MSMB (microseminoprotein beta)

Gene
Gene SNPs Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4477
Gene name Gene Name - the full gene name approved by the HGNC.
Microseminoprotein beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MSMB
Synonyms (NCBI Gene) Gene synonyms aliases
HPC13, IGBF, MSP, MSPB, PN44, PRPS, PSP, PSP-94, PSP57, PSP94
Disease Acronyms (UniProt) Disease acronyms from UniProt database
HPC13, PSP
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q11.22
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as a
SNPs SNP information provided by dbSNP.
Gene SNPs Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all(1)
SNP ID Visualize variation Clinical significance Consequence
rs10993994 A>G Risk-factor Upstream transcript variant
Transcription factors
Gene SNPs Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all(3)
Transcription factor Regulation Reference
CNOT7 Unknown 15937477
CNOT8 Unknown 15937477
CREB1 Unknown 9704017
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all(5)
GO ID Ontology Definition Evidence Reference
GO:0003674 Function Molecular_function ND
GO:0005515 Function Protein binding IPI 25416956
GO:0005615 Component Extracellular space TAS 7566962
GO:0005634 Component Nucleus TAS 7566962
GO:0008150 Process Biological_process ND
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Transcription factors Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
157145 7372 ENSG00000263639
Protein
Gene SNPs Transcription factors Gene ontology Other IDs Protein Associated diseases
UniProt ID P08118
Protein name Beta-microseminoprotein (Immunoglobulin-binding factor) (IGBF) (PN44) (Prostate secreted seminal plasma protein) (Prostate secretory protein of 94 amino acids) (PSP-94) (PSP94) (Seminal plasma beta-inhibin)
PDB 2IZ3 , 3IX0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05825 PSP94 21 → 114 Beta-microseminoprotein (PSP-94) Domain
Tissue specificity TISSUE SPECIFICITY: Strongly expressed in prostate, liver, kidney, breast and penis. Also expressed in pancreas, esophagus, stomach, deodenum, colon, trachea, lung, salivary glands and fallopian tube. PSP94 is expressed in lung and breast, whereas PSP57 i
Sequence
Sequence length 114
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene SNPs Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Prostate cancer Malignant neoplasm of prostate, Prostate carcinoma, Prostate cancer, familial, Familial prostate cancer rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 18264096, 20676098, 17013881, 18264097, 24753544, 25939597, 26443449, 26034056, 24740154, 29892016, 31226226, 31562322, 19997100, 19383797
Prostate cancer, hereditary Prostate Cancer, Hereditary, 13 rs387906327, rs193929331, rs74315365, rs397516896, rs794729219, rs121913349, rs587782641, rs1114167673, rs1597371666, rs2073394466
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Nasopharyngeal carcinoma Nasopharyngeal carcinoma These data suggest that KAT7 can contribute NPC cell growth and survival through up-regulation of NPC-essential genes. 20512145 ClinVar, CBGDA
Eczema Eczema GWAS
Show/Hide Text Mining Associations (12)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 21261984, 37225691
Airway Remodeling Associate 31443657
Carcinogenesis Associate 33122083
Carcinoma Signet Ring Cell Associate 37225691
Carcinoma Squamous Cell Associate 16470182
Gout Associate 17701896
Neoplasms Associate 19383797, 19644707, 19997100, 21240253, 21261984, 22887727, 23391636, 26501111, 37406106
Ovarian Neoplasms Associate 25188517
Prostatic Neoplasms Inhibit 19153072, 19997100, 31089709
Prostatic Neoplasms Associate 19153072, 19318432, 19383797, 19434657, 19644707, 19997100, 20424135, 20569440, 20696662, 20717903, 20736317, 20967219, 21071540, 21085629, 21240253
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