MT1A (metallothionein 1A)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4489
Gene name Gene Name - the full gene name approved by the HGNC.
Metallothionein 1A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MT1A
Synonyms (NCBI Gene) Gene synonyms aliases
MT-1A, MT-IA, MT1, MT1S, MTC
Disease Acronyms (UniProt) Disease acronyms from UniProt database
MTC
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q13
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate meta
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(162)
miRTarBase ID miRNA Experiments Reference
MIRT724135 hsa-miR-370-5p HITS-CLIP 19536157
MIRT724134 hsa-miR-4639-3p HITS-CLIP 19536157
MIRT724133 hsa-miR-130b-5p HITS-CLIP 19536157
MIRT724132 hsa-miR-3665 HITS-CLIP 19536157
MIRT724131 hsa-miR-657 HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(17)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 16442532, 16778767
GO:0005634 Component Nucleus IBA 21873635
GO:0005634 Component Nucleus ISS
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005737 Component Cytoplasm ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
156350 7393 ENSG00000205362
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P04731
Protein name Metallothionein-1A (MT-1A) (Metallothionein-IA) (MT-IA)
Protein function Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00131 Metallothio 1 → 61 Metallothionein Domain
Sequence
Sequence length 61
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Mineral absorption   Metallothioneins bind metals
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Carcinoma Squamous cell carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 17418620
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Nasopharyngeal carcinoma Nasopharyngeal carcinoma These data suggest that KAT7 can contribute NPC cell growth and survival through up-regulation of NPC-essential genes. 23209447 ClinVar, CBGDA
Show/Hide Text Mining Associations (20)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 27610375
Astrocytoma Associate 15367334
Astrocytoma Stimulate 30932010
Diabetes Mellitus Associate 18349110
Diabetes Mellitus Type 2 Associate 18349110
Down Syndrome Associate 35741790
Esophageal Neoplasms Associate 37027423
Glioblastoma Associate 30932010
Glycogen Storage Disease Type IV Stimulate 30932010
Lung Neoplasms Associate 23947958