Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4507
Gene name	Methylthioadenosine phosphorylase
Gene symbol	MTAP
Synonyms (NCBI Gene)	BDMFDMSFHDMSMFHHEL-249LGMBFMSAPc86fus
Chromosome	9
Chromosome location	9p21.3
Summary	This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted

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miRTarBase ID	miRNA	Experiments	Reference
MIRT000961	hsa-miR-21-5p	Western blotNorthern blot	19013014
MIRT000961	hsa-miR-21-5p	qRT-PCR	19013014
MIRT000961	hsa-miR-21-5p	Luciferase reporter assay	19013014
MIRT020610	hsa-miR-155-5p	Proteomics	18668040
MIRT025319	hsa-miR-34a-5p	Sequencing	20371350
MIRT025319	hsa-miR-34a-5p	Proteomics	21566225
MIRT025319	hsa-miR-34a-5p	Proteomics	21566225
MIRT000961	hsa-miR-21-5p	Microarray	18591254
MIRT000961	hsa-miR-21-5p	Microarray	18591254
MIRT662554	hsa-miR-4714-5p	HITS-CLIP	23824327
MIRT662553	hsa-miR-514a-5p	HITS-CLIP	23824327
MIRT662552	hsa-miR-3664-5p	HITS-CLIP	23824327
MIRT662551	hsa-miR-5693	HITS-CLIP	23824327
MIRT662550	hsa-miR-1267	HITS-CLIP	23824327
MIRT662549	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT662548	hsa-miR-550b-3p	HITS-CLIP	23824327
MIRT662547	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT662546	hsa-miR-3135b	HITS-CLIP	23824327
MIRT662545	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT662544	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT662543	hsa-miR-3652	HITS-CLIP	23824327
MIRT662541	hsa-miR-4430	HITS-CLIP	23824327
MIRT662542	hsa-miR-200c-5p	HITS-CLIP	23824327
MIRT662540	hsa-miR-550a-3p	HITS-CLIP	23824327
MIRT662539	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT662538	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT662537	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT662536	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT662535	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT662534	hsa-miR-5698	HITS-CLIP	23824327
MIRT527968	hsa-miR-495-3p	PAR-CLIP	22012620
MIRT527967	hsa-miR-5688	PAR-CLIP	22012620
MIRT527966	hsa-miR-4717-3p	PAR-CLIP	22012620
MIRT527965	hsa-miR-1237-3p	PAR-CLIP	22012620
MIRT527964	hsa-miR-1248	PAR-CLIP	22012620
MIRT527963	hsa-miR-412-3p	PAR-CLIP	22012620
MIRT527962	hsa-miR-6754-3p	PAR-CLIP	22012620
MIRT527961	hsa-miR-6837-3p	PAR-CLIP	22012620
MIRT527960	hsa-miR-4778-3p	PAR-CLIP	22012620
MIRT527959	hsa-miR-130a-5p	PAR-CLIP	22012620
MIRT527958	hsa-miR-23a-3p	PAR-CLIP	22012620
MIRT527957	hsa-miR-23b-3p	PAR-CLIP	22012620
MIRT527956	hsa-miR-23c	PAR-CLIP	22012620
MIRT527955	hsa-miR-6868-3p	PAR-CLIP	22012620
MIRT454726	hsa-miR-4662a-3p	PAR-CLIP	23592263
MIRT454725	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT454724	hsa-miR-577	PAR-CLIP	23592263
MIRT454723	hsa-miR-4709-5p	PAR-CLIP	23592263
MIRT454722	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT454721	hsa-miR-421	PAR-CLIP	23592263
MIRT454720	hsa-miR-5585-3p	PAR-CLIP	23592263
MIRT662554	hsa-miR-4714-5p	HITS-CLIP	23824327
MIRT662553	hsa-miR-514a-5p	HITS-CLIP	23824327
MIRT662552	hsa-miR-3664-5p	HITS-CLIP	23824327
MIRT662551	hsa-miR-5693	HITS-CLIP	23824327
MIRT662550	hsa-miR-1267	HITS-CLIP	23824327
