Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	441250
Gene name Gene Name - the full gene name approved by the HGNC.	TRNA-yW synthesizing protein 1 homolog B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TYW1B
Synonyms (NCBI Gene) Gene synonyms aliases	LINC00069, NCRNA00069, RSAFD2
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q11.22-q11.23
Summary Summary of gene provided in NCBI Entrez Gene.	Wybutosine is a hypermodified guanosine found in phenylalanine tRNA. Wybutosine functions to stabilize codon-anticodon interactions during ribosome decoding and therefore supports the maintenance of the reading frame. In yeast, the homolog of this gene is

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miRTarBase ID	miRNA	Experiments
MIRT1465782	hsa-miR-1304	CLIP-seq
MIRT1465783	hsa-miR-203	CLIP-seq
MIRT1465784	hsa-miR-205	CLIP-seq
MIRT1465785	hsa-miR-2355-3p	CLIP-seq
MIRT1465786	hsa-miR-3200-3p	CLIP-seq
MIRT1465787	hsa-miR-3691-3p	CLIP-seq
MIRT1465788	hsa-miR-4326	CLIP-seq
MIRT1465789	hsa-miR-4529-5p	CLIP-seq
MIRT1465790	hsa-miR-4646-3p	CLIP-seq
MIRT1465791	hsa-miR-4691-5p	CLIP-seq
MIRT1465792	hsa-miR-4694-5p	CLIP-seq
MIRT1465793	hsa-miR-4703-3p	CLIP-seq
MIRT1465794	hsa-miR-548b-3p	CLIP-seq
MIRT1465795	hsa-miR-676	CLIP-seq
MIRT2140041	hsa-miR-1179	CLIP-seq
MIRT2140042	hsa-miR-1207-5p	CLIP-seq
MIRT2140043	hsa-miR-1266	CLIP-seq
MIRT2140044	hsa-miR-130a	CLIP-seq
MIRT2140045	hsa-miR-130b	CLIP-seq
MIRT2140046	hsa-miR-301a	CLIP-seq
MIRT2140047	hsa-miR-301b	CLIP-seq
MIRT2140048	hsa-miR-3117-5p	CLIP-seq
MIRT2140049	hsa-miR-3128	CLIP-seq
MIRT2140050	hsa-miR-3136-3p	CLIP-seq
MIRT2140051	hsa-miR-3664-3p	CLIP-seq
MIRT2140052	hsa-miR-3666	CLIP-seq
MIRT2140053	hsa-miR-3921	CLIP-seq
MIRT2140054	hsa-miR-4295	CLIP-seq
MIRT2140055	hsa-miR-4436a	CLIP-seq
MIRT2140056	hsa-miR-4461	CLIP-seq
MIRT2140057	hsa-miR-4508	CLIP-seq
MIRT2140058	hsa-miR-4518	CLIP-seq
MIRT2140059	hsa-miR-4536	CLIP-seq
MIRT2140060	hsa-miR-454	CLIP-seq
MIRT2140061	hsa-miR-4639-3p	CLIP-seq
MIRT2140062	hsa-miR-4653-5p	CLIP-seq
MIRT2140063	hsa-miR-4666-5p	CLIP-seq
MIRT2140064	hsa-miR-4671-3p	CLIP-seq
MIRT2140065	hsa-miR-4675	CLIP-seq
MIRT2140066	hsa-miR-4682	CLIP-seq
MIRT2140067	hsa-miR-4693-3p	CLIP-seq
MIRT2140068	hsa-miR-4720-5p	CLIP-seq
MIRT2140069	hsa-miR-4736	CLIP-seq
MIRT2140070	hsa-miR-4741	CLIP-seq
MIRT2140071	hsa-miR-4759	CLIP-seq
MIRT2140072	hsa-miR-4763-3p	CLIP-seq
MIRT2140073	hsa-miR-4766-5p	CLIP-seq
MIRT2140074	hsa-miR-4799-3p	CLIP-seq
MIRT2140075	hsa-miR-4802-3p	CLIP-seq
MIRT2140076	hsa-miR-494	CLIP-seq
MIRT2140077	hsa-miR-663b	CLIP-seq
MIRT2140078	hsa-miR-766	CLIP-seq
MIRT2140043	hsa-miR-1266	CLIP-seq
MIRT1465782	hsa-miR-1304	CLIP-seq
MIRT2140044	hsa-miR-130a	CLIP-seq
MIRT2140045	hsa-miR-130b	CLIP-seq
MIRT1465784	hsa-miR-205	CLIP-seq
MIRT1465785	hsa-miR-2355-3p	CLIP-seq
MIRT2140046	hsa-miR-301a	CLIP-seq
