Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4588
Gene name	Mucin 6, oligomeric mucus/gel-forming (gene/pseudogene)
Gene symbol	MUC6
Synonyms (NCBI Gene)	MUC-6
Chromosome	11
Chromosome location	11p15.5
Summary	This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. [pr

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018331	hsa-miR-335-5p	Microarray	18185580
MIRT1166376	hsa-miR-125a-5p	CLIP-seq
MIRT1166377	hsa-miR-125b	CLIP-seq
MIRT1166378	hsa-miR-1285	CLIP-seq
MIRT1166379	hsa-miR-1913	CLIP-seq
MIRT1166380	hsa-miR-214	CLIP-seq
MIRT1166381	hsa-miR-296-5p	CLIP-seq
MIRT1166382	hsa-miR-3187-5p	CLIP-seq
MIRT1166383	hsa-miR-324-3p	CLIP-seq
MIRT1166384	hsa-miR-326	CLIP-seq
MIRT1166385	hsa-miR-330-5p	CLIP-seq
MIRT1166386	hsa-miR-345	CLIP-seq
MIRT1166387	hsa-miR-3619-5p	CLIP-seq
MIRT1166388	hsa-miR-378g	CLIP-seq
MIRT1166389	hsa-miR-4290	CLIP-seq
MIRT1166390	hsa-miR-4314	CLIP-seq
MIRT1166391	hsa-miR-4319	CLIP-seq
MIRT1166392	hsa-miR-4438	CLIP-seq
MIRT1166393	hsa-miR-4446-3p	CLIP-seq
MIRT1166394	hsa-miR-4450	CLIP-seq
MIRT1166395	hsa-miR-4455	CLIP-seq
MIRT1166396	hsa-miR-4486	CLIP-seq
MIRT1166397	hsa-miR-4492	CLIP-seq
MIRT1166398	hsa-miR-4498	CLIP-seq
MIRT1166399	hsa-miR-4505	CLIP-seq
MIRT1166400	hsa-miR-4522	CLIP-seq
MIRT1166401	hsa-miR-4530	CLIP-seq
MIRT1166402	hsa-miR-4667-5p	CLIP-seq
MIRT1166403	hsa-miR-4700-5p	CLIP-seq
MIRT1166404	hsa-miR-4731-5p	CLIP-seq
MIRT1166405	hsa-miR-4732-3p	CLIP-seq
MIRT1166406	hsa-miR-609	CLIP-seq
MIRT1166407	hsa-miR-612	CLIP-seq
MIRT1166408	hsa-miR-670	CLIP-seq
MIRT1166409	hsa-miR-761	CLIP-seq
MIRT1166410	hsa-miR-762	CLIP-seq
MIRT1166389	hsa-miR-4290	CLIP-seq
MIRT2276800	hsa-miR-1184	CLIP-seq
MIRT2276801	hsa-miR-1205	CLIP-seq
MIRT2276802	hsa-miR-1207-5p	CLIP-seq
MIRT2276803	hsa-miR-1237	CLIP-seq
MIRT2276804	hsa-miR-1254	CLIP-seq
MIRT2276805	hsa-miR-1293	CLIP-seq
MIRT2276806	hsa-miR-138	CLIP-seq
MIRT2276807	hsa-miR-146b-3p	CLIP-seq
MIRT2276808	hsa-miR-150	CLIP-seq
MIRT2276809	hsa-miR-184	CLIP-seq
MIRT2276810	hsa-miR-1909	CLIP-seq
MIRT2276811	hsa-miR-1910	CLIP-seq
MIRT2276812	hsa-miR-205	CLIP-seq
MIRT2276813	hsa-miR-2278	CLIP-seq
MIRT2276814	hsa-miR-3074-5p	CLIP-seq
MIRT2276815	hsa-miR-3116	CLIP-seq
MIRT2276816	hsa-miR-3120-5p	CLIP-seq
MIRT2276817	hsa-miR-3157-5p	CLIP-seq
MIRT2276818	hsa-miR-3158-5p	CLIP-seq
MIRT2276819	hsa-miR-3173-5p	CLIP-seq
MIRT2276820	hsa-miR-3179	CLIP-seq
MIRT2276821	hsa-miR-3192	CLIP-seq
MIRT2276822	hsa-miR-3202	CLIP-seq
