MPO (myeloperoxidase)

Gene
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4353
Gene name Gene Name - the full gene name approved by the HGNC.
Myeloperoxidase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MPO
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q22
Summary Summary of gene provided in NCBI Entrez Gene.
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heav
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(10)
SNP ID Visualize variation Clinical significance Consequence
rs35897051 T>G Pathogenic Splice acceptor variant
rs78950939 T>C Pathogenic Missense variant, coding sequence variant
rs119468010 G>A Pathogenic Coding sequence variant, missense variant
rs119469012 A>C,G Pathogenic Coding sequence variant, missense variant
rs119469013 C>A,T Pathogenic Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(57)
miRTarBase ID miRNA Experiments Reference
MIRT532437 hsa-miR-8485 PAR-CLIP 20371350
MIRT532436 hsa-miR-1324 PAR-CLIP 20371350
MIRT532435 hsa-miR-4716-5p PAR-CLIP 20371350
MIRT532437 hsa-miR-8485 PAR-CLIP 22012620
MIRT532436 hsa-miR-1324 PAR-CLIP 22012620
Transcription factors
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
Transcription factor Regulation Reference
RUNX1 Unknown 11023523
SP1 Activation 17521322;8662930
SP1 Unknown 12057865
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001878 Process Response to yeast IEA
GO:0002149 Process Hypochlorous acid biosynthetic process IEA
GO:0002679 Process Respiratory burst involved in defense response IEA
GO:0003682 Function Chromatin binding TAS 2829220
GO:0004601 Function Peroxidase activity IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
606989 7218 ENSG00000005381
Protein
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P05164
Protein name Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain]
Protein function Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid
PDB 1CXP , 1D2V , 1D5L , 1D7W , 1DNU , 1DNW , 1MHL , 1MYP , 3F9P , 3ZS0 , 3ZS1 , 4C1M , 4DL1 , 4EJX , 5FIW , 5MFA , 5UZU , 6AZP , 6BMT , 7OIH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03098 An_peroxidase 173 → 718 Animal haem peroxidase Domain
Sequence
Sequence length 745
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Drug metabolism - other enzymes
Phagosome
Neutrophil extracellular trap formation
Transcriptional misregulation in cancer
Acute myeloid leukemia 		  Neutrophil degranulation
Events associated with phagocytolytic activity of PMN cells
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
Myeloperoxidase Deficiency myeloperoxidase deficiency rs119468010, rs536522394, rs119469012, rs119469013, rs119469014, rs762933005 N/A
Show/Hide Unknown Diseases (3)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Angioedema Hereditary angioedema with normal C1Inh N/A N/A ClinVar
Multiple Sclerosis Multiple sclerosis N/A N/A GWAS
Oligodendroglioma Oligodendroglioma N/A N/A GWAS
Show/Hide Text Mining Associations (294)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 11238037, 17512353, 26307104
Acute Generalized Exanthematous Pustulosis Associate 32758448
Acute Kidney Injury Associate 22739978
Acute On Chronic Liver Failure Associate 34552111, 37816833
Adenoma Associate 22126566
Aggressive Periodontitis Associate 20364045
Alzheimer Disease Associate 32171317, 37959001
Aneurysm Ruptured Associate 34611229
Angina Unstable Inhibit 12097534, 8606272
Angina Unstable Stimulate 32481400