Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	4340
Gene name	Myelin oligodendrocyte glycoprotein
Gene symbol	MOG
Synonyms (NCBI Gene)	BTN6BTNL11MOGIG2NRCLP7
Chromosome	6
Chromosome location	6p22.1
Summary	The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may

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SNP ID	Visualize variation	Clinical significance	Consequence
rs387906655	C>G	Pathogenic	Missense variant, coding sequence variant, intron variant

180

Show/Hide all (180)

miRTarBase ID	miRNA	Experiments	Reference
MIRT684185	hsa-miR-6890-3p	HITS-CLIP	23313552
MIRT684184	hsa-miR-6736-3p	HITS-CLIP	23313552
MIRT684183	hsa-miR-660-3p	HITS-CLIP	23313552
MIRT684182	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT684181	hsa-miR-6852-5p	HITS-CLIP	23313552
MIRT684180	hsa-miR-6742-3p	HITS-CLIP	23313552
MIRT684179	hsa-miR-1304-3p	HITS-CLIP	23313552
MIRT684178	hsa-miR-6787-3p	HITS-CLIP	23313552
MIRT684177	hsa-miR-4772-3p	HITS-CLIP	23313552
MIRT684176	hsa-miR-4695-3p	HITS-CLIP	23313552
MIRT684175	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT684174	hsa-miR-6791-3p	HITS-CLIP	23313552
MIRT684173	hsa-miR-6829-3p	HITS-CLIP	23313552
MIRT684172	hsa-miR-23a-5p	HITS-CLIP	23313552
MIRT684171	hsa-miR-23b-5p	HITS-CLIP	23313552
MIRT684170	hsa-miR-1343-3p	HITS-CLIP	23313552
MIRT684169	hsa-miR-6783-3p	HITS-CLIP	23313552
MIRT684168	hsa-miR-5001-3p	HITS-CLIP	23313552
MIRT684167	hsa-miR-6836-3p	HITS-CLIP	23313552
MIRT684166	hsa-miR-498	HITS-CLIP	23313552
MIRT445538	hsa-miR-4428	PAR-CLIP	22100165
MIRT445536	hsa-miR-3185	PAR-CLIP	22100165
MIRT445538	hsa-miR-4428	PAR-CLIP	22100165
MIRT445537	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT445536	hsa-miR-3185	PAR-CLIP	22100165
MIRT684185	hsa-miR-6890-3p	HITS-CLIP	23313552
MIRT684184	hsa-miR-6736-3p	HITS-CLIP	23313552
MIRT684183	hsa-miR-660-3p	HITS-CLIP	23313552
MIRT684182	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT684181	hsa-miR-6852-5p	HITS-CLIP	23313552
MIRT684180	hsa-miR-6742-3p	HITS-CLIP	23313552
MIRT684179	hsa-miR-1304-3p	HITS-CLIP	23313552
MIRT684178	hsa-miR-6787-3p	HITS-CLIP	23313552
MIRT684177	hsa-miR-4772-3p	HITS-CLIP	23313552
MIRT684176	hsa-miR-4695-3p	HITS-CLIP	23313552
MIRT684175	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT684174	hsa-miR-6791-3p	HITS-CLIP	23313552
MIRT684173	hsa-miR-6829-3p	HITS-CLIP	23313552
MIRT684172	hsa-miR-23a-5p	HITS-CLIP	23313552
MIRT684171	hsa-miR-23b-5p	HITS-CLIP	23313552
MIRT684170	hsa-miR-1343-3p	HITS-CLIP	23313552
MIRT684169	hsa-miR-6783-3p	HITS-CLIP	23313552
MIRT684168	hsa-miR-5001-3p	HITS-CLIP	23313552
MIRT684167	hsa-miR-6836-3p	HITS-CLIP	23313552
MIRT684166	hsa-miR-498	HITS-CLIP	23313552
