Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	4599
Gene name	MX dynamin like GTPase 1
Gene symbol	MX1
Synonyms (NCBI Gene)	IFI-78KIFI78MXMxAlncMX1-215
Chromosome	21
Chromosome location	21q22.3
Summary	This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA a

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miRTarBase ID	miRNA	Experiments	Reference
MIRT734368	hsa-miR-221-3p	ELISALuciferase reporter assayRNA-seqWestern blotting	32209695
MIRT734369	hsa-miR-125b-5p	ELISALuciferase reporter assayRNA-seqWestern blotting	32209695
MIRT2575804	hsa-miR-1292	CLIP-seq
MIRT2575805	hsa-miR-1324	CLIP-seq
MIRT2575806	hsa-miR-141	CLIP-seq
MIRT2575807	hsa-miR-1825	CLIP-seq
MIRT2575808	hsa-miR-188-5p	CLIP-seq
MIRT2575809	hsa-miR-191	CLIP-seq
MIRT2575810	hsa-miR-1910	CLIP-seq
MIRT2575811	hsa-miR-197	CLIP-seq
MIRT2575812	hsa-miR-199a-5p	CLIP-seq
MIRT2575813	hsa-miR-199b-5p	CLIP-seq
MIRT2575814	hsa-miR-200a	CLIP-seq
MIRT2575815	hsa-miR-204	CLIP-seq
MIRT2575816	hsa-miR-205	CLIP-seq
MIRT2575817	hsa-miR-210	CLIP-seq
MIRT2575818	hsa-miR-211	CLIP-seq
MIRT2575819	hsa-miR-223	CLIP-seq
MIRT2575820	hsa-miR-2276	CLIP-seq
MIRT2575821	hsa-miR-3074-5p	CLIP-seq
MIRT2575822	hsa-miR-3120-5p	CLIP-seq
MIRT2575823	hsa-miR-3146	CLIP-seq
MIRT2575824	hsa-miR-3151	CLIP-seq
MIRT2575825	hsa-miR-3154	CLIP-seq
MIRT2575826	hsa-miR-3163	CLIP-seq
MIRT2575827	hsa-miR-3166	CLIP-seq
MIRT2575828	hsa-miR-3175	CLIP-seq
MIRT2575829	hsa-miR-3179	CLIP-seq
MIRT2575830	hsa-miR-3200-5p	CLIP-seq
MIRT2575831	hsa-miR-320e	CLIP-seq
MIRT2575832	hsa-miR-340	CLIP-seq
MIRT2575833	hsa-miR-342-3p	CLIP-seq
MIRT2575834	hsa-miR-345	CLIP-seq
MIRT2575835	hsa-miR-3607-5p	CLIP-seq
MIRT2575836	hsa-miR-3611	CLIP-seq
MIRT2575837	hsa-miR-3616-3p	CLIP-seq
MIRT2575838	hsa-miR-3647-3p	CLIP-seq
MIRT2575839	hsa-miR-3662	CLIP-seq
MIRT2575840	hsa-miR-3663-3p	CLIP-seq
MIRT2575841	hsa-miR-370	CLIP-seq
MIRT2575842	hsa-miR-3915	CLIP-seq
MIRT2575843	hsa-miR-3919	CLIP-seq
MIRT2575844	hsa-miR-3928	CLIP-seq
MIRT2575845	hsa-miR-4258	CLIP-seq
MIRT2575846	hsa-miR-4267	CLIP-seq
MIRT2575847	hsa-miR-4268	CLIP-seq
MIRT2575848	hsa-miR-4283	CLIP-seq
MIRT2575849	hsa-miR-4291	CLIP-seq
MIRT2575850	hsa-miR-4302	CLIP-seq