MIRT2140047	hsa-miR-301b	CLIP-seq
MIRT2360696	hsa-miR-3124-3p	CLIP-seq
MIRT2360697	hsa-miR-3622a-3p	CLIP-seq
MIRT2360698	hsa-miR-3622b-3p	CLIP-seq
MIRT2140052	hsa-miR-3666	CLIP-seq
MIRT1465787	hsa-miR-3691-3p	CLIP-seq
MIRT2140054	hsa-miR-4295	CLIP-seq
MIRT2140058	hsa-miR-4518	CLIP-seq
MIRT1465789	hsa-miR-4529-5p	CLIP-seq
MIRT2140060	hsa-miR-454	CLIP-seq
MIRT1465790	hsa-miR-4646-3p	CLIP-seq
MIRT2140064	hsa-miR-4671-3p	CLIP-seq
MIRT1465792	hsa-miR-4694-5p	CLIP-seq
MIRT1465794	hsa-miR-548b-3p	CLIP-seq
MIRT2360699	hsa-miR-570	CLIP-seq
MIRT1465795	hsa-miR-676	CLIP-seq
MIRT2360700	hsa-miR-759	CLIP-seq
MIRT2140041	hsa-miR-1179	CLIP-seq
MIRT2140042	hsa-miR-1207-5p	CLIP-seq
MIRT2140043	hsa-miR-1266	CLIP-seq
MIRT2140048	hsa-miR-3117-5p	CLIP-seq
MIRT2140049	hsa-miR-3128	CLIP-seq
MIRT2140051	hsa-miR-3664-3p	CLIP-seq
MIRT2396563	hsa-miR-369-3p	CLIP-seq
MIRT2396564	hsa-miR-374a	CLIP-seq
MIRT2396565	hsa-miR-374b	CLIP-seq
MIRT2140055	hsa-miR-4436a	CLIP-seq
MIRT2140058	hsa-miR-4518	CLIP-seq
MIRT2140059	hsa-miR-4536	CLIP-seq
MIRT2140061	hsa-miR-4639-3p	CLIP-seq
MIRT2140063	hsa-miR-4666-5p	CLIP-seq
MIRT2396566	hsa-miR-4670-3p	CLIP-seq
MIRT2140068	hsa-miR-4720-5p	CLIP-seq
MIRT2140069	hsa-miR-4736	CLIP-seq
MIRT2140071	hsa-miR-4759	CLIP-seq
MIRT2140072	hsa-miR-4763-3p	CLIP-seq
MIRT2140074	hsa-miR-4799-3p	CLIP-seq
MIRT2140075	hsa-miR-4802-3p	CLIP-seq
MIRT2396567	hsa-miR-572	CLIP-seq
MIRT2140078	hsa-miR-766	CLIP-seq
MIRT2140041	hsa-miR-1179	CLIP-seq
MIRT2140042	hsa-miR-1207-5p	CLIP-seq
MIRT2654308	hsa-miR-125a-3p	CLIP-seq
MIRT2140043	hsa-miR-1266	CLIP-seq
MIRT2140044	hsa-miR-130a	CLIP-seq
MIRT2140045	hsa-miR-130b	CLIP-seq
MIRT2654309	hsa-miR-1324	CLIP-seq
MIRT2654310	hsa-miR-208a	CLIP-seq
MIRT2654311	hsa-miR-208b	CLIP-seq
MIRT2140046	hsa-miR-301a	CLIP-seq
MIRT2140047	hsa-miR-301b	CLIP-seq
MIRT2140048	hsa-miR-3117-5p	CLIP-seq
MIRT2654312	hsa-miR-3120-3p	CLIP-seq
MIRT2140049	hsa-miR-3128	CLIP-seq
MIRT2654313	hsa-miR-3166	CLIP-seq
MIRT2654314	hsa-miR-34b	CLIP-seq
MIRT2654315	hsa-miR-3617	CLIP-seq
MIRT2140051	hsa-miR-3664-3p	CLIP-seq
MIRT2140052	hsa-miR-3666	CLIP-seq
MIRT2654316	hsa-miR-3689d	CLIP-seq
MIRT2396563	hsa-miR-369-3p	CLIP-seq
MIRT2396564	hsa-miR-374a	CLIP-seq
MIRT2396565	hsa-miR-374b	CLIP-seq
MIRT2654317	hsa-miR-374c	CLIP-seq
MIRT2654318	hsa-miR-4290	CLIP-seq
MIRT2140054	hsa-miR-4295	CLIP-seq
MIRT2654319	hsa-miR-4433	CLIP-seq
MIRT2140055	hsa-miR-4436a	CLIP-seq
MIRT2654320	hsa-miR-4459	CLIP-seq
MIRT2140058	hsa-miR-4518	CLIP-seq
MIRT2140060	hsa-miR-454	CLIP-seq
MIRT2140061	hsa-miR-4639-3p	CLIP-seq
MIRT2654321	hsa-miR-4639-5p	CLIP-seq
MIRT2654322	hsa-miR-4640-5p	CLIP-seq
MIRT2396566	hsa-miR-4670-3p	CLIP-seq
MIRT2140064	hsa-miR-4671-3p	CLIP-seq
MIRT2654323	hsa-miR-4701-5p	CLIP-seq
MIRT2654324	hsa-miR-4717-3p	CLIP-seq
MIRT2140068	hsa-miR-4720-5p	CLIP-seq
MIRT2654325	hsa-miR-4726-5p	CLIP-seq
MIRT2140069	hsa-miR-4736	CLIP-seq
