MRC1 (mannose receptor C-type 1)

Gene
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4360
Gene name Gene Name - the full gene name approved by the HGNC.
Mannose receptor C-type 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MRC1
Synonyms (NCBI Gene) Gene synonyms aliases
CD206, CLEC13D, CLEC13DL, MMR, MRC1L1, bA541I19.1, hMR
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10p12.33
Summary Summary of gene provided in NCBI Entrez Gene.
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
SNP ID Visualize variation Clinical significance Consequence
rs606231248 G>A Risk-factor Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(23)
miRTarBase ID miRNA Experiments Reference
MIRT442609 hsa-miR-4480 PAR-CLIP 22100165
MIRT442608 hsa-miR-4448 PAR-CLIP 22100165
MIRT442609 hsa-miR-4480 PAR-CLIP 22100165
MIRT442608 hsa-miR-4448 PAR-CLIP 22100165
MIRT1157619 hsa-miR-105 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(24)
GO ID Ontology Definition Evidence Reference
GO:0001618 Function Virus receptor activity IEA
GO:0004888 Function Transmembrane signaling receptor activity IEA
GO:0005515 Function Protein binding IPI 11222859
GO:0005537 Function D-mannose binding IEA
GO:0005537 Function D-mannose binding TAS 2373685
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
153618 7228 ENSG00000260314
Protein
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P22897
Protein name Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206)
Protein function Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.; (Microbial infection) Acts as a phagocytic receptor for bacteria, fungi and other pathogens.; (Microbial i
PDB 1EGG , 1EGI , 5XTS , 5XTW , 6INN , 6INO , 6INU , 6INV , 6IOE , 7JUB , 7JUC , 7JUD , 7JUE , 7JUF , 7JUG , 7JUH , 7L61 , 7L62 , 7L63 , 7L64 , 7L65 , 7L66 , 7L67 , 7L68
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00652 Ricin_B_lectin 23 → 118 Ricin-type beta-trefoil lectin domain Domain
PF00040 fn2 168 → 209 Fibronectin type II domain Domain
PF00059 Lectin_C 236 → 342 Lectin C-type domain Domain
PF00059 Lectin_C 380 → 488 Lectin C-type domain Domain
PF00059 Lectin_C 521 → 627 Lectin C-type domain Domain
PF00059 Lectin_C 669 → 779 Lectin C-type domain Domain
PF00059 Lectin_C 817 → 924 Lectin C-type domain Domain
PF00059 Lectin_C 966 → 1081 Lectin C-type domain Domain
PF00059 Lectin_C 1112 → 1214 Lectin C-type domain Domain
PF00059 Lectin_C 1252 → 1357 Lectin C-type domain Domain
Sequence 
MRLPLLLVFASVIPGAVLLLDTRQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRW
VSESQIMSVAFKLCLGVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYG
NRQEKNIMLYKGSGLWSRWKIYGTTDNLCSRGYEAMYTLLGNANGATCAFPFKFENKWYA
DCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFEGSESLWNKDPLTSVSYQINSKSALTW
HQARKSCQQQNAELLSITEIHEQTYLTGLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRY
LNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQKLGYICKKGNTTLNSFVIPSESDVPT
HCPSQWWPYAGHCYKIHRDEKKIQRDALTTCRKEGGDLTSIHTIEELDFIISQLGYEPND
ELWIGLNDIKIQMYFEWSDGTPVTFTKWLRGEPSHENNRQEDCVVMKGKDGYWADRGCEW
PLGYICKMKSRSQGPEIVEVEKGCRKGWKKHHFYCYMIGHTLSTFAEANQTCNNENAYLT
TIEDRYEQAFLTSFVGLRPEKYFWTGLSDIQTKGTFQWTIEEEVRFTHWNSDMPGRKPGC
VAMRTGIAGGLWDVLKCDEKAKFVCKHWAEGVTHPPKPTTTPEPKCPEDWGASSRTSLCF
KLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYG
SPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPTMSWNDINCEHLNNWICQIQ
KGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQS
ESEKKFLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCV
TMYSNSGFWNDINCGYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIF
GFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTF
LWTDGRGVHYTNWGKGYPGGRRSSLSYEDADCVVIIGGASNEAGKWMDDTCDSKRGYICQ
TRSDPSLTNPPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNA
FAWLQMETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSACVYLDLDGYWK
TAHCNESFYFLCKRSDEIPATEPPQLPGRCPESDHTAWIPFHGHCYYIESSYTRNWGQAS
LECLRMGSSLVSIESAAESSFLSYRVEPLKSKTNFWIGLFRNVEGTWLWINNSPVSFVNW
NTGDPSGERNDCVALHASSGFWSNIHCSSYKGYICKRPKIIDAKPTHELLTTKADTRKMD
PSKPSSNVAGVVIIVILLILTGAGLAAYFFYKKRRVHLPQEGAFENTLYFNSQSSPGTSD
MKDLVGNIEQNEHSVI
Sequence length 1456
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Phagosome
Tuberculosis 		  Cross-presentation of soluble exogenous antigens (endosomes)
Modulation by Mtb of host immune system
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Leprosy Leprosy, susceptibility to, 1 N/A N/A ClinVar
Show/Hide Text Mining Associations (123)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adrenoleukodystrophy Associate 29860501
Anemia Iron Deficiency Inhibit 27999815
Anti Neutrophil Cytoplasmic Antibody Associated Vasculitis Associate 36183584
Arthritis Juvenile Associate 21526507, 32787920, 33836809
Arthritis Rheumatoid Associate 39321281
Asthma Associate 33840588
Atherosclerosis Associate 28818858
Autism Spectrum Disorder Associate 32129578
Blast Injuries Inhibit 36508265
Brain Injuries Associate 39191768