MIRT445538	hsa-miR-4428	PAR-CLIP	22100165
MIRT445536	hsa-miR-3185	PAR-CLIP	22100165
MIRT445538	hsa-miR-4428	PAR-CLIP	22100165
MIRT445537	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT445536	hsa-miR-3185	PAR-CLIP	22100165
MIRT1155104	hsa-miR-106a	CLIP-seq
MIRT1155105	hsa-miR-106b	CLIP-seq
MIRT1155106	hsa-miR-1200	CLIP-seq
MIRT1155107	hsa-miR-1234	CLIP-seq
MIRT1155108	hsa-miR-130a	CLIP-seq
MIRT1155109	hsa-miR-130b	CLIP-seq
MIRT1155110	hsa-miR-17	CLIP-seq
MIRT1155111	hsa-miR-197	CLIP-seq
MIRT1155112	hsa-miR-19a	CLIP-seq
MIRT1155113	hsa-miR-19b	CLIP-seq
MIRT1155114	hsa-miR-20a	CLIP-seq
MIRT1155115	hsa-miR-20b	CLIP-seq
MIRT1155116	hsa-miR-301a	CLIP-seq
MIRT1155117	hsa-miR-301b	CLIP-seq
MIRT1155118	hsa-miR-3140-5p	CLIP-seq
MIRT1155119	hsa-miR-3187-3p	CLIP-seq
MIRT1155120	hsa-miR-3545-3p	CLIP-seq
MIRT1155121	hsa-miR-3659	CLIP-seq
MIRT1155122	hsa-miR-3663-5p	CLIP-seq
MIRT1155123	hsa-miR-3666	CLIP-seq
MIRT1155124	hsa-miR-4255	CLIP-seq
MIRT1155125	hsa-miR-4295	CLIP-seq
MIRT1155126	hsa-miR-4326	CLIP-seq
MIRT1155127	hsa-miR-4435	CLIP-seq
MIRT1155128	hsa-miR-454	CLIP-seq
MIRT1155129	hsa-miR-4635	CLIP-seq
MIRT1155130	hsa-miR-4680-5p	CLIP-seq
MIRT1155131	hsa-miR-4701-5p	CLIP-seq
MIRT1155132	hsa-miR-4707-3p	CLIP-seq
MIRT1155133	hsa-miR-4716-5p	CLIP-seq
MIRT1155134	hsa-miR-4755-3p	CLIP-seq
MIRT1155135	hsa-miR-4766-5p	CLIP-seq
MIRT1155136	hsa-miR-4781-3p	CLIP-seq
MIRT1155137	hsa-miR-519a	CLIP-seq
MIRT1155138	hsa-miR-519b-3p	CLIP-seq
MIRT1155139	hsa-miR-519c-3p	CLIP-seq
MIRT1155140	hsa-miR-519d	CLIP-seq
MIRT1155141	hsa-miR-548s	CLIP-seq
MIRT1155142	hsa-miR-588	CLIP-seq
MIRT1155143	hsa-miR-759	CLIP-seq
MIRT1155144	hsa-miR-93	CLIP-seq
MIRT1155111	hsa-miR-197	CLIP-seq
MIRT1155145	hsa-miR-3170	CLIP-seq
MIRT1155119	hsa-miR-3187-3p	CLIP-seq
MIRT1155120	hsa-miR-3545-3p	CLIP-seq
MIRT1155122	hsa-miR-3663-5p	CLIP-seq
MIRT1155127	hsa-miR-4435	CLIP-seq
MIRT1155129	hsa-miR-4635	CLIP-seq
MIRT1155130	hsa-miR-4680-5p	CLIP-seq
MIRT1155131	hsa-miR-4701-5p	CLIP-seq
MIRT1155132	hsa-miR-4707-3p	CLIP-seq
MIRT1155133	hsa-miR-4716-5p	CLIP-seq
MIRT1155134	hsa-miR-4755-3p	CLIP-seq
MIRT1155136	hsa-miR-4781-3p	CLIP-seq
MIRT1155146	hsa-miR-4795-3p	CLIP-seq
MIRT1155147	hsa-miR-5096	CLIP-seq
MIRT1155141	hsa-miR-548s	CLIP-seq
MIRT1155142	hsa-miR-588	CLIP-seq
MIRT1155148	hsa-miR-1323	CLIP-seq
MIRT1155111	hsa-miR-197	CLIP-seq
MIRT1155145	hsa-miR-3170	CLIP-seq
MIRT1155119	hsa-miR-3187-3p	CLIP-seq
MIRT1155120	hsa-miR-3545-3p	CLIP-seq
MIRT1155122	hsa-miR-3663-5p	CLIP-seq
MIRT1155149	hsa-miR-3926	CLIP-seq
MIRT1155127	hsa-miR-4435	CLIP-seq
MIRT1155129	hsa-miR-4635	CLIP-seq
MIRT1155130	hsa-miR-4680-5p	CLIP-seq
MIRT1155131	hsa-miR-4701-5p	CLIP-seq
