Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4437
Gene name Gene Name - the full gene name approved by the HGNC.	MutS homolog 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MSH3
Synonyms (NCBI Gene) Gene synonyms aliases	DUP, FAP4, MRP1
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q14.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer.

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SNP ID	Visualize variation	Clinical significance	Consequence
rs41545019	T>G	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, missense variant
rs61754780	G>T	Likely-pathogenic	Splice acceptor variant
rs200639359	G>A	Likely-pathogenic	Splice acceptor variant
rs201033017	C>T	Pathogenic	Coding sequence variant, stop gained
rs367544716	G>A	Likely-pathogenic	Splice acceptor variant
rs374133543	C>T	Pathogenic	Coding sequence variant, stop gained
rs376456666	T>C	Likely-pathogenic	Splice donor variant
rs376667075	C>T	Pathogenic	Coding sequence variant, stop gained
rs539295465	C>T	Pathogenic	Coding sequence variant, stop gained
rs578113271	C>G,T	Pathogenic	Coding sequence variant, stop gained, missense variant
rs587776701	A>-,AA	Pathogenic	Coding sequence variant, frameshift variant
rs749929790	G>A	Likely-pathogenic	Splice donor variant
rs750876165	A>C,G	Likely-pathogenic	Splice acceptor variant
rs751236312	->A	Pathogenic	Coding sequence variant, frameshift variant
rs751326348	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs756632960	G>T	Pathogenic	Stop gained, coding sequence variant
rs757194485	AG>-	Pathogenic	Frameshift variant, coding sequence variant
rs758191157	C>G	Pathogenic	Stop gained, coding sequence variant
rs763478027	TGTT>-	Pathogenic	Coding sequence variant, frameshift variant
rs766672143	A>-	Pathogenic	Coding sequence variant, frameshift variant
rs771721952	A>-	Pathogenic	Coding sequence variant, frameshift variant
rs777054839	G>A,T	Pathogenic, uncertain-significance	Coding sequence variant, stop gained, missense variant
rs778610412	AG>-	Pathogenic	Coding sequence variant, frameshift variant
rs866260675	G>A,C	Pathogenic	Splice acceptor variant
rs886037878	A>C	Pathogenic	Splice acceptor variant
rs952650934	C>T	Pathogenic	Stop gained, coding sequence variant
rs1204002507	AT>-	Pathogenic	Frameshift variant, coding sequence variant
rs1234762807	->A	Pathogenic	Coding sequence variant, frameshift variant
rs1455445683	TTTA>-	Pathogenic	Coding sequence variant, frameshift variant
rs1475633334	TTCCCGG>-	Pathogenic	Coding sequence variant, frameshift variant
rs1554070317	A>G	Likely-pathogenic	Splice acceptor variant
rs1561486630	C>G	Pathogenic	Coding sequence variant, stop gained
rs1561486632	AGAG>-,AG	Pathogenic	Coding sequence variant, stop gained, frameshift variant
rs1580027407	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs1580027713	T>C	Likely-pathogenic	Splice donor variant
rs1580033751	->ATAT	Pathogenic	Frameshift variant, coding sequence variant
rs1580035033	->A	Pathogenic	Frameshift variant, coding sequence variant
rs1580035037	A>T	Pathogenic, likely-pathogenic	Stop gained, coding sequence variant
rs1580045730	T>C	Likely-pathogenic	Splice donor variant
rs1580053768	G>A	Likely-pathogenic	Splice donor variant
rs1580066605	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs1580091499	TGAC>-	Pathogenic	Frameshift variant, coding sequence variant
rs1580091512	CA>-	Pathogenic	Frameshift variant, coding sequence variant
