Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	440854
Gene name Gene Name - the full gene name approved by the HGNC.	Calpain 14
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CAPN14
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p23.1
Summary Summary of gene provided in NCBI Entrez Gene.	Calpains are a family of cytosolic calcium-activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin-cytoskeletal interactions, and synaptic plasticity (Dear et al., 2000 [PubMed 10

Show/Hide all(38)

miRTarBase ID	miRNA	Experiments
MIRT861905	hsa-miR-1224-3p	CLIP-seq
MIRT861906	hsa-miR-1253	CLIP-seq
MIRT861907	hsa-miR-1295	CLIP-seq
MIRT861908	hsa-miR-3121-5p	CLIP-seq
MIRT861909	hsa-miR-3124-3p	CLIP-seq
MIRT861910	hsa-miR-3163	CLIP-seq
MIRT861911	hsa-miR-3194-5p	CLIP-seq
MIRT861912	hsa-miR-3198	CLIP-seq
MIRT861913	hsa-miR-3646	CLIP-seq
MIRT861914	hsa-miR-3673	CLIP-seq
MIRT861915	hsa-miR-3685	CLIP-seq
MIRT861916	hsa-miR-384	CLIP-seq
MIRT861917	hsa-miR-4251	CLIP-seq
MIRT861918	hsa-miR-4309	CLIP-seq
MIRT861919	hsa-miR-4690-3p	CLIP-seq
MIRT861920	hsa-miR-4717-5p	CLIP-seq
MIRT861921	hsa-miR-4760-5p	CLIP-seq
MIRT861922	hsa-miR-496	CLIP-seq
MIRT861923	hsa-miR-579	CLIP-seq
MIRT861924	hsa-miR-590-3p	CLIP-seq
MIRT2193358	hsa-miR-188-5p	CLIP-seq
MIRT2193359	hsa-miR-2355-3p	CLIP-seq
MIRT861908	hsa-miR-3121-5p	CLIP-seq
MIRT2193360	hsa-miR-3616-5p	CLIP-seq
MIRT2193361	hsa-miR-3647-5p	CLIP-seq
MIRT2193362	hsa-miR-3935	CLIP-seq
MIRT2193363	hsa-miR-4301	CLIP-seq
MIRT2193364	hsa-miR-4646-3p	CLIP-seq
MIRT2193365	hsa-miR-4762-3p	CLIP-seq
MIRT2193366	hsa-miR-4766-5p	CLIP-seq
MIRT2193367	hsa-miR-563	CLIP-seq
MIRT2193368	hsa-miR-573	CLIP-seq
MIRT2193369	hsa-miR-676	CLIP-seq
MIRT861912	hsa-miR-3198	CLIP-seq
MIRT861918	hsa-miR-4309	CLIP-seq
MIRT861921	hsa-miR-4760-5p	CLIP-seq
MIRT861922	hsa-miR-496	CLIP-seq
MIRT861924	hsa-miR-590-3p	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	IBA
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	IEA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
610229	16664	ENSG00000214711

Protein

UniProt ID

A8MX76

Protein name

Calpain-14 (EC 3.4.22.-) (Calcium-activated neutral proteinase 14) (CANP 14)

Protein function

Calcium-regulated non-lysosomal thiol-protease.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00648	Peptidase_C2	44 → 334	Calpain family cysteine protease	Family
PF01067	Calpain_III	355 → 491	Calpain large subunit, domain III	Domain

Tissue specificity

TISSUE SPECIFICITY: Not expressed in tissues tested.

Sequence

MSLWPPFRCRWKLAPRYSRRASPQQPQQDFEALLAECLRNGCLFEDTSFPATLSSIGSGS
LLQKLPPRLQWKRPPELHSNPQFYFAKAKRLDLCQGIVGDCWFLAALQALALHQDILSRV
VPLNQSFTEKYAGIFRFWFWHYGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEK
AYAKLSGSYEDLQSGQVSEALVDFTGGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTH
SGEKILENGLVEGHAYTLTGIRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLS
PKEKILLLRKDNDGEFWMTLQDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKR
STAGGQRQLLQDTFWKNPQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRHRCRKRKPLLAI
GFYLYRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEA
HQKSEFVLRVFSRKHIFYEIGSNSGVVFSKEIEDQNERQDEFFTKFFEKHPEINAVQLQN
LLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQD
RGSGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVF
QNLTQDGKGIYLQKPEWMMMALYS

Sequence length

684

Interactions

View interactions

	Reactome
			Degradation of the extracellular matrix

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Amyotrophic Lateral Sclerosis	amyotrophic lateral sclerosis	N/A	N/A	ClinVar
Diabetes	Mild age-related type 2 diabetes	N/A	N/A	GWAS
Endometriosis	Endometriosis	N/A	N/A	GWAS
Eosinophilia	Eosinophilic esophagitis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Bacteremia	Associate	35254093
Eosinophilic Esophagitis	Associate	25017104, 25407941, 26258919, 29029802, 29129581, 31909633, 33446329, 34815391, 37652141
Eosinophilic Esophagitis	Stimulate	30626591
Ige Responsiveness Atopic	Associate	29129581
Inflammation	Associate	37652141
Otitis Media	Associate	23133572
Otitis Media with Effusion	Associate	23133572

CAPN14 (calpain 14)