MIRT2276823	hsa-miR-323-5p	CLIP-seq
MIRT2276824	hsa-miR-3689a-3p	CLIP-seq
MIRT2276825	hsa-miR-3689c	CLIP-seq
MIRT2276826	hsa-miR-371b-3p	CLIP-seq
MIRT2276827	hsa-miR-3907	CLIP-seq
MIRT2276828	hsa-miR-4323	CLIP-seq
MIRT2276829	hsa-miR-4421	CLIP-seq
MIRT1166392	hsa-miR-4438	CLIP-seq
MIRT2276830	hsa-miR-4447	CLIP-seq
MIRT1166394	hsa-miR-4450	CLIP-seq
MIRT1166395	hsa-miR-4455	CLIP-seq
MIRT2276831	hsa-miR-4456	CLIP-seq
MIRT2276832	hsa-miR-4472	CLIP-seq
MIRT2276833	hsa-miR-4483	CLIP-seq
MIRT2276834	hsa-miR-4488	CLIP-seq
MIRT1166397	hsa-miR-4492	CLIP-seq
MIRT1166398	hsa-miR-4498	CLIP-seq
MIRT1166399	hsa-miR-4505	CLIP-seq
MIRT2276835	hsa-miR-4514	CLIP-seq
MIRT2276836	hsa-miR-4536	CLIP-seq
MIRT2276837	hsa-miR-4651	CLIP-seq
MIRT1166402	hsa-miR-4667-5p	CLIP-seq
MIRT2276838	hsa-miR-4670-5p	CLIP-seq
MIRT2276839	hsa-miR-4690-3p	CLIP-seq
MIRT2276840	hsa-miR-4690-5p	CLIP-seq
MIRT2276841	hsa-miR-4692	CLIP-seq
MIRT2276842	hsa-miR-4697-5p	CLIP-seq
MIRT1166403	hsa-miR-4700-5p	CLIP-seq
MIRT2276843	hsa-miR-4713-5p	CLIP-seq
MIRT2276844	hsa-miR-4725-5p	CLIP-seq
MIRT2276845	hsa-miR-4727-5p	CLIP-seq
MIRT2276846	hsa-miR-4728-5p	CLIP-seq
MIRT1166404	hsa-miR-4731-5p	CLIP-seq
MIRT2276847	hsa-miR-4747-5p	CLIP-seq
MIRT2276848	hsa-miR-4763-3p	CLIP-seq
MIRT2276849	hsa-miR-4768-3p	CLIP-seq
MIRT2276850	hsa-miR-4804-5p	CLIP-seq
MIRT2276851	hsa-miR-504	CLIP-seq
MIRT2276852	hsa-miR-532-3p	CLIP-seq
MIRT2276853	hsa-miR-541	CLIP-seq
MIRT2276854	hsa-miR-550a	CLIP-seq
MIRT2276855	hsa-miR-608	CLIP-seq
MIRT1166406	hsa-miR-609	CLIP-seq
MIRT2276856	hsa-miR-654-5p	CLIP-seq
MIRT2276857	hsa-miR-661	CLIP-seq
MIRT2276858	hsa-miR-665	CLIP-seq
MIRT1166410	hsa-miR-762	CLIP-seq
MIRT2276859	hsa-miR-874	CLIP-seq
MIRT2276860	hsa-miR-885-3p	CLIP-seq
MIRT2276812	hsa-miR-205	CLIP-seq
MIRT2276813	hsa-miR-2278	CLIP-seq
MIRT2276817	hsa-miR-3157-5p	CLIP-seq
MIRT2276828	hsa-miR-4323	CLIP-seq
MIRT2276835	hsa-miR-4514	CLIP-seq
MIRT2276839	hsa-miR-4690-3p	CLIP-seq
MIRT2276840	hsa-miR-4690-5p	CLIP-seq
MIRT2276841	hsa-miR-4692	CLIP-seq
MIRT2276849	hsa-miR-4768-3p	CLIP-seq
MIRT2276858	hsa-miR-665	CLIP-seq
MIRT2276812	hsa-miR-205	CLIP-seq
MIRT2276813	hsa-miR-2278	CLIP-seq
MIRT2276817	hsa-miR-3157-5p	CLIP-seq
MIRT2276828	hsa-miR-4323	CLIP-seq
MIRT2276835	hsa-miR-4514	CLIP-seq
MIRT2276839	hsa-miR-4690-3p	CLIP-seq
MIRT2276840	hsa-miR-4690-5p	CLIP-seq
MIRT2276841	hsa-miR-4692	CLIP-seq
MIRT2276849	hsa-miR-4768-3p	CLIP-seq
MIRT2276858	hsa-miR-665	CLIP-seq