MIRT662549	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT662548	hsa-miR-550b-3p	HITS-CLIP	23824327
MIRT662547	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT662546	hsa-miR-3135b	HITS-CLIP	23824327
MIRT662545	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT662544	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT662543	hsa-miR-3652	HITS-CLIP	23824327
MIRT662541	hsa-miR-4430	HITS-CLIP	23824327
MIRT662542	hsa-miR-200c-5p	HITS-CLIP	23824327
MIRT662540	hsa-miR-550a-3p	HITS-CLIP	23824327
MIRT662539	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT662538	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT662537	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT662536	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT662535	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT662534	hsa-miR-5698	HITS-CLIP	23824327
MIRT527968	hsa-miR-495-3p	PAR-CLIP	22012620
MIRT527967	hsa-miR-5688	PAR-CLIP	22012620
MIRT527966	hsa-miR-4717-3p	PAR-CLIP	22012620
MIRT527965	hsa-miR-1237-3p	PAR-CLIP	22012620
MIRT527964	hsa-miR-1248	PAR-CLIP	22012620
MIRT527963	hsa-miR-412-3p	PAR-CLIP	22012620
MIRT527962	hsa-miR-6754-3p	PAR-CLIP	22012620
MIRT527961	hsa-miR-6837-3p	PAR-CLIP	22012620
MIRT527960	hsa-miR-4778-3p	PAR-CLIP	22012620
MIRT527959	hsa-miR-130a-5p	PAR-CLIP	22012620
MIRT527958	hsa-miR-23a-3p	PAR-CLIP	22012620
MIRT527957	hsa-miR-23b-3p	PAR-CLIP	22012620
MIRT527956	hsa-miR-23c	PAR-CLIP	22012620
MIRT527955	hsa-miR-6868-3p	PAR-CLIP	22012620
MIRT454726	hsa-miR-4662a-3p	PAR-CLIP	23592263
MIRT454725	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT454724	hsa-miR-577	PAR-CLIP	23592263
MIRT454723	hsa-miR-4709-5p	PAR-CLIP	23592263
MIRT454722	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT454721	hsa-miR-421	PAR-CLIP	23592263
MIRT454720	hsa-miR-5585-3p	PAR-CLIP	23592263
MIRT1162199	hsa-miR-1193	CLIP-seq
MIRT1162200	hsa-miR-1204	CLIP-seq
MIRT1162201	hsa-miR-1253	CLIP-seq
MIRT1162202	hsa-miR-1262	CLIP-seq
MIRT1162203	hsa-miR-1279	CLIP-seq
MIRT1162204	hsa-miR-128	CLIP-seq
MIRT1162205	hsa-miR-1290	CLIP-seq
MIRT1162206	hsa-miR-1293	CLIP-seq
MIRT1162207	hsa-miR-1299	CLIP-seq
MIRT1162208	hsa-miR-142-3p	CLIP-seq
MIRT1162209	hsa-miR-142-5p	CLIP-seq
MIRT1162210	hsa-miR-1470	CLIP-seq
MIRT1162211	hsa-miR-154	CLIP-seq
MIRT1162212	hsa-miR-15a	CLIP-seq
MIRT1162213	hsa-miR-15b	CLIP-seq
MIRT1162214	hsa-miR-16	CLIP-seq
MIRT1162215	hsa-miR-188-3p	CLIP-seq
MIRT1162216	hsa-miR-195	CLIP-seq
MIRT1162217	hsa-miR-1972	CLIP-seq
MIRT1162218	hsa-miR-1976	CLIP-seq
MIRT1162219	hsa-miR-2392	CLIP-seq
MIRT1162220	hsa-miR-2467-5p	CLIP-seq
MIRT1162221	hsa-miR-27a	CLIP-seq
MIRT1162222	hsa-miR-27b	CLIP-seq
MIRT1162223	hsa-miR-298	CLIP-seq
MIRT1162224	hsa-miR-3123	CLIP-seq
MIRT1162225	hsa-miR-3144-5p	CLIP-seq
MIRT1162226	hsa-miR-3154	CLIP-seq
MIRT1162227	hsa-miR-3156-3p	CLIP-seq
MIRT1162228	hsa-miR-3163	CLIP-seq
MIRT1162229	hsa-miR-3175	CLIP-seq
MIRT1162230	hsa-miR-3179	CLIP-seq
MIRT1162231	hsa-miR-3182	CLIP-seq
MIRT1162232	hsa-miR-3191	CLIP-seq
MIRT1162233	hsa-miR-3199	CLIP-seq
MIRT1162234	hsa-miR-338-5p	CLIP-seq
MIRT1162235	hsa-miR-340	CLIP-seq
MIRT1162236	hsa-miR-3606	CLIP-seq