rs1580091639	TTTCATCAGAGATGTAAGTATCCGGTAAACTGTATTTAAAAAGAAATTAATTTGTAAATTATTATTTTTAAATGACAGTCATAATTGTGCCATATTTATGGGGTACAATGTGATGTTTTGAAACATATAAACAATATGGAGTGATTAAATTAACCTAATTAACACATTCCTCACCTCATTTAAATATCATTTTTTGTGGTGAGACATTTGAAATTTCTCTTAGTTATTTTGAAATATATATTATTACTGCTGTAG	Likely-pathogenic	Intron variant, splice donor variant, coding sequence variant
rs1580546655	GA>-	Pathogenic	Frameshift variant, coding sequence variant
rs1580546793	C>T	Pathogenic	Stop gained, coding sequence variant
rs1580550290	C>G	Pathogenic	Stop gained, coding sequence variant
rs1580553607	T>-	Pathogenic, likely-pathogenic	Frameshift variant, coding sequence variant
rs1580553624	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs1580553669	->G	Pathogenic	Frameshift variant, coding sequence variant
rs1580556516	C>T	Pathogenic	Stop gained, coding sequence variant
rs1580589397	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs1580589429	GG>C	Pathogenic	Frameshift variant, coding sequence variant
rs1580589463	G>A	Likely-pathogenic	Splice donor variant
rs1580597385	C>-	Pathogenic	Frameshift variant, coding sequence variant
rs1580597397	->AA	Pathogenic	Frameshift variant, coding sequence variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004747	hsa-miR-326	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	19883630
MIRT042726	hsa-miR-345-5p	CLASH	23622248
MIRT040556	hsa-miR-92b-3p	CLASH	23622248
MIRT719506	hsa-miR-590-3p	HITS-CLIP	19536157
MIRT719505	hsa-miR-6872-3p	HITS-CLIP	19536157
MIRT719504	hsa-miR-4735-5p	HITS-CLIP	19536157
MIRT719503	hsa-miR-4775	HITS-CLIP	19536157
MIRT711546	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT711545	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT711544	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT711543	hsa-miR-6787-3p	HITS-CLIP	19536157
MIRT711542	hsa-miR-3120-5p	HITS-CLIP	19536157
MIRT447593	hsa-miR-3182	HITS-CLIP	19536157
MIRT711541	hsa-miR-23a-5p	HITS-CLIP	19536157
MIRT711540	hsa-miR-23b-5p	HITS-CLIP	19536157
MIRT711539	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT711537	hsa-miR-6783-3p	HITS-CLIP	19536157
MIRT711538	hsa-miR-6888-3p	HITS-CLIP	19536157
MIRT711536	hsa-miR-498	HITS-CLIP	19536157
MIRT711535	hsa-miR-4743-3p	HITS-CLIP	19536157
MIRT711534	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT711533	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT685538	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT685537	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT685536	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT685535	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT685534	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT685533	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT685532	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT685531	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT685530	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT685529	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT685528	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT685527	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT685526	hsa-miR-302e	HITS-CLIP	23313552
MIRT685525	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT685524	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT685523	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT685522	hsa-miR-520b	HITS-CLIP	23313552
MIRT685521	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT685520	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT685519	hsa-miR-520e	HITS-CLIP	23313552
