Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	4489
Gene name	Metallothionein 1A
Gene symbol	MT1A
Synonyms (NCBI Gene)	MT-1AMT-IAMT1MT1SMTC
Chromosome	16
Chromosome location	16q13
Summary	This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate meta

162

Show/Hide all (162)

miRTarBase ID	miRNA	Experiments	Reference
MIRT724135	hsa-miR-370-5p	HITS-CLIP	19536157
MIRT724134	hsa-miR-4639-3p	HITS-CLIP	19536157
MIRT724133	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT724132	hsa-miR-3665	HITS-CLIP	19536157
MIRT724131	hsa-miR-657	HITS-CLIP	19536157
MIRT724130	hsa-miR-668-3p	HITS-CLIP	19536157
MIRT724129	hsa-miR-3944-5p	HITS-CLIP	19536157
MIRT724128	hsa-miR-143-5p	HITS-CLIP	19536157
MIRT724127	hsa-miR-6794-3p	HITS-CLIP	19536157
MIRT724126	hsa-miR-7159-3p	HITS-CLIP	19536157
MIRT724125	hsa-miR-4482-3p	HITS-CLIP	19536157
MIRT724124	hsa-miR-2113	HITS-CLIP	19536157
MIRT714701	hsa-miR-6777-3p	HITS-CLIP	19536157
MIRT714702	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT714699	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT714700	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT714698	hsa-miR-6861-5p	HITS-CLIP	19536157
MIRT714697	hsa-miR-555	HITS-CLIP	19536157
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT714696	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT714695	hsa-miR-6783-3p	HITS-CLIP	19536157
MIRT714694	hsa-miR-670-3p	HITS-CLIP	19536157
MIRT714693	hsa-miR-1238-3p	HITS-CLIP	19536157
MIRT620780	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT620779	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT620778	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT620777	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620773	hsa-miR-3977	HITS-CLIP	23824327
MIRT620772	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT620780	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT620779	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT620778	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT620777	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620773	hsa-miR-3977	HITS-CLIP	23824327
MIRT620772	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT620780	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT620779	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT620778	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT620777	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620773	hsa-miR-3977	HITS-CLIP	23824327
MIRT620772	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT620780	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT620779	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT620778	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT620777	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620773	hsa-miR-3977	HITS-CLIP	23824327
MIRT620772	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT615895	hsa-miR-3154	HITS-CLIP	23824327
MIRT615894	hsa-miR-6757-5p	HITS-CLIP	23824327
MIRT615893	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT615892	hsa-miR-6128	HITS-CLIP	23824327
MIRT615891	hsa-miR-7515	HITS-CLIP	23824327
MIRT615890	hsa-miR-542-3p	HITS-CLIP	23824327
MIRT615889	hsa-miR-1299	HITS-CLIP	23824327
MIRT615888	hsa-miR-516b-5p	HITS-CLIP	23824327
MIRT615887	hsa-miR-4782-5p	HITS-CLIP	23824327
MIRT615886	hsa-miR-5706	HITS-CLIP	23824327
MIRT615895	hsa-miR-3154	HITS-CLIP	23824327
MIRT615894	hsa-miR-6757-5p	HITS-CLIP	23824327
MIRT615893	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT615892	hsa-miR-6128	HITS-CLIP	23824327
MIRT615891	hsa-miR-7515	HITS-CLIP	23824327
MIRT615890	hsa-miR-542-3p	HITS-CLIP	23824327
MIRT615889	hsa-miR-1299	HITS-CLIP	23824327
MIRT615888	hsa-miR-516b-5p	HITS-CLIP	23824327
MIRT615887	hsa-miR-4782-5p	HITS-CLIP	23824327
MIRT615886	hsa-miR-5706	HITS-CLIP	23824327
MIRT724135	hsa-miR-370-5p	HITS-CLIP	19536157
MIRT724134	hsa-miR-4639-3p	HITS-CLIP	19536157
MIRT724133	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT724132	hsa-miR-3665	HITS-CLIP	19536157
MIRT724131	hsa-miR-657	HITS-CLIP	19536157
MIRT724130	hsa-miR-668-3p	HITS-CLIP	19536157
MIRT724129	hsa-miR-3944-5p	HITS-CLIP	19536157
MIRT724128	hsa-miR-143-5p	HITS-CLIP	19536157
MIRT724127	hsa-miR-6794-3p	HITS-CLIP	19536157
MIRT724126	hsa-miR-7159-3p	HITS-CLIP	19536157
MIRT724125	hsa-miR-4482-3p	HITS-CLIP	19536157
