Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4343
Gene name	Mov10 RNA helicase
Gene symbol	MOV10
Synonyms (NCBI Gene)	fSAP113gb110
Chromosome	1
Chromosome location	1p13.2

108

Show/Hide all (108)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001356	hsa-miR-1-3p	pSILAC	18668040
MIRT020999	hsa-miR-155-5p	Proteomics	18668040
MIRT023156	hsa-miR-124-3p	Microarray	18668037
MIRT001356	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT001356	hsa-miR-1-3p	Proteomics	18668040
MIRT025576	hsa-miR-34a-5p	Sequencing	20371350
MIRT032076	hsa-miR-16-5p	Proteomics	18668040
MIRT032076	hsa-miR-16-5p	Sequencing	20371350
MIRT052355	hsa-let-7b-5p	CLASH	23622248
MIRT040443	hsa-miR-615-3p	CLASH	23622248
MIRT040443	hsa-miR-615-3p	CLASH	23622248
MIRT1155859	hsa-miR-1207-3p	CLIP-seq
MIRT1155860	hsa-miR-15a	CLIP-seq
MIRT1155861	hsa-miR-15b	CLIP-seq
MIRT1155862	hsa-miR-16	CLIP-seq
MIRT1155863	hsa-miR-195	CLIP-seq
MIRT1155864	hsa-miR-3127-3p	CLIP-seq
MIRT1155865	hsa-miR-3184	CLIP-seq
MIRT1155866	hsa-miR-361-3p	CLIP-seq
MIRT1155867	hsa-miR-3667-3p	CLIP-seq
MIRT1155868	hsa-miR-3679-3p	CLIP-seq
MIRT1155869	hsa-miR-3942-3p	CLIP-seq
MIRT1155870	hsa-miR-423-5p	CLIP-seq
MIRT1155871	hsa-miR-424	CLIP-seq
MIRT1155872	hsa-miR-432	CLIP-seq
MIRT1155873	hsa-miR-4443	CLIP-seq
MIRT1155874	hsa-miR-4524	CLIP-seq
MIRT1155875	hsa-miR-4659a-3p	CLIP-seq
MIRT1155876	hsa-miR-4659b-3p	CLIP-seq
MIRT1155877	hsa-miR-4688	CLIP-seq
MIRT1155878	hsa-miR-4780	CLIP-seq
MIRT1155879	hsa-miR-486-3p	CLIP-seq
MIRT1155880	hsa-miR-497	CLIP-seq
MIRT1155881	hsa-miR-503	CLIP-seq
MIRT1155882	hsa-miR-592	CLIP-seq
MIRT1155883	hsa-miR-597	CLIP-seq
MIRT1155884	hsa-miR-616	CLIP-seq
MIRT1155885	hsa-miR-623	CLIP-seq
MIRT1155886	hsa-miR-646	CLIP-seq
MIRT1155887	hsa-miR-759	CLIP-seq
MIRT1155859	hsa-miR-1207-3p	CLIP-seq
MIRT1155865	hsa-miR-3184	CLIP-seq
MIRT1155870	hsa-miR-423-5p	CLIP-seq
MIRT1155872	hsa-miR-432	CLIP-seq
MIRT1155873	hsa-miR-4443	CLIP-seq
MIRT1155877	hsa-miR-4688	CLIP-seq
MIRT1155878	hsa-miR-4780	CLIP-seq
MIRT1155879	hsa-miR-486-3p	CLIP-seq
MIRT1155885	hsa-miR-623	CLIP-seq
MIRT2273764	hsa-miR-1	CLIP-seq
MIRT2273765	hsa-miR-135a	CLIP-seq
MIRT2273766	hsa-miR-135b	CLIP-seq
MIRT2273767	hsa-miR-1470	CLIP-seq
MIRT1155860	hsa-miR-15a	CLIP-seq
MIRT1155861	hsa-miR-15b	CLIP-seq
MIRT1155862	hsa-miR-16	CLIP-seq
MIRT2273768	hsa-miR-1909	CLIP-seq
MIRT1155863	hsa-miR-195	CLIP-seq
MIRT2273769	hsa-miR-206	CLIP-seq
MIRT2273770	hsa-miR-214	CLIP-seq
MIRT2273771	hsa-miR-2355-5p	CLIP-seq
MIRT2273772	hsa-miR-30a	CLIP-seq
MIRT2273773	hsa-miR-30b	CLIP-seq
MIRT2273774	hsa-miR-30c	CLIP-seq
MIRT2273775	hsa-miR-30d	CLIP-seq
MIRT2273776	hsa-miR-30e	CLIP-seq
MIRT1155864	hsa-miR-3127-3p	CLIP-seq
MIRT1155866	hsa-miR-361-3p	CLIP-seq
MIRT2273777	hsa-miR-3614-3p	CLIP-seq
MIRT2273778	hsa-miR-3619-5p	CLIP-seq
MIRT1155867	hsa-miR-3667-3p	CLIP-seq
MIRT2273779	hsa-miR-3673	CLIP-seq
MIRT1155868	hsa-miR-3679-3p	CLIP-seq
MIRT2273780	hsa-miR-3940-5p	CLIP-seq
MIRT1155869	hsa-miR-3942-3p	CLIP-seq
MIRT1155871	hsa-miR-424	CLIP-seq
MIRT2273781	hsa-miR-4297	CLIP-seq
MIRT2273782	hsa-miR-4421	CLIP-seq
MIRT2273783	hsa-miR-4469	CLIP-seq
MIRT2273784	hsa-miR-4507	CLIP-seq
MIRT1155874	hsa-miR-4524	CLIP-seq
MIRT2273785	hsa-miR-4530	CLIP-seq
MIRT2273786	hsa-miR-4651	CLIP-seq
MIRT1155875	hsa-miR-4659a-3p	CLIP-seq
MIRT1155876	hsa-miR-4659b-3p	CLIP-seq
MIRT2273787	hsa-miR-4667-3p	CLIP-seq
MIRT2273788	hsa-miR-4713-5p	CLIP-seq
MIRT2273789	hsa-miR-4728-5p	CLIP-seq
MIRT1155878	hsa-miR-4780	CLIP-seq
MIRT1155880	hsa-miR-497	CLIP-seq
MIRT1155881	hsa-miR-503	CLIP-seq
MIRT1155882	hsa-miR-592	CLIP-seq
MIRT1155883	hsa-miR-597	CLIP-seq
MIRT2273790	hsa-miR-608	CLIP-seq
MIRT2273791	hsa-miR-613	CLIP-seq
MIRT1155884	hsa-miR-616	CLIP-seq
MIRT1155885	hsa-miR-623	CLIP-seq
MIRT1155886	hsa-miR-646	CLIP-seq
MIRT1155887	hsa-miR-759	CLIP-seq
MIRT2273792	hsa-miR-761	CLIP-seq
MIRT2273768	hsa-miR-1909	CLIP-seq
MIRT2273770	hsa-miR-214	CLIP-seq
MIRT2273771	hsa-miR-2355-5p	CLIP-seq
MIRT2273778	hsa-miR-3619-5p	CLIP-seq
MIRT2273785	hsa-miR-4530	CLIP-seq
MIRT2273788	hsa-miR-4713-5p	CLIP-seq
MIRT2273789	hsa-miR-4728-5p	CLIP-seq
MIRT2273792	hsa-miR-761	CLIP-seq

