SULT1C3 (sulfotransferase family 1C member 3)

Gene

• Entrez ID: 442038
• Gene name: Sulfotransferase family 1C member 3
• Gene symbol: SULT1C3
• Synonyms (NCBI Gene): ST1C3
• Chromosome: 2
• Chromosome location: 2q12.3

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004027	Function	Alcohol sulfotransferase activity	IDA	17936463
GO:0004027	Function	Alcohol sulfotransferase activity	IEA
GO:0004062	Function	Aryl sulfotransferase activity	IBA
GO:0004062	Function	Aryl sulfotransferase activity	IDA	28992322
GO:0004062	Function	Aryl sulfotransferase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006790	Process	Sulfur compound metabolic process	IDA	28992322
GO:0006790	Process	Sulfur compound metabolic process	IEA
GO:0006805	Process	Xenobiotic metabolic process	IDA	28992322
GO:0008146	Function	Sulfotransferase activity	IEA
GO:0008203	Process	Cholesterol metabolic process	IDA	28992322
GO:0016740	Function	Transferase activity	IEA
GO:0047704	Function	Bile-salt sulfotransferase activity	IDA	28992322
GO:0050427	Process	3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA	17425406
GO:0050656	Function	3'-phosphoadenosine 5'-phosphosulfate binding	IDA	17425406
GO:0051923	Process	Sulfation	IBA

Other IDs

• MIM: 617151
• HGNC: 33543
• e!Ensembl: ENSG00000196228

Protein

• UniProt ID: Q6IMI6
• Protein name: Sulfotransferase 1C3 (ST1C3) (EC 2.8.2.1) (EC 2.8.2.2)
• Protein function: [Isoform 1]: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor. Has sulfotransferase activity towards various substrates, such as bile acids, thyroid hormones and toward xenobiotic compounds such as chloro p
• PDB: 2H8K, 2REO
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00685	Sulfotransfer_1	46 → 297	Sulfotransferase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: [Isoform 1]: Not detectable in any of the tissues tested. {ECO:0000269|PubMed:14676822}.; TISSUE SPECIFICITY: [Isoform 2]: Expressed in the small intestine. {ECO:0000269|PubMed:24335392}.
• Sequence:

  MAKIEKNAPTMEKKPELFNIMEVDGVPTLILSKEWWEKVCNFQAKPDDLILATYPKSGTT
  WMHEILDMILNDGDVEKCKRAQTLDRHAFLELKFPHKEKPDLEFVLEMSSPQLIKTHLPS
  HLIPPSIWKENCKIVYVARNPKDCLVSYYHFHRMASFMPDPQNLEEFYEKFMSGKVVGGS
  WFDHVKGWWAAKDMHRILYLFYEDIKKDPKREIEKILKFLEKDISEEILNKIIYHTSFDV
  MKQNPMTNYTTLPTSIMDHSISPFMRKGMPGDWKNYFTVAQNEEFDKDYQKKMAGSTLTF
  RTEI

• Sequence length: 304

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTISM SPECTRUM DISORDER	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Colonic Neoplasms	Associate	24335392, 27565680	★☆☆☆☆ Found in Text Mining only