MIRT2575851	hsa-miR-4303	CLIP-seq
MIRT2575852	hsa-miR-4310	CLIP-seq
MIRT2575853	hsa-miR-4328	CLIP-seq
MIRT2575854	hsa-miR-4446-3p	CLIP-seq
MIRT2575855	hsa-miR-4448	CLIP-seq
MIRT2575856	hsa-miR-4475	CLIP-seq
MIRT2575857	hsa-miR-4489	CLIP-seq
MIRT2575858	hsa-miR-4492	CLIP-seq
MIRT2575859	hsa-miR-4498	CLIP-seq
MIRT2575860	hsa-miR-4508	CLIP-seq
MIRT2575861	hsa-miR-4528	CLIP-seq
MIRT2575862	hsa-miR-455-3p	CLIP-seq
MIRT2575863	hsa-miR-4649-3p	CLIP-seq
MIRT2575864	hsa-miR-4656	CLIP-seq
MIRT2575865	hsa-miR-4668-3p	CLIP-seq
MIRT2575866	hsa-miR-4679	CLIP-seq
MIRT2575867	hsa-miR-4697-3p	CLIP-seq
MIRT2575868	hsa-miR-4708-3p	CLIP-seq
MIRT2575869	hsa-miR-4712-5p	CLIP-seq
MIRT2575870	hsa-miR-4721	CLIP-seq
MIRT2575871	hsa-miR-4761-5p	CLIP-seq
MIRT2575872	hsa-miR-4797-5p	CLIP-seq
MIRT2575873	hsa-miR-486-3p	CLIP-seq
MIRT2575874	hsa-miR-516a-3p	CLIP-seq
MIRT2575875	hsa-miR-548c-3p	CLIP-seq
MIRT2575876	hsa-miR-558	CLIP-seq
MIRT2575877	hsa-miR-592	CLIP-seq
MIRT2575878	hsa-miR-597	CLIP-seq
MIRT2575879	hsa-miR-605	CLIP-seq
MIRT2575880	hsa-miR-622	CLIP-seq
MIRT2575881	hsa-miR-629	CLIP-seq
MIRT2575882	hsa-miR-648	CLIP-seq
MIRT2575883	hsa-miR-758	CLIP-seq
MIRT2575884	hsa-miR-760	CLIP-seq
MIRT2575885	hsa-miR-762	CLIP-seq
MIRT2575886	hsa-miR-770-5p	CLIP-seq
MIRT2575887	hsa-miR-941	CLIP-seq
MIRT2575804	hsa-miR-1292	CLIP-seq
MIRT2575805	hsa-miR-1324	CLIP-seq
MIRT2575806	hsa-miR-141	CLIP-seq
MIRT2575807	hsa-miR-1825	CLIP-seq
MIRT2575808	hsa-miR-188-5p	CLIP-seq
MIRT2575809	hsa-miR-191	CLIP-seq
MIRT2575810	hsa-miR-1910	CLIP-seq
MIRT2575811	hsa-miR-197	CLIP-seq
MIRT2575812	hsa-miR-199a-5p	CLIP-seq
MIRT2575813	hsa-miR-199b-5p	CLIP-seq
MIRT2575814	hsa-miR-200a	CLIP-seq
MIRT2575815	hsa-miR-204	CLIP-seq
MIRT2575816	hsa-miR-205	CLIP-seq
MIRT2575817	hsa-miR-210	CLIP-seq
MIRT2575818	hsa-miR-211	CLIP-seq
MIRT2575819	hsa-miR-223	CLIP-seq
MIRT2575820	hsa-miR-2276	CLIP-seq
MIRT2575821	hsa-miR-3074-5p	CLIP-seq
MIRT2575822	hsa-miR-3120-5p	CLIP-seq
MIRT2575823	hsa-miR-3146	CLIP-seq
MIRT2575824	hsa-miR-3151	CLIP-seq
MIRT2575825	hsa-miR-3154	CLIP-seq
MIRT2575826	hsa-miR-3163	CLIP-seq
MIRT2575827	hsa-miR-3166	CLIP-seq
MIRT2575828	hsa-miR-3175	CLIP-seq
MIRT2575829	hsa-miR-3179	CLIP-seq
