IQSEC3 (IQ motif and Sec7 domain ArfGEF 3)

Gene

• Entrez ID: 440073
• Gene name: IQ motif and Sec7 domain ArfGEF 3
• Gene symbol: IQSEC3
• Synonyms (NCBI Gene): -
• Chromosome: 12
• Chromosome location: 12p13.33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT629248	hsa-miR-548ad-3p	HITS-CLIP	23824327
MIRT629247	hsa-miR-8485	HITS-CLIP	23824327
MIRT573507	hsa-miR-8080	PAR-CLIP	20371350
MIRT573506	hsa-miR-4779	PAR-CLIP	20371350
MIRT573505	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT573504	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT573502	hsa-miR-4292	PAR-CLIP	20371350
MIRT573503	hsa-miR-6791-5p	PAR-CLIP	20371350
MIRT573501	hsa-miR-3192-5p	PAR-CLIP	20371350
MIRT573500	hsa-miR-5008-5p	PAR-CLIP	20371350
MIRT573499	hsa-miR-4533	PAR-CLIP	20371350
MIRT573498	hsa-miR-765	PAR-CLIP	20371350
MIRT573497	hsa-miR-1291	PAR-CLIP	20371350
MIRT573496	hsa-miR-6775-3p	PAR-CLIP	20371350
MIRT573495	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT573494	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT573493	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT573492	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT573491	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT573490	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT573488	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT573489	hsa-miR-6799-5p	PAR-CLIP	20371350
MIRT573487	hsa-miR-4271	PAR-CLIP	20371350
MIRT573486	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT573485	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT573484	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT573483	hsa-miR-1273h-5p	PAR-CLIP	20371350
MIRT573482	hsa-miR-30b-3p	PAR-CLIP	20371350
MIRT573481	hsa-miR-3689a-3p	PAR-CLIP	20371350
MIRT573480	hsa-miR-3689b-3p	PAR-CLIP	20371350
MIRT573479	hsa-miR-3689c	PAR-CLIP	20371350
MIRT573478	hsa-miR-6779-5p	PAR-CLIP	20371350
MIRT573477	hsa-miR-6780a-5p	PAR-CLIP	20371350
MIRT629248	hsa-miR-548ad-3p	HITS-CLIP	23824327
MIRT629247	hsa-miR-8485	HITS-CLIP	23824327
MIRT573507	hsa-miR-8080	PAR-CLIP	20371350
MIRT573506	hsa-miR-4779	PAR-CLIP	20371350
MIRT573505	hsa-miR-4716-3p	PAR-CLIP	20371350
MIRT573504	hsa-miR-6794-5p	PAR-CLIP	20371350
MIRT573502	hsa-miR-4292	PAR-CLIP	20371350
MIRT573503	hsa-miR-6791-5p	PAR-CLIP	20371350
MIRT573501	hsa-miR-3192-5p	PAR-CLIP	20371350
MIRT573500	hsa-miR-5008-5p	PAR-CLIP	20371350
MIRT573499	hsa-miR-4533	PAR-CLIP	20371350
MIRT573498	hsa-miR-765	PAR-CLIP	20371350
MIRT573497	hsa-miR-1291	PAR-CLIP	20371350
MIRT573496	hsa-miR-6775-3p	PAR-CLIP	20371350
MIRT573495	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT573494	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT573493	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT573492	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT573491	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT573490	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT573488	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT573489	hsa-miR-6799-5p	PAR-CLIP	20371350
MIRT573487	hsa-miR-4271	PAR-CLIP	20371350
