Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	445571
Gene name	Zn regulated GTPase metalloprotein activator 1C
Gene symbol	ZNG1C
Synonyms (NCBI Gene)	CBWD3bA561O23.1
Chromosome	9
Chromosome location	9q21.11

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019864	hsa-miR-375	Microarray	20215506
MIRT2497497	hsa-miR-1207-3p	CLIP-seq
MIRT2497498	hsa-miR-2113	CLIP-seq
MIRT2497499	hsa-miR-2276	CLIP-seq
MIRT2497500	hsa-miR-297	CLIP-seq
MIRT2497501	hsa-miR-30a	CLIP-seq
MIRT2497502	hsa-miR-30b	CLIP-seq
MIRT2497503	hsa-miR-30c	CLIP-seq
MIRT2497504	hsa-miR-30d	CLIP-seq
MIRT2497505	hsa-miR-30e	CLIP-seq
MIRT2497506	hsa-miR-3117-5p	CLIP-seq
MIRT2497507	hsa-miR-3145-3p	CLIP-seq
MIRT2497508	hsa-miR-3145-5p	CLIP-seq
MIRT2497509	hsa-miR-3149	CLIP-seq
MIRT2497510	hsa-miR-3152-3p	CLIP-seq
MIRT2497511	hsa-miR-3168	CLIP-seq
MIRT2497512	hsa-miR-340	CLIP-seq
MIRT2497513	hsa-miR-3611	CLIP-seq
MIRT2497514	hsa-miR-3662	CLIP-seq
MIRT2497515	hsa-miR-3675-3p	CLIP-seq
MIRT2497516	hsa-miR-380	CLIP-seq
MIRT2497517	hsa-miR-382	CLIP-seq
MIRT2497518	hsa-miR-410	CLIP-seq
MIRT2497519	hsa-miR-4263	CLIP-seq
MIRT2497520	hsa-miR-4282	CLIP-seq
MIRT2497521	hsa-miR-4495	CLIP-seq
MIRT2497522	hsa-miR-4528	CLIP-seq
MIRT2497523	hsa-miR-4670-3p	CLIP-seq
MIRT2497524	hsa-miR-4772-3p	CLIP-seq
MIRT2497525	hsa-miR-4795-3p	CLIP-seq
MIRT2497526	hsa-miR-488	CLIP-seq
MIRT2497527	hsa-miR-581	CLIP-seq
MIRT2497528	hsa-miR-607	CLIP-seq
MIRT2497529	hsa-miR-653	CLIP-seq
MIRT2497530	hsa-miR-656	CLIP-seq
MIRT2497531	hsa-miR-758	CLIP-seq
MIRT2497497	hsa-miR-1207-3p	CLIP-seq
MIRT2497498	hsa-miR-2113	CLIP-seq
MIRT2497499	hsa-miR-2276	CLIP-seq
MIRT2497501	hsa-miR-30a	CLIP-seq
MIRT2497502	hsa-miR-30b	CLIP-seq
MIRT2497503	hsa-miR-30c	CLIP-seq
MIRT2497504	hsa-miR-30d	CLIP-seq
MIRT2497505	hsa-miR-30e	CLIP-seq
MIRT2497506	hsa-miR-3117-5p	CLIP-seq
MIRT2497507	hsa-miR-3145-3p	CLIP-seq
MIRT2497508	hsa-miR-3145-5p	CLIP-seq
MIRT2497510	hsa-miR-3152-3p	CLIP-seq
MIRT2497511	hsa-miR-3168	CLIP-seq
MIRT2497512	hsa-miR-340	CLIP-seq
MIRT2497513	hsa-miR-3611	CLIP-seq
MIRT2497514	hsa-miR-3662	CLIP-seq
MIRT2497515	hsa-miR-3675-3p	CLIP-seq
MIRT2497516	hsa-miR-380	CLIP-seq
MIRT2497517	hsa-miR-382	CLIP-seq
MIRT2497519	hsa-miR-4263	CLIP-seq
MIRT2497520	hsa-miR-4282	CLIP-seq
MIRT2497521	hsa-miR-4495	CLIP-seq
MIRT2497522	hsa-miR-4528	CLIP-seq
MIRT2497523	hsa-miR-4670-3p	CLIP-seq
MIRT2497524	hsa-miR-4772-3p	CLIP-seq
MIRT2497525	hsa-miR-4795-3p	CLIP-seq
MIRT2497526	hsa-miR-488	CLIP-seq
MIRT2497527	hsa-miR-581	CLIP-seq
MIRT2497528	hsa-miR-607	CLIP-seq
MIRT2497529	hsa-miR-653	CLIP-seq
MIRT2497531	hsa-miR-758	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005525	Function	GTP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
611080	18519	ENSG00000196873

Q5JTY5

Protein name

Zinc-regulated GTPase metalloprotein activator 1C (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 3) (COBW domain-containing protein 3)

Protein function

Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from po

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02492	cobW	43 → 231	CobW/HypB/UreG, nucleotide-binding domain	Domain
PF07683	CobW_C	274 → 377	Cobalamin synthesis protein cobW C-terminal domain	Domain

Sequence

MLPAVGSVDEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLN
YILTEQHSKRVAVILNESGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDNGLRAI
ENLMQKKGKFDDILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLTE
EKPDGLINEATRQVALADIILINKTDLVPEEDVKKLRTTIRSINGLGQILETQRSRVDLS
NVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWE
KNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLI
GRNLDKDILKQLFIATVTETEKQWTTHFKEDQVCT

Sequence length

395

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OCULAR SARCOIDOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ZNG1C (Zn regulated GTPase metalloprotein activator 1C)