MIRT1162237	hsa-miR-361-3p	CLIP-seq
MIRT1162238	hsa-miR-3647-3p	CLIP-seq
MIRT1162239	hsa-miR-3653	CLIP-seq
MIRT1162240	hsa-miR-3655	CLIP-seq
MIRT1162241	hsa-miR-3658	CLIP-seq
MIRT1162242	hsa-miR-378	CLIP-seq
MIRT1162243	hsa-miR-378b	CLIP-seq
MIRT1162244	hsa-miR-378c	CLIP-seq
MIRT1162245	hsa-miR-378d	CLIP-seq
MIRT1162246	hsa-miR-378e	CLIP-seq
MIRT1162247	hsa-miR-378f	CLIP-seq
MIRT1162248	hsa-miR-378h	CLIP-seq
MIRT1162249	hsa-miR-378i	CLIP-seq
MIRT1162250	hsa-miR-3912	CLIP-seq
MIRT1162251	hsa-miR-3915	CLIP-seq
MIRT1162252	hsa-miR-3919	CLIP-seq
MIRT1162253	hsa-miR-3925-5p	CLIP-seq
MIRT1162254	hsa-miR-3928	CLIP-seq
MIRT1162255	hsa-miR-422a	CLIP-seq
MIRT1162256	hsa-miR-424	CLIP-seq
MIRT1162257	hsa-miR-4261	CLIP-seq
MIRT1162258	hsa-miR-4272	CLIP-seq
MIRT1162259	hsa-miR-4278	CLIP-seq
MIRT1162260	hsa-miR-4282	CLIP-seq
MIRT1162261	hsa-miR-4301	CLIP-seq
MIRT1162262	hsa-miR-431	CLIP-seq
MIRT1162263	hsa-miR-4434	CLIP-seq
MIRT1162264	hsa-miR-4436b-5p	CLIP-seq
MIRT1162265	hsa-miR-4477a	CLIP-seq
MIRT1162266	hsa-miR-4483	CLIP-seq
MIRT1162267	hsa-miR-4516	CLIP-seq
MIRT1162268	hsa-miR-4524	CLIP-seq
MIRT1162269	hsa-miR-4638-3p	CLIP-seq
MIRT1162270	hsa-miR-4650-5p	CLIP-seq
MIRT1162271	hsa-miR-4652-5p	CLIP-seq
MIRT1162272	hsa-miR-4659a-3p	CLIP-seq
MIRT1162273	hsa-miR-4659b-3p	CLIP-seq
MIRT1162274	hsa-miR-4662a-5p	CLIP-seq
MIRT1162275	hsa-miR-4666-3p	CLIP-seq
MIRT1162276	hsa-miR-4667-3p	CLIP-seq
MIRT1162277	hsa-miR-4676-5p	CLIP-seq
MIRT1162278	hsa-miR-4701-3p	CLIP-seq
MIRT1162279	hsa-miR-4705	CLIP-seq
MIRT1162280	hsa-miR-4716-3p	CLIP-seq
MIRT1162281	hsa-miR-4717-5p	CLIP-seq
MIRT1162282	hsa-miR-4723-5p	CLIP-seq
MIRT1162283	hsa-miR-4764-3p	CLIP-seq
MIRT1162284	hsa-miR-4777-3p	CLIP-seq
MIRT1162285	hsa-miR-4782-5p	CLIP-seq
MIRT1162286	hsa-miR-4790-3p	CLIP-seq
MIRT1162287	hsa-miR-4793-5p	CLIP-seq
MIRT1162288	hsa-miR-491-5p	CLIP-seq
MIRT1162289	hsa-miR-495	CLIP-seq
MIRT1162290	hsa-miR-497	CLIP-seq
MIRT1162291	hsa-miR-503	CLIP-seq
MIRT1162292	hsa-miR-511	CLIP-seq
MIRT1162293	hsa-miR-516b	CLIP-seq
MIRT1162294	hsa-miR-532-3p	CLIP-seq
MIRT1162295	hsa-miR-548a-5p	CLIP-seq
MIRT1162296	hsa-miR-548ab	CLIP-seq
MIRT1162297	hsa-miR-548ac	CLIP-seq
MIRT1162298	hsa-miR-548ae	CLIP-seq
MIRT1162299	hsa-miR-548aj	CLIP-seq
MIRT1162300	hsa-miR-548ak	CLIP-seq
MIRT1162301	hsa-miR-548am	CLIP-seq
MIRT1162302	hsa-miR-548b-5p	CLIP-seq
MIRT1162303	hsa-miR-548c-5p	CLIP-seq
MIRT1162304	hsa-miR-548d-3p	CLIP-seq
MIRT1162305	hsa-miR-548d-5p	CLIP-seq
MIRT1162306	hsa-miR-548h	CLIP-seq
MIRT1162307	hsa-miR-548i	CLIP-seq
MIRT1162308	hsa-miR-548j	CLIP-seq
MIRT1162309	hsa-miR-548n	CLIP-seq
MIRT1162310	hsa-miR-548p	CLIP-seq
MIRT1162311	hsa-miR-548w	CLIP-seq
MIRT1162312	hsa-miR-548x	CLIP-seq
MIRT1162313	hsa-miR-548y	CLIP-seq
MIRT1162314	hsa-miR-548z	CLIP-seq
MIRT1162315	hsa-miR-552	CLIP-seq
MIRT1162316	hsa-miR-555	CLIP-seq
MIRT1162317	hsa-miR-559	CLIP-seq
MIRT1162318	hsa-miR-570	CLIP-seq
MIRT1162319	hsa-miR-575	CLIP-seq
MIRT1162320	hsa-miR-583	CLIP-seq
MIRT1162321	hsa-miR-600	CLIP-seq
MIRT1162322	hsa-miR-624	CLIP-seq
MIRT1162323	hsa-miR-633	CLIP-seq
MIRT1162324	hsa-miR-640	CLIP-seq
MIRT1162325	hsa-miR-646	CLIP-seq