MIRT573486	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT573485	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT573484	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT573483	hsa-miR-1273h-5p	PAR-CLIP	20371350
MIRT573482	hsa-miR-30b-3p	PAR-CLIP	20371350
MIRT573481	hsa-miR-3689a-3p	PAR-CLIP	20371350
MIRT573480	hsa-miR-3689b-3p	PAR-CLIP	20371350
MIRT573479	hsa-miR-3689c	PAR-CLIP	20371350
MIRT573478	hsa-miR-6779-5p	PAR-CLIP	20371350
MIRT573477	hsa-miR-6780a-5p	PAR-CLIP	20371350
MIRT1070276	hsa-miR-1200	CLIP-seq
MIRT1070277	hsa-miR-1324	CLIP-seq
MIRT1070278	hsa-miR-145	CLIP-seq
MIRT1070279	hsa-miR-149	CLIP-seq
MIRT1070280	hsa-miR-184	CLIP-seq
MIRT1070281	hsa-miR-1909	CLIP-seq
MIRT1070282	hsa-miR-1913	CLIP-seq
MIRT1070283	hsa-miR-200b	CLIP-seq
MIRT1070284	hsa-miR-200c	CLIP-seq
MIRT1070285	hsa-miR-2467-3p	CLIP-seq
MIRT1070286	hsa-miR-3074-5p	CLIP-seq
MIRT1070287	hsa-miR-3169	CLIP-seq
MIRT1070288	hsa-miR-3175	CLIP-seq
MIRT1070289	hsa-miR-3184	CLIP-seq
MIRT1070290	hsa-miR-3192	CLIP-seq
MIRT1070291	hsa-miR-324-3p	CLIP-seq
MIRT1070292	hsa-miR-3614-5p	CLIP-seq
MIRT1070293	hsa-miR-3616-3p	CLIP-seq
MIRT1070294	hsa-miR-3664-3p	CLIP-seq
MIRT1070295	hsa-miR-3669	CLIP-seq
MIRT1070296	hsa-miR-3915	CLIP-seq
MIRT1070297	hsa-miR-3925-3p	CLIP-seq
MIRT1070298	hsa-miR-3928	CLIP-seq
MIRT1070299	hsa-miR-3929	CLIP-seq
MIRT1070300	hsa-miR-421	CLIP-seq
MIRT1070301	hsa-miR-423-5p	CLIP-seq
MIRT1070302	hsa-miR-4277	CLIP-seq
MIRT1070303	hsa-miR-429	CLIP-seq
MIRT1070304	hsa-miR-4324	CLIP-seq
MIRT1070305	hsa-miR-4419b	CLIP-seq
MIRT1070306	hsa-miR-4436a	CLIP-seq
MIRT1070307	hsa-miR-4478	CLIP-seq
MIRT1070308	hsa-miR-450b-3p	CLIP-seq
MIRT1070309	hsa-miR-4515	CLIP-seq
MIRT1070310	hsa-miR-4691-3p	CLIP-seq
MIRT1070311	hsa-miR-4709-5p	CLIP-seq
MIRT1070312	hsa-miR-4722-3p	CLIP-seq
MIRT1070313	hsa-miR-4726-3p	CLIP-seq
MIRT1070314	hsa-miR-4755-3p	CLIP-seq
MIRT1070315	hsa-miR-544b	CLIP-seq
MIRT1070316	hsa-miR-764	CLIP-seq
MIRT1070317	hsa-miR-766	CLIP-seq
MIRT1070318	hsa-miR-769-3p	CLIP-seq
MIRT1070319	hsa-miR-892b	CLIP-seq
MIRT1550188	hsa-miR-1254	CLIP-seq
MIRT1550189	hsa-miR-1908	CLIP-seq
MIRT1070282	hsa-miR-1913	CLIP-seq
MIRT1550190	hsa-miR-2861	CLIP-seq
MIRT1550191	hsa-miR-3116	CLIP-seq
MIRT1550192	hsa-miR-3127-5p	CLIP-seq
MIRT1070291	hsa-miR-324-3p	CLIP-seq
MIRT1550193	hsa-miR-3621	CLIP-seq
MIRT1550194	hsa-miR-3918	CLIP-seq
MIRT1550195	hsa-miR-4446-3p	CLIP-seq
MIRT1550196	hsa-miR-4651	CLIP-seq
MIRT1070312	hsa-miR-4722-3p	CLIP-seq
MIRT1550197	hsa-miR-4757-5p	CLIP-seq
MIRT1550198	hsa-miR-541	CLIP-seq
MIRT1550199	hsa-miR-608	CLIP-seq
MIRT1550200	hsa-miR-615-5p	CLIP-seq
MIRT1550201	hsa-miR-654-5p	CLIP-seq
MIRT1550202	hsa-miR-661	CLIP-seq
MIRT1550203	hsa-miR-663	CLIP-seq
MIRT2017286	hsa-miR-1233	CLIP-seq
MIRT2017287	hsa-miR-1286	CLIP-seq
MIRT2017288	hsa-miR-1301	CLIP-seq
MIRT2017289	hsa-miR-146b-3p	CLIP-seq
MIRT1070282	hsa-miR-1913	CLIP-seq
MIRT2017290	hsa-miR-193a-5p	CLIP-seq
MIRT1550190	hsa-miR-2861	CLIP-seq
MIRT2017291	hsa-miR-3173-5p	CLIP-seq
MIRT1070291	hsa-miR-324-3p	CLIP-seq
MIRT2017292	hsa-miR-342-5p	CLIP-seq