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Transcription factor	Regulation	Reference
NFKB1	Unknown	15979574
RELA	Unknown	15979574
SP1	Activation	15979574
SP3	Activation	15979574

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005201	Function	Extracellular matrix structural constituent	IBA
GO:0005201	Function	Extracellular matrix structural constituent	NAS	7680650
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005796	Component	Golgi lumen	IEA
GO:0005796	Component	Golgi lumen	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0030277	Process	Maintenance of gastrointestinal epithelium	NAS	7680650
GO:0031012	Component	Extracellular matrix	IBA

MIM	HGNC	e!Ensembl
158374	7517	ENSG00000184956

Q6W4X9

Protein name

Mucin-6 (MUC-6) (Gastric mucin-6)

Protein function

May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces a

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00094	VWD	45 → 193	von Willebrand factor type D domain	Family
PF08742	C8	231 → 297	C8 domain	Domain
PF01826	TIL	302 → 357	Trypsin Inhibitor like cysteine rich domain	Domain
PF00094	VWD	397 → 550	von Willebrand factor type D domain	Family
PF08742	C8	591 → 660	C8 domain	Domain
PF01826	TIL	764 → 827	Trypsin Inhibitor like cysteine rich domain	Domain
PF00094	VWD	868 → 1019	von Willebrand factor type D domain	Family
PF08742	C8	1060 → 1127	C8 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly ex