MIRT2575830	hsa-miR-3200-5p	CLIP-seq
MIRT2575831	hsa-miR-320e	CLIP-seq
MIRT2575832	hsa-miR-340	CLIP-seq
MIRT2575833	hsa-miR-342-3p	CLIP-seq
MIRT2575834	hsa-miR-345	CLIP-seq
MIRT2575835	hsa-miR-3607-5p	CLIP-seq
MIRT2575836	hsa-miR-3611	CLIP-seq
MIRT2575837	hsa-miR-3616-3p	CLIP-seq
MIRT2575838	hsa-miR-3647-3p	CLIP-seq
MIRT2685562	hsa-miR-3652	CLIP-seq
MIRT2575839	hsa-miR-3662	CLIP-seq
MIRT2575840	hsa-miR-3663-3p	CLIP-seq
MIRT2575841	hsa-miR-370	CLIP-seq
MIRT2575842	hsa-miR-3915	CLIP-seq
MIRT2575843	hsa-miR-3919	CLIP-seq
MIRT2575844	hsa-miR-3928	CLIP-seq
MIRT2575845	hsa-miR-4258	CLIP-seq
MIRT2575846	hsa-miR-4267	CLIP-seq
MIRT2575847	hsa-miR-4268	CLIP-seq
MIRT2575848	hsa-miR-4283	CLIP-seq
MIRT2575849	hsa-miR-4291	CLIP-seq
MIRT2575850	hsa-miR-4302	CLIP-seq
MIRT2575851	hsa-miR-4303	CLIP-seq
MIRT2575852	hsa-miR-4310	CLIP-seq
MIRT2575853	hsa-miR-4328	CLIP-seq
MIRT2685563	hsa-miR-4430	CLIP-seq
MIRT2575854	hsa-miR-4446-3p	CLIP-seq
MIRT2575855	hsa-miR-4448	CLIP-seq
MIRT2575856	hsa-miR-4475	CLIP-seq
MIRT2575857	hsa-miR-4489	CLIP-seq
MIRT2575858	hsa-miR-4492	CLIP-seq
MIRT2575859	hsa-miR-4498	CLIP-seq
MIRT2575860	hsa-miR-4508	CLIP-seq
MIRT2685564	hsa-miR-4520a-3p	CLIP-seq
MIRT2575861	hsa-miR-4528	CLIP-seq
MIRT2575862	hsa-miR-455-3p	CLIP-seq
MIRT2685565	hsa-miR-4638-3p	CLIP-seq
MIRT2575863	hsa-miR-4649-3p	CLIP-seq
MIRT2575864	hsa-miR-4656	CLIP-seq
MIRT2575865	hsa-miR-4668-3p	CLIP-seq
MIRT2575866	hsa-miR-4679	CLIP-seq
MIRT2575867	hsa-miR-4697-3p	CLIP-seq
MIRT2575868	hsa-miR-4708-3p	CLIP-seq
MIRT2575869	hsa-miR-4712-5p	CLIP-seq
MIRT2575870	hsa-miR-4721	CLIP-seq
MIRT2575871	hsa-miR-4761-5p	CLIP-seq
MIRT2575872	hsa-miR-4797-5p	CLIP-seq
MIRT2575873	hsa-miR-486-3p	CLIP-seq
MIRT2575874	hsa-miR-516a-3p	CLIP-seq
MIRT2575875	hsa-miR-548c-3p	CLIP-seq
MIRT2575876	hsa-miR-558	CLIP-seq
MIRT2575877	hsa-miR-592	CLIP-seq
MIRT2575878	hsa-miR-597	CLIP-seq
MIRT2575879	hsa-miR-605	CLIP-seq
MIRT2575880	hsa-miR-622	CLIP-seq
MIRT2575881	hsa-miR-629	CLIP-seq
MIRT2575882	hsa-miR-648	CLIP-seq
MIRT2575883	hsa-miR-758	CLIP-seq
MIRT2575884	hsa-miR-760	CLIP-seq
MIRT2575885	hsa-miR-762	CLIP-seq
MIRT2575886	hsa-miR-770-5p	CLIP-seq
MIRT2575887	hsa-miR-941	CLIP-seq

