Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	441250
Gene name	TRNA-yW synthesizing protein 1 homolog B
Gene symbol	TYW1B
Synonyms (NCBI Gene)	LINC00069NCRNA00069RSAFD2
Chromosome	7
Chromosome location	7q11.22-q11.23
Summary	Wybutosine is a hypermodified guanosine found in phenylalanine tRNA. Wybutosine functions to stabilize codon-anticodon interactions during ribosome decoding and therefore supports the maintenance of the reading frame. In yeast, the homolog of this gene is

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Show/Hide all (222)

miRTarBase ID	miRNA	Experiments
MIRT1465782	hsa-miR-1304	CLIP-seq
MIRT1465783	hsa-miR-203	CLIP-seq
MIRT1465784	hsa-miR-205	CLIP-seq
MIRT1465785	hsa-miR-2355-3p	CLIP-seq
MIRT1465786	hsa-miR-3200-3p	CLIP-seq
MIRT1465787	hsa-miR-3691-3p	CLIP-seq
MIRT1465788	hsa-miR-4326	CLIP-seq
MIRT1465789	hsa-miR-4529-5p	CLIP-seq
MIRT1465790	hsa-miR-4646-3p	CLIP-seq
MIRT1465791	hsa-miR-4691-5p	CLIP-seq
MIRT1465792	hsa-miR-4694-5p	CLIP-seq
MIRT1465793	hsa-miR-4703-3p	CLIP-seq
MIRT1465794	hsa-miR-548b-3p	CLIP-seq
MIRT1465795	hsa-miR-676	CLIP-seq
MIRT2140041	hsa-miR-1179	CLIP-seq
MIRT2140042	hsa-miR-1207-5p	CLIP-seq
MIRT2140043	hsa-miR-1266	CLIP-seq
MIRT2140044	hsa-miR-130a	CLIP-seq
MIRT2140045	hsa-miR-130b	CLIP-seq
MIRT2140046	hsa-miR-301a	CLIP-seq
MIRT2140047	hsa-miR-301b	CLIP-seq
MIRT2140048	hsa-miR-3117-5p	CLIP-seq
MIRT2140049	hsa-miR-3128	CLIP-seq
MIRT2140050	hsa-miR-3136-3p	CLIP-seq
MIRT2140051	hsa-miR-3664-3p	CLIP-seq
MIRT2140052	hsa-miR-3666	CLIP-seq
MIRT2140053	hsa-miR-3921	CLIP-seq
MIRT2140054	hsa-miR-4295	CLIP-seq
MIRT2140055	hsa-miR-4436a	CLIP-seq
MIRT2140056	hsa-miR-4461	CLIP-seq
MIRT2140057	hsa-miR-4508	CLIP-seq
MIRT2140058	hsa-miR-4518	CLIP-seq
MIRT2140059	hsa-miR-4536	CLIP-seq
MIRT2140060	hsa-miR-454	CLIP-seq
MIRT2140061	hsa-miR-4639-3p	CLIP-seq
MIRT2140062	hsa-miR-4653-5p	CLIP-seq
MIRT2140063	hsa-miR-4666-5p	CLIP-seq
MIRT2140064	hsa-miR-4671-3p	CLIP-seq
MIRT2140065	hsa-miR-4675	CLIP-seq
MIRT2140066	hsa-miR-4682	CLIP-seq
MIRT2140067	hsa-miR-4693-3p	CLIP-seq
MIRT2140068	hsa-miR-4720-5p	CLIP-seq
MIRT2140069	hsa-miR-4736	CLIP-seq
MIRT2140070	hsa-miR-4741	CLIP-seq
MIRT2140071	hsa-miR-4759	CLIP-seq
MIRT2140072	hsa-miR-4763-3p	CLIP-seq
MIRT2140073	hsa-miR-4766-5p	CLIP-seq
MIRT2140074	hsa-miR-4799-3p	CLIP-seq
MIRT2140075	hsa-miR-4802-3p	CLIP-seq
MIRT2140076	hsa-miR-494	CLIP-seq
MIRT2140077	hsa-miR-663b	CLIP-seq
MIRT2140078	hsa-miR-766	CLIP-seq
MIRT2140043	hsa-miR-1266	CLIP-seq
MIRT1465782	hsa-miR-1304	CLIP-seq
MIRT2140044	hsa-miR-130a	CLIP-seq
MIRT2140045	hsa-miR-130b	CLIP-seq
MIRT1465784	hsa-miR-205	CLIP-seq
MIRT1465785	hsa-miR-2355-3p	CLIP-seq
MIRT2140046	hsa-miR-301a	CLIP-seq
MIRT2140047	hsa-miR-301b	CLIP-seq
MIRT2360696	hsa-miR-3124-3p	CLIP-seq
MIRT2360697	hsa-miR-3622a-3p	CLIP-seq
MIRT2360698	hsa-miR-3622b-3p	CLIP-seq
MIRT2140052	hsa-miR-3666	CLIP-seq
MIRT1465787	hsa-miR-3691-3p	CLIP-seq
MIRT2140054	hsa-miR-4295	CLIP-seq
MIRT2140058	hsa-miR-4518	CLIP-seq