MIRT1162326	hsa-miR-661	CLIP-seq
MIRT1162327	hsa-miR-664	CLIP-seq
MIRT1162328	hsa-miR-665	CLIP-seq
MIRT1162329	hsa-miR-764	CLIP-seq
MIRT1556704	hsa-miR-3662	CLIP-seq
MIRT2046502	hsa-miR-1178	CLIP-seq
MIRT2046503	hsa-miR-122	CLIP-seq
MIRT2046504	hsa-miR-1228	CLIP-seq
MIRT2046505	hsa-miR-1270	CLIP-seq
MIRT2046506	hsa-miR-1292	CLIP-seq
MIRT2046507	hsa-miR-129-5p	CLIP-seq
MIRT1162209	hsa-miR-142-5p	CLIP-seq
MIRT2046508	hsa-miR-146a	CLIP-seq
MIRT2046509	hsa-miR-146b-5p	CLIP-seq
MIRT2046510	hsa-miR-185	CLIP-seq
MIRT2046511	hsa-miR-1915	CLIP-seq
MIRT1162218	hsa-miR-1976	CLIP-seq
MIRT2046512	hsa-miR-2276	CLIP-seq
MIRT2046513	hsa-miR-299-3p	CLIP-seq
MIRT2046514	hsa-miR-3115	CLIP-seq
MIRT2046515	hsa-miR-3149	CLIP-seq
MIRT2046516	hsa-miR-3151	CLIP-seq
MIRT2046517	hsa-miR-3194-3p	CLIP-seq
MIRT1162235	hsa-miR-340	CLIP-seq
MIRT2046518	hsa-miR-3690	CLIP-seq
MIRT2046519	hsa-miR-377	CLIP-seq
MIRT2046520	hsa-miR-3921	CLIP-seq
MIRT1162253	hsa-miR-3925-5p	CLIP-seq
MIRT2046521	hsa-miR-4254	CLIP-seq
MIRT1162258	hsa-miR-4272	CLIP-seq
MIRT2046522	hsa-miR-4284	CLIP-seq
MIRT2046523	hsa-miR-4306	CLIP-seq
MIRT2046524	hsa-miR-4447	CLIP-seq
MIRT2046525	hsa-miR-4450	CLIP-seq
MIRT2046526	hsa-miR-4471	CLIP-seq
MIRT2046527	hsa-miR-4472	CLIP-seq
MIRT2046528	hsa-miR-4531	CLIP-seq
MIRT2046529	hsa-miR-4644	CLIP-seq
MIRT2046530	hsa-miR-4653-5p	CLIP-seq
MIRT1162272	hsa-miR-4659a-3p	CLIP-seq
MIRT1162273	hsa-miR-4659b-3p	CLIP-seq
MIRT2046531	hsa-miR-4699-3p	CLIP-seq
MIRT2046532	hsa-miR-4726-3p	CLIP-seq
MIRT2046533	hsa-miR-4735-5p	CLIP-seq
MIRT2046534	hsa-miR-4772-3p	CLIP-seq
MIRT2046535	hsa-miR-4775	CLIP-seq
MIRT1162284	hsa-miR-4777-3p	CLIP-seq
MIRT1162287	hsa-miR-4793-5p	CLIP-seq
MIRT1162288	hsa-miR-491-5p	CLIP-seq
MIRT2046536	hsa-miR-513b	CLIP-seq
MIRT1162316	hsa-miR-555	CLIP-seq
MIRT1162320	hsa-miR-583	CLIP-seq
MIRT2046537	hsa-miR-590-3p	CLIP-seq
MIRT2046538	hsa-miR-620	CLIP-seq
MIRT2046539	hsa-miR-767-3p	CLIP-seq
MIRT2046502	hsa-miR-1178	CLIP-seq
MIRT2275614	hsa-miR-1200	CLIP-seq
MIRT2275615	hsa-miR-1208	CLIP-seq
MIRT2046503	hsa-miR-122	CLIP-seq
MIRT2046504	hsa-miR-1228	CLIP-seq
MIRT2275616	hsa-miR-1243	CLIP-seq
MIRT1162202	hsa-miR-1262	CLIP-seq
MIRT1162203	hsa-miR-1279	CLIP-seq
MIRT1162204	hsa-miR-128	CLIP-seq
MIRT1162205	hsa-miR-1290	CLIP-seq
MIRT2046506	hsa-miR-1292	CLIP-seq
MIRT1162206	hsa-miR-1293	CLIP-seq
MIRT2275617	hsa-miR-1305	CLIP-seq
MIRT1162209	hsa-miR-142-5p	CLIP-seq
MIRT2275618	hsa-miR-146b-3p	CLIP-seq
MIRT1162210	hsa-miR-1470	CLIP-seq
MIRT1162212	hsa-miR-15a	CLIP-seq
MIRT1162213	hsa-miR-15b	CLIP-seq
MIRT1162214	hsa-miR-16	CLIP-seq
MIRT1162215	hsa-miR-188-3p	CLIP-seq
MIRT2046511	hsa-miR-1915	CLIP-seq
MIRT1162216	hsa-miR-195	CLIP-seq
MIRT1162218	hsa-miR-1976	CLIP-seq
MIRT2275619	hsa-miR-200b	CLIP-seq
MIRT2275620	hsa-miR-200c	CLIP-seq
MIRT2275621	hsa-miR-2052	CLIP-seq
MIRT2275622	hsa-miR-216a	CLIP-seq
MIRT2046512	hsa-miR-2276	CLIP-seq
MIRT1162221	hsa-miR-27a	CLIP-seq
MIRT1162222	hsa-miR-27b	CLIP-seq
MIRT2046513	hsa-miR-299-3p	CLIP-seq
MIRT2275623	hsa-miR-302f	CLIP-seq
MIRT2046514	hsa-miR-3115	CLIP-seq
MIRT1162224	hsa-miR-3123	CLIP-seq
MIRT2275624	hsa-miR-3126-5p	CLIP-seq
