MST1 (macrophage stimulating 1)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4485
Gene name Gene Name - the full gene name approved by the HGNC.
Macrophage stimulating 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MST1
Synonyms (NCBI Gene) Gene synonyms aliases
D3F15S2, DNF15S2, HGFL, MSP, NF15S2
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p21.31
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(4)
miRTarBase ID miRNA Experiments Reference
MIRT025230 hsa-miR-34a-5p Proteomics 21566225
MIRT025230 hsa-miR-34a-5p Proteomics 21566225
MIRT735859 hsa-miR-1184 Western blotting, qRT-PCR 32681581
MIRT735859 hsa-miR-1184 Western blotting, Immunoprecipitaion (IP), qRT-PCR 32681581
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
EZH2 Repression 24499724
MYC Repression 24499724
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0004175 Function Endopeptidase activity IBA
GO:0005515 Function Protein binding IPI 22087277, 25193665, 32296183
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
142408 7380 ENSG00000173531
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P26927
Protein name Hepatocyte growth factor-like protein (Macrophage stimulatory protein) (Macrophage-stimulating protein) (MSP) [Cleaved into: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain]
PDB 2ASU , 4QT8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00024 PAN_1 16 → 106 PAN domain Domain
PF00051 Kringle 110 → 186 Kringle domain Domain
PF00051 Kringle 191 → 268 Kringle domain Domain
PF00051 Kringle 283 → 361 Kringle domain Domain
PF00051 Kringle 370 → 448 Kringle domain Domain
PF00089 Trypsin 484 → 704 Trypsin Domain
Sequence
Sequence length 711
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Calcium signaling pathway   Signaling by MST1
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (6)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Crohn Disease Crohn's disease N/A N/A GWAS
Inflammatory Bowel Disease Inflammatory bowel disease N/A N/A GWAS
Myocardial Infarction Myocardial infarction N/A N/A GWAS
Sclerosing Cholangitis Primary sclerosing cholangitis N/A N/A GWAS
Show/Hide Text Mining Associations (66)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 35229723
Amyotrophic Lateral Sclerosis Associate 22069488
Amyotrophic lateral sclerosis 1 Associate 22069488
Arthritis Rheumatoid Associate 32692720
Breast Neoplasms Associate 19307182, 28387539, 34449481, 35654829
Breast Neoplasms Inhibit 33760220
Bronchiectasis Stimulate 10955755
Carcinogenesis Associate 20920251, 23419720, 2536219, 27238285
Carcinoma Hepatocellular Associate 23347832, 23419720, 27765911, 27881216, 28465479, 34565286
Carcinoma Non Small Cell Lung Associate 2536219, 30320378