MIRT685518	hsa-miR-3159	HITS-CLIP	23313552
MIRT216879	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT216880	hsa-miR-520h	HITS-CLIP	23313552
MIRT685517	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT685516	hsa-miR-1224-3p	HITS-CLIP	23313552
MIRT685515	hsa-miR-1234-3p	HITS-CLIP	23313552
MIRT685514	hsa-miR-7107-5p	HITS-CLIP	23313552
MIRT685513	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT685512	hsa-miR-1913	HITS-CLIP	23313552
MIRT685511	hsa-miR-324-3p	HITS-CLIP	23313552
MIRT685510	hsa-miR-18a-3p	HITS-CLIP	23313552
MIRT447596	hsa-miR-1246	PAR-CLIP	22100165
MIRT447595	hsa-miR-216b-3p	PAR-CLIP	22100165
MIRT447594	hsa-miR-4742-3p	PAR-CLIP	22100165
MIRT447593	hsa-miR-3182	PAR-CLIP	22100165
MIRT447591	hsa-miR-4635	PAR-CLIP	22100165
MIRT447592	hsa-miR-3686	PAR-CLIP	22100165
MIRT447596	hsa-miR-1246	PAR-CLIP	22100165
MIRT447595	hsa-miR-216b-3p	PAR-CLIP	22100165
MIRT447594	hsa-miR-4742-3p	PAR-CLIP	22100165
MIRT447593	hsa-miR-3182	PAR-CLIP	22100165
MIRT447591	hsa-miR-4635	PAR-CLIP	22100165
MIRT447592	hsa-miR-3686	PAR-CLIP	22100165
MIRT685538	hsa-miR-106a-5p	qRT-PCR	25950430
MIRT706010	hsa-miR-145-5p	Luciferase reporter assay, qRT-PCR, Western blot	26852750
MIRT706010	hsa-miR-145-5p	Luciferase reporter assay, qRT-PCR, Western blot	26852750
MIRT003199	hsa-miR-7-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR	26108539
MIRT719506	hsa-miR-590-3p	HITS-CLIP	19536157
MIRT719505	hsa-miR-6872-3p	HITS-CLIP	19536157
MIRT719504	hsa-miR-4735-5p	HITS-CLIP	19536157
MIRT719503	hsa-miR-4775	HITS-CLIP	19536157
MIRT711546	hsa-miR-939-3p	HITS-CLIP	19536157
MIRT711545	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT711544	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT711543	hsa-miR-6787-3p	HITS-CLIP	19536157
MIRT711542	hsa-miR-3120-5p	HITS-CLIP	19536157
MIRT447593	hsa-miR-3182	HITS-CLIP	19536157
MIRT711541	hsa-miR-23a-5p	HITS-CLIP	19536157
MIRT711540	hsa-miR-23b-5p	HITS-CLIP	19536157
MIRT711539	hsa-miR-1343-3p	HITS-CLIP	19536157
MIRT711537	hsa-miR-6783-3p	HITS-CLIP	19536157
MIRT711538	hsa-miR-6888-3p	HITS-CLIP	19536157
MIRT711536	hsa-miR-498	HITS-CLIP	19536157
MIRT711535	hsa-miR-4743-3p	HITS-CLIP	19536157
MIRT711534	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT711533	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT685538	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT685537	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT685536	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT685535	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT685534	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT685533	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT685532	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT685531	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT685530	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT685529	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT685528	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT685527	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT685526	hsa-miR-302e	HITS-CLIP	23313552
MIRT685525	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT685524	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT685523	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT685522	hsa-miR-520b	HITS-CLIP	23313552
MIRT685521	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT685520	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT685519	hsa-miR-520e	HITS-CLIP	23313552
