Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4539
Gene name Gene Name - the full gene name approved by the HGNC.
Mitochondrially encoded NADH 4L dehydrogenase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ND4L
Synonyms (NCBI Gene) Gene synonyms aliases
MTND4L
Chromosome Chromosome number
MT
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
-
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT052064 hsa-let-7b-5p CLASH 23622248
MIRT052064 hsa-let-7b-5p CLASH 23622248
MIRT051743 hsa-let-7c-5p CLASH 23622248
MIRT048170 hsa-miR-196a-5p CLASH 23622248
MIRT038985 hsa-miR-15a-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005747 Component Mitochondrial respiratory chain complex I IBA 21873635
GO:0005747 Component Mitochondrial respiratory chain complex I NAS 3921850
GO:0006120 Process Mitochondrial electron transport, NADH to ubiquinone NAS 3921850
GO:0008137 Function NADH dehydrogenase (ubiquinone) activity IBA 21873635
GO:0008137 Function NADH dehydrogenase (ubiquinone) activity NAS 3921850
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
516004 7460 HGNC
Protein
UniProt ID P03901
Protein name NADH-ubiquinone oxidoreductase chain 4L (EC 7.1.1.2) (NADH dehydrogenase subunit 4L) (ND4L)
Protein function Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:28844695). Part of the enzyme
PDB 5XTC , 5XTD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00420 Oxidored_q2 3 98 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Family
Sequence
Sequence length 98
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Oxidative phosphorylation
Metabolic pathways
Thermogenesis
Retrograde endocannabinoid signaling
Alzheimer disease
Parkinson disease
Amyotrophic lateral sclerosis
Huntington disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Chemical carcinogenesis - reactive oxygen species
Diabetic cardiomyopathy
 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Wolff-parkinson-white syndrome Preexcitation Syndrome rs111033205, rs121908987, rs3218716, rs199472712, rs869312065, rs1554284604, rs1553197939, rs1553624186, rs1553631968, rs1555100687, rs1555418832
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Hereditary leber optic atrophy Optic Atrophy, Hereditary, Leber rs199476133, rs199476135, rs199476137, rs199476138, rs207460000, rs199476104, rs199476105, rs199476106, rs199476108, rs199476109, rs267606893, rs267606898, rs267606899, rs1556423844, rs199476112
View all (14 more)
11935318, 8680405
Myopathy Myopathy rs137854521, rs386834236, rs121908557, rs121909092, rs111033570, rs104894299, rs104894294, rs121909273, rs121909274, rs121909275, rs199474699, rs199476140, rs118192165, rs118192169, rs118192166
View all (81 more)
Associations from Text Mining
Disease Name Relationship Type References
Acidosis Lactic Associate 16404428
Alzheimer Disease Associate 34152079
Carcinoma Renal Cell Associate 16404428
Esophageal Neoplasms Associate 16620376
HAIR AN syndrome Associate 32601317
Huntington Disease Associate 38447791
Leigh Disease Associate 14684687
MELAS Syndrome Associate 16404428
Mitochondrial Diseases Associate 14684687
Mitochondrial Encephalomyopathies Associate 16404428