CAPN14 (calpain 14)

Gene

• Entrez ID: 440854
• Gene name: Calpain 14
• Gene symbol: CAPN14
• Synonyms (NCBI Gene): -
• Chromosome: 2
• Chromosome location: 2p23.1
• Summary: Calpains are a family of cytosolic calcium-activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin-cytoskeletal interactions, and synaptic plasticity (Dear et al., 2000 [PubMed 10

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT861905	hsa-miR-1224-3p	CLIP-seq
MIRT861906	hsa-miR-1253	CLIP-seq
MIRT861907	hsa-miR-1295	CLIP-seq
MIRT861908	hsa-miR-3121-5p	CLIP-seq
MIRT861909	hsa-miR-3124-3p	CLIP-seq
MIRT861910	hsa-miR-3163	CLIP-seq
MIRT861911	hsa-miR-3194-5p	CLIP-seq
MIRT861912	hsa-miR-3198	CLIP-seq
MIRT861913	hsa-miR-3646	CLIP-seq
MIRT861914	hsa-miR-3673	CLIP-seq
MIRT861915	hsa-miR-3685	CLIP-seq
MIRT861916	hsa-miR-384	CLIP-seq
MIRT861917	hsa-miR-4251	CLIP-seq
MIRT861918	hsa-miR-4309	CLIP-seq
MIRT861919	hsa-miR-4690-3p	CLIP-seq
MIRT861920	hsa-miR-4717-5p	CLIP-seq
MIRT861921	hsa-miR-4760-5p	CLIP-seq
MIRT861922	hsa-miR-496	CLIP-seq
MIRT861923	hsa-miR-579	CLIP-seq
MIRT861924	hsa-miR-590-3p	CLIP-seq
MIRT2193358	hsa-miR-188-5p	CLIP-seq
MIRT2193359	hsa-miR-2355-3p	CLIP-seq
MIRT861908	hsa-miR-3121-5p	CLIP-seq
MIRT2193360	hsa-miR-3616-5p	CLIP-seq
MIRT2193361	hsa-miR-3647-5p	CLIP-seq
MIRT2193362	hsa-miR-3935	CLIP-seq
MIRT2193363	hsa-miR-4301	CLIP-seq
MIRT2193364	hsa-miR-4646-3p	CLIP-seq
MIRT2193365	hsa-miR-4762-3p	CLIP-seq
MIRT2193366	hsa-miR-4766-5p	CLIP-seq
MIRT2193367	hsa-miR-563	CLIP-seq
MIRT2193368	hsa-miR-573	CLIP-seq
MIRT2193369	hsa-miR-676	CLIP-seq
MIRT861912	hsa-miR-3198	CLIP-seq
MIRT861918	hsa-miR-4309	CLIP-seq
MIRT861921	hsa-miR-4760-5p	CLIP-seq
MIRT861922	hsa-miR-496	CLIP-seq
MIRT861924	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	IBA
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	IEA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 610229
• HGNC: 16664
• e!Ensembl: ENSG00000214711

Protein

• UniProt ID: A8MX76
• Protein name: Calpain-14 (EC 3.4.22.-) (Calcium-activated neutral proteinase 14) (CANP 14)
• Protein function: Calcium-regulated non-lysosomal thiol-protease.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00648	Peptidase_C2	44 → 334	Calpain family cysteine protease	Family
  PF01067	Calpain_III	355 → 491	Calpain large subunit, domain III	Domain

• Tissue specificity: TISSUE SPECIFICITY: Not expressed in tissues tested.
• Sequence:

  MSLWPPFRCRWKLAPRYSRRASPQQPQQDFEALLAECLRNGCLFEDTSFPATLSSIGSGS
  LLQKLPPRLQWKRPPELHSNPQFYFAKAKRLDLCQGIVGDCWFLAALQALALHQDILSRV
  VPLNQSFTEKYAGIFRFWFWHYGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEK
  AYAKLSGSYEDLQSGQVSEALVDFTGGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTH
  SGEKILENGLVEGHAYTLTGIRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLS
  PKEKILLLRKDNDGEFWMTLQDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKR
  STAGGQRQLLQDTFWKNPQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRHRCRKRKPLLAI
  GFYLYRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEA
  HQKSEFVLRVFSRKHIFYEIGSNSGVVFSKEIEDQNERQDEFFTKFFEKHPEINAVQLQN
  LLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQD
  RGSGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVF
  QNLTQDGKGIYLQKPEWMMMALYS

• Sequence length: 684

Pathways

Reactome:

Degradation of the extracellular matrix

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Amyotrophic lateral sclerosis	Conflicting classifications of pathogenicity	rs181906086	RCV001260194
Familial cancer of breast	Uncertain significance	rs746140880	RCV005929273

Associations from Text Mining
Disease Name	Relationship Type	References
Bacteremia	Associate	35254093
Eosinophilic Esophagitis	Associate	25017104, 25407941, 26258919, 29029802, 29129581, 31909633, 33446329, 34815391, 37652141
Eosinophilic Esophagitis	Stimulate	30626591
Ige Responsiveness Atopic	Associate	29129581
Inflammation	Associate	37652141
Otitis Media	Associate	23133572
Otitis Media with Effusion	Associate	23133572