MIRT685518	hsa-miR-3159	HITS-CLIP	23313552
MIRT216879	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT216880	hsa-miR-520h	HITS-CLIP	23313552
MIRT685517	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT685516	hsa-miR-1224-3p	HITS-CLIP	23313552
MIRT685515	hsa-miR-1234-3p	HITS-CLIP	23313552
MIRT685514	hsa-miR-7107-5p	HITS-CLIP	23313552
MIRT685513	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT685512	hsa-miR-1913	HITS-CLIP	23313552
MIRT685511	hsa-miR-324-3p	HITS-CLIP	23313552
MIRT685510	hsa-miR-18a-3p	HITS-CLIP	23313552
MIRT447596	hsa-miR-1246	PAR-CLIP	22100165
MIRT447595	hsa-miR-216b-3p	PAR-CLIP	22100165
MIRT447594	hsa-miR-4742-3p	PAR-CLIP	22100165
MIRT447593	hsa-miR-3182	PAR-CLIP	22100165
MIRT447591	hsa-miR-4635	PAR-CLIP	22100165
MIRT447592	hsa-miR-3686	PAR-CLIP	22100165
MIRT447596	hsa-miR-1246	PAR-CLIP	22100165
MIRT447595	hsa-miR-216b-3p	PAR-CLIP	22100165
MIRT447594	hsa-miR-4742-3p	PAR-CLIP	22100165
MIRT447593	hsa-miR-3182	PAR-CLIP	22100165
MIRT447591	hsa-miR-4635	PAR-CLIP	22100165
MIRT447592	hsa-miR-3686	PAR-CLIP	22100165
MIRT1161164	hsa-miR-122	CLIP-seq
MIRT1161165	hsa-miR-125a-3p	CLIP-seq
MIRT1161166	hsa-miR-1267	CLIP-seq
MIRT1161167	hsa-miR-1273f	CLIP-seq
MIRT1161168	hsa-miR-1289	CLIP-seq
MIRT1161169	hsa-miR-129-5p	CLIP-seq
MIRT1161170	hsa-miR-143	CLIP-seq
MIRT1161171	hsa-miR-3135b	CLIP-seq
MIRT1161172	hsa-miR-3170	CLIP-seq
MIRT1161173	hsa-miR-3187-3p	CLIP-seq
MIRT1161174	hsa-miR-3194-3p	CLIP-seq
MIRT1161175	hsa-miR-3198	CLIP-seq
MIRT1161176	hsa-miR-3200-3p	CLIP-seq
MIRT1161177	hsa-miR-320e	CLIP-seq
MIRT1161178	hsa-miR-3545-3p	CLIP-seq
MIRT1161179	hsa-miR-3663-5p	CLIP-seq
MIRT1161180	hsa-miR-3934	CLIP-seq
MIRT1161181	hsa-miR-4294	CLIP-seq
MIRT1161182	hsa-miR-4309	CLIP-seq
MIRT1161183	hsa-miR-431	CLIP-seq
MIRT1161184	hsa-miR-4423-5p	CLIP-seq
MIRT1161185	hsa-miR-4435	CLIP-seq
MIRT1161186	hsa-miR-4476	CLIP-seq
MIRT1161187	hsa-miR-4534	CLIP-seq
MIRT1161188	hsa-miR-4659a-5p	CLIP-seq
MIRT1161189	hsa-miR-4659b-5p	CLIP-seq
MIRT1161190	hsa-miR-4680-5p	CLIP-seq
MIRT1161191	hsa-miR-4701-5p	CLIP-seq
MIRT1161192	hsa-miR-4708-5p	CLIP-seq
MIRT1161193	hsa-miR-4716-5p	CLIP-seq
MIRT1161194	hsa-miR-4755-3p	CLIP-seq
MIRT1161195	hsa-miR-4770	CLIP-seq
MIRT1161196	hsa-miR-4776-3p	CLIP-seq
MIRT1161197	hsa-miR-4781-3p	CLIP-seq
MIRT1161198	hsa-miR-548s	CLIP-seq
MIRT1161199	hsa-miR-548u	CLIP-seq
MIRT1161200	hsa-miR-552	CLIP-seq
MIRT1161201	hsa-miR-588	CLIP-seq
MIRT1161202	hsa-miR-7	CLIP-seq
MIRT1161203	hsa-miR-764	CLIP-seq
MIRT1161204	hsa-miR-924	CLIP-seq
MIRT1161205	hsa-miR-933	CLIP-seq
MIRT2046256	hsa-miR-1203	CLIP-seq
MIRT2046257	hsa-miR-1281	CLIP-seq
MIRT2046258	hsa-miR-1915	CLIP-seq
MIRT2046259	hsa-miR-1976	CLIP-seq
MIRT2046260	hsa-miR-3199	CLIP-seq
MIRT1161177	hsa-miR-320e	CLIP-seq
MIRT2046261	hsa-miR-335	CLIP-seq
MIRT1161180	hsa-miR-3934	CLIP-seq
MIRT2046262	hsa-miR-4279	CLIP-seq
MIRT2046263	hsa-miR-4317	CLIP-seq
MIRT1161184	hsa-miR-4423-5p	CLIP-seq
MIRT2046264	hsa-miR-4722-3p	CLIP-seq
MIRT2046265	hsa-miR-4726-3p	CLIP-seq
MIRT1161200	hsa-miR-552	CLIP-seq
MIRT1161205	hsa-miR-933	CLIP-seq
MIRT2275360	hsa-miR-106a	CLIP-seq
MIRT2275361	hsa-miR-106b	CLIP-seq
MIRT2046256	hsa-miR-1203	CLIP-seq
MIRT1161164	hsa-miR-122	CLIP-seq
MIRT2046257	hsa-miR-1281	CLIP-seq
MIRT2275362	hsa-miR-1307	CLIP-seq
MIRT2275363	hsa-miR-150	CLIP-seq
MIRT2275364	hsa-miR-17	CLIP-seq
MIRT2046258	hsa-miR-1915	CLIP-seq
MIRT2046259	hsa-miR-1976	CLIP-seq
MIRT2275365	hsa-miR-20a	CLIP-seq