MIRT1162225	hsa-miR-3144-5p	CLIP-seq
MIRT2046516	hsa-miR-3151	CLIP-seq
MIRT1162227	hsa-miR-3156-3p	CLIP-seq
MIRT2275625	hsa-miR-3157-3p	CLIP-seq
MIRT2275626	hsa-miR-3173-3p	CLIP-seq
MIRT2275627	hsa-miR-3173-5p	CLIP-seq
MIRT1162232	hsa-miR-3191	CLIP-seq
MIRT1162233	hsa-miR-3199	CLIP-seq
MIRT1162235	hsa-miR-340	CLIP-seq
MIRT2275628	hsa-miR-342-3p	CLIP-seq
MIRT2275629	hsa-miR-3616-5p	CLIP-seq
MIRT2275630	hsa-miR-3647-5p	CLIP-seq
MIRT2275631	hsa-miR-3654	CLIP-seq
MIRT2275632	hsa-miR-3668	CLIP-seq
MIRT2275633	hsa-miR-3686	CLIP-seq
MIRT2275634	hsa-miR-3692	CLIP-seq
MIRT2275635	hsa-miR-374c	CLIP-seq
MIRT2046519	hsa-miR-377	CLIP-seq
MIRT2275636	hsa-miR-3909	CLIP-seq
MIRT1162252	hsa-miR-3919	CLIP-seq
MIRT1162253	hsa-miR-3925-5p	CLIP-seq
MIRT2275637	hsa-miR-3973	CLIP-seq
MIRT1162256	hsa-miR-424	CLIP-seq
MIRT1162258	hsa-miR-4272	CLIP-seq
MIRT2275638	hsa-miR-4279	CLIP-seq
MIRT2275639	hsa-miR-429	CLIP-seq
MIRT1162261	hsa-miR-4301	CLIP-seq
MIRT1162262	hsa-miR-431	CLIP-seq
MIRT2275640	hsa-miR-4324	CLIP-seq
MIRT2275641	hsa-miR-4330	CLIP-seq
MIRT2275642	hsa-miR-4420	CLIP-seq
MIRT2046524	hsa-miR-4447	CLIP-seq
MIRT2046525	hsa-miR-4450	CLIP-seq
MIRT2046526	hsa-miR-4471	CLIP-seq
MIRT2046527	hsa-miR-4472	CLIP-seq
MIRT1162266	hsa-miR-4483	CLIP-seq
MIRT2275643	hsa-miR-452	CLIP-seq
MIRT2275644	hsa-miR-4522	CLIP-seq
MIRT1162268	hsa-miR-4524	CLIP-seq
MIRT2275645	hsa-miR-4540	CLIP-seq
MIRT2275646	hsa-miR-4635	CLIP-seq
MIRT1162271	hsa-miR-4652-5p	CLIP-seq
MIRT1162276	hsa-miR-4667-3p	CLIP-seq
MIRT2275647	hsa-miR-4676-3p	CLIP-seq
MIRT2275648	hsa-miR-4691-5p	CLIP-seq
MIRT2275649	hsa-miR-4698	CLIP-seq
MIRT1162278	hsa-miR-4701-3p	CLIP-seq
MIRT2275650	hsa-miR-4715-5p	CLIP-seq
MIRT2275651	hsa-miR-4722-3p	CLIP-seq
MIRT2046532	hsa-miR-4726-3p	CLIP-seq
MIRT2275652	hsa-miR-4732-5p	CLIP-seq
MIRT2275653	hsa-miR-4742-3p	CLIP-seq
MIRT2275654	hsa-miR-4756-3p	CLIP-seq
MIRT1162283	hsa-miR-4764-3p	CLIP-seq
MIRT1162284	hsa-miR-4777-3p	CLIP-seq
MIRT2275655	hsa-miR-4779	CLIP-seq
MIRT2275656	hsa-miR-487a	CLIP-seq
MIRT1162288	hsa-miR-491-5p	CLIP-seq
MIRT1162290	hsa-miR-497	CLIP-seq
MIRT2275657	hsa-miR-498	CLIP-seq
MIRT2275658	hsa-miR-499-3p	CLIP-seq
MIRT2275659	hsa-miR-499a-3p	CLIP-seq
MIRT2275660	hsa-miR-501-5p	CLIP-seq
MIRT1162291	hsa-miR-503	CLIP-seq
MIRT2046536	hsa-miR-513b	CLIP-seq
MIRT1162294	hsa-miR-532-3p	CLIP-seq
MIRT2275661	hsa-miR-539	CLIP-seq
MIRT2275662	hsa-miR-544b	CLIP-seq
MIRT2275663	hsa-miR-548k	CLIP-seq
MIRT2275664	hsa-miR-550b	CLIP-seq
MIRT1162315	hsa-miR-552	CLIP-seq
MIRT1162316	hsa-miR-555	CLIP-seq
MIRT2275665	hsa-miR-573	CLIP-seq
MIRT2275666	hsa-miR-576-3p	CLIP-seq
MIRT1162320	hsa-miR-583	CLIP-seq
MIRT1162325	hsa-miR-646	CLIP-seq
MIRT2275667	hsa-miR-647	CLIP-seq
MIRT2275668	hsa-miR-655	CLIP-seq
MIRT2275669	hsa-miR-873	CLIP-seq
MIRT2275670	hsa-miR-874	CLIP-seq
MIRT1162199	hsa-miR-1193	CLIP-seq
MIRT1162209	hsa-miR-142-5p	CLIP-seq
MIRT1162218	hsa-miR-1976	CLIP-seq
MIRT1162219	hsa-miR-2392	CLIP-seq
MIRT1162235	hsa-miR-340	CLIP-seq
MIRT1162316	hsa-miR-555	CLIP-seq
MIRT1162324	hsa-miR-640	CLIP-seq
MIRT2275632	hsa-miR-3668	CLIP-seq
MIRT2275637	hsa-miR-3973	CLIP-seq