MIRT2017293	hsa-miR-3944-5p	CLIP-seq
MIRT2017294	hsa-miR-4283	CLIP-seq
MIRT2017295	hsa-miR-4308	CLIP-seq
MIRT2017296	hsa-miR-4419a	CLIP-seq
MIRT1550195	hsa-miR-4446-3p	CLIP-seq
MIRT2017297	hsa-miR-4459	CLIP-seq
MIRT2017298	hsa-miR-4510	CLIP-seq
MIRT2017299	hsa-miR-4640-5p	CLIP-seq
MIRT1550196	hsa-miR-4651	CLIP-seq
MIRT2017300	hsa-miR-4660	CLIP-seq
MIRT2017301	hsa-miR-4664-5p	CLIP-seq
MIRT2017302	hsa-miR-4667-5p	CLIP-seq
MIRT2017303	hsa-miR-4675	CLIP-seq
MIRT2017304	hsa-miR-4700-5p	CLIP-seq
MIRT2017305	hsa-miR-4722-5p	CLIP-seq
MIRT2017306	hsa-miR-4726-5p	CLIP-seq
MIRT2017307	hsa-miR-4741	CLIP-seq
MIRT1550197	hsa-miR-4757-5p	CLIP-seq
MIRT2017308	hsa-miR-5047	CLIP-seq
MIRT1550198	hsa-miR-541	CLIP-seq
MIRT1550199	hsa-miR-608	CLIP-seq
MIRT2017309	hsa-miR-626	CLIP-seq
MIRT1550201	hsa-miR-654-5p	CLIP-seq
MIRT2017310	hsa-miR-874	CLIP-seq
MIRT2017286	hsa-miR-1233	CLIP-seq
MIRT2017287	hsa-miR-1286	CLIP-seq
MIRT2249199	hsa-miR-1302	CLIP-seq
MIRT1070281	hsa-miR-1909	CLIP-seq
MIRT1070282	hsa-miR-1913	CLIP-seq
MIRT2249200	hsa-miR-3122	CLIP-seq
MIRT1070291	hsa-miR-324-3p	CLIP-seq
MIRT2249201	hsa-miR-3913-5p	CLIP-seq
MIRT2017293	hsa-miR-3944-5p	CLIP-seq
MIRT2017294	hsa-miR-4283	CLIP-seq
MIRT2249202	hsa-miR-4298	CLIP-seq
MIRT2017296	hsa-miR-4419a	CLIP-seq
MIRT2017297	hsa-miR-4459	CLIP-seq
MIRT2249203	hsa-miR-4489	CLIP-seq
MIRT2017298	hsa-miR-4510	CLIP-seq
MIRT1550196	hsa-miR-4651	CLIP-seq
MIRT2249204	hsa-miR-4667-3p	CLIP-seq
MIRT2017302	hsa-miR-4667-5p	CLIP-seq
MIRT2017304	hsa-miR-4700-5p	CLIP-seq
MIRT2017305	hsa-miR-4722-5p	CLIP-seq
MIRT2249205	hsa-miR-4731-5p	CLIP-seq
MIRT1550199	hsa-miR-608	CLIP-seq
MIRT2249206	hsa-miR-615-3p	CLIP-seq
MIRT2249207	hsa-miR-637	CLIP-seq
MIRT2249208	hsa-miR-642b	CLIP-seq
MIRT1070282	hsa-miR-1913	CLIP-seq
MIRT1550190	hsa-miR-2861	CLIP-seq
MIRT2389460	hsa-miR-3144-5p	CLIP-seq
MIRT2389461	hsa-miR-3191	CLIP-seq
MIRT1070291	hsa-miR-324-3p	CLIP-seq
MIRT2389462	hsa-miR-326	CLIP-seq
MIRT2389463	hsa-miR-330-5p	CLIP-seq
MIRT1550196	hsa-miR-4651	CLIP-seq
MIRT2389464	hsa-miR-4652-5p	CLIP-seq
MIRT2017302	hsa-miR-4667-5p	CLIP-seq
MIRT2017304	hsa-miR-4700-5p	CLIP-seq
MIRT1550197	hsa-miR-4757-5p	CLIP-seq
MIRT1550198	hsa-miR-541	CLIP-seq
MIRT1550199	hsa-miR-608	CLIP-seq
MIRT2249207	hsa-miR-637	CLIP-seq
MIRT1550201	hsa-miR-654-5p	CLIP-seq
MIRT1550202	hsa-miR-661	CLIP-seq
MIRT1070276	hsa-miR-1200	CLIP-seq
MIRT1070285	hsa-miR-2467-3p	CLIP-seq
MIRT1070296	hsa-miR-3915	CLIP-seq
MIRT1070298	hsa-miR-3928	CLIP-seq
MIRT1070304	hsa-miR-4324	CLIP-seq
MIRT1070315	hsa-miR-544b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0014069	Component	Postsynaptic density	IEA
GO:0014069	Component	Postsynaptic density	ISS
GO:0030036	Process	Actin cytoskeleton organization	IBA
GO:0032012	Process	Regulation of ARF protein signal transduction	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0060077	Component	Inhibitory synapse	IEA
GO:0098690	Component	Glycinergic synapse	IEA
GO:0098982	Component	GABA-ergic synapse	IEA
GO:0099629	Component	Postsynaptic specialization of symmetric synapse	IEA