MIRT2275366	hsa-miR-20b	CLIP-seq
MIRT2275367	hsa-miR-302a	CLIP-seq
MIRT2275368	hsa-miR-302b	CLIP-seq
MIRT2275369	hsa-miR-302c	CLIP-seq
MIRT2275370	hsa-miR-302d	CLIP-seq
MIRT1161171	hsa-miR-3135b	CLIP-seq
MIRT1161172	hsa-miR-3170	CLIP-seq
MIRT1161173	hsa-miR-3187-3p	CLIP-seq
MIRT2046260	hsa-miR-3199	CLIP-seq
MIRT1161176	hsa-miR-3200-3p	CLIP-seq
MIRT1161177	hsa-miR-320e	CLIP-seq
MIRT1161178	hsa-miR-3545-3p	CLIP-seq
MIRT1161179	hsa-miR-3663-5p	CLIP-seq
MIRT2275371	hsa-miR-372	CLIP-seq
MIRT2275372	hsa-miR-373	CLIP-seq
MIRT1161180	hsa-miR-3934	CLIP-seq
MIRT2046262	hsa-miR-4279	CLIP-seq
MIRT2046263	hsa-miR-4317	CLIP-seq
MIRT1161184	hsa-miR-4423-5p	CLIP-seq
MIRT2275373	hsa-miR-4426	CLIP-seq
MIRT1161185	hsa-miR-4435	CLIP-seq
MIRT2275374	hsa-miR-4438	CLIP-seq
MIRT2275375	hsa-miR-4638-5p	CLIP-seq
MIRT2275376	hsa-miR-4647	CLIP-seq
MIRT1161188	hsa-miR-4659a-5p	CLIP-seq
MIRT1161189	hsa-miR-4659b-5p	CLIP-seq
MIRT2275377	hsa-miR-4662b	CLIP-seq
MIRT1161190	hsa-miR-4680-5p	CLIP-seq
MIRT2275378	hsa-miR-4695-3p	CLIP-seq
MIRT1161191	hsa-miR-4701-5p	CLIP-seq
MIRT1161193	hsa-miR-4716-5p	CLIP-seq
MIRT2046264	hsa-miR-4722-3p	CLIP-seq
MIRT2046265	hsa-miR-4726-3p	CLIP-seq
MIRT2275379	hsa-miR-4731-5p	CLIP-seq
MIRT1161194	hsa-miR-4755-3p	CLIP-seq
MIRT2275380	hsa-miR-4757-5p	CLIP-seq
MIRT1161196	hsa-miR-4776-3p	CLIP-seq
MIRT1161197	hsa-miR-4781-3p	CLIP-seq
MIRT2275381	hsa-miR-5095	CLIP-seq
MIRT2275382	hsa-miR-512-3p	CLIP-seq
MIRT2275383	hsa-miR-519d	CLIP-seq
MIRT2275384	hsa-miR-520g	CLIP-seq
MIRT1161198	hsa-miR-548s	CLIP-seq
MIRT1161200	hsa-miR-552	CLIP-seq
MIRT1161201	hsa-miR-588	CLIP-seq
MIRT2275385	hsa-miR-93	CLIP-seq
MIRT1161164	hsa-miR-122	CLIP-seq
MIRT1161166	hsa-miR-1267	CLIP-seq
MIRT1161168	hsa-miR-1289	CLIP-seq
MIRT2275363	hsa-miR-150	CLIP-seq
MIRT1161171	hsa-miR-3135b	CLIP-seq
MIRT1161174	hsa-miR-3194-3p	CLIP-seq
MIRT1161175	hsa-miR-3198	CLIP-seq
MIRT1161176	hsa-miR-3200-3p	CLIP-seq
MIRT1161177	hsa-miR-320e	CLIP-seq
MIRT1161181	hsa-miR-4294	CLIP-seq
MIRT1161182	hsa-miR-4309	CLIP-seq
MIRT1161183	hsa-miR-431	CLIP-seq
MIRT2046263	hsa-miR-4317	CLIP-seq
MIRT1161184	hsa-miR-4423-5p	CLIP-seq
MIRT2275380	hsa-miR-4757-5p	CLIP-seq
MIRT1161204	hsa-miR-924	CLIP-seq
MIRT2275360	hsa-miR-106a	CLIP-seq
MIRT2275361	hsa-miR-106b	CLIP-seq
MIRT2046257	hsa-miR-1281	CLIP-seq
MIRT2275363	hsa-miR-150	CLIP-seq
MIRT2275364	hsa-miR-17	CLIP-seq
MIRT2046258	hsa-miR-1915	CLIP-seq
MIRT2046259	hsa-miR-1976	CLIP-seq
MIRT2275365	hsa-miR-20a	CLIP-seq
MIRT2275366	hsa-miR-20b	CLIP-seq
MIRT2275367	hsa-miR-302a	CLIP-seq
MIRT2275368	hsa-miR-302b	CLIP-seq
MIRT2275369	hsa-miR-302c	CLIP-seq
MIRT2275370	hsa-miR-302d	CLIP-seq
MIRT2046260	hsa-miR-3199	CLIP-seq
MIRT1161176	hsa-miR-3200-3p	CLIP-seq
MIRT2046261	hsa-miR-335	CLIP-seq
MIRT2275371	hsa-miR-372	CLIP-seq
MIRT2275372	hsa-miR-373	CLIP-seq
MIRT1161180	hsa-miR-3934	CLIP-seq
MIRT2046262	hsa-miR-4279	CLIP-seq
MIRT2046264	hsa-miR-4722-3p	CLIP-seq
MIRT2046265	hsa-miR-4726-3p	CLIP-seq
MIRT2275379	hsa-miR-4731-5p	CLIP-seq
MIRT2275380	hsa-miR-4757-5p	CLIP-seq
MIRT2275382	hsa-miR-512-3p	CLIP-seq
MIRT2275383	hsa-miR-519d	CLIP-seq
MIRT2275384	hsa-miR-520g	CLIP-seq
MIRT1161200	hsa-miR-552	CLIP-seq
MIRT2275385	hsa-miR-93	CLIP-seq
MIRT1161205	hsa-miR-933	CLIP-seq
MIRT2046257	hsa-miR-1281	CLIP-seq
MIRT2046258	hsa-miR-1915	CLIP-seq
MIRT2046259	hsa-miR-1976	CLIP-seq
MIRT2046261	hsa-miR-335	CLIP-seq
MIRT2046262	hsa-miR-4279	CLIP-seq
MIRT2046264	hsa-miR-4722-3p	CLIP-seq
MIRT2046265	hsa-miR-4726-3p	CLIP-seq