MIRT1465789	hsa-miR-4529-5p	CLIP-seq
MIRT2140060	hsa-miR-454	CLIP-seq
MIRT1465790	hsa-miR-4646-3p	CLIP-seq
MIRT2140064	hsa-miR-4671-3p	CLIP-seq
MIRT1465792	hsa-miR-4694-5p	CLIP-seq
MIRT1465794	hsa-miR-548b-3p	CLIP-seq
MIRT2360699	hsa-miR-570	CLIP-seq
MIRT1465795	hsa-miR-676	CLIP-seq
MIRT2360700	hsa-miR-759	CLIP-seq
MIRT2140041	hsa-miR-1179	CLIP-seq
MIRT2140042	hsa-miR-1207-5p	CLIP-seq
MIRT2140043	hsa-miR-1266	CLIP-seq
MIRT2140048	hsa-miR-3117-5p	CLIP-seq
MIRT2140049	hsa-miR-3128	CLIP-seq
MIRT2140051	hsa-miR-3664-3p	CLIP-seq
MIRT2396563	hsa-miR-369-3p	CLIP-seq
MIRT2396564	hsa-miR-374a	CLIP-seq
MIRT2396565	hsa-miR-374b	CLIP-seq
MIRT2140055	hsa-miR-4436a	CLIP-seq
MIRT2140058	hsa-miR-4518	CLIP-seq
MIRT2140059	hsa-miR-4536	CLIP-seq
MIRT2140061	hsa-miR-4639-3p	CLIP-seq
MIRT2140063	hsa-miR-4666-5p	CLIP-seq
MIRT2396566	hsa-miR-4670-3p	CLIP-seq
MIRT2140068	hsa-miR-4720-5p	CLIP-seq
MIRT2140069	hsa-miR-4736	CLIP-seq
MIRT2140071	hsa-miR-4759	CLIP-seq
MIRT2140072	hsa-miR-4763-3p	CLIP-seq
MIRT2140074	hsa-miR-4799-3p	CLIP-seq
MIRT2140075	hsa-miR-4802-3p	CLIP-seq
MIRT2396567	hsa-miR-572	CLIP-seq
MIRT2140078	hsa-miR-766	CLIP-seq
MIRT2140041	hsa-miR-1179	CLIP-seq
MIRT2140042	hsa-miR-1207-5p	CLIP-seq
MIRT2654308	hsa-miR-125a-3p	CLIP-seq
MIRT2140043	hsa-miR-1266	CLIP-seq
MIRT2140044	hsa-miR-130a	CLIP-seq
MIRT2140045	hsa-miR-130b	CLIP-seq
MIRT2654309	hsa-miR-1324	CLIP-seq
MIRT2654310	hsa-miR-208a	CLIP-seq
MIRT2654311	hsa-miR-208b	CLIP-seq
MIRT2140046	hsa-miR-301a	CLIP-seq
MIRT2140047	hsa-miR-301b	CLIP-seq
MIRT2140048	hsa-miR-3117-5p	CLIP-seq
MIRT2654312	hsa-miR-3120-3p	CLIP-seq
MIRT2140049	hsa-miR-3128	CLIP-seq
MIRT2654313	hsa-miR-3166	CLIP-seq
MIRT2654314	hsa-miR-34b	CLIP-seq
MIRT2654315	hsa-miR-3617	CLIP-seq
MIRT2140051	hsa-miR-3664-3p	CLIP-seq
MIRT2140052	hsa-miR-3666	CLIP-seq
MIRT2654316	hsa-miR-3689d	CLIP-seq
MIRT2396563	hsa-miR-369-3p	CLIP-seq
MIRT2396564	hsa-miR-374a	CLIP-seq
MIRT2396565	hsa-miR-374b	CLIP-seq
MIRT2654317	hsa-miR-374c	CLIP-seq
MIRT2654318	hsa-miR-4290	CLIP-seq
MIRT2140054	hsa-miR-4295	CLIP-seq
MIRT2654319	hsa-miR-4433	CLIP-seq
MIRT2140055	hsa-miR-4436a	CLIP-seq
MIRT2654320	hsa-miR-4459	CLIP-seq
MIRT2140058	hsa-miR-4518	CLIP-seq
MIRT2140060	hsa-miR-454	CLIP-seq
MIRT2140061	hsa-miR-4639-3p	CLIP-seq
MIRT2654321	hsa-miR-4639-5p	CLIP-seq
MIRT2654322	hsa-miR-4640-5p	CLIP-seq
MIRT2396566	hsa-miR-4670-3p	CLIP-seq
MIRT2140064	hsa-miR-4671-3p	CLIP-seq
MIRT2654323	hsa-miR-4701-5p	CLIP-seq
MIRT2654324	hsa-miR-4717-3p	CLIP-seq
MIRT2140068	hsa-miR-4720-5p	CLIP-seq
MIRT2654325	hsa-miR-4726-5p	CLIP-seq
MIRT2140069	hsa-miR-4736	CLIP-seq
MIRT2140071	hsa-miR-4759	CLIP-seq
MIRT2140072	hsa-miR-4763-3p	CLIP-seq
MIRT2654326	hsa-miR-4768-3p	CLIP-seq
MIRT2140074	hsa-miR-4799-3p	CLIP-seq
MIRT2654327	hsa-miR-483-3p	CLIP-seq
MIRT2654328	hsa-miR-499-5p	CLIP-seq
MIRT2654329	hsa-miR-548aa	CLIP-seq
MIRT2654330	hsa-miR-549	CLIP-seq
MIRT2396567	hsa-miR-572	CLIP-seq
MIRT2654331	hsa-miR-576-5p	CLIP-seq
MIRT2654332	hsa-miR-588	CLIP-seq