MIRT2140071	hsa-miR-4759	CLIP-seq
MIRT2140072	hsa-miR-4763-3p	CLIP-seq
MIRT2654326	hsa-miR-4768-3p	CLIP-seq
MIRT2140074	hsa-miR-4799-3p	CLIP-seq
MIRT2654327	hsa-miR-483-3p	CLIP-seq
MIRT2654328	hsa-miR-499-5p	CLIP-seq
MIRT2654329	hsa-miR-548aa	CLIP-seq
MIRT2654330	hsa-miR-549	CLIP-seq
MIRT2396567	hsa-miR-572	CLIP-seq
MIRT2654331	hsa-miR-576-5p	CLIP-seq
MIRT2654332	hsa-miR-588	CLIP-seq
MIRT2654333	hsa-miR-600	CLIP-seq
MIRT2654334	hsa-miR-604	CLIP-seq
MIRT2654335	hsa-miR-626	CLIP-seq
MIRT2654336	hsa-miR-641	CLIP-seq
MIRT2654337	hsa-miR-647	CLIP-seq
MIRT2654338	hsa-miR-655	CLIP-seq
MIRT2140078	hsa-miR-766	CLIP-seq
MIRT2654339	hsa-miR-922	CLIP-seq
MIRT2654340	hsa-miR-935	CLIP-seq
MIRT2140041	hsa-miR-1179	CLIP-seq
MIRT2140042	hsa-miR-1207-5p	CLIP-seq
MIRT2140043	hsa-miR-1266	CLIP-seq
MIRT2140044	hsa-miR-130a	CLIP-seq
MIRT2140045	hsa-miR-130b	CLIP-seq
MIRT2654309	hsa-miR-1324	CLIP-seq
MIRT1465783	hsa-miR-203	CLIP-seq
MIRT1465784	hsa-miR-205	CLIP-seq
MIRT2654310	hsa-miR-208a	CLIP-seq
MIRT2654311	hsa-miR-208b	CLIP-seq
MIRT1465785	hsa-miR-2355-3p	CLIP-seq
MIRT2140046	hsa-miR-301a	CLIP-seq
MIRT2140047	hsa-miR-301b	CLIP-seq
MIRT2140048	hsa-miR-3117-5p	CLIP-seq
MIRT2654312	hsa-miR-3120-3p	CLIP-seq
MIRT2140049	hsa-miR-3128	CLIP-seq
MIRT2654313	hsa-miR-3166	CLIP-seq
MIRT1465786	hsa-miR-3200-3p	CLIP-seq
MIRT2654315	hsa-miR-3617	CLIP-seq
MIRT2140051	hsa-miR-3664-3p	CLIP-seq
MIRT2140052	hsa-miR-3666	CLIP-seq
MIRT2654316	hsa-miR-3689d	CLIP-seq
MIRT2396563	hsa-miR-369-3p	CLIP-seq
MIRT2396564	hsa-miR-374a	CLIP-seq
MIRT2396565	hsa-miR-374b	CLIP-seq
MIRT2654317	hsa-miR-374c	CLIP-seq
MIRT2654318	hsa-miR-4290	CLIP-seq
MIRT2140054	hsa-miR-4295	CLIP-seq
MIRT2654319	hsa-miR-4433	CLIP-seq
MIRT2140055	hsa-miR-4436a	CLIP-seq
MIRT2654320	hsa-miR-4459	CLIP-seq
MIRT2140058	hsa-miR-4518	CLIP-seq
MIRT2140060	hsa-miR-454	CLIP-seq
MIRT2140061	hsa-miR-4639-3p	CLIP-seq
MIRT2654321	hsa-miR-4639-5p	CLIP-seq
MIRT2654322	hsa-miR-4640-5p	CLIP-seq
MIRT1465790	hsa-miR-4646-3p	CLIP-seq
MIRT2396566	hsa-miR-4670-3p	CLIP-seq
MIRT2140064	hsa-miR-4671-3p	CLIP-seq
MIRT2654323	hsa-miR-4701-5p	CLIP-seq
MIRT2654324	hsa-miR-4717-3p	CLIP-seq
MIRT2140068	hsa-miR-4720-5p	CLIP-seq
MIRT2654325	hsa-miR-4726-5p	CLIP-seq
MIRT2140069	hsa-miR-4736	CLIP-seq
MIRT2140071	hsa-miR-4759	CLIP-seq
MIRT2140072	hsa-miR-4763-3p	CLIP-seq
MIRT2654326	hsa-miR-4768-3p	CLIP-seq
MIRT2140074	hsa-miR-4799-3p	CLIP-seq
MIRT2654327	hsa-miR-483-3p	CLIP-seq
MIRT2654328	hsa-miR-499-5p	CLIP-seq
MIRT2654330	hsa-miR-549	CLIP-seq
MIRT2396567	hsa-miR-572	CLIP-seq
MIRT2654332	hsa-miR-588	CLIP-seq
MIRT2654333	hsa-miR-600	CLIP-seq
MIRT2654334	hsa-miR-604	CLIP-seq
MIRT2654335	hsa-miR-626	CLIP-seq
MIRT2654336	hsa-miR-641	CLIP-seq
MIRT2654337	hsa-miR-647	CLIP-seq
MIRT2654338	hsa-miR-655	CLIP-seq
MIRT1465795	hsa-miR-676	CLIP-seq
MIRT2140078	hsa-miR-766	CLIP-seq
MIRT2654339	hsa-miR-922	CLIP-seq

Show/Hide all(6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0010181	Function	FMN binding	IEA
GO:0031591	Process	Wybutosine biosynthetic process	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA
GO:0051539	Function	4 iron, 4 sulfur cluster binding	IEA
GO:0102521	Function	TRNA-4-demethylwyosine synthase activity	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Protein

UniProt ID

Q6NUM6

Protein name

S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 2) (tRNA wybutosine-synthesizing protein 1 homolog B)

Protein function

Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methyl

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00258	Flavodoxin_1	43 → 186	Flavodoxin	Domain
PF04055	Radical_SAM	346 → 528	Radical SAM superfamily	Domain
PF08608	Wyosine_form	530 → 593	Wyosine base formation	Family

Sequence

MDPSADTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIEMQGFATVLAEAVTSLDL
PVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGK
TYLKGMRDAVFGLGNSAYASHFNKVGKNVDKWLWMLGVHRVMSRGEGDCDVVKSKHGSIE
ANFRAWKTKFISQLQALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSQEQDELHHRDT
KEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGR
NEDGERRAMITPALREALTKQVDAPRERSLLQTHILWNESHRCMETTPSLACANKCVFCW
WHHNNPVGTEWLWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHCALSL
VGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDSLKKI
DRPLFKDFWQQFLDSLKALAVKQQRTVYRLMLVKAWNVDELQAYAQLVSLGNPDFIEVKG
VTYCRESSASSLTMAHVPWHEEVVQFVRELVDLIPEYEIACEHEHSNCLLIAHRKFKIGG
EWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERSFDPKDTRHQRKN
KSKAISGC

Sequence length

668

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Parkinson disease	Parkinson Disease	rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432 View all (84 more)	17052657

TYW1B (tRNA-yW synthesizing protein 1 homolog B)