Show/Hide all(33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003690	Function	Double-stranded DNA binding	IBA
GO:0003697	Function	Single-stranded DNA binding	IDA	11809883
GO:0005515	Function	Protein binding	IPI	8942985, 9774676, 11005803, 14657349, 16025128, 19377479, 22179786, 25416956, 29892012, 31515488, 32296183, 33961781, 34591612
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	26300262
GO:0005654	Component	Nucleoplasm	TAS
GO:0006281	Process	DNA repair	IDA	8942985
GO:0006281	Process	DNA repair	IEA
GO:0006298	Process	Mismatch repair	IBA
GO:0006298	Process	Mismatch repair	IDA	9677427, 17715146
GO:0006298	Process	Mismatch repair	IEA
GO:0006298	Process	Mismatch repair	IMP	8782829
GO:0006312	Process	Mitotic recombination	IBA
GO:0006974	Process	DNA damage response	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016447	Process	Somatic recombination of immunoglobulin gene segments	IBA
GO:0019899	Function	Enzyme binding	IPI	11427529, 26300262
GO:0030983	Function	Mismatched DNA binding	IDA	8942985
GO:0030983	Function	Mismatched DNA binding	IEA
GO:0032137	Function	Guanine/thymine mispair binding	IDA	11809883
GO:0032139	Function	Dinucleotide insertion or deletion binding	IDA	8942985
GO:0032142	Function	Single guanine insertion binding	IDA	8942985
GO:0032181	Function	Dinucleotide repeat insertion binding	IDA	8942985
GO:0032302	Component	MutSbeta complex	IDA	8942985
GO:0032302	Component	MutSbeta complex	IPI	22179786
GO:0032357	Function	Oxidized purine DNA binding	IDA	11756455
GO:0042803	Function	Protein homodimerization activity	IDA	8942985
GO:0043570	Process	Maintenance of DNA repeat elements	IMP	16388310
GO:0045910	Process	Negative regulation of DNA recombination	IDA	17715146
GO:0140664	Function	ATP-dependent DNA damage sensor activity	IEA

