seq
MIRT2176897	hsa-miR-4257	CLIP-seq
MIRT2176898	hsa-miR-4262	CLIP-seq
MIRT2176899	hsa-miR-4289	CLIP-seq
MIRT2176900	hsa-miR-4468	CLIP-seq
MIRT2176901	hsa-miR-4677-3p	CLIP-seq
MIRT2176902	hsa-miR-4679	CLIP-seq
MIRT2176903	hsa-miR-508-5p	CLIP-seq
MIRT2176904	hsa-miR-520a-5p	CLIP-seq
MIRT2176905	hsa-miR-525-5p	CLIP-seq
MIRT803288	hsa-miR-544	CLIP-seq
MIRT2176906	hsa-miR-593	CLIP-seq
MIRT2384536	hsa-miR-4436b-5p	CLIP-seq
MIRT2444130	hsa-miR-1470	CLIP-seq
MIRT2444131	hsa-miR-1912	CLIP-seq
MIRT2444132	hsa-miR-3134	CLIP-seq
MIRT1937236	hsa-miR-3151	CLIP-seq
MIRT2444133	hsa-miR-4447	CLIP-seq
MIRT2444134	hsa-miR-4472	CLIP-seq
MIRT1937238	hsa-miR-4667-3p	CLIP-seq
MIRT2444135	hsa-miR-491-5p	CLIP-seq
MIRT2444136	hsa-miR-548ag	CLIP-seq
MIRT2444137	hsa-miR-548ai	CLIP-seq
MIRT2444130	hsa-miR-1470	CLIP-seq
MIRT2444131	hsa-miR-1912	CLIP-seq
MIRT2444132	hsa-miR-3134	CLIP-seq
MIRT1937238	hsa-miR-4667-3p	CLIP-seq
MIRT2444130	hsa-miR-1470	CLIP-seq
MIRT2444131	hsa-miR-1912	CLIP-seq
MIRT2444132	hsa-miR-3134	CLIP-seq
MIRT1937238	hsa-miR-4667-3p	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001764	Process	Neuron migration	IBA
GO:0001764	Process	Neuron migration	IEA
GO:0001764	Process	Neuron migration	IEA
GO:0005515	Function	Protein binding	IPI	31169361, 32296183
GO:0005768	Component	Endosome	IBA
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0007158	Process	Neuron cell-cell adhesion	IBA
GO:0007158	Process	Neuron cell-cell adhesion	IEA
GO:0007626	Process	Locomotory behavior	IEA
GO:0009897	Component	External side of plasma membrane	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0016477	Process	Cell migration	IEA
GO:0030136	Component	Clathrin-coated vesicle	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0098609	Process	Cell-cell adhesion	IEA

MIM	HGNC	e!Ensembl
600904	773	ENSG00000152092

O14525

Protein name

Astrotactin-1

Protein function

Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal ce

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14670	FXa_inhibition	660 → 707		Domain
PF18411	Annexin_like	1153 → 1245	Annexin-like domain	Domain

Sequence

MALAGLCALLACCWGPAAVLATAAGDVDPSKELECKLKSITVSALPFLRENDLSIMHSPS
ASEPKLLFSVRNDFPGEMVVVDDLENTELPYFVLEISGNTEDIPLVRWRQQWLENGTLLF
HIHHQDGAPSLPGQDPTEEPQHESAEEELRILHISVMGGMIALLLSILCLVMILYTRRRW
CKRRRVPQPQKSASAEAANEIHYIPSVLIGGHGRESLRNARVQGHNSSGTLSIRETPILD
GYEYDITDLRHHLQRECMNGGEDFASQVTRTLDSLQGCNEKSGMDLTPGSDNAKLSLMNK
YKDNIIATSPVDSNHQQATLLSHTSSSQRKRINNKARAGSAFLNPEGDSGTEAENDPQLT
FYTDPSRSRRRSRVGSPRSPVNKTTLTLISITSCVIGLVCSSHVNCPLVVKITLHVPEHL
IADGSRFILLEGSQLDASDWLNPAQVVLFSQQNSSGPWAMDLCARRLLDPCEHQCDPETG
RREHRAAGECLCYEGYMKDPVHKHLCIRNEWGTNQGPWPYTIFQRGFDLVLGEQPSDKIF
RFTYTLGEGMWLPLSKSFVIPPAELAINPSAKCKTDMTVMEDAVEVREELMTSSSFDSLE
VLLDSFGPVRDCSKDNGGCSKNFRCISDRKLDSTGCVCPSGLSPMKDSSGCYDRHIGVDC
SDGFNGGCEQLCLQQMAPFPDDPTLYNILMFCGCIEDYKLGVDGRSCQLITETCPEGSDC
GESRELPMNQTLFGEMFFGYNNHSKEVAAGQVLKGTFRQNNFARGLDQQLPDGLVVATVP
LENQCLEEISEPTPDPDFLTGMVNFSEVSGYPVLQHWKVRSVMYHIKLNQVAISQALSNA
LHSLDGATSRADFVALLDQFGNHYIQEAIYGFEESCSIWYPNKQVQRRLWLEYEDISKGN
SPSDESEERERDPKVLTFPEYITSLSDSGTKHMAAGVRMECHSKGRCPSSCPLCHVTSSP
DTPAEPVLLEVTKAAPIYELVTNNQTQRLLQEATMSSLWCSGTGDVIEDWCRCDSTAFGA
DGLPTCAPLPQPVLRLSTVHEPSSTLVVLEWEHSEPPIGVQIVDYLLRQEKVTDRMDHSK
VETETVLSFVDDIISGAKSPCAMPSQVPDKQLTTISLIIRCLEPDTIYMFTLWGVDNTGR
RSRPSDVIVKTPCPVVDDVKAQEIADKIYNLFNGYTSGKEQQTAYNTLLDLGSPTLHRVL
YHYNQHYESFGEFTWRCEDELGPRKAGLILSQLGDLSSWCNGLLQEPKISLRRSSLKYLG
CRYSEIKPYGLDWAELSRDLRKTCEEQTLSIPYNDYGDSKEI

Sequence length

1302

Interactions

View interactions

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Abnormal brain morphology	Likely pathogenic	rs138686233	RCV000454328

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Abnormal corpus callosum morphology	Conflicting classifications of pathogenicity; Uncertain significance	rs151246825, rs759502995	RCV000656102 RCV000656103
ASTN1-related disorder	Likely benign	rs61756323, rs148482637	RCV003929010 RCV003981503
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs752367629	RCV004557869

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alcoholism	Associate	22488871
Bipolar Disorder	Associate	22488871
Carcinoma Hepatocellular	Inhibit	32945491
Macular dystrophy corneal type 1	Associate	29706646
Neoplasms	Inhibit	32945491, 36803573
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	27650541
Schimke immunoosseous dysplasia	Associate	25849153
Schizophrenia	Associate	22488871
Small Cell Lung Carcinoma	Associate	25863124
Substance Related Disorders	Associate	22488871
Uterine Cervical Neoplasms	Associate	36803573

ASTN1 (astrotactin 1)