Show/Hide all (38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000932	Component	P-body	IDA	16289642, 24726324, 27974568
GO:0000932	Component	P-body	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IDA	23093941, 24726324
GO:0003723	Function	RNA binding	IEA
GO:0003724	Function	RNA helicase activity	IEA
GO:0004386	Function	Helicase activity	IEA
GO:0005515	Function	Protein binding	IPI	16289642, 17507929, 18552826, 20543829, 21282530, 21903422, 23093941, 23125361, 24726324, 25220460, 25464849, 27974568, 30122351, 32353859, 32707033, 33060197, 33961781, 34029587, 34316702, 34517762, 34578187, 35107372, 35271311, 35709258, 36217030
GO:0005524	Function	ATP binding	IEA
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0010494	Component	Cytoplasmic stress granule	IEA
GO:0010526	Process	Transposable element silencing	IDA	23093941
GO:0010526	Process	Transposable element silencing	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0031047	Process	Regulatory ncRNA-mediated gene silencing	IEA
GO:0032574	Function	5'-3' RNA helicase activity	IDA	24726324
GO:0032574	Function	5'-3' RNA helicase activity	IEA
GO:0035194	Process	Regulatory ncRNA-mediated post-transcriptional gene silencing	IBA
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IMP	17507929
GO:0035279	Process	MiRNA-mediated gene silencing by mRNA destabilization	IDA	16289642
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IDA	30122351
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IEA
GO:0043186	Component	P granule	IBA
GO:0051607	Process	Defense response to virus	IMP	27974568
GO:0061014	Process	Positive regulation of mRNA catabolic process	IDA	24726324
GO:0061158	Process	3'-UTR-mediated mRNA destabilization	IDA	24726324
GO:0141008	Process	Transposable element silencing by mRNA destabilization	IDA	30122351
GO:0150011	Process	Regulation of neuron projection arborization	ISS