MIM	HGNC	e!Ensembl
600887	7326	ENSG00000113318

Protein

UniProt ID

P20585

Protein name

DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1)

Protein function

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields ap

PDB

3THW , 3THX , 3THY , 3THZ , 8OLX , 8OM5 , 8OM9 , 8OMA , 8OMO , 8OMQ , 8R7C , 8R7E , 8R7V , 8RZ7 , 8RZ8 , 8RZ9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01624	MutS_I	230 → 343	MutS domain I	Domain
PF05188	MutS_II	366 → 523	MutS domain II	Domain
PF05192	MutS_III	540 → 838	MutS domain III	Domain
PF00488	MutS_V	892 → 1094	MutS domain V	Domain

Sequence

MSRRKPASGGLAASSSAPARQAVLSRFFQSTGSLKSTSSSTGAADQVDPGAAAAAAAAAA
AAPPAPPAPAFPPQLPPHIATEIDRRKKRPLENDGPVKKKVKKVQQKEGGSDLGMSGNSE
PKKCLRTRNVSKSLEKLKEFCCDSALPQSRVQTESLQERFAVLPKCTDFDDISLLHAKNA
VSSEDSKRQINQKDTTLFDLSQFGSSNTSHENLQKTASKSANKRSKSIYTPLELQYIEMK
QQHKDAVLCVECGYKYRFFGEDAEIAARELNIYCHLDHNFMTASIPTHRLFVHVRRLVAK
GYKVGVVKQTETAALKAIGDNRSSLFSRKLTALYTKSTLIGEDVNPLIKLDDAVNVDEIM
TDTSTSYLLCISENKENVRDKKKGNIFIGIVGVQPATGEVVFDSFQDSASRSELETRMSS
LQPVELLLPSALSEQTEALIHRATSVSVQDDRIRVERMDNIYFEYSHAFQAVTEFYAKDT
VDIKGSQIISGIVNLEKPVICSLAAIIKYLKEFNLEKMLSKPENFKQLSSKMEFMTINGT
TLRNLEILQNQTDMKTKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLREINARLDAVSEV
LHSESSVFGQIENHLRKLPDIERGLCSIYHKKCSTQEFFLIVKTLYHLKSEFQAIIPAVN
SHIQSDLLRTVILEIPELLSPVEHYLKILNEQAAKVGDKTELFKDLSDFPLIKKRKDEIQ
GVIDEIRMHLQEIRKILKNPSAQYVTVSGQEFMIEIKNSAVSCIPTDWVKVGSTKAVSRF
HSPFIVENYRHLNQLREQLVLDCSAEWLDFLEKFSEHYHSLCKAVHHLATVDCIFSLAKV
AKQGDYCRPTVQEERKIVIKNGRHPVIDVLLGEQDQYVPNNTDLSEDSERVMIITGPNMG
GKSSYIKQVALITIMAQIGSYVPAEEATIGIVDGIFTRMGAADNIYKGQSTFMEELTDTA
EIIRKATSQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCELEKN
YSHQVGNYHMGFLVSEDESKLDPGAAEQVPDFVTFLYQITRGIAARSYGLNVAKLADVPG
EILKKAAHKSKELEGLINTKRKRLKYFAKLWTMHNAQDLQKWTEEFNMEETQTSLLH

Sequence length

1137

Interactions

View interactions

	KEGG		Reactome
	Platinum drug resistance Mismatch repair Pathways in cancer Colorectal cancer		Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2

Show/Hide Causal Diseases (3)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Adenomatous Polyposis	familial adenomatous polyposis 4	rs1580546793, rs756190979, rs766672143, rs1580035033, rs374133543, rs371356175, rs776738086, rs1580066605, rs1580553669, rs758191157, rs886037878, rs550626088, rs1580589463, rs771721952, rs952650934 View all (46 more)	N/A
Endometrial carcinoma	endometrial carcinoma	rs376667075, rs374133543, rs1580553624, rs758191157, rs1744149615, rs1488467945, rs1580546793, rs1561486630, rs371356175, rs1580553669, rs1580053768, rs771721952, rs770330684, rs1580091499, rs1580597397 View all (33 more)	N/A
neoplasm	Neoplasm	rs587776701	N/A

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Gastrointestinal stromal tumor	gastrointestinal stromal tumor	N/A	N/A	ClinVar
Glioblastoma	Glioblastoma	N/A	N/A	GWAS
Huntington Disease	Huntington's disease progression	N/A	N/A	GWAS
Lynch Syndrome	Lynch syndrome	N/A	N/A	GenCC