Other IDs

• MIM: 612118
• HGNC: 29193
• e!Ensembl: ENSG00000120645

Protein

• UniProt ID: Q9UPP2
• Protein name: IQ motif and SEC7 domain-containing protein 3
• Protein function: Acts as a guanine nucleotide exchange factor (GEF) for ARF1.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01369	Sec7	651 → 839	Sec7 domain	Domain
  PF16453	IQ_SEC7_PH	859 → 996	PH domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed specifically in the adult brain, predominantly in the cerebral cortex and the olfactory bulb, but not in the fetal brain. Expressed only in mature neurons, but not in undifferentiated neural stem precursor cells (NSPCs), nor
• Sequence:

  MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRERIDELERRLDELSAENRSLWEHQQLL
  QAQPPPGLVPPSSAPLPAAPATAPAAAARAQEPLQDQGQRSAAAPHPAPDRPPRQHHGQL
  LEQPQRGPGSRAHTPQSPHKHLGTQGAVTDKEKERPPSCCAAAGALLQHKSPSALGKGVL
  SRRPENETVLHQFCCPAADACSDLASQSDGSCTQAGGGMEDSVVAAAAVAAGRPSAHAPK
  AQAQELQEEEERPGAGAASPRAGPQHKASPGRQQPALATALCPHAPAASDYELSLDLKNK
  QIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRSPT
  AESLAAEKALMEGYGLVGLPLVRSPSLPPTFAGTLTELEDSFTEQVQSLAKSIDDALSTW
  SLKTMCSLRESGAYQLHQALQAAAGPPGLEAEGRAPESAGPGPGDDAAETPGLPPAHSGT
  LMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGETSGREAPEA
  PAVGREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSS
  STSTKSAKSGSEASASASKDALQAMILSLPRYHCENPASCKSPTLSTDTLRKRLYRIGLN
  LFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCV
  VDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIF
  ILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELK
  SNEDHVTYVTKVEKSIVGMKTVLSVPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFND
  LLVILKLCPKKKSSSTYTFCKSVGLLGMQFQLFENEYYSHGITLVTPLSGSEKKQVLHFC
  ALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQGTKTLSFKPCGAQGDPQSKQGSP
  TAKREAALRERPAESTVEVSIHNRLQTSQHNSGLGAERGAPVPPPDLQPSPPRQQTPPLP
  PPPPTPPGTLVQCQQIVKVIVLDKPCLARMEPLLSQALSCYTSSSSDSCGSTPLGGPGSP
  VKVTHQPPLPPPPPPYNHPHQFCPPGSLLHGHRYSSGSRSLV

• Sequence length: 1182

Pathways

KEGG:

Endocytosis

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Arthrogryposis multiplex congenita	Uncertain significance	rs1448451909, rs189467547	RCV000855507 RCV000855508
Fetal akinesia deformation sequence 1	Uncertain significance	rs1448451909, rs189467547	RCV000855507 RCV000855508
IQSEC3-related disorder	Conflicting classifications of pathogenicity; Likely benign; Uncertain significance	rs200670002, rs145014866, rs139400594, rs782257201	RCV003929039 RCV003933918 RCV003931445 RCV003964330

Associations from Text Mining
Disease Name	Relationship Type	References
Autistic Disorder	Inhibit	27219343
Breast Neoplasms	Associate	33170908
Fetal akinesia syndrome X linked	Associate	31680123
Glioma	Stimulate	35676651
Mental Disorders	Associate	27219343
Neuromuscular Diseases	Associate	31680123