MIRT2275652	hsa-miR-4732-5p	CLIP-seq
MIRT2275663	hsa-miR-548k	CLIP-seq
MIRT1162205	hsa-miR-1290	CLIP-seq
MIRT2046507	hsa-miR-129-5p	CLIP-seq
MIRT1162209	hsa-miR-142-5p	CLIP-seq
MIRT2454533	hsa-miR-203	CLIP-seq
MIRT2046515	hsa-miR-3149	CLIP-seq
MIRT1162235	hsa-miR-340	CLIP-seq
MIRT2454534	hsa-miR-411	CLIP-seq
MIRT2046533	hsa-miR-4735-5p	CLIP-seq
MIRT2046535	hsa-miR-4775	CLIP-seq
MIRT1162288	hsa-miR-491-5p	CLIP-seq
MIRT1162316	hsa-miR-555	CLIP-seq
MIRT1162320	hsa-miR-583	CLIP-seq
MIRT2046537	hsa-miR-590-3p	CLIP-seq
MIRT1162209	hsa-miR-142-5p	CLIP-seq
MIRT1162235	hsa-miR-340	CLIP-seq
MIRT1162316	hsa-miR-555	CLIP-seq
MIRT1162320	hsa-miR-583	CLIP-seq
MIRT2046506	hsa-miR-1292	CLIP-seq
MIRT2046507	hsa-miR-129-5p	CLIP-seq
MIRT1162209	hsa-miR-142-5p	CLIP-seq
MIRT2046513	hsa-miR-299-3p	CLIP-seq
MIRT2046514	hsa-miR-3115	CLIP-seq
MIRT2046515	hsa-miR-3149	CLIP-seq
MIRT2046516	hsa-miR-3151	CLIP-seq
MIRT1162233	hsa-miR-3199	CLIP-seq
MIRT1162235	hsa-miR-340	CLIP-seq
MIRT2454534	hsa-miR-411	CLIP-seq
MIRT2046524	hsa-miR-4447	CLIP-seq
MIRT2046525	hsa-miR-4450	CLIP-seq
MIRT2046526	hsa-miR-4471	CLIP-seq
MIRT2046527	hsa-miR-4472	CLIP-seq
MIRT1162272	hsa-miR-4659a-3p	CLIP-seq
MIRT1162273	hsa-miR-4659b-3p	CLIP-seq
MIRT2046533	hsa-miR-4735-5p	CLIP-seq
MIRT2046535	hsa-miR-4775	CLIP-seq
MIRT1162288	hsa-miR-491-5p	CLIP-seq
MIRT1162315	hsa-miR-552	CLIP-seq
MIRT1162316	hsa-miR-555	CLIP-seq
MIRT1162320	hsa-miR-583	CLIP-seq
MIRT2046537	hsa-miR-590-3p	CLIP-seq
MIRT1162329	hsa-miR-764	CLIP-seq
MIRT2046506	hsa-miR-1292	CLIP-seq
MIRT2046507	hsa-miR-129-5p	CLIP-seq
MIRT1162209	hsa-miR-142-5p	CLIP-seq
MIRT2046513	hsa-miR-299-3p	CLIP-seq
MIRT2046514	hsa-miR-3115	CLIP-seq
MIRT2046515	hsa-miR-3149	CLIP-seq
MIRT2046516	hsa-miR-3151	CLIP-seq
MIRT1162233	hsa-miR-3199	CLIP-seq
MIRT1162235	hsa-miR-340	CLIP-seq
MIRT2454534	hsa-miR-411	CLIP-seq
MIRT2046524	hsa-miR-4447	CLIP-seq
MIRT2046525	hsa-miR-4450	CLIP-seq
MIRT2046526	hsa-miR-4471	CLIP-seq
MIRT2046527	hsa-miR-4472	CLIP-seq
MIRT2046533	hsa-miR-4735-5p	CLIP-seq
MIRT2046535	hsa-miR-4775	CLIP-seq
MIRT1162288	hsa-miR-491-5p	CLIP-seq
MIRT1162315	hsa-miR-552	CLIP-seq
MIRT1162316	hsa-miR-555	CLIP-seq
MIRT1162320	hsa-miR-583	CLIP-seq
MIRT2046537	hsa-miR-590-3p	CLIP-seq
MIRT1162329	hsa-miR-764	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0004645	Function	1,4-alpha-oligoglucan phosphorylase activity	TAS	8687427
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	8687427
GO:0006166	Process	Purine ribonucleoside salvage	IEA
GO:0006738	Process	Nicotinamide riboside catabolic process	IDA	19001417
GO:0009116	Process	Nucleoside metabolic process	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0016763	Function	Pentosyltransferase activity	IEA
GO:0017061	Function	S-methyl-5-thioadenosine phosphorylase activity	IBA
GO:0017061	Function	S-methyl-5-thioadenosine phosphorylase activity	IEA
GO:0019509	Process	L-methionine salvage from methylthioadenosine	IBA
GO:0019509	Process	L-methionine salvage from methylthioadenosine	IEA
GO:0032259	Process	Methylation	IEA
GO:0033574	Process	Response to testosterone	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867