Show/Hide Text Mining Associations (78)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma	Associate	9764589
Adenoma	Associate	26510091, 34843512
Adenomatous Polyposis Coli	Associate	34250384, 34843512, 35675019
Arthritis Rheumatoid	Associate	15547100
Astrocytoma	Associate	27476653
Attenuated familial adenomatous polyposis	Associate	31285513, 34250384, 35675019
Brain Neoplasms	Associate	37423059
Breast Neoplasms	Associate	10098729, 15517899, 18701435, 19781088, 21700777, 25927356, 34250384, 39844241
Carcinogenesis	Associate	10934138, 34250384, 34843512
Carcinoma Adenoid Cystic	Associate	35218645
Carcinoma Non Small Cell Lung	Associate	28093084
Carcinoma Pancreatic Ductal	Associate	30532127
Carcinoma Renal Cell	Associate	37426643
Cataract Age Related Nuclear	Inhibit	35334159
Chemotherapy Related Cognitive Impairment	Associate	28093084
Colitis Ulcerative	Inhibit	31789935
Colonic Neoplasms	Associate	20979647, 23724141, 36108931
Colonic Neoplasms	Stimulate	24484585
Colorectal Adenomatous Polyposis Autosomal Recessive	Associate	27476653
Colorectal Neoplasms	Associate	10665647, 12057899, 18922920, 20565851, 22343000, 23226332, 23724141, 25461668, 25996601, 26247575, 26510091, 27430658, 27696107, 31127692, 33636974 View all (7 more)
Colorectal Neoplasms	Inhibit	31789935
Colorectal Neoplasms Hereditary Nonpolyposis	Associate	26247575, 29568967, 36833239
Dermatitis	Associate	30590005
Desmoplastic Small Round Cell Tumor	Associate	32393201
Diarrhea	Associate	30590005
DNA Repair Deficiency Disorders	Associate	27131875
Drug Related Side Effects and Adverse Reactions	Associate	23724141, 25996601
Dystonia 3 Torsion X Linked	Associate	34050153, 35481544
Endometrial Neoplasms	Associate	9756907
Esophageal Squamous Cell Carcinoma	Associate	26857264
Friedreich Ataxia	Associate	22787155
HAIR AN syndrome	Inhibit	32197467
Hematologic Diseases	Associate	28093084
Hereditary Breast and Ovarian Cancer Syndrome	Associate	10098729
Huntington Disease	Associate	34050153
Hypoxia	Inhibit	22343000, 26752111
Immunologic Deficiency Syndromes	Inhibit	23209772
Inflammation	Associate	25461668, 28066040, 31789935
Inflammation	Inhibit	26752111
Intestinal Polyposis	Associate	29367705, 34250384
Leukemia Lymphoma Adult T Cell	Associate	15682421
Leukoplakia	Associate	23437280
Liver Failure	Associate	35675019
Lymphoma Large B Cell Diffuse	Associate	24098683
Lymphoma Non Hodgkin	Associate	24098683
Mesothelioma	Associate	31887429
Microsatellite Instability	Associate	10665647, 10666234, 10934138, 20565851, 20979647, 23246972, 26247575, 31292272
Microsatellite Instability	Inhibit	16080527
Multiple Myeloma	Associate	30809292
Multiple Sclerosis	Associate	28892075
Myelodysplastic Syndromes	Associate	23339595
Nasopharyngeal Carcinoma	Associate	28656302
Neoplasm Invasiveness	Associate	35218645
Neoplasm Metastasis	Associate	26752111, 28066040
Neoplasms	Associate	10665647, 10666234, 18922920, 20565851, 20708618, 21821902, 22496206, 22623965, 25461668, 26247575, 26752111, 27476653, 28656302, 28892075, 30942098 View all (11 more)
Neoplasms	Inhibit	21108794
Neoplastic Syndromes Hereditary	Associate	27476653
Nystagmus Pathologic	Associate	32157568
Osteoarthritis	Associate	15547100
Osteosarcoma	Associate	36271359
Ovarian Neoplasms	Associate	16080527, 18723338
Pancreatic Neoplasms	Associate	21212431, 37024097
Peutz Jeghers Syndrome	Associate	20845481
Pheochromocytoma	Associate	40235160
Polycythemia Vera	Associate	37024097
Polyps	Associate	20845481
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	14510941, 16281935
Prostatic Neoplasms	Associate	18355840, 23464402
Rectal Neoplasms	Associate	30590005
Retinal Dysplasia	Inhibit	31789935
Salivary Gland Neoplasms	Associate	35218645
Sigmoid Neoplasms	Associate	20979647
Squamous Cell Carcinoma of Head and Neck	Associate	23437280, 25906090, 33714009
Stomach Neoplasms	Associate	23317227, 26857264, 27476653
Tachycardia Atrioventricular Nodal Reentry	Associate	22496206
Tuberculosis Multidrug Resistant	Associate	24032744, 28388564
Turcot syndrome	Associate	10861262, 23724141
Urinary Bladder Neoplasms	Associate	11506498

MSH3 (mutS homolog 3)