Sequence

MVQRWLLLSCCGALLSAGLANTSYTSPGLQRLKDSPQTAPDKGQCSTWGAGHFSTFDHHV
YDFSGTCNYIFAATCKDAFPTFSVQLRRGPDGSISRIIVELGASVVTVSEAIISVKDIGV
ISLPYTSNGLQITPFGQSVRLVAKQLELELEVVWGPDSHLMVLVERKYMGQMCGLCGNFD
GKVTNEFVSEEGKFLEPHKFAALQKLDDPGEICTFQDIPSTHVRQAQHARICTQLLTLVA
PECSVSKEPFVLSCQADVAAAPQPGPQNSSCATLSEYSRQCSMVGQPVRRWRSPGLCSVG
QCPANQVYQECGSACVKTCSNPQHSCSSSCTFGCFCPEGTVLNDLSNNHTCVPVTQCPCV
LHGAMYAPGEVTIAACQTCRCTLGRWVCTERPCPGHCSLEGGSFVTTFDARPYRFHGTCT
YILLQSPQLPEDGALMAVYDKSGVSHSETSLVAVVYLSRQDKIVISQDEVVTNNGEAKWL
PYKTRNITVFRQTSTHLQMATSFGLELVVQLRPIFQAYVTVGPQFRGQTRGLCGNFNGDT
TDDFTTSMGIAEGTASLFVDSWRAGNCPAALERETDPCSMSQLNKVCAETHCSMLLRTGT
VFERCHATVNPAPFYKRCVYQACNYEETFPHICAALGDYVHACSLRGVLLWGWRSSVDNC
TIPCTGNTTFSYNSQACERTCLSLSDRATECHHSAVPVDGCNCPDGTYLNQKGECVRKAQ
CPCILEGYKFILAEQSTVINGITCHCINGRLSCPQRPQMFLASCQAPKTFKSCSQSSENK
FGAACAPTCQMLATGVACVPTKCEPGCVCAEGLYENADGQCVPPEECPCEFSGVSYPGGA
ELHTDCRTCSCSRGRWACQQGTHCPSTCTLYGEGHVITFDGQRFVFDGNCEYILATDVCG
VNDSQPTFKILTENVICGNSGVTCSRAIKIFLGGLSVVLADRNYTVTGEEPHVQLGVTPG
ALSLVVDISIPGRYNLTLIWNRHMTILIRIARASQDPLCGLCGNFNGNMKDDFETRSRYV
ASSELELVNSWKESPLCGDVSFVTDPCSLNAFRRSWAERKCSVINSQTFATCHSKVYHLP
YYEACVRDACGCDSGGDCECLCDAVAAYAQACLDKGVCVDWRTPAFCPIYCGFYNTHTQD
GHGEYQYTQEANCTWHYQPCLCPSQPQSVPGSNIEGCYNCSQDEYFDHEEGVCVPCMPPT
TPQPPTTPQLPTTGSRPTQVWPMTGTSTTIGLLSSTGPSPSSNHTPASPTQTPLLPATLT
SSKPTASSGEPPRPTTAVTPQATSGLPPTATLRSTATKPTVTQATTRATASTASPATTST
AQSTTRTTMTLPTPATSGTSPTLPKSTNQELPGTTATQTTGPRPTPASTTGPTTPQPGQP
TRPTATETTQTRTTTEYTTPQTPHTTHSPPTAGSPVPSTGPVTATSFHATTTYPTPSHPE
TTLPTHVPPFSTSLVTPSTHTVITPTHAQMATSASNHSAPTGTIPPPTTLKATGSTHTAP
PITPTTSGTSQAHSSFSTNKTPTSLHSHTSSTHHPEVTPTSTTTITPNPTSTRTRTPVAH
TNSATSSRPPPPFTTHSPPTGSSPFSSTGPMTATSFKTTTTYPTPSHPQTTLPTHVPPFS
TSLVTPSTHTVITPTHAQMATSASIHSMPTGTIPPPTTLKATGSTHTAPTMTLTTSGTSQ
ALSSLNTAKTSTSLHSHTSSTHHAEATSTSTTNITPNPTSTGTPPMTVTTSGTSQSRSSF
STAKTSTSLHSHTSSTHHPEVTSTSTTSITPNHTSTGTRTPVAHTTSATSSRLPTPFTTH
SPPTGTTPISSTGPVTATSFQTTTTYPTPSHPHTTLPTHVPSFSTSLVTPSTHTVIIPTH
TQMATSASIHSMPTGTIPPPTTIKATGSTHTAPPMTPTTSGTSQSPSSFSTAKTSTSLPY
HTSSTHHPEVTPTSTTNITPKHTSTGTRTPVAHTTSASSSRLPTPFTTHSPPTGSSPFSS
TGPMTATSFQTTTTYPTPSHPQTTLPTHVPPFSTSLVTPSTHTVIITTHTQMATSASIHS
TPTGTVPPPTTLKATGSTHTAPPMTVTTSGTSQTHSSFSTATASSSFISSSSWLPQNSSS
RPPSSPITTQLPHLSSATTPVSTTNQLSSSFSPSPSAPSTVSSYVPSSHSSPQTSSPSVG
TSSSFVSAPVHSTTLSSGSHSSLSTHPTTASVSASPLFPSSPAASTTIRATLPHTISSPF
TLSALLPISTVTVSPTPSSHLASSTIAFPSTPRTTASTHTAPAFSSQSTTSRSTSLTTRV
PTSGFVSLTSGVTGIPTSPVTNLTTRHPGPTLSPTTRFLTSSLTAHGSTPASAPVSSLGT
PTPTSPGVCSVREQQEEITFKGCMANVTVTRCEGACISAASFNIITQQVDARCSCCRPLH
SYEQQLELPCPDPSTPGRRLVLTLQVFSHCVCSSVACGD

Sequence length

2439

Interactions

View interactions

	Reactome
			Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs574997229	RCV004557820
Prostate cancer	Uncertain significance	rs148581741	RCV000149179

