MT1M (metallothionein 1M)

Gene

• Entrez ID: 4499
• Gene name: Metallothionein 1M
• Gene symbol: MT1M
• Synonyms (NCBI Gene): MT-1M, MT-IM, MT1, MT1K
• Chromosome: 16
• Chromosome location: 16q13
• Summary: This gene encodes a member of the metallothionein superfamily, type 1 family. Metallothioneins have a high content of cysteine residues that bind various heavy metals. These genes are transcriptionally regulated by both heavy metals and glucocorticoids. [

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028853	hsa-miR-26b-5p	Microarray	19088304

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	ISS
GO:0006882	Process	Intracellular zinc ion homeostasis	IBA
GO:0008270	Function	Zinc ion binding	ISS
GO:0010273	Process	Detoxification of copper ion	IBA
GO:0045926	Process	Negative regulation of growth	ISS
GO:0046872	Function	Metal ion binding	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0071276	Process	Cellular response to cadmium ion	IBA
GO:0071280	Process	Cellular response to copper ion	IBA
GO:0071294	Process	Cellular response to zinc ion	IBA
GO:0071294	Process	Cellular response to zinc ion	ISS

Other IDs

• MIM: 156357
• HGNC: 14296
• e!Ensembl: ENSG00000205364

Protein

• UniProt ID: Q8N339
• Protein name: Metallothionein-1M (MT-1M) (Metallothionein-IM) (MT-IM)
• Protein function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00131	Metallothio	1 → 61	Metallothionein	Domain

• Sequence:

  MDPNCSCTTGVSCACTGSCTCKECKCTSCKKSCCSCCPVGCAKCAHGCVCKGTLENCSCC
  A

• Sequence length: 61

Pathways

KEGG:

Mineral absorption

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CORONARY STENOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Alzheimer Disease	Associate	39188714	★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Associate	39188714	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Inhibit	33820882	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	24782625, 27808371, 29461597, 34423049, 37120619, 37259059	★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Hypertrophic	Associate	35328083	★☆☆☆☆ Found in Text Mining only
Crohn Disease	Associate	36466876	★☆☆☆☆ Found in Text Mining only
Dermatomyositis	Associate	37259059	★☆☆☆☆ Found in Text Mining only
Down Syndrome	Associate	35741790	★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Associate	19472401	★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Inhibit	33820882	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Associate	19472401	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Inhibit	33820882	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	24782625	★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	33820882	★☆☆☆☆ Found in Text Mining only
Periodontal Diseases	Associate	31540037	★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Associate	29461597	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Associate	29461597	★☆☆☆☆ Found in Text Mining only