MPO (myeloperoxidase)

Gene Gene information from NCBI Gene database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 4353
Gene name Myeloperoxidase
Gene symbol MPO
Synonyms (NCBI Gene)
-
Chromosome 17
Chromosome location 17q22
Summary Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heav
SNPs SNP information provided by dbSNP.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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SNP ID Visualize variation Clinical significance Consequence
rs35897051 T>G Pathogenic Splice acceptor variant
rs78950939 T>C Pathogenic Missense variant, coding sequence variant
rs119468010 G>A Pathogenic Coding sequence variant, missense variant
rs119469012 A>C,G Pathogenic Coding sequence variant, missense variant
rs119469013 C>A,T Pathogenic Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT532437 hsa-miR-8485 PAR-CLIP 20371350
MIRT532436 hsa-miR-1324 PAR-CLIP 20371350
MIRT532435 hsa-miR-4716-5p PAR-CLIP 20371350
MIRT532437 hsa-miR-8485 PAR-CLIP 22012620
MIRT532436 hsa-miR-1324 PAR-CLIP 22012620
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
RUNX1 Unknown 11023523
SP1 Activation 17521322;8662930
SP1 Unknown 12057865
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001878 Process Response to yeast IEA
GO:0002149 Process Hypochlorous acid biosynthetic process IEA
GO:0002679 Process Respiratory burst involved in defense response IEA
GO:0003682 Function Chromatin binding TAS 2829220
GO:0004601 Function Peroxidase activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
606989 7218 ENSG00000005381
Protein Protein information from UniProt database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P05164
Protein name Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain]
Protein function Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid
PDB 1CXP , 1D2V , 1D5L , 1D7W , 1DNU , 1DNW , 1MHL , 1MYP , 3F9P , 3ZS0 , 3ZS1 , 4C1M , 4DL1 , 4EJX , 5FIW , 5MFA , 5UZU , 6AZP , 6BMT , 7OIH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03098 An_peroxidase 173 → 718 Animal haem peroxidase Domain
Sequence
Sequence length 745
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Drug metabolism - other enzymes
Phagosome
Neutrophil extracellular trap formation
Transcriptional misregulation in cancer
Acute myeloid leukemia 		  Neutrophil degranulation
Events associated with phagocytolytic activity of PMN cells
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (4)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Likely pathogenic rs762526880 RCV005922469
Alzheimer disease type 1 Likely pathogenic; Pathogenic rs119468010, rs762526880 RCV002490304
RCV002503272
MPO-related disorder Likely pathogenic; Pathogenic rs754632893, rs119468010, rs536522394, rs119469014 RCV003416446
RCV003415644
RCV003952340
RCV003894789
Myeloperoxidase deficiency Likely pathogenic; Pathogenic rs754632893, rs181494077, rs119468010, rs536522394, rs119469012, rs119469013, rs119469014, rs773478778, rs1970491995, rs762933005, rs762526880 RCV001784671
RCV001784672
RCV000003810
RCV000003813
RCV000003815
RCV000003819
RCV000003820
RCV003388922
RCV004566634
RCV005356058
RCV002503272
Show/Hide Unknown Diseases (5)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Alzheimer disease Uncertain significance rs1970460686 RCV001198130
Cervical cancer Likely benign rs35670089 RCV005907517
Hereditary angioedema with normal C1Inh not provided rs1598044103 RCV001027426
Lung cancer, protection against, in smokers protective; risk factor rs2333227 RCV000003818
Show/Hide Text Mining Associations (294)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 11238037, 17512353, 26307104
Acute Generalized Exanthematous Pustulosis Associate 32758448
Acute Kidney Injury Associate 22739978
Acute On Chronic Liver Failure Associate 34552111, 37816833
Adenoma Associate 22126566
Aggressive Periodontitis Associate 20364045
Alzheimer Disease Associate 32171317, 37959001
Aneurysm Ruptured Associate 34611229
Angina Unstable Inhibit 12097534, 8606272
Angina Unstable Stimulate 32481400