MIRT724124	hsa-miR-2113	HITS-CLIP	19536157
MIRT714701	hsa-miR-6777-3p	HITS-CLIP	19536157
MIRT714702	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT714699	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT714700	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT714698	hsa-miR-6861-5p	HITS-CLIP	19536157
MIRT714697	hsa-miR-555	HITS-CLIP	19536157
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT714696	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT714695	hsa-miR-6783-3p	HITS-CLIP	19536157
MIRT714694	hsa-miR-670-3p	HITS-CLIP	19536157
MIRT714693	hsa-miR-1238-3p	HITS-CLIP	19536157
MIRT620780	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT620779	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT620778	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT620777	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620773	hsa-miR-3977	HITS-CLIP	23824327
MIRT620772	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT620780	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT620779	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT620778	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT620777	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620773	hsa-miR-3977	HITS-CLIP	23824327
MIRT620772	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT620780	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT620779	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT620778	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT620777	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620773	hsa-miR-3977	HITS-CLIP	23824327
MIRT620772	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT620780	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT620779	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT620778	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT620777	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT620776	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT620775	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT620774	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT620773	hsa-miR-3977	HITS-CLIP	23824327
MIRT620772	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT615895	hsa-miR-3154	HITS-CLIP	23824327
MIRT615894	hsa-miR-6757-5p	HITS-CLIP	23824327
MIRT615893	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT615892	hsa-miR-6128	HITS-CLIP	23824327
MIRT615891	hsa-miR-7515	HITS-CLIP	23824327
MIRT615890	hsa-miR-542-3p	HITS-CLIP	23824327
MIRT615889	hsa-miR-1299	HITS-CLIP	23824327
MIRT615888	hsa-miR-516b-5p	HITS-CLIP	23824327
MIRT615887	hsa-miR-4782-5p	HITS-CLIP	23824327
MIRT615886	hsa-miR-5706	HITS-CLIP	23824327
MIRT615895	hsa-miR-3154	HITS-CLIP	23824327
MIRT615894	hsa-miR-6757-5p	HITS-CLIP	23824327
MIRT615893	hsa-miR-875-3p	HITS-CLIP	23824327
MIRT615892	hsa-miR-6128	HITS-CLIP	23824327
MIRT615891	hsa-miR-7515	HITS-CLIP	23824327
MIRT615890	hsa-miR-542-3p	HITS-CLIP	23824327
MIRT615889	hsa-miR-1299	HITS-CLIP	23824327
MIRT615888	hsa-miR-516b-5p	HITS-CLIP	23824327
MIRT615887	hsa-miR-4782-5p	HITS-CLIP	23824327
MIRT615886	hsa-miR-5706	HITS-CLIP	23824327

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16442532, 16778767
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	TAS
GO:0006882	Process	Intracellular zinc ion homeostasis	IBA
GO:0008270	Function	Zinc ion binding	ISS
GO:0010273	Process	Detoxification of copper ion	IBA
GO:0045926	Process	Negative regulation of growth	ISS
GO:0046872	Function	Metal ion binding	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0071276	Process	Cellular response to cadmium ion	IBA
GO:0071276	Process	Cellular response to cadmium ion	IEP	16827180
GO:0071280	Process	Cellular response to copper ion	IBA
GO:0071294	Process	Cellular response to zinc ion	IBA
GO:0071294	Process	Cellular response to zinc ion	IEP	11168427

MIM	HGNC	e!Ensembl
156350	7393	ENSG00000205362

P04731

Protein name

Metallothionein-1A (MT-1A) (Metallothionein-IA) (MT-IA)

Protein function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00131	Metallothio	1 → 61	Metallothionein	Domain

Sequence

MDPNCSCATGGSCTCTGSCKCKECKCTSCKKSCCSCCPMSCAKCAQGCICKGASEKCSCC
A

Sequence length

Interactions

View interactions

	KEGG		Reactome
	Mineral absorption		Metallothioneins bind metals

MT1A (metallothionein 1A)