MIRT1155132	hsa-miR-4707-3p	CLIP-seq
MIRT1155133	hsa-miR-4716-5p	CLIP-seq
MIRT1155134	hsa-miR-4755-3p	CLIP-seq
MIRT1155136	hsa-miR-4781-3p	CLIP-seq
MIRT1155147	hsa-miR-5096	CLIP-seq
MIRT1155150	hsa-miR-548o	CLIP-seq
MIRT1155141	hsa-miR-548s	CLIP-seq
MIRT1155142	hsa-miR-588	CLIP-seq
MIRT1155151	hsa-miR-941	CLIP-seq
MIRT1155107	hsa-miR-1234	CLIP-seq
MIRT2044361	hsa-miR-1236	CLIP-seq
MIRT2044362	hsa-miR-1289	CLIP-seq
MIRT2044363	hsa-miR-1343	CLIP-seq
MIRT2044364	hsa-miR-1976	CLIP-seq
MIRT2044365	hsa-miR-2052	CLIP-seq
MIRT2044366	hsa-miR-3155	CLIP-seq
MIRT2044367	hsa-miR-3155b	CLIP-seq
MIRT1155119	hsa-miR-3187-3p	CLIP-seq
MIRT2044368	hsa-miR-3198	CLIP-seq
MIRT1155120	hsa-miR-3545-3p	CLIP-seq
MIRT1155122	hsa-miR-3663-5p	CLIP-seq
MIRT2044369	hsa-miR-4279	CLIP-seq
MIRT2044370	hsa-miR-4294	CLIP-seq
MIRT2044371	hsa-miR-4307	CLIP-seq
MIRT2044372	hsa-miR-4309	CLIP-seq
MIRT2044373	hsa-miR-432	CLIP-seq
MIRT2044374	hsa-miR-4325	CLIP-seq
MIRT1155127	hsa-miR-4435	CLIP-seq
MIRT2044375	hsa-miR-4480	CLIP-seq
MIRT2044376	hsa-miR-450b-5p	CLIP-seq
MIRT1155129	hsa-miR-4635	CLIP-seq
MIRT1155130	hsa-miR-4680-5p	CLIP-seq
MIRT2044377	hsa-miR-4691-5p	CLIP-seq
MIRT1155131	hsa-miR-4701-5p	CLIP-seq
MIRT1155132	hsa-miR-4707-3p	CLIP-seq
MIRT2044378	hsa-miR-4722-3p	CLIP-seq
MIRT1155134	hsa-miR-4755-3p	CLIP-seq
MIRT2044379	hsa-miR-484	CLIP-seq
MIRT2044380	hsa-miR-507	CLIP-seq
MIRT1155141	hsa-miR-548s	CLIP-seq
MIRT2044381	hsa-miR-557	CLIP-seq
MIRT1155142	hsa-miR-588	CLIP-seq
MIRT2044382	hsa-miR-7	CLIP-seq
MIRT2454379	hsa-miR-1203	CLIP-seq
MIRT2044363	hsa-miR-1343	CLIP-seq
MIRT2044364	hsa-miR-1976	CLIP-seq
MIRT2044369	hsa-miR-4279	CLIP-seq
MIRT2044378	hsa-miR-4722-3p	CLIP-seq
MIRT2044363	hsa-miR-1343	CLIP-seq
MIRT2044364	hsa-miR-1976	CLIP-seq
MIRT2044369	hsa-miR-4279	CLIP-seq
MIRT2044378	hsa-miR-4722-3p	CLIP-seq
MIRT2572434	hsa-miR-564	CLIP-seq
MIRT2454379	hsa-miR-1203	CLIP-seq
MIRT2044363	hsa-miR-1343	CLIP-seq
MIRT2044364	hsa-miR-1976	CLIP-seq
MIRT2044369	hsa-miR-4279	CLIP-seq
MIRT2044378	hsa-miR-4722-3p	CLIP-seq
MIRT2685208	hsa-miR-483-3p	CLIP-seq
MIRT2572434	hsa-miR-564	CLIP-seq
MIRT2685209	hsa-miR-668	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001618	Function	Virus receptor activity	IEA
GO:0001817	Process	Regulation of cytokine production	IBA
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	8530032
GO:0007155	Process	Cell adhesion	IEA
GO:0007417	Process	Central nervous system development	TAS	1373175
GO:0009897	Component	External side of plasma membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0046718	Process	Symbiont entry into host cell	IEA
GO:0050852	Process	T cell receptor signaling pathway	IBA

