MSMB (microseminoprotein beta)

Gene Gene information from NCBI Gene database.
Gene SNPs Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID 4477
Gene name Microseminoprotein beta
Gene symbol MSMB
Synonyms (NCBI Gene)
HPC13IGBFMSPMSPBPN44PRPSPSPPSP-94PSP57PSP94
Chromosome 10
Chromosome location 10q11.22
Summary The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as a
SNPs SNP information provided by dbSNP.
1
Gene SNPs Transcription factors Gene ontology Other IDs Protein Associated diseases
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SNP ID Visualize variation Clinical significance Consequence
rs10993994 A>G Risk-factor Upstream transcript variant
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene SNPs Transcription factors Gene ontology Other IDs Protein Associated diseases
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Transcription factor Regulation Reference
CNOT7 Unknown 15937477
CNOT8 Unknown 15937477
CREB1 Unknown 9704017
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene SNPs Transcription factors Gene ontology Other IDs Protein Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956
GO:0005576 Component Extracellular region IEA
GO:0005615 Component Extracellular space TAS 7566962
GO:0005634 Component Nucleus TAS 7566962
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs Transcription factors Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
157145 7372 ENSG00000263639
Protein Protein information from UniProt database.
Gene SNPs Transcription factors Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P08118
Protein name Beta-microseminoprotein (Immunoglobulin-binding factor) (IGBF) (PN44) (Prostate secreted seminal plasma protein) (Prostate secretory protein of 94 amino acids) (PSP-94) (PSP94) (Seminal plasma beta-inhibin)
PDB 2IZ3 , 3IX0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05825 PSP94 21 → 114 Beta-microseminoprotein (PSP-94) Domain
Tissue specificity TISSUE SPECIFICITY: Strongly expressed in prostate, liver, kidney, breast and penis. Also expressed in pancreas, esophagus, stomach, deodenum, colon, trachea, lung, salivary glands and fallopian tube. PSP94 is expressed in lung and breast, whereas PSP57 i
Sequence
Sequence length 114
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene SNPs Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Prostate cancer, hereditary, 13 risk factor rs10993994 RCV000015312
Show/Hide Text Mining Associations (12)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 21261984, 37225691
Airway Remodeling Associate 31443657
Carcinogenesis Associate 33122083
Carcinoma Signet Ring Cell Associate 37225691
Carcinoma Squamous Cell Associate 16470182
Gout Associate 17701896
Neoplasms Associate 19383797, 19644707, 19997100, 21240253, 21261984, 22887727, 23391636, 26501111, 37406106
Ovarian Neoplasms Associate 25188517
Prostatic Neoplasms Inhibit 19153072, 19997100, 31089709
Prostatic Neoplasms Associate 19153072, 19318432, 19383797, 19434657, 19644707, 19997100, 20424135, 20569440, 20696662, 20717903, 20736317, 20967219, 21071540, 21085629, 21240253
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