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Transcription factor	Regulation	Reference
CREB5	Activation	21132541

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0002376	Process	Immune system process	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IEA
GO:0005515	Function	Protein binding	IPI	15047845, 15757897, 21859714, 25416956, 28514442, 30833792, 32296183, 33961781
GO:0005525	Function	GTP binding	IEA
GO:0005525	Function	GTP binding	TAS	2154602
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005635	Component	Nuclear envelope	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	21859714
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	HDA	16780588
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005874	Component	Microtubule	IBA
GO:0005886	Component	Plasma membrane	IBA
GO:0006915	Process	Apoptotic process	TAS	9389754
GO:0006952	Process	Defense response	TAS	2154602
GO:0007165	Process	Signal transduction	TAS	9389754
GO:0008017	Function	Microtubule binding	IBA
GO:0009615	Process	Response to virus	IMP	15047845
GO:0016020	Component	Membrane	IEA
GO:0016185	Process	Synaptic vesicle budding from presynaptic endocytic zone membrane	IBA
GO:0031965	Component	Nuclear membrane	IDA
GO:0034340	Process	Response to type I interferon	TAS	21859714
GO:0042802	Function	Identical protein binding	IPI	20428112, 25295396, 25416956, 32296183
GO:0045071	Process	Negative regulation of viral genome replication	IDA	14687945, 15047845, 16202617
GO:0045087	Process	Innate immune response	IEA
GO:0045087	Process	Innate immune response	TAS	16202617
GO:0045202	Component	Synapse	IBA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	15047845
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051607	Process	Defense response to virus	IBA
GO:0051607	Process	Defense response to virus	IDA	21478870
GO:0051607	Process	Defense response to virus	IEA
GO:0070106	Process	Interleukin-27-mediated signaling pathway	IEP	32270034
GO:0098793	Component	Presynapse	IEA
GO:0140374	Process	Antiviral innate immune response	IEP	25930096

MIM	HGNC	e!Ensembl
147150	7532	ENSG00000157601

P20591

Protein name

Interferon-induced GTP-binding protein Mx1 (Interferon-induced protein p78) (IFI-78K) (Interferon-regulated resistance GTP-binding protein MxA) (Myxoma resistance protein 1) (Myxovirus resistance protein 1) [Cleaved into: Interferon-induced GTP-binding pr

Protein function

Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid.

PDB

3LJB , 3SZR , 3ZYS , 4P4S , 4P4T , 4P4U , 5GTM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00350	Dynamin_N	73 → 249	Dynamin family	Domain
PF01031	Dynamin_M	260 → 547	Dynamin central region	Family
PF02212	GED	569 → 660	Dynamin GTPase effector domain	Family

Sequence

MVVSEVDIAKADPAAASHPLLLNGDATVAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLR
ALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEDKW
RGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLP
GITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGD
RTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSEALQREK
IFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKY
GVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIEN
NFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMV
RLAFTDVSIKNFEEFFNLHRTAKSKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQVYRG
ALQKVREKELEEEKKKKSWDFGAFQSSSATDSSMEEIFQHLMAYHQEASKRISSHIPLII
QFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDTSDKRKFLKERLARLTQARRRLAQF
PG

Sequence length

662

Interactions

View interactions

	KEGG		Reactome
	Viral life cycle - HIV-1 Hepatitis C Measles Influenza A Human papillomavirus infection Coronavirus disease - COVID-19		ISG15 antiviral mechanism Interferon alpha/beta signaling

MX1 (MX dynamin like GTPase 1)