MIM	HGNC	e!Ensembl
159465	7197	ENSG00000204655

Q16653

Protein name

Myelin-oligodendrocyte glycoprotein

Protein function

Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. ; (Microbial infection) A

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	36 → 145	Immunoglobulin V-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.

Sequence

MASLSRPSLPSCLCSFLLLLLLQVSSSYAGQFRVIGPRHPIRALVGDEVELPCRISPGKN
ATGMEVGWYRPPFSRVVHLYRNGKDQDGDQAPEYRGRTELLKDAIGEGKVTLRIRNVRFS
DEGGFTCFFRDHSYQEEAAMELKVEDPFYWVSPGVLVLLAVLPVLLLQITVGLIFLCLQY
RLRGKLRAEIENLHRTFDPHFLRVPCWKITLFVIVPVLGPLVALIICYNWLHRRLAGQFL
EELRNPF

Sequence length

247

Interactions

View interactions

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Narcolepsy 7	Pathogenic	rs387906655	RCV000022667

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
MOG-related disorder	Benign; Likely benign	rs2857766, rs370604035, rs3130253, rs537236203, rs34758289	RCV003974343 RCV003903889 RCV003984491 RCV003937297 RCV003979023

Show/Hide Text Mining Associations (27)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	24586351
Aphasia Conduction	Associate	34725263
Bipolar Disorder	Associate	25539505
Celiac Disease	Associate	31554915
Communicable Diseases	Associate	35990698
Demyelinating Autoimmune Diseases CNS	Associate	30825703
Demyelinating Diseases	Stimulate	29288492, 37370056
Demyelinating Diseases	Associate	29468668, 32430437, 34725263
Encephalitis	Associate	35990698
Encephalomyelitis	Associate	30847372
Encephalomyelitis Acute Disseminated	Associate	29468668
Focal cortical dysplasia of Taylor	Associate	34301297
Hyperlipoproteinemia Type II	Associate	28473662
Immunologic Deficiency Syndromes	Associate	33384291
Leukoencephalopathies	Associate	31691183
Multiple Sclerosis	Associate	12355425, 16295526, 16295528, 17573820, 21653833, 31228212, 9808202
Multiple Sclerosis	Inhibit	37192682
Multiple Sclerosis	Stimulate	37215118
Myelitis	Associate	37846133
Narcolepsy	Associate	25197808
Neoplasms Adipose Tissue	Associate	37676424
Neurodegenerative Diseases	Associate	24586351
Neuromyelitis Optica	Associate	24415568, 27788675, 27793206, 29468668, 30825703, 40103346
Obsessive Compulsive Disorder	Associate	33302097
Optic Neuritis	Associate	24415568, 28125740, 30055153, 30825703, 34272440, 36969199
Schizophrenia	Associate	22675524, 25539505
Spinal Cord Diseases	Associate	24415568

MOG (myelin oligodendrocyte glycoprotein)