MIM	HGNC	e!Ensembl
156540	7413	ENSG00000099810

Q13126

Protein name

S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase)

Protein function

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the meth

PDB

1CB0 , 1CG6 , 1K27 , 1SD1 , 1SD2 , 3LN5 , 3OZC , 3OZD , 3OZE , 5EUB , 5TC5 , 5TC6 , 5TC7 , 5TC8 , 6DYZ , 6DZ0 , 6DZ2 , 6DZ3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01048	PNP_UDP_1	11 → 256	Phosphorylase superfamily	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed.

Sequence

MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLAR
HGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMR
PQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSR
AESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTL
KENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH

Sequence length

283

Interactions

View interactions

	KEGG		Reactome
	Cysteine and methionine metabolism Metabolic pathways		Methionine salvage pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

143

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Diaphyseal medullary stenosis-bone malignancy syndrome	Pathogenic	rs2131048129, rs2131048008	RCV000022659 RCV000022660

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Familial prostate cancer	Benign	rs143080527	RCV005900555
Gastric cancer	Benign	rs79546636, rs147319145	RCV005900558 RCV005900554
Hepatocellular carcinoma	Benign	rs147319145	RCV005900552
Lung cancer	Benign	rs143080527	RCV005900556
Malignant tumor of esophagus	Benign	rs79546636, rs147319145	RCV005900557 RCV005900553
MTAP-related disorder	Benign; Likely benign	rs201864201, rs147319145, rs147028761, rs750076531	RCV003970080 RCV003902431 RCV003966809 RCV003908417