Show/Hide Text Mining Associations (72)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	11076872, 15143335, 18080919, 22027009, 23382633, 24603585, 25759539, 31689805, 33020993, 38062562
Adenocarcinoma	Inhibit	17401217, 21829465
Adenocarcinoma Mucinous	Associate	29698701, 30258209, 33024306
Adenocarcinoma of Lung	Associate	36367122
Adenoma	Associate	16804962, 18360351, 19855374, 20929551, 33569969, 38062108
Adjustment Disorders	Associate	17227128
Adrenal Gland Neoplasms	Associate	40478615
Alzheimer Disease	Associate	31748784
Anemia	Associate	33569969
Atresia of small intestine	Associate	24603585
Barrett Esophagus	Associate	11076872, 15563666, 17401217, 24550372
Biliary Tract Neoplasms	Associate	33020993
Breast Neoplasms	Associate	11253133, 15976813, 27846863
Breast Neoplasms Male	Associate	37581476
Carcinogenesis	Associate	12077147, 16545139, 20139757, 23573304
Carcinoma Adenosquamous	Associate	30258209
Carcinoma Ductal	Associate	23446997
Carcinoma Intraductal Noninfiltrating	Associate	11253133
Carcinoma Lobular	Associate	31506488
Carcinoma Non Small Cell Lung	Associate	24947164
Carcinoma Pancreatic Ductal	Associate	25906442
Carcinoma Signet Ring Cell	Associate	23573307, 28453172
Carcinoma Small Cell	Associate	24722639
Carcinoma Squamous Cell	Associate	28099906
Cholangiocarcinoma	Associate	29698701
Colonic Polyps	Associate	19855374, 20929551
Colorectal Neoplasms	Associate	23807779, 25081749, 27298226, 39333321
COVID 19	Associate	34448730
Crohn Disease	Associate	11559653, 33690604
Death	Inhibit	25197366
Dermatofibrosarcoma	Associate	35441365
Duodenal Ulcer	Associate	33608531
Ermine phenotype	Associate	21106111
Gastric Outlet Obstruction	Associate	33569969
Helicobacter Infections	Stimulate	15280409
Helicobacter Infections	Associate	16545139, 18938748
Hypersensitivity Immediate	Associate	20139757
Infections	Associate	23703470
Inflammatory Bowel Diseases	Associate	11559653
Intestinal Diseases	Associate	14960508, 16545139
Klatskin Tumor	Associate	31401234
Lymphatic Metastasis	Associate	20139757, 37581476
Lymphatic Metastasis	Inhibit	34672134
Lymphoma Non Hodgkin	Associate	23382633
Mouth Neoplasms	Associate	25881098
Mucositis	Associate	11559653
Neoplasm Invasiveness	Associate	11253133
Neoplasms	Associate	16804962, 17143961, 21883895, 22027009, 23112547, 23573304, 24138592, 26111977, 27298226, 27984235, 28685935, 30803560, 31279344, 33020993, 34032698 View all (6 more)
Neoplasms	Inhibit	25197366, 34808019
Neoplasms Cystic Mucinous and Serous	Associate	20139757, 26900302
Neoplasms Glandular and Epithelial	Associate	21228366
Ovarian Cysts	Associate	17479161
Pancreatic Diseases	Associate	34808019
Pancreatic Intraductal Neoplasms	Associate	20139757, 28685935, 28776573, 32806726
Pancreatic Neoplasms	Associate	24303806, 28099906, 28685935, 29550476
Pancreatic Neoplasms	Inhibit	34808019
Peptic Ulcer	Associate	33608531
Polyps	Associate	19855374
Prostatic Neoplasms	Associate	32800727
Pseudolymphoma	Associate	15962383
Retinal Dysplasia	Associate	11076872, 18360351
Retinal Dysplasia	Inhibit	15962383, 17401217
Squamous Cell Carcinoma of Head and Neck	Associate	37581476
Stomach Diseases	Associate	15143335, 15962383
Stomach Neoplasms	Associate	10940270, 11278696, 12719460, 15354218, 15962383, 18938748, 19924550, 21777278, 24138592, 25945027, 26685087, 31243897, 31506488, 34840985, 36450891, 37085819, 37967684, 38041130 View all (3 more)
Stomach Neoplasms	Inhibit	34672134
Triple Negative Breast Neoplasms	Associate	15976813
Ulcer	Associate	11559653, 12171961
Urinary Bladder Neoplasms	Associate	25197366
Uterine Cervical Dysplasia	Associate	28685935, 33020993
Uterine Cervical Neoplasms	Associate	33020993
Wounds and Injuries	Associate	19924550

MUC6 (mucin 6, oligomeric mucus/gel-forming (gene/pseudogene))