MIRT2654333	hsa-miR-600	CLIP-seq
MIRT2654334	hsa-miR-604	CLIP-seq
MIRT2654335	hsa-miR-626	CLIP-seq
MIRT2654336	hsa-miR-641	CLIP-seq
MIRT2654337	hsa-miR-647	CLIP-seq
MIRT2654338	hsa-miR-655	CLIP-seq
MIRT2140078	hsa-miR-766	CLIP-seq
MIRT2654339	hsa-miR-922	CLIP-seq
MIRT2654340	hsa-miR-935	CLIP-seq
MIRT2140041	hsa-miR-1179	CLIP-seq
MIRT2140042	hsa-miR-1207-5p	CLIP-seq
MIRT2140043	hsa-miR-1266	CLIP-seq
MIRT2140044	hsa-miR-130a	CLIP-seq
MIRT2140045	hsa-miR-130b	CLIP-seq
MIRT2654309	hsa-miR-1324	CLIP-seq
MIRT1465783	hsa-miR-203	CLIP-seq
MIRT1465784	hsa-miR-205	CLIP-seq
MIRT2654310	hsa-miR-208a	CLIP-seq
MIRT2654311	hsa-miR-208b	CLIP-seq
MIRT1465785	hsa-miR-2355-3p	CLIP-seq
MIRT2140046	hsa-miR-301a	CLIP-seq
MIRT2140047	hsa-miR-301b	CLIP-seq
MIRT2140048	hsa-miR-3117-5p	CLIP-seq
MIRT2654312	hsa-miR-3120-3p	CLIP-seq
MIRT2140049	hsa-miR-3128	CLIP-seq
MIRT2654313	hsa-miR-3166	CLIP-seq
MIRT1465786	hsa-miR-3200-3p	CLIP-seq
MIRT2654315	hsa-miR-3617	CLIP-seq
MIRT2140051	hsa-miR-3664-3p	CLIP-seq
MIRT2140052	hsa-miR-3666	CLIP-seq
MIRT2654316	hsa-miR-3689d	CLIP-seq
MIRT2396563	hsa-miR-369-3p	CLIP-seq
MIRT2396564	hsa-miR-374a	CLIP-seq
MIRT2396565	hsa-miR-374b	CLIP-seq
MIRT2654317	hsa-miR-374c	CLIP-seq
MIRT2654318	hsa-miR-4290	CLIP-seq
MIRT2140054	hsa-miR-4295	CLIP-seq
MIRT2654319	hsa-miR-4433	CLIP-seq
MIRT2140055	hsa-miR-4436a	CLIP-seq
MIRT2654320	hsa-miR-4459	CLIP-seq
MIRT2140058	hsa-miR-4518	CLIP-seq
MIRT2140060	hsa-miR-454	CLIP-seq
MIRT2140061	hsa-miR-4639-3p	CLIP-seq
MIRT2654321	hsa-miR-4639-5p	CLIP-seq
MIRT2654322	hsa-miR-4640-5p	CLIP-seq
MIRT1465790	hsa-miR-4646-3p	CLIP-seq
MIRT2396566	hsa-miR-4670-3p	CLIP-seq
MIRT2140064	hsa-miR-4671-3p	CLIP-seq
MIRT2654323	hsa-miR-4701-5p	CLIP-seq
MIRT2654324	hsa-miR-4717-3p	CLIP-seq
MIRT2140068	hsa-miR-4720-5p	CLIP-seq
MIRT2654325	hsa-miR-4726-5p	CLIP-seq
MIRT2140069	hsa-miR-4736	CLIP-seq
MIRT2140071	hsa-miR-4759	CLIP-seq
MIRT2140072	hsa-miR-4763-3p	CLIP-seq
MIRT2654326	hsa-miR-4768-3p	CLIP-seq
MIRT2140074	hsa-miR-4799-3p	CLIP-seq
MIRT2654327	hsa-miR-483-3p	CLIP-seq
MIRT2654328	hsa-miR-499-5p	CLIP-seq
MIRT2654330	hsa-miR-549	CLIP-seq
MIRT2396567	hsa-miR-572	CLIP-seq
MIRT2654332	hsa-miR-588	CLIP-seq
MIRT2654333	hsa-miR-600	CLIP-seq
MIRT2654334	hsa-miR-604	CLIP-seq
MIRT2654335	hsa-miR-626	CLIP-seq
MIRT2654336	hsa-miR-641	CLIP-seq
MIRT2654337	hsa-miR-647	CLIP-seq
MIRT2654338	hsa-miR-655	CLIP-seq
MIRT1465795	hsa-miR-676	CLIP-seq
MIRT2140078	hsa-miR-766	CLIP-seq
MIRT2654339	hsa-miR-922	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0008033	Process	TRNA processing	IEA
GO:0010181	Function	FMN binding	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0031591	Process	Wybutosine biosynthetic process	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051536	Function	Iron-sulfur cluster binding	IEA
GO:0051539	Function	4 iron, 4 sulfur cluster binding	IEA
GO:0102521	Function	TRNA-4-demethylwyosine synthase activity	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q6NUM6