Show/Hide Text Mining Associations (91)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acrospiroma	Associate	35963436
Adenocarcinoma	Inhibit	35747993
Adenocarcinoma of Lung	Associate	31965001, 40138743
Adenoma	Associate	23361049
Astrocytoma	Associate	27172220, 33077924, 37032198, 38019246
Biliary Tract Diseases	Associate	40138743
Breast Neoplasms	Associate	14506228, 20513530, 22522925, 26751376, 32570693, 36361596, 36913304
Brenner Tumor	Associate	31695154
Calcinosis Cutis	Associate	29268653
Carcinogenesis	Associate	17552003, 27929028
Carcinogenesis	Inhibit	35766227
Carcinoma Adenosquamous	Inhibit	35747993
Carcinoma Hepatocellular	Associate	21356366, 38330461
Carcinoma in Situ	Associate	34518040
Carcinoma Non Small Cell Lung	Associate	33691794, 35747993, 38159439
Carcinoma Pancreatic Ductal	Associate	28720843, 38054349, 38330461
Carcinoma Renal Cell	Associate	27229762, 35945149, 35979371, 38017544
Carcinoma Squamous Cell	Inhibit	35747993
Cholangiocarcinoma	Associate	38330461
Chordoma	Associate	23019410
Chromosome Deletion	Inhibit	38641323
Colonic Neoplasms	Associate	15492751
Colorectal Neoplasms	Associate	23361049, 27433286, 29268653, 38330461
Coronary Artery Disease	Associate	21307941, 22664640
Diarrhea 5 With Tufting Enteropathy Congenital	Associate	34518040
Drug Related Side Effects and Adverse Reactions	Associate	21282358
Dysplastic Nevus Syndrome	Associate	34518040
Esophageal Squamous Cell Carcinoma	Associate	27960044
Fibrosarcoma	Associate	21131597
Gastrointestinal Neoplasms	Associate	38330461
Glioblastoma	Associate	19478948, 21649900, 21884817, 26936918, 31533041, 32093414, 33077924, 34244484, 35264604
Glioma	Associate	30558563, 32093414, 33077924, 37032198, 38109891
Glucosephosphate Dehydrogenase Deficiency	Associate	38092371
Glycogen Storage Disease Type V	Associate	11985785, 27479139
Helicobacter Infections	Associate	17552003
Hematologic Neoplasms	Inhibit	35963436
Huntington Disease	Inhibit	38641323
Inflammation	Associate	27433286
Intracranial Aneurysm	Associate	30994044
Keratosis	Associate	18163473
Leukoplakia Oral	Associate	18163473
Lung Diseases	Inhibit	40138743
Lung Neoplasms	Associate	19478948, 21282358, 33155773, 35766227
Lymphoma T Cell	Associate	8874207
Lymphoma T Cell Cutaneous	Inhibit	26872600
Melanoma	Inhibit	12875987, 20500769
Melanoma	Associate	15596045, 19578365, 21343389, 21962134, 21983785, 22685558, 23361049, 23393597, 23816148, 25837821, 26909863, 27479139, 29317335, 34724200, 35357426, 37277447 View all (1 more)
Melanoma Cutaneous Malignant	Associate	20574843, 21962134
Meningeal Carcinomatosis	Associate	32759977
Mesothelioma	Associate	31821740, 35459788, 35945149, 37295554, 38017544, 38092371
Mesothelioma Malignant	Associate	29053210, 31821740, 33493384, 33795785, 35459788, 35738002
Moyamoya disease 1	Associate	30994044
Mycosis Fungoides	Inhibit	26872600
Nasopharyngeal Carcinoma	Inhibit	26656376
Neoplasm Invasiveness	Associate	38017544
Neoplasm Metastasis	Inhibit	20500769, 35766227
Neoplasm Metastasis	Associate	29268653, 31965001, 38641323
Neoplasms	Associate	11985785, 15305192, 16207477, 19478948, 21131597, 22522925, 23884293, 26656376, 26912360, 27433286, 27556634, 27929028, 28880543, 29243509, 31533041 View all (15 more)
Neoplasms	Inhibit	12875987, 14506228, 15492751, 16989737, 18163473, 18712977, 21282358, 21356366, 26751376, 26872600, 26909863, 31249865, 3134658, 37277447, 37295554
Neoplasms	Stimulate	34518040
Neoplasms Glandular and Epithelial	Associate	31685964
Neuroblastoma	Associate	36361596
Nevus	Associate	19578365, 20574843, 21962134, 23361049
Nevus Pigmented	Associate	12875987
Oligodendroglioma	Associate	37032198
Oropharyngeal Neoplasms	Associate	25271301
Osteosarcoma	Inhibit	19478948
Osteosarcoma	Associate	35430564
Pancreatic Neoplasms	Associate	40138743
Pancreatitis	Inhibit	40138743
Peritoneal Neoplasms	Associate	38092371
Peritonitis	Associate	20081810, 38092371
Peritonitis	Inhibit	36138075
Pleural Effusion	Associate	29053210
Polycythemia Vera	Inhibit	34795367
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	21282358
Precursor Cell Lymphoblastic Leukemia Lymphoma	Inhibit	8874207
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	19478948
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Inhibit	8650244
Prostatic Neoplasms	Stimulate	34518040
Retinal Dysplasia	Associate	18163473
Sarcoma	Associate	30314519, 32759977
Sarcoma Ewing	Associate	29243509
Sezary Syndrome	Inhibit	26872600
Squamous Cell Carcinoma of Head and Neck	Associate	34518040
Stomach Neoplasms	Associate	17552003
Triple Negative Breast Neoplasms	Associate	36913304
Uniparental Disomy	Associate	21152100
Upton Young syndrome	Associate	25307738
Urethral Neoplasms	Associate	38219954, 38641323
Urinary Bladder Neoplasms	Associate	27270441

MTAP (methylthioadenosine phosphorylase)