Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4357
Gene name Gene Name - the full gene name approved by the HGNC.
Mercaptopyruvate sulfurtransferase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MPST
Synonyms (NCBI Gene) Gene synonyms aliases
MST, TST2, TUM1
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q12.3
Summary Summary of gene provided in NCBI Entrez Gene.
This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this prot
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016463 hsa-miR-193b-3p Microarray 20304954
MIRT021491 hsa-miR-191-5p Sequencing 20371350
MIRT1156968 hsa-miR-298 CLIP-seq
MIRT1156969 hsa-miR-4633-3p CLIP-seq
MIRT2274152 hsa-miR-105 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000098 Process Sulfur amino acid catabolic process TAS
GO:0001822 Process Kidney development IEA
GO:0001889 Process Liver development IEA
GO:0004792 Function Thiosulfate sulfurtransferase activity IBA 21873635
GO:0005515 Function Protein binding IPI 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602496 7223 ENSG00000128309
Protein
UniProt ID P25325
Protein name 3-mercaptopyruvate sulfurtransferase (MST) (EC 2.8.1.2)
Protein function Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), cont
PDB 3OLH , 4JGT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00581 Rhodanese 12 138 Rhodanese-like domain Domain
PF00581 Rhodanese 165 282 Rhodanese-like domain Domain
Sequence
Sequence length 297
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cysteine and methionine metabolism
Sulfur metabolism
Metabolic pathways
Sulfur relay system
  Degradation of cysteine and homocysteine
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Melanoma melanoma rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340
View all (64 more)
25205294
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Renal Cell Associate 32871814
Chronic Limb Threatening Ischemia Inhibit 25977470
Colonic Diseases Associate 38631098
Colorectal Neoplasms Inhibit 16500920
Colorectal Neoplasms Associate 36113340, 38631098
Down Syndrome Associate 32340322
Gastrointestinal Neoplasms Associate 38631098
Inflammation Stimulate 33554726
Kidney Neoplasms Associate 29793450
Melanoma Associate 37892173, 38070581