MIM	HGNC	e!Ensembl
610742	7200	ENSG00000155363

Q9HCE1

Protein name

Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein)

Protein function

5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission (PubMed:23093941). Plays

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13604	AAA_30	498 → 696		Domain
PF13087	AAA_12	698 → 923	AAA domain	Domain

Sequence

MPSKFSCRQLREAGQCFESFLVVRGLDMETDRERLRTIYNRDFKISFGTPAPGFSSMLYG
MKIANLAYVTKTRVRFFRLDRWADVRFPEKRRMKLGSDISKHHKSLLAKIFYDRAEYLHG
KHGVDVEVQGPHEARDGQLLIRLDLNRKEVLTLRLRNGGTQSVTLTHLFPLCRTPQFAFY
NEDQELPCPLGPGECYELHVHCKTSFVGYFPATVLWELLGPGESGSEGAGTFYIARFLAA
VAHSPLAAQLKPMTPFKRTRITGNPVVTNRIEEGERPDRAKGYDLELSMALGTYYPPPRL
RQLLPMLLQGTSIFTAPKEIAEIKAQLETALKWRNYEVKLRLLLHLEELQMEHDIRHYDL
ESVPMTWDPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSETHQEDPITYKGFVHKV
ELDRVKLSFSMSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWLLWPMLFPVAPRD
VPLLPSDVKLKLYDRSLESNPEQLQAMRHIVTGTTRPAPYIIFGPPGTGKTVTLVEAIKQ
VVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYRLLAPSRDIRMVPEDIKPCCNWDA
KKGEYVFPAKKKLQEYRVLITTLITAGRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIA
GLMEVKETGDPGGQLVLAGDPRQLGPVLRSPLTQKHGLGYSLLERLLTYNSLYKKGPDGY
DPQFITKLLRNYRSHPTILDIPNQLYYEGELQACADVVDRERFCRWAGLPRQGFPIIFHG
VMGKDEREGNSPSFFNPEEAATVTSYLKLLLAPSSKKGKARLSPRSVGVISPYRKQVEKI
RYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLK
NPKRFNVAVTRAKALLIIVGNPLLLGHDPDWKVFLEFCKENGGYTGCPFPAKLDLQQGQN
LLQGLSKLSPSTSGPHSHDYLPQEREGEGGLSLQVEPEWRNEL

Sequence length

1003

Interactions

View interactions

	Reactome
			Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSIVE DISEASE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOV10-related disorder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN FAILURE, PREMATURE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Premature ovarian failure	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Acute Retroviral Syndrome	Associate	20215113	★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of Lung	Associate	33001583	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Inhibit	29315404	★★★★★ ★☆☆☆☆ Found in Text Mining only
COVID 19	Associate	34031419	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	20543829	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	29970450	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Associate	31693728	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pre Eclampsia	Associate	33269545	★★★★★ ★☆☆☆☆ Found in Text Mining only
Preeclamptic toxemia	Associate	33269545	★★★★★ ★☆☆☆☆ Found in Text Mining only
Respiratory Distress Syndrome	Associate	37565892	★★★★★ ★☆☆☆☆ Found in Text Mining only
RNA Virus Infections	Inhibit	27016603	★★★★★ ★☆☆☆☆ Found in Text Mining only
Virus Diseases	Associate	34031419	★★★★★ ★☆☆☆☆ Found in Text Mining only

MOV10 (Mov10 RNA helicase)