Protein name

S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 2) (tRNA wybutosine-synthesizing protein 1 homolog B)

Protein function

Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methyl

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00258	Flavodoxin_1	43 → 186	Flavodoxin	Domain
PF04055	Radical_SAM	346 → 528	Radical SAM superfamily	Domain
PF08608	Wyosine_form	530 → 593	Wyosine base formation	Family

Sequence

MDPSADTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIEMQGFATVLAEAVTSLDL
PVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGK
TYLKGMRDAVFGLGNSAYASHFNKVGKNVDKWLWMLGVHRVMSRGEGDCDVVKSKHGSIE
ANFRAWKTKFISQLQALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSQEQDELHHRDT
KEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGR
NEDGERRAMITPALREALTKQVDAPRERSLLQTHILWNESHRCMETTPSLACANKCVFCW
WHHNNPVGTEWLWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHCALSL
VGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDSLKKI
DRPLFKDFWQQFLDSLKALAVKQQRTVYRLMLVKAWNVDELQAYAQLVSLGNPDFIEVKG
VTYCRESSASSLTMAHVPWHEEVVQFVRELVDLIPEYEIACEHEHSNCLLIAHRKFKIGG
EWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERSFDPKDTRHQRKN
KSKAISGC

Sequence length

668

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Cervical cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

TYW1B (tRNA